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Summary Expression Phenotypes Gene Literature (77) GO Terms (6) Nucleotides (123) Proteins (58) Interactants (71) Wiki

Papers associated with p2rx4

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Dissection of P2X4 and P2X7 Receptor Current Components in BV-2 Microglia., Trang M, Schmalzing G, Müller CE, Markwardt F., Int J Mol Sci. November 11, 2020; 21 (22):   

Cross-Talk between P2X and NMDA Receptors., Rodriguez L, Yi C, Chu C, Duriez Q, Watanabe S, Ryu M, Reyes B, Asatryan L, Boué-Grabot E, Davies D., Int J Mol Sci. September 29, 2020; 21 (19):                           

Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity., Popova M, Rodriguez L, Trudell JR, Nguyen S, Bloomfield M, Davies DL, Asatryan L., Int J Mol Sci. April 2, 2020; 21 (7):             

Identification of aurintricarboxylic acid as a potent allosteric antagonist of P2X1 and P2X3 receptors., Obrecht AS, Urban N, Schaefer M, Röse A, Kless A, Meents JE, Lampert A, Abdelrahman A, Müller CE, Schmalzing G, Hausmann R., Neuropharmacology. November 1, 2019; 158 107749.

A challenge finding P2X1 and P2X4 ligands., Beswick P, Wahab B, Honey MA, Paradowski M, Jiang K, Lochner M, Murrell-Lagnado RD, Thompson AJ., Neuropharmacology. October 1, 2019; 157 107674.

Bile acids inhibit human purinergic receptor P2X4 in a heterologous expression system., Ilyaskin AV, Sure F, Nesterov V, Haerteis S, Korbmacher C., J Gen Physiol. June 3, 2019; 151 (6): 820-833.                    

Comparative Embryonic Spatio-Temporal Expression Profile Map of the Xenopus P2X Receptor Family., Blanchard C, Boué-Grabot E, Massé K., Front Cell Neurosci. January 1, 2019; 13 340.                    

Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region., Huo H, Fryatt AG, Farmer LK, Schmid R, Evans RJ., J Biol Chem. August 17, 2018; 293 (33): 12820-12831.                

Interaction of Purinergic P2X4 and P2X7 Receptor Subunits., Schneider M, Prudic K, Pippel A, Klapperstück M, Braam U, Müller CE, Schmalzing G, Markwardt F., Front Pharmacol. May 26, 2017; 8 860.                        

Structural insights into the nucleotide base specificity of P2X receptors., Kasuya G, Fujiwara Y, Tsukamoto H, Morinaga S, Ryu S, Touhara K, Ishitani R, Furutani Y, Hattori M, Nureki O., Sci Rep. March 23, 2017; 7 45208.            

Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder., Huynh N, Arabian N, Naito A, Louie S, Jakowec MW, Asatryan L, Davies DL., Neuropharmacology. February 1, 2017; 113 (Pt A): 60-70.

Two P2X1 receptor transcripts able to form functional channels are present in most human monocytes., López-López C, Jaramillo-Polanco J, Portales-Pérez DP, Gómez-Coronado KS, Rodríguez-Meléndez JG, Cortés-García JD, Espinosa-Luna R, Montaño LM, Barajas-López C., Eur J Pharmacol. December 15, 2016; 793 82-88.

Lidocaine preferentially inhibits the function of purinergic P2X7 receptors expressed in Xenopus oocytes., Okura D, Horishita T, Ueno S, Yanagihara N, Sudo Y, Uezono Y, Minami T, Kawasaki T, Sata T., Anesth Analg. March 1, 2015; 120 (3): 597-605.

Use of chimeras, point mutants, and molecular modeling to map the antagonist-binding site of 4,4',4″,4‴-(carbonylbis-(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakisbenzene-1,3-disulfonic acid (NF449) at P2X1 receptors for ATP., Farmer LK, Schmid R, Evans RJ., J Biol Chem. January 16, 2015; 290 (3): 1559-69.              

Basolateral P2X₄channels stimulate ENaC activity in Xenopus cortical collecting duct A6 cells., Thai TL, Yu L, Eaton DC, Duke BJ, Al-Khalili O, Lam HY, Ma H, Bao HF., Am J Physiol Renal Physiol. October 1, 2014; 307 (7): F806-13.

Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders., Asatryan L, Yardley MM, Khoja S, Trudell JR, Hyunh N, Louie SG, Petasis NA, Alkana RL, Davies DL., Int J Neuropsychopharmacol. June 1, 2014; 17 (6): 907-16.

Signal transmission within the P2X2 trimeric receptor., Keceli B, Kubo Y., J Gen Physiol. June 1, 2014; 143 (6): 761-82.                      

Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors., Popova M, Trudell J, Li K, Alkana R, Davies D, Asatryan L., Purinergic Signal. December 1, 2013; 9 (4): 621-32.

Conserved extracellular cysteines differentially regulate the potentiation produced by Zn2+ in rat P2X4 receptors., Li CY, Xiong KM, Wu YX, Liu YW, Chen L, Stewart RR, Peoples RW, Yi CL., Eur J Pharmacol. May 5, 2013; 707 (1-3): 11-6.

Salt bridge switching from Arg290/Glu167 to Arg290/ATP promotes the closed-to-open transition of the P2X2 receptor., Hausmann R, Günther J, Kless A, Kuhlmann D, Kassack MU, Bahrenberg G, Markwardt F, Schmalzing G., Mol Pharmacol. January 1, 2013; 83 (1): 73-84.

High Ca(2+) permeability of a peptide-gated DEG/ENaC from Hydra., Dürrnagel S, Falkenburger BH, Gründer S., J Gen Physiol. October 1, 2012; 140 (4): 391-402.                

[Characteristic and effect of cadmium on ATP-activated currents mediated by P2X4 receptors]., Zhang YQ, Zhang YQ, Tian WH, Peng F, Xu Z, Nie YL., Zhongguo Ying Yong Sheng Li Xue Za Zhi. September 1, 2012; 28 (5): 430-4.

Ivermectin reduces alcohol intake and preference in mice., Yardley MM, Wyatt L, Khoja S, Asatryan L, Ramaker MJ, Finn DA, Alkana RL, Huynh N, Louie SG, Petasis NA, Bortolato M, Davies DL., Neuropharmacology. August 1, 2012; 63 (2): 190-201.

Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor., Lörinczi É, Bhargava Y, Marino SF, Taly A, Kaczmarek-Hájek K, Barrantes-Freer A, Dutertre S, Grutter T, Rettinger J, Nicke A., Proc Natl Acad Sci U S A. July 10, 2012; 109 (28): 11396-401.

P2X4 receptor channels form large noncytolytic pores in resting and activated microglia., Bernier LP, Ase AR, Boué-Grabot E, Séguéla P., Glia. May 1, 2012; 60 (5): 728-37.

P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties., Compan V, Ulmann L, Stelmashenko O, Chemin J, Chaumont S, Rassendren F., J Neurosci. March 21, 2012; 32 (12): 4284-96.

Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel., Roberts JA, Allsopp RC, El Ajouz S, Vial C, Schmid R, Young MT, Evans RJ., Proc Natl Acad Sci U S A. March 20, 2012; 109 (12): 4663-7.

[Mg(2+) inhibits ATP-activated current mediated by rat P2X4 receptors expressed in Xenopus oocytes]., Peng F, Zhang YQ, Zhang YQ, Zeng Y, Zhou YL., Sheng Li Xue Bao. February 25, 2012; 64 (1): 75-81.

Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop., El-Ajouz S, Ray D, Allsopp RC, Evans RJ., Br J Pharmacol. January 1, 2012; 165 (2): 390-400.          

Covalent modification of mutant rat P2X2 receptors with a thiol-reactive fluorophore allows channel activation by zinc or acidic pH without ATP., Dellal SS, Hume RI., PLoS One. January 1, 2012; 7 (10): e47147.                    

Cloning and characterization of a P2X receptor expressed in the central nervous system of Lymnaea stagnalis., Bavan S, Straub VA, Webb TE, Ennion SJ., PLoS One. January 1, 2012; 7 (11): e50487.                

Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gating., Allsopp RC, El Ajouz S, Schmid R, Evans RJ., J Biol Chem. August 19, 2011; 286 (33): 29207-17.              

Cross-talk between P2X4 and gamma-aminobutyric acid, type A receptors determines synaptic efficacy at a central synapse., Jo YH, Donier E, Martinez A, Garret M, Toulmé E, Boué-Grabot E., J Biol Chem. June 3, 2011; 286 (22): 19993-20004.

Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor., Baqi Y, Hausmann R, Rosefort C, Rettinger J, Schmalzing G, Müller CE., J Med Chem. February 10, 2011; 54 (3): 817-30.

Purinergic receptor-mediated Ca signaling in the olfactory bulb and the neurogenic area of the lateral ventricles., Hassenklöver T, Schulz P, Peters A, Schwartz P, Schild D, Manzini I., Purinergic Signal. December 1, 2010; 6 (4): 429-45.                

Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors., Asatryan L, Popova M, Perkins D, Trudell JR, Alkana RL, Davies DL., J Pharmacol Exp Ther. September 1, 2010; 334 (3): 720-8.

Selective potentiation of homomeric P2X2 ionotropic ATP receptors by a fast non-genomic action of progesterone., De Roo M, Boué-Grabot E, Schlichter R., Neuropharmacology. March 1, 2010; 58 (3): 569-77.

A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors., Popova M, Asatryan L, Ostrovskaya O, Wyatt LR, Li K, Alkana RL, Davies DL., J Neurochem. January 1, 2010; 112 (1): 307-17.

Reactive oxygen species potentiate the P2X2 receptor activity through intracellular Cys430., Coddou C, Codocedo JF, Li S, Lillo JG, Acuña-Castillo C, Bull P, Stojilkovic SS, Huidobro-Toro JP., J Neurosci. September 30, 2009; 29 (39): 12284-91.

Neurosteroids differentially modulate P2X ATP-gated channels through non-genomic interactions., Codocedo JF, Rodríguez FE, Huidobro-Toro JP., J Neurochem. July 1, 2009; 110 (2): 734-44.

Conserved extracellular cysteines differentially regulate the inhibitory effect of ethanol in rat P2X4 receptors., Yi CL, Liu YW, Xiong KM, Stewart RR, Peoples RW, Tian X, Zhou L, Ai YX, Li ZW, Wang QW, Li CY., Biochem Biophys Res Commun. March 27, 2009; 381 (1): 102-6.

Homotrimeric complexes are the dominant assembly state of native P2X7 subunits., Nicke A., Biochem Biophys Res Commun. December 19, 2008; 377 (3): 803-8.

Phosphoinositides regulate P2X4 ATP-gated channels through direct interactions., Bernier LP, Ase AR, Chevallier S, Blais D, Zhao Q, Boué-Grabot E, Logothetis D, Séguéla P., J Neurosci. November 26, 2008; 28 (48): 12938-45.

Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors., Roberts JA, Digby HR, Kara M, El Ajouz S, Sutcliffe MJ, Evans RJ., J Biol Chem. July 18, 2008; 283 (29): 20126-36.                

Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition., Coddou C, Acuña-Castillo C, Bull P, Huidobro-Toro JP., J Biol Chem. December 21, 2007; 282 (51): 36879-86.

Basolateral P2X4-like receptors regulate the extracellular ATP-stimulated epithelial Na+ channel activity in renal epithelia., Zhang Y, Sanchez D, Gorelik J, Klenerman D, Lab M, Edwards C, Korchev Y., Am J Physiol Renal Physiol. June 1, 2007; 292 (6): F1734-40.

Differential effects of propofol and ethanol on P2X4 receptors expressed in Xenopus oocytes., Davies DL, Kuo ST, Alkana RL., Int Congr Ser. November 1, 2005; 1283 285-287.

Regulatory interdependence of cloned epithelial Na+ channels and P2X receptors., Wildman SS, Marks J, Churchill LJ, Peppiatt CM, Chraibi A, Shirley DG, Horisberger JD, King BF, Unwin RJ., J Am Soc Nephrol. September 1, 2005; 16 (9): 2586-97.

The mechanism by which ethanol inhibits rat P2X4 receptors is altered by mutation of histidine 241., Xiong K, Hu XQ, Stewart RR, Weight FF, Li C., Br J Pharmacol. July 1, 2005; 145 (5): 576-86.

Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels., Silberberg SD, Chang TH, Swartz KJ., J Gen Physiol. April 1, 2005; 125 (4): 347-59.                

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