Papers associated with tpx2

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	Requirement for Nudel and dynein for assembly of the lamin B spindle matrix., Ma L, Tsai MY, Wang S, Lu B, Chen R, Yates JR, Zhu X, Zheng Y., Nat Cell Biol. March 1, 2009; 11 (3): 247-56.
	Biochemical characterization of GSK1070916, a potent and selective inhibitor of Aurora B and Aurora C kinases with an extremely long residence time1., Anderson K, Lai Z, McDonald OB, Stuart JD, Nartey EN, Hardwicke MA, Newlander K, Dhanak D, Adams J, Patrick D, Copeland RA, Tummino PJ, Yang J., Biochem J. May 13, 2009; 420 (2): 259-65.
	Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly., Groen AC, Maresca TJ, Gatlin JC, Salmon ED, Mitchison TJ., Mol Biol Cell. June 1, 2009; 20 (11): 2766-73.
	Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A., Eckerdt F, Pascreau G, Phistry M, Lewellyn AL, DePaoli-Roach AA, Maller JL., Cell Cycle. August 1, 2009; 8 (15): 2413-9.
	Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B., Hans F, Skoufias DA, Dimitrov S, Margolis RL., Mol Biol Cell. August 1, 2009; 20 (15): 3491-502.
	ISWI is a RanGTP-dependent MAP required for chromosome segregation., Yokoyama H, Rybina S, Santarella-Mellwig R, Mattaj IW, Karsenti E., J Cell Biol. December 14, 2009; 187 (6): 813-29.
	Novel binding of the mitotic regulator TPX2 (target protein for Xenopus kinesin-like protein 2) to importin-alpha., Giesecke A, Stewart M., J Biol Chem. June 4, 2010; 285 (23): 17628-35.
	Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis., Bompard G, Rabeharivelo G, Frank M, Cau J, Delsert C, Morin N., J Cell Biol. September 6, 2010; 190 (5): 807-22.
	Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma., Li B, Qi XQ, Chen X, Huang X, Liu GY, Chen HR, Huang CG, Luo C, Lu YC., Dev Biol. September 17, 2010; 1352 200-7.
	Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation., Joukov V, De Nicolo A, Rodriguez A, Walter JC, Livingston DM., Proc Natl Acad Sci U S A. December 7, 2010; 107 (49): 21022-7.
	Microtubule assembly in meiotic extract requires glycogen., Groen AC, Coughlin M, Mitchison TJ., Mol Biol Cell. September 1, 2011; 22 (17): 3139-51.
	Structural basis of specific binding between Aurora A and TPX2 by molecular dynamics simulations., Cheng Y, Zhang F, Chen Q, Gao J, Cui W, Ji M, Tung CH., J Chem Inf Model. October 24, 2011; 51 (10): 2626-35.
	Functional analysis of the microtubule-interacting transcriptome., Sharp JA, Plant JJ, Ohsumi TK, Borowsky M, Blower MD., Mol Biol Cell. November 1, 2011; 22 (22): 4312-23.
	Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts., Halpin D, Kalab P, Wang J, Weis K, Heald R., PLoS Biol. December 1, 2011; 9 (12): e1001225.
	[Establishment of a targeting protein for Xenopus kinesin-like protein 2 C' terminal SBP-3 x Flag tagged HCT 116 colorectal cancer cell model]., Huang ZB, Zhang ZY, Zhang XD, Miao SY, Wang LF, Du RL., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. December 1, 2011; 33 (6): 624-8.
	Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic., Dodson CA, Bayliss R., J Biol Chem. January 6, 2012; 287 (2): 1150-7.
	A novel Aurora kinase A inhibitor MK-8745 predicts TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines., Chowdhury A, Chowdhury S, Tsai MY., Leuk Lymphoma. March 1, 2012; 53 (3): 462-71.
	A novel role for TPX2 as a scaffold and co-activator protein of the Chromosomal Passenger Complex., Iyer J, Tsai MY., Cell Signal. August 1, 2012; 24 (8): 1677-89.
	Crystal structure of human aurora B in complex with INCENP and VX-680., Elkins JM, Santaguida S, Musacchio A, Knapp S., J Med Chem. September 13, 2012; 55 (17): 7841-8.
	On the molecular mechanisms of mitotic kinase activation., Bayliss R, Fry A, Haq T, Yeoh S., Open Biol. November 1, 2012; 2 (11): 120136.
	Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation., Neumayer G, Helfricht A, Shim SY, Le HT, Lundin C, Belzil C, Chansard M, Yu Y, Lees-Miller SP, Gruss OJ, van Attikum H, Helleday T, Nguyen MD., J Biol Chem. December 7, 2012; 287 (50): 42206-22.
	Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2., Petry S, Groen AC, Ishihara K, Mitchison TJ, Vale RD., Cell. February 14, 2013; 152 (4): 768-77.
	Mitotic spindle scaling during Xenopus development by kif2a and importin α., Wilbur JD, Heald R., Elife. February 19, 2013; 2 e00290.
	The centriolar satellite protein SSX2IP promotes centrosome maturation., Bärenz F, Inoue D, Yokoyama H, Tegha-Dunghu J, Freiss S, Draeger S, Mayilo D, Cado I, Merker S, Klinger M, Hoeckendorf B, Pilz S, Hupfeld K, Steinbeisser H, Lorenz H, Ruppert T, Wittbrodt J, Gruss OJ., J Cell Biol. July 8, 2013; 202 (1): 81-95.
	The Prp19 complex directly functions in mitotic spindle assembly., Hofmann JC, Tegha-Dunghu J, Dräger S, Will CL, Lührmann R, Gruss OJ., PLoS One. September 3, 2013; 8 (9): e74851.
	Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration., Bernis C, Swift-Taylor B, Nord M, Carmona S, Chook YM, Forbes DJ., Mol Biol Cell. April 1, 2014; 25 (7): 992-1009.
	TPX2 regulates tumor growth in human cervical carcinoma cells., Jiang P, Shen K, Wang X, Song H, Yue Y, Liu T., Mol Med Rep. June 1, 2014; 9 (6): 2347-51.
	TPX2 overexpression in medullary thyroid carcinoma mediates TT cell proliferation., Yang X, Liu G, Xiao H, Yu F, Xiang X, Lu Y, Li W, Liu X, Li S, Shi Y., Pathol Oncol Res. July 1, 2014; 20 (3): 641-8.
	TPX2 knockdown suppressed hepatocellular carcinoma cell invasion via inactivating AKT signaling and inhibiting MMP2 and MMP9 expression., Liu Q, Yang P, Tu K, Zhang H, Zheng X, Yao Y, Liu Q., Chin J Cancer Res. August 1, 2014; 26 (4): 410-7.
	TPX2 levels modulate meiotic spindle size and architecture in Xenopus egg extracts., Helmke KJ, Heald R., J Cell Biol. August 4, 2014; 206 (3): 385-93.
	TPX2 is a prognostic marker and contributes to growth and metastasis of human hepatocellular carcinoma., Huang Y, Guo W, Kan H., Int J Mol Sci. October 9, 2014; 15 (10): 18148-61.
	Positive Surgical Margin, HPV Persistence, and Expression of Both TPX2 and PD-L1 Are Associated with Persistence/Recurrence of Cervical Intraepithelial Neoplasia after Cervical Conization., Zhang H, Zhang T, You Z, Zhang Y., PLoS One. January 1, 2015; 10 (12): e0142868.
	Purification of nuclear localization signal-containing proteins and its application to investigation of the mechanisms of the cell division cycle., Christodoulou A, Yokoyama H., Small GTPases. January 1, 2015; 6 (1): 20-7.
	Microtubule nucleation in mitosis by a RanGTP-dependent protein complex., Scrofani J, Sardon T, Meunier S, Vernos I., Curr Biol. January 19, 2015; 25 (2): 131-140.
	Phosphorylation of targeting protein for Xenopus kinesin-like protein 2 (TPX2) at threonine 72 in spindle assembly., Shim SY, Perez de Castro I, Neumayer G, Wang J, Park SK, Sanada K, Nguyen MD., J Biol Chem. April 3, 2015; 290 (14): 9122-34.
	The Ran-GTP gradient spatially regulates XCTK2 in the spindle., Weaver LN, Ems-McClung SC, Chen SH, Yang G, Shaw SL, Walczak CE., Curr Biol. June 1, 2015; 25 (11): 1509-14.
	Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly., Burgess SG, Peset I, Joseph N, Cavazza T, Vernos I, Pfuhl M, Gergely F, Bayliss R., PLoS Genet. July 1, 2015; 11 (7): e1005345.
	GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules., Wei JH, Zhang ZC, Wynn RM, Seemann J., Cell. July 16, 2015; 162 (2): 287-99.
	TPX2 as a novel prognostic biomarker for hepatocellular carcinoma., Liu Q, Tu K, Zhang H, Zheng X, Yao Y, Liu Q., Hepatol Res. August 1, 2015; 45 (8): 906-18.
	TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux., Fu J, Bian M, Xin G, Deng Z, Luo J, Guo X, Chen H, Wang Y, Jiang Q, Zhang C., J Cell Biol. August 3, 2015; 210 (3): 373-83.
	An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis., Meunier S, Shvedunova M, Van Nguyen N, Avila L, Vernos I, Akhtar A., Nat Commun. August 5, 2015; 6 7889.
	TPX2 promotes migration and invasion of human breast cancer cells., Yang Y, Li DP, Shen N, Yu XC, Li JB, Song Q, Zhang JH., Asian Pac J Trop Med. December 1, 2015; 8 (12): 1064-1070.
	FSH Regulates mRNA Translation in Mouse Oocytes and Promotes Developmental Competence., Franciosi F, Manandhar S, Conti M., Endocrinology. February 1, 2016; 157 (2): 872-82.
	A versatile multivariate image analysis pipeline reveals features of Xenopus extract spindles., Grenfell AW, Strzelecka M, Crowder ME, Helmke KJ, Schlaitz AL, Heald R., J Cell Biol. April 11, 2016; 213 (1): 127-36.
	Xenopus LAP2β protein knockdown affects location of lamin B and nucleoporins and has effect on assembly of cell nucleus and cell viability., Dubińska-Magiera M, Chmielewska M, Kozioł K, Machowska M, Hutchison CJ, Goldberg MW, Rzepecki R., Protoplasma. May 1, 2016; 253 (3): 943-956.
	TPX2 in human clear cell renal carcinoma: Expression, function and prognostic significance., Chen QI, Cao B, Nan N, Wang YU, Zhai XU, Li Y, Chong T., Oncol Lett. May 1, 2016; 11 (5): 3515-3521.
	Mitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus., Grenfell AW, Heald R, Strzelecka M., J Cell Biol. July 18, 2016; 214 (2): 133-41.
	Overexpressed targeting protein for Xklp2 (TPX2) serves as a promising prognostic marker and therapeutic target for gastric cancer., Liang B, Zheng W, Fang L, Wu L, Zhou F, Yin X, Yu X, Zou Z., Cancer Biol Ther. August 2, 2016; 17 (8): 824-32.
	The sequential activation of the mitotic microtubule assembly pathways favors bipolar spindle formation., Cavazza T, Malgaretti P, Vernos I., Mol Biol Cell. October 1, 2016; 27 (19): 2935-45.
	Expression of microtubule-associated protein TPX2 in human gastric carcinoma and its prognostic significance., Shao C, Duan C, Wang J, Luan S, Gao Y, Jin D, Wang D, Li Y, Xu L., Cancer Cell Int. October 10, 2016; 16 79.

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