???pagination.result.count???
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. , Lagna G, Hata A, Hemmati-Brivanlou A , Massagué J., Nature. October 31, 1996; 383 (6603): 832-6.
Cancer gets Mad: DPC4 and other TGFbeta pathway genes in human cancer. , Moskaluk CA, Kern SE., Biochim Biophys Acta. December 9, 1996; 1288 (3): M31-3.
Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway. , Nakao A, Röijer E, Imamura T, Souchelnytskyi S, Stenman G, Heldin CH, ten Dijke P., J Biol Chem. January 31, 1997; 272 (5): 2896-900.
The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function. , Zhang Y , Musci T , Derynck R., Curr Biol. April 1, 1997; 7 (4): 270-6.
Smad5 induces ventral fates in Xenopus embryo. , Suzuki A , Chang C , Yingling JM, Wang XF , Hemmati-Brivanlou A ., Dev Biol. April 15, 1997; 184 (2): 402-5.
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. , Hata A, Lo RS, Wotton D, Lagna G, Massagué J., Nature. July 3, 1997; 388 (6637): 82-7.
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. , Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P., EMBO J. September 1, 1997; 16 (17): 5353-62.
Smad4 and FAST-1 in the assembly of activin-responsive factor. , Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M ., Nature. September 4, 1997; 389 (6646): 85-9.
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. , Nakao A, Afrakhte M, Morén A, Nakayama T , Christian JL , Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P., Nature. October 9, 1997; 389 (6651): 631-5.
Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. , Candia AF , Watabe T, Hawley SH, Onichtchouk D, Zhang Y , Derynck R, Niehrs C , Cho KW ., Development. November 1, 1997; 124 (22): 4467-80.
Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase. , Chen Y , Bhushan A , Vale W., Proc Natl Acad Sci U S A. November 25, 1997; 94 (24): 12938-43.
Dual role of the Smad4/ DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. , Liu F, Pouponnot C, Massagué J., Genes Dev. December 1, 1997; 11 (23): 3157-67.
Smad6 inhibits BMP/ Smad1 signaling by specifically competing with the Smad4 tumor suppressor. , Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A ., Genes Dev. January 15, 1998; 12 (2): 186-97.
Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line. , Shimizu A, Kato M, Nakao A, Imamura T, ten Dijke P, Heldin CH, Kawabata M, Shimada S, Miyazono K., Genes Cells. February 1, 1998; 3 (2): 125-34.
Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells. , Zhou S, Buckhaults P, Zawel L, Bunz F, Riggins G, Dai JL, Kern SE, Kinzler KW, Vogelstein B., Proc Natl Acad Sci U S A. March 3, 1998; 95 (5): 2412-6.
Characterization of human FAST-1, a TGF beta and activin signal transducer. , Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B., Mol Cell. July 1, 1998; 2 (1): 121-7.
Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. , Labbé E, Silvestri C, Hoodless PA, Wrana JL, Attisano L., Mol Cell. July 1, 1998; 2 (1): 109-20.
Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. , Weinstein M, Yang X, Li C, Xu X, Gotay J, Deng CX., Proc Natl Acad Sci U S A. August 4, 1998; 95 (16): 9378-83.
Smad3 mutant mice develop metastatic colorectal cancer. , Zhu Y, Richardson JA, Parada LF, Graff JM ., Cell. September 18, 1998; 94 (6): 703-14.
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. , Macías-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL., J Biol Chem. October 2, 1998; 273 (40): 25628-36.
A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. , Weisberg E, Winnier GE, Chen X, Farnsworth CL, Hogan BL , Whitman M ., Mech Dev. December 1, 1998; 79 (1-2): 17-27.
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. , Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL., Cell. December 11, 1998; 95 (6): 779-91.
FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals. , Liu B, Dou CL, Prabhu L, Lai E ., Mol Cell Biol. January 1, 1999; 19 (1): 424-30.
Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3. , Yagi K, Goto D, Hamamoto T, Takenoshita S, Kato M, Miyazono K., J Biol Chem. January 8, 1999; 274 (2): 703-9.
Dominant-negative Smad2 mutants inhibit activin/ Vg1 signaling and disrupt axis formation in Xenopus. , Hoodless PA, Tsukazaki T, Nishimatsu S, Attisano L, Wrana JL, Thomsen GH ., Dev Biol. March 15, 1999; 207 (2): 364-79.
Identification of two Smad4 proteins in Xenopus. Their common and distinct properties. , Masuyama N, Hanafusa H , Kusakabe M , Shibuya H , Nishida E ., J Biol Chem. April 23, 1999; 274 (17): 12163-70.
Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals. , Christian JL , Nakayama T ., Bioessays. May 1, 1999; 21 (5): 382-90.
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. , Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH ., Nature. August 12, 1999; 400 (6745): 687-93.
The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis. , Yeo CY, Chen X, Whitman M ., J Biol Chem. September 10, 1999; 274 (37): 26584-90.
Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes. , Howell M, Itoh F, Pierreux CE, Valgeirsdottir S, Itoh S, ten Dijke P, Hill CS ., Dev Biol. October 15, 1999; 214 (2): 354-69.
Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding. , Nagarajan RP, Liu J , Chen Y ., J Biol Chem. October 29, 1999; 274 (44): 31229-35.
FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo. , Watanabe M, Whitman M ., Development. December 1, 1999; 126 (24): 5621-34.
Activation of Stat3 by cytokine receptor gp130 ventralizes Xenopus embryos independent of BMP-4. , Nishinakamura R, Matsumoto Y, Matsuda T, Ariizumi T, Heike T, Asashima M , Yokota T., Dev Biol. December 15, 1999; 216 (2): 481-90.
Left- right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. , Saijoh Y, Adachi H, Sakuma R, Yeo CY, Yashiro K, Watanabe M, Hashiguchi H, Mochida K, Ohishi S, Kawabata M, Miyazono K, Whitman M , Hamada H., Mol Cell. January 1, 2000; 5 (1): 35-47.
OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. , Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A , Massagué J., Cell. January 21, 2000; 100 (2): 229-40.
Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling. , Sirard C, Kim S, Mirtsos C, Tadich P, Hoodless PA, Itié A, Maxson R, Wrana JL, Mak TW., J Biol Chem. January 21, 2000; 275 (3): 2063-70.
Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. , Germain S, Howell M, Esslemont GM, Hill CS ., Genes Dev. February 15, 2000; 14 (4): 435-51.
Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. , Nishita M, Hashimoto MK, Ogata S, Laurent MN, Ueno N , Shibuya H , Cho KW ., Nature. February 17, 2000; 403 (6771): 781-5.
Cloning and characterization of zebrafish smad2, smad3 and smad4. , Dick A, Mayr T, Bauer H, Meier A, Hammerschmidt M., Gene. April 4, 2000; 246 (1-2): 69-80.
Heterogeneities in the biological and biochemical functions of Smad2 and Smad4 mutants naturally occurring in human lung cancers. , Yanagisawa K, Uchida K, Nagatake M, Masuda A, Sugiyama M, Saito T, Yamaki K, Takahashi T, Osada H., Oncogene. May 4, 2000; 19 (19): 2305-11.
Mouse smad8 phosphorylation downstream of BMP receptors ALK-2, ALK-3, and ALK-6 induces its association with Smad4 and transcriptional activity. , Kawai S, Faucheu C, Gallea S, Spinella-Jaegle S, Atfi A, Baron R, Roman SR., Biochem Biophys Res Commun. May 19, 2000; 271 (3): 682-7.
Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB. , Nagarajan RP, Chen F, Li W , Vig E, Harrington MA, Nakshatri H, Chen Y ., Biochem J. June 15, 2000; 348 Pt 3 591-6.
A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction. , Kim RH, Wang D, Tsang M , Martin J, Huff C, de Caestecker MP, Parks WT, Meng X, Lechleider RJ, Wang T, Roberts AB ., Genes Dev. July 1, 2000; 14 (13): 1605-16.
Smad1 and Smad4 are components of the bone morphogenetic protein-4 ( BMP-4)-induced transcription complex of the Xvent-2B promoter. , Henningfeld KA , Rastegar S, Adler G, Knöchel W ., J Biol Chem. July 21, 2000; 275 (29): 21827-35.
Structural basis for the functional difference between Smad2 and Smad3 in FAST-2 (forkhead activin signal transducer-2)-mediated transcription. , Nagarajan RP, Chen Y ., Biochem J. August 15, 2000; 350 Pt 1 253-9.
Identification and characterization of constitutively active Smad2 mutants: evaluation of formation of Smad complex and subcellular distribution. , Funaba M, Mathews LS., Mol Endocrinol. October 1, 2000; 14 (10): 1583-91.
Expression regulation of hyaluronan synthase in corneal endothelial cells. , Usui T, Amano S, Oshika T, Suzuki K, Miyata K, Araie M, Heldin P, Yamashita H., Invest Ophthalmol Vis Sci. October 1, 2000; 41 (11): 3261-7.
Recombinant expression and purification of smad proteins. , Funaba M, Mathews LS., Protein Expr Purif. December 1, 2000; 20 (3): 507-13.
Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus. , Pierreux CE, Nicolás FJ, Hill CS ., Mol Cell Biol. December 1, 2000; 20 (23): 9041-54.
Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. , Wang W, Mariani FV , Harland RM , Luo K., Proc Natl Acad Sci U S A. December 19, 2000; 97 (26): 14394-9.