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Summary Expression Phenotypes Gene Literature (168) GO Terms (13) Nucleotides (51) Proteins (32) Interactants (654) Wiki
XB-GENEPAGE-866804

Papers associated with slc12a3



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The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity., Tran U, Zakin L, Schweickert A, Agrawal R, Döger R, Blum M, De Robertis EM, Wessely O., Development. April 1, 2010; 137 (7): 1107-16.              


Xenopus development from late gastrulation to feeding tadpole in simulated microgravity., Olson WM, Wiens DJ, Gaul TL, Rodriguez M, Hauptmeier CL., Int J Dev Biol. January 1, 2010; 54 (1): 167-74.  


RHAMM mRNA expression in proliferating and migrating cells of the developing central nervous system., Casini P, Nardi I, Ori M., Gene Expr Patterns. January 1, 2010; 10 (2-3): 93-7.              


The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1., Agrawal R, Tran U, Wessely O., Development. December 1, 2009; 136 (23): 3927-36.              


Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway., Rozansky DJ, Cornwall T, Subramanya AR, Rogers S, Yang YF, David LL, Zhu X, Yang CL, Ellison DH., J Clin Invest. September 1, 2009; 119 (9): 2601-12.


Coexistence of normotensive primary aldosteronism in two patients with Gitelman's syndrome and novel thiazide-sensitive Na-Cl cotransporter mutations., Miao Z, Gao Y, Bindels RJ, Yu W, Lang Y, Chen N, Ren H, Sun F, Li Y, Wang X, Shao L., Eur J Endocrinol. August 1, 2009; 161 (2): 275-83.


WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction., Subramanya AR, Liu J, Ellison DH, Wade JB, Welling PA., J Biol Chem. July 3, 2009; 284 (27): 18471-80.


Renal and brain isoforms of WNK3 have opposite effects on NCCT expression., Glover M, Zuber AM, O'Shaughnessy KM., J Am Soc Nephrol. June 1, 2009; 20 (6): 1314-22.


Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway., San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G., Proc Natl Acad Sci U S A. March 17, 2009; 106 (11): 4384-9.


WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter., San-Cristobal P, Ponce-Coria J, Vázquez N, Bobadilla NA, Gamba G., Am J Physiol Renal Physiol. October 1, 2008; 295 (4): F1199-206.


Renal Na+-K+-Cl- cotransporter activity and vasopressin-induced trafficking are lipid raft-dependent., Welker P, Böhlick A, Mutig K, Salanova M, Kahl T, Schlüter H, Blottner D, Ponce-Coria J, Gamba G, Bachmann S., Am J Physiol Renal Physiol. September 1, 2008; 295 (3): F789-802.


Surface expression of epithelial Na channel protein in rat kidney., Frindt G, Ergonul Z, Palmer LG., J Gen Physiol. June 1, 2008; 131 (6): 617-27.                            


Cotransporters, WNKs and hypertension: an update., Flatman PW., Curr Opin Nephrol Hypertens. March 1, 2008; 17 (2): 186-92.


Organization of the pronephric kidney revealed by large-scale gene expression mapping., Raciti D, Reggiani L, Geffers L, Jiang Q, Bacchion F, Subrizi AE, Clements D, Tindal C, Davidson DR, Kaissling B, Brändli AW., Genome Biol. January 1, 2008; 9 (5): R84.                                                                        


Identification and gene expression of versican during early development of Xenopus., Casini P, Ori M, Avenoso A, D'Ascola A, Traina P, Mattina W, Perris R, Campo GM, Calatroni A, Nardi I, Campo S., Int J Dev Biol. January 1, 2008; 52 (7): 993-8.      


Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway., Ko B, Joshi LM, Cooke LL, Vazquez N, Musch MW, Hebert SC, Gamba G, Hoover RS., Proc Natl Acad Sci U S A. December 11, 2007; 104 (50): 20120-5.


The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex., Yang CL, Zhu X, Ellison DH., J Clin Invest. November 1, 2007; 117 (11): 3403-11.


Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families., Keszei AP, Tislér A, Backx PH, Andrulis IL, Bull SB, Logan AG., J Hypertens. October 1, 2007; 25 (10): 2074-81.


The prepattern transcription factor Irx3 directs nephron segment identity., Reggiani L, Raciti D, Airik R, Kispert A, Brändli AW., Genes Dev. September 15, 2007; 21 (18): 2358-70.                


Xenopus Bicaudal-C is required for the differentiation of the amphibian pronephros., Tran U, Pickney LM, Ozpolat BD, Wessely O., Dev Biol. July 1, 2007; 307 (1): 152-64.                  


WNK4 kinase is a negative regulator of K+-Cl- cotransporters., Garzón-Muvdi T, Pacheco-Alvarez D, Gagnon KB, Vázquez N, Ponce-Coria J, Moreno E, Delpire E, Gamba G., Am J Physiol Renal Physiol. April 1, 2007; 292 (4): F1197-207.


Transcriptional and functional analyses of SLC12A3 mutations: new clues for the pathogenesis of Gitelman syndrome., Riveira-Munoz E, Chang Q, Godefroid N, Hoenderop JG, Bindels RJ, Dahan K, Devuyst O, Belgian Network for Study of Gitelman Syndrome., J Am Soc Nephrol. April 1, 2007; 18 (4): 1271-83.


TSC-box is essential for the nuclear localization and antiproliferative effect of XTSC-22., Hashiguchi A, Hitachi K, Inui M, Okabayashi K, Asashima M., Dev Growth Differ. April 1, 2007; 49 (3): 197-204.


An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis., Ring AM, Leng Q, Rinehart J, Wilson FH, Kahle KT, Hebert SC, Lifton RP., Proc Natl Acad Sci U S A. March 6, 2007; 104 (10): 4025-9.


A novel gene, BENI is required for the convergent extension during Xenopus laevis gastrulation., Homma M, Inui M, Fukui A, Michiue T, Okabayashi K, Asashima M., Dev Biol. March 1, 2007; 303 (1): 270-80.          


WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4., Jiang Y, Ferguson WB, Peng JB., Am J Physiol Renal Physiol. February 1, 2007; 292 (2): F545-54.


Gene expression in Xenopus laevis embryos after Triadimefon exposure., Papis E, Bernardini G, Gornati R, Menegola E, Prati M., Gene Expr Patterns. January 1, 2007; 7 (1-2): 137-42.          


Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved., Golbang AP, Cope G, Hamad A, Murthy M, Liu CH, Cuthbert AW, O'shaughnessy KM., Am J Physiol Renal Physiol. December 1, 2006; 291 (6): F1369-76.


The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion., Pacheco-Alvarez D, Cristóbal PS, Meade P, Moreno E, Vazquez N, Muñoz E, Díaz A, Juárez ME, Giménez I, Gamba G., J Biol Chem. September 29, 2006; 281 (39): 28755-63.


Triadimefon causes branchial arch malformations in Xenopus laevis embryos., Papis E, Bernardini G, Gornati R, Prati M., Environ Sci Pollut Res Int. July 1, 2006; 13 (4): 251-5.


WNK1 affects surface expression of the ROMK potassium channel independent of WNK4., Cope G, Murthy M, Golbang AP, Hamad A, Liu CH, Cuthbert AW, O'Shaughnessy KM., J Am Soc Nephrol. July 1, 2006; 17 (7): 1867-74.


Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding., Moreno E, Cristóbal PS, Rivera M, Vázquez N, Bobadilla NA, Gamba G., J Biol Chem. June 23, 2006; 281 (25): 17266-75.


WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells., Cai H, Cebotaru V, Wang YH, Zhang XM, Cebotaru L, Guggino SE, Guggino WB., Kidney Int. June 1, 2006; 69 (12): 2162-70.


WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1)., Leng Q, Kahle KT, Rinehart J, MacGregor GG, Wilson FH, Canessa CM, Lifton RP, Hebert SC., J Physiol. March 1, 2006; 571 (Pt 2): 275-86.


Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform., Subramanya AR, Yang CL, Zhu X, Ellison DH., Am J Physiol Renal Physiol. March 1, 2006; 290 (3): F619-24.


WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway., de Los Heros P, Kahle KT, Rinehart J, Bobadilla NA, Vázquez N, San Cristobal P, Mount DB, Lifton RP, Hebert SC, Gamba G., Proc Natl Acad Sci U S A. February 7, 2006; 103 (6): 1976-81.


XHas2 activity is required during somitogenesis and precursor cell migration in Xenopus development., Ori M, Nardini M, Casini P, Perris R, Nardi I., Development. February 1, 2006; 133 (4): 631-40.                        


Hoxa2 knockdown in Xenopus results in hyoid to mandibular homeosis., Baltzinger M, Ori M, Pasqualetti M, Nardi I, Rijli FM., Dev Dyn. December 1, 2005; 234 (4): 858-67.          


WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis., Rinehart J, Kahle KT, de Los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP., Proc Natl Acad Sci U S A. November 15, 2005; 102 (46): 16777-82.


A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene., Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't Hoff W, Cuthbert A, O'Shaughnessy KM., Hypertension. August 1, 2005; 46 (2): 295-300.


Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells., Yang SS, Yamauchi K, Rai T, Hiyama A, Sohara E, Suzuki T, Itoh T, Suda S, Sasaki S, Uchida S., Biochem Biophys Res Commun. May 6, 2005; 330 (2): 410-4.        


WNK kinases and the control of blood pressure., Cope G, Golbang A, O'Shaughnessy KM., Pharmacol Ther. May 1, 2005; 106 (2): 221-31.


[WNK1 and WNK4, new players in salt and water homeostasis], Hadchouel J, Delaloy C, Jeunemaitre X., Med Sci (Paris). January 1, 2005; 21 (1): 55-60.


Role of TSC-22 during early embryogenesis in Xenopus laevis., Hashiguchi A, Okabayashi K, Asashima M., Dev Growth Differ. December 1, 2004; 46 (6): 535-44.                


Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease., Sabath E, Meade P, Berkman J, de los Heros P, Moreno E, Bobadilla NA, Vázquez N, Ellison DH, Gamba G., Am J Physiol Renal Physiol. August 1, 2004; 287 (2): F195-203.


Effects of chemical chaperones on partially retarded NaCl cotransporter mutants associated with Gitelman's syndrome in a mouse cortical collecting duct cell line., de Jong JC, Willems PH, Goossens M, Vandewalle A, van den Heuvel LP, Knoers NV, Bindels RJ., Nephrol Dial Transplant. May 1, 2004; 19 (5): 1069-76.


Regulated gene expression of hyaluronan synthases during Xenopus laevis development., Nardini M, Ori M, Vigetti D, Gornati R, Nardi I, Perris R., Gene Expr Patterns. May 1, 2004; 4 (3): 303-8.        


A single nucleotide polymorphism alters the activity of the renal Na+:Cl- cotransporter and reveals a role for transmembrane segment 4 in chloride and thiazide affinity., Moreno E, Tovar-Palacio C, de los Heros P, Guzmán B, Bobadilla NA, Vázquez N, Riccardi D, Poch E, Gamba G., J Biol Chem. April 16, 2004; 279 (16): 16553-60.


WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion., Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP., Nat Genet. December 1, 2003; 35 (4): 372-6.


The structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer., de Jong JC, Willems PH, Mooren FJ, van den Heuvel LP, Knoers NV, Bindels RJ., J Biol Chem. July 4, 2003; 278 (27): 24302-7.

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