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Summary Expression Phenotypes Gene Literature (168) GO Terms (13) Nucleotides (51) Proteins (32) Interactants (654) Wiki
XB-GENEPAGE-866804

Papers associated with slc12a3



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referenced by:

Thiosemicarbazide-induced osteolathyrism in metamorphosing Xenopus laevis., Newman SM, Dumont JN., J Exp Zool. March 1, 1983; 225 (3): 411-21.

The effects of thiosemicarbazide on development in the wood frog, Rana sylvatica. I. Concentration effects., Riley EE, Weil MR., Ecotoxicol Environ Saf. October 1, 1986; 12 (2): 154-60.

Comparative joint actions of semicarbazide and thiosemicarbazide on induction of malformations and osteolathyrism in mixtures with benzoic hydrazide., Dawson DA., Teratog Carcinog Mutagen. January 1, 1993; 13 (1): 23-33.

Expression of (Na, K) ATPase/Ca-ATPase chimeric proteins in Xenopus oocytes revealed that the COOH-terminal one-third of the (Na, K) ATPase alpha-subunit is involved in assembly with the beta-subunit., Morohashi M, Ueno S, Takeda K, Kawamura M., J UOEH. December 1, 1994; 16 (4): 277-86.

The sacral neural crest contributes neurons and glia to the post-umbilical gut: spatiotemporal analysis of the development of the enteric nervous system., Burns AJ, Douarin NM., Development. November 1, 1998; 125 (21): 4335-47.

cDNA cloning and distribution of the Xenopus follistatin-related protein., Okabayashi K, Shoji H, Onuma Y, Nakamura T, Nose K, Sugino H, Asashima M., Biochem Biophys Res Commun. January 8, 1999; 254 (1): 42-8.                  

Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction., Monroy A, Plata C, Hebert SC, Gamba G., Am J Physiol Renal Physiol. July 1, 2000; 279 (1): F161-9.

Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/beta-catenin signaling., Vallin J, Thuret R, Giacomello E, Faraldo MM, Thiery JP, Broders F., J Biol Chem. August 10, 2001; 276 (32): 30350-8.              

Interaction with grp58 increases activity of the thiazide-sensitive Na-Cl cotransporter., Wyse B, Ali N, Ellison DH., Am J Physiol Renal Physiol. March 1, 2002; 282 (3): F424-30.

Functional differences between flounder and rat thiazide-sensitive Na-Cl cotransporter., Vázquez N, Monroy A, Dorantes E, Muñoz-Clares RA, Gamba G., Am J Physiol Renal Physiol. April 1, 2002; 282 (4): F599-607.

Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells., Saitoh T, Mine T, Katoh M., Int J Oncol. May 1, 2002; 20 (5): 999-1003.

Functional expression of mutations in the human NaCl cotransporter: evidence for impaired routing mechanisms in Gitelman's syndrome., De Jong JC, Van Der Vliet WA, Van Den Heuvel LP, Willems PH, Knoers NV, Bindels RJ., J Am Soc Nephrol. June 1, 2002; 13 (6): 1442-8.

Biochemical and toxicological evaluation of agent-cofactor reactivity as a mechanism of action for osteolathyrism., Dawson DA, Rinaldi AC, Pöch G., Toxicology. August 15, 2002; 177 (2-3): 267-84.

Expression of voltage-dependent potassium channels in the developing visual system of Xenopus laevis., Pollock NS, Ferguson SC, McFarlane S., J Comp Neurol. October 28, 2002; 452 (4): 381-91.                

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4., Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP., Proc Natl Acad Sci U S A. January 21, 2003; 100 (2): 680-4.

N-Glycosylation at two sites critically alters thiazide binding and activity of the rat thiazide-sensitive Na(+):Cl(-) cotransporter., Hoover RS, Poch E, Monroy A, Vázquez N, Nishio T, Gamba G, Hebert SC., J Am Soc Nephrol. February 1, 2003; 14 (2): 271-82.

WNK kinases regulate thiazide-sensitive Na-Cl cotransport., Yang CL, Angell J, Mitchell R, Ellison DH., J Clin Invest. April 1, 2003; 111 (7): 1039-45.

The structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer., de Jong JC, Willems PH, Mooren FJ, van den Heuvel LP, Knoers NV, Bindels RJ., J Biol Chem. July 4, 2003; 278 (27): 24302-7.

WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion., Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP., Nat Genet. December 1, 2003; 35 (4): 372-6.

A single nucleotide polymorphism alters the activity of the renal Na+:Cl- cotransporter and reveals a role for transmembrane segment 4 in chloride and thiazide affinity., Moreno E, Tovar-Palacio C, de los Heros P, Guzmán B, Bobadilla NA, Vázquez N, Riccardi D, Poch E, Gamba G., J Biol Chem. April 16, 2004; 279 (16): 16553-60.

Effects of chemical chaperones on partially retarded NaCl cotransporter mutants associated with Gitelman's syndrome in a mouse cortical collecting duct cell line., de Jong JC, Willems PH, Goossens M, Vandewalle A, van den Heuvel LP, Knoers NV, Bindels RJ., Nephrol Dial Transplant. May 1, 2004; 19 (5): 1069-76.

Regulated gene expression of hyaluronan synthases during Xenopus laevis development., Nardini M, Ori M, Vigetti D, Gornati R, Nardi I, Perris R., Gene Expr Patterns. May 1, 2004; 4 (3): 303-8.        

Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease., Sabath E, Meade P, Berkman J, de los Heros P, Moreno E, Bobadilla NA, Vázquez N, Ellison DH, Gamba G., Am J Physiol Renal Physiol. August 1, 2004; 287 (2): F195-203.

Role of TSC-22 during early embryogenesis in Xenopus laevis., Hashiguchi A, Okabayashi K, Asashima M., Dev Growth Differ. December 1, 2004; 46 (6): 535-44.                

[WNK1 and WNK4, new players in salt and water homeostasis], Hadchouel J, Delaloy C, Jeunemaitre X., Med Sci (Paris). January 1, 2005; 21 (1): 55-60.

WNK kinases and the control of blood pressure., Cope G, Golbang A, O'Shaughnessy KM., Pharmacol Ther. May 1, 2005; 106 (2): 221-31.

Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells., Yang SS, Yamauchi K, Rai T, Hiyama A, Sohara E, Suzuki T, Itoh T, Suda S, Sasaki S, Uchida S., Biochem Biophys Res Commun. May 6, 2005; 330 (2): 410-4.        

A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene., Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't Hoff W, Cuthbert A, O'Shaughnessy KM., Hypertension. August 1, 2005; 46 (2): 295-300.

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis., Rinehart J, Kahle KT, de Los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP., Proc Natl Acad Sci U S A. November 15, 2005; 102 (46): 16777-82.

Hoxa2 knockdown in Xenopus results in hyoid to mandibular homeosis., Baltzinger M, Ori M, Pasqualetti M, Nardi I, Rijli FM., Dev Dyn. December 1, 2005; 234 (4): 858-67.          

XHas2 activity is required during somitogenesis and precursor cell migration in Xenopus development., Ori M, Nardini M, Casini P, Perris R, Nardi I., Development. February 1, 2006; 133 (4): 631-40.                        

WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway., de Los Heros P, Kahle KT, Rinehart J, Bobadilla NA, Vázquez N, San Cristobal P, Mount DB, Lifton RP, Hebert SC, Gamba G., Proc Natl Acad Sci U S A. February 7, 2006; 103 (6): 1976-81.

WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1)., Leng Q, Kahle KT, Rinehart J, MacGregor GG, Wilson FH, Canessa CM, Lifton RP, Hebert SC., J Physiol. March 1, 2006; 571 (Pt 2): 275-86.

Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform., Subramanya AR, Yang CL, Zhu X, Ellison DH., Am J Physiol Renal Physiol. March 1, 2006; 290 (3): F619-24.

WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells., Cai H, Cebotaru V, Wang YH, Zhang XM, Cebotaru L, Guggino SE, Guggino WB., Kidney Int. June 1, 2006; 69 (12): 2162-70.

Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding., Moreno E, Cristóbal PS, Rivera M, Vázquez N, Bobadilla NA, Gamba G., J Biol Chem. June 23, 2006; 281 (25): 17266-75.

Triadimefon causes branchial arch malformations in Xenopus laevis embryos., Papis E, Bernardini G, Gornati R, Prati M., Environ Sci Pollut Res Int. July 1, 2006; 13 (4): 251-5.

WNK1 affects surface expression of the ROMK potassium channel independent of WNK4., Cope G, Murthy M, Golbang AP, Hamad A, Liu CH, Cuthbert AW, O'Shaughnessy KM., J Am Soc Nephrol. July 1, 2006; 17 (7): 1867-74.

The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion., Pacheco-Alvarez D, Cristóbal PS, Meade P, Moreno E, Vazquez N, Muñoz E, Díaz A, Juárez ME, Giménez I, Gamba G., J Biol Chem. September 29, 2006; 281 (39): 28755-63.

Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved., Golbang AP, Cope G, Hamad A, Murthy M, Liu CH, Cuthbert AW, O'shaughnessy KM., Am J Physiol Renal Physiol. December 1, 2006; 291 (6): F1369-76.

Gene expression in Xenopus laevis embryos after Triadimefon exposure., Papis E, Bernardini G, Gornati R, Menegola E, Prati M., Gene Expr Patterns. January 1, 2007; 7 (1-2): 137-42.          

WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4., Jiang Y, Ferguson WB, Peng JB., Am J Physiol Renal Physiol. February 1, 2007; 292 (2): F545-54.

A novel gene, BENI is required for the convergent extension during Xenopus laevis gastrulation., Homma M, Inui M, Fukui A, Michiue T, Okabayashi K, Asashima M., Dev Biol. March 1, 2007; 303 (1): 270-80.          

An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis., Ring AM, Leng Q, Rinehart J, Wilson FH, Kahle KT, Hebert SC, Lifton RP., Proc Natl Acad Sci U S A. March 6, 2007; 104 (10): 4025-9.

WNK4 kinase is a negative regulator of K+-Cl- cotransporters., Garzón-Muvdi T, Pacheco-Alvarez D, Gagnon KB, Vázquez N, Ponce-Coria J, Moreno E, Delpire E, Gamba G., Am J Physiol Renal Physiol. April 1, 2007; 292 (4): F1197-207.

Transcriptional and functional analyses of SLC12A3 mutations: new clues for the pathogenesis of Gitelman syndrome., Riveira-Munoz E, Chang Q, Godefroid N, Hoenderop JG, Bindels RJ, Dahan K, Devuyst O, Belgian Network for Study of Gitelman Syndrome., J Am Soc Nephrol. April 1, 2007; 18 (4): 1271-83.

TSC-box is essential for the nuclear localization and antiproliferative effect of XTSC-22., Hashiguchi A, Hitachi K, Inui M, Okabayashi K, Asashima M., Dev Growth Differ. April 1, 2007; 49 (3): 197-204.

Xenopus Bicaudal-C is required for the differentiation of the amphibian pronephros., Tran U, Pickney LM, Ozpolat BD, Wessely O., Dev Biol. July 1, 2007; 307 (1): 152-64.                  

The prepattern transcription factor Irx3 directs nephron segment identity., Reggiani L, Raciti D, Airik R, Kispert A, Brändli AW., Genes Dev. September 15, 2007; 21 (18): 2358-70.                

Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families., Keszei AP, Tislér A, Backx PH, Andrulis IL, Bull SB, Logan AG., J Hypertens. October 1, 2007; 25 (10): 2074-81.

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