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Summary Expression Phenotypes Gene Literature (31) GO Terms (2) Nucleotides (199) Proteins (42) Interactants (46) Wiki
XB-GENEPAGE-5758111

Papers associated with prss8



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An epithelial serine protease activates the amiloride-sensitive sodium channel., Vallet V, Chraibi A, Gaeggeler HP, Horisberger JD, Rossier BC., Nature. October 9, 1997; 389 (6651): 607-10.

Dome formation and tubule morphogenesis by Xenopus kidney A6 cell cultures exposed to microgravity simulated with a 3D-clinostat and to hypergravity., Ichigi J, Asashima M., In Vitro Cell Dev Biol Anim. January 1, 2001; 37 (1): 31-44.

Activation of epithelial sodium channels by prostasin in Xenopus oocytes., Adachi M, Kitamura K, Miyoshi T, Narikiyo T, Iwashita K, Shiraishi N, Nonoguchi H, Tomita K., J Am Soc Nephrol. June 1, 2001; 12 (6): 1114-1121.

Regulation of prostasin by aldosterone in the kidney., Narikiyo T, Kitamura K, Adachi M, Miyoshi T, Iwashita K, Shiraishi N, Nonoguchi H, Chen LM, Chai KX, Chao J, Tomita K., J Clin Invest. February 1, 2002; 109 (3): 401-8.

Regulation of the epithelial sodium channel by serine proteases in human airways., Donaldson SH, Hirsh A, Li DC, Holloway G, Chao J, Boucher RC, Gabriel SE., J Biol Chem. March 8, 2002; 277 (10): 8338-45.

CAP1 expression is developmentally regulated in Xenopus., KhosrowShahian F, Hubberstey AV, Crawford MJ., Mech Dev. May 1, 2002; 113 (2): 211-4.    

Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus Oocytes., Vuagniaux G, Vallet V, Jaeger NF, Hummler E, Rossier BC., J Gen Physiol. August 1, 2002; 120 (2): 191-201.          

Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line., Tong Z, Illek B, Bhagwandin VJ, Verghese GM, Caughey GH., Am J Physiol Lung Cell Mol Physiol. November 1, 2004; 287 (5): L928-35.

Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching., Gardiner MR, Daggett DF, Zon LI, Perkins AC., Dev Dyn. December 1, 2005; 234 (4): 992-6.

Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone., Wakida N, Kitamura K, Tuyen DG, Maekawa A, Miyoshi T, Adachi M, Shiraishi N, Ko T, Ha V, Nonoguchi H, Tomita K., Kidney Int. October 1, 2006; 70 (8): 1432-8.

Regulation of the epithelial Na+ channel by peptidases., Planès C, Caughey GH., Curr Top Dev Biol. January 1, 2007; 78 23-46.

A novel neutrophil elastase inhibitor prevents elastase activation and surface cleavage of the epithelial sodium channel expressed in Xenopus laevis oocytes., Harris M, Firsov D, Vuagniaux G, Stutts MJ, Rossier BC., J Biol Chem. January 5, 2007; 282 (1): 58-64.

Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit., Bruns JB, Carattino MD, Sheng S, Maarouf AB, Weisz OA, Pilewski JM, Hughey RP, Kleyman TR., J Biol Chem. March 2, 2007; 282 (9): 6153-60.

Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation., Carattino MD, Hughey RP, Kleyman TR., J Biol Chem. September 12, 2008; 283 (37): 25290-25295.

Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels., Diakov A, Bera K, Mokrushina M, Krueger B, Korbmacher C., J Physiol. October 1, 2008; 586 (19): 4587-608.

Plasmin activates epithelial Na+ channels by cleaving the gamma subunit., Passero CJ, Mueller GM, Rondon-Berrios H, Tofovic SP, Hughey RP, Kleyman TR., J Biol Chem. December 26, 2008; 283 (52): 36586-91.

Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel., Passero CJ, Carattino MD, Kashlan OB, Myerburg MM, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. October 1, 2010; 299 (4): F854-61.

TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site., Passero CJ, Mueller GM, Myerburg MM, Carattino MD, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. January 1, 2012; 302 (1): F1-8.

Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity., Frateschi S, Keppner A, Malsure S, Iwaszkiewicz J, Sergi C, Merillat AM, Fowler-Jaeger N, Randrianarison N, Planès C, Hummler E., Am J Pathol. August 1, 2012; 181 (2): 605-15.

Tissue kallikrein activation of the epithelial Na channel., Patel AB, Chao J, Palmer LG., Am J Physiol Renal Physiol. August 15, 2012; 303 (4): F540-50.

Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel., Haerteis S, Krappitz M, Diakov A, Krappitz A, Rauh R, Korbmacher C., J Gen Physiol. October 1, 2012; 140 (4): 375-89.                      

Plasma membrane events associated with the meiotic divisions in the amphibian oocyte: insights into the evolution of insulin transduction systems and cell signaling., Morrill GA, Kostellow AB, Moore RD, Gupta RK., BMC Dev Biol. January 23, 2013; 13 3.              

Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea., Faller N, Gautschi I, Schild L., PLoS One. January 1, 2014; 9 (4): e94267.            

Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites., Haerteis S, Krappitz A, Krappitz M, Murphy JE, Bertog M, Krueger B, Nacken R, Chung H, Hollenberg MD, Knecht W, Bunnett NW, Korbmacher C., J Biol Chem. July 4, 2014; 289 (27): 19067-78.

Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second protease., Carattino MD, Mueller GM, Palmer LG, Frindt G, Rued AC, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. November 1, 2014; 307 (9): F1080-7.

Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures., Tan CD, Hobbs C, Sameni M, Sloane BF, Stutts MJ, Tarran R., J Physiol. December 1, 2014; 592 (23): 5251-68.

Sodium channel Nax is a regulator in epithelial sodium homeostasis., Xu W, Hong SJ, Zhong A, Xie P, Jia S, Xie Z, Zeitchek M, Niknam-Bienia S, Zhao J, Porterfield DM, Surmeier DJ, Leung KP, Galiano RD, Mustoe TA., Sci Transl Med. November 4, 2015; 7 (312): 312ra177.

Plasma kallikrein activates the epithelial sodium channel in vitro but is not essential for volume retention in nephrotic mice., Haerteis S, Schork A, Dörffel T, Bohnert BN, Nacken R, Wörn M, Xiao M, Essigke D, Janessa A, Schmaier AH, Feener EP, Häring HU, Bertog M, Korbmacher C, Artunc F., Acta Physiol (Oxf). September 1, 2018; 224 (1): e13060.

Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice., Essigke D, Ilyaskin AV, Wörn M, Bohnert BN, Xiao M, Daniel C, Amann K, Birkenfeld AL, Szabo R, Bugge TH, Korbmacher C, Artunc F., Acta Physiol (Oxf). May 1, 2021; 232 (1): e13640.

Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice., Artunc F, Bohnert BN, Schneider JC, Staudner T, Sure F, Ilyaskin AV, Wörn M, Essigke D, Janessa A, Nielsen NV, Birkenfeld AL, Etscheid M, Haerteis S, Korbmacher C, Kanse SM., Pflugers Arch. February 1, 2022; 474 (2): 217-229.

Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel's γ-subunit., Sure F, Bertog M, Afonso S, Diakov A, Rinke R, Madej MG, Wittmann S, Gramberg T, Korbmacher C, Ilyaskin AV., J Biol Chem. June 1, 2022; 298 (6): 102004.                                        

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