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Summary Expression Phenotypes Gene Literature (96) GO Terms (5) Nucleotides (93) Proteins (44) Interactants (546) Wiki
XB-GENEPAGE-998105

Papers associated with pik3ca



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Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by phosphatidylinositol 3-kinase., Symes K, Mercola M., Proc Natl Acad Sci U S A. September 3, 1996; 93 (18): 9641-4.

Wortmannin, an inhibitor of phosphatidyl-inositol 3-kinase, induces oocyte maturation through a MPF-MAPK-dependent pathway., Carnero A, Lacal JC., FEBS Lett. January 30, 1998; 422 (2): 155-9.

alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase., Yoshii S, Tanaka M, Otsuki Y, Wang DY, Guo RJ, Zhu Y, Takeda R, Hanai H, Kaneko E, Sugimura H., Oncogene. October 7, 1999; 18 (41): 5680-90.

An ATM homologue from Arabidopsis thaliana: complete genomic organisation and expression analysis., Garcia V, Salanoubat M, Choisne N, Tissier A., Nucleic Acids Res. April 15, 2000; 28 (8): 1692-9.  

Phosphatidylinositol-3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction., Carballada R, Yasuo H, Lemaire P., Development. January 1, 2001; 128 (1): 35-44.            

SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport., Wang J, Barbry P, Maiyar AC, Rozansky DJ, Bhargava A, Leong M, Firestone GL, Pearce D., Am J Physiol Renal Physiol. February 1, 2001; 280 (2): F303-13.

Transduction cascades initiated by fibroblast growth factor 1 on Xenopus oocytes expressing MDA-MB-231 mRNAs. Role of Grb2, phosphatidylinositol 3-kinase, Src tyrosine kinase, and phospholipase Cgamma., Browaeys-Poly E, Cailliau K, Vilain JP., Cell Signal. May 1, 2001; 13 (5): 363-8.

The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes., Bagowski CP, Myers JW, Ferrell JE., J Biol Chem. October 5, 2001; 276 (40): 37708-14.

Phosphoinositide 3-kinase-gamma induces Xenopus oocyte maturation via lipid kinase activity., Hehl S, Stoyanov B, Oehrl W, Schönherr R, Wetzker R, Heinemann SH., Biochem J. December 15, 2001; 360 (Pt 3): 691-8.

Hypotonic induction of SGK1 and Na+ transport in A6 cells., Rozansky DJ, Wang J, Doan N, Purdy T, Faulk T, Bhargava A, Dawson K, Pearce D., Am J Physiol Renal Physiol. July 1, 2002; 283 (1): F105-13.

The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase., Do SH, Fang HY, Ham BM, Zuo Z., Anesth Analg. November 1, 2002; 95 (5): 1263-8, table of contents.

SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion., Schmidt MHH, Chen B, Randazzo LM, Bogler O., J Cell Sci. July 15, 2003; 116 (Pt 14): 2845-55.

Inhibition of lysophosphatidic acid acyltransferase beta disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells., Coon M, Ball A, Pound J, Ap S, Hollenback D, White T, Tulinsky J, Bonham L, Morrison DK, Finney R, Singer JW., Mol Cancer Ther. October 1, 2003; 2 (10): 1067-78.

Phosphatidylinositol 3-kinase signaling is involved in neurogenesis during Xenopus embryonic development., Peng Y, Jiang BH, Yang PH, Cao Z, Shi X, Lin MC, He ML, Kung HF., J Biol Chem. July 2, 2004; 279 (27): 28509-14.

The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1., Kinsella JM, Laidlaw HA, Tang T, Harvey J, Sutherland C, Ashford ML., BMC Pharmacol. August 24, 2004; 4 17.            

Carbamazepine enhances the activity of glutamate transporter type 3 via phosphatidylinositol 3-kinase., Lee G, Huang Y, Washington JM, Briggs NW, Zuo Z., Epilepsy Res. January 1, 2005; 66 (1-3): 145-53.

Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma., Voigt P, Brock C, Nürnberg B, Schaefer M., J Biol Chem. February 11, 2005; 280 (6): 5121-7.

Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3., Strutz-Seebohm N, Seebohm G, Mack AF, Wagner HJ, Just L, Skutella T, Lang UE, Henke G, Striegel M, Hollmann M, Rouach N, Nicoll RA, McCormick JA, Wang J, Pearce D, Lang F., J Physiol. June 1, 2005; 565 (Pt 2): 381-90.

Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis., Van Stry M, Kazlauskas A, Schreiber SL, Symes K., Proc Natl Acad Sci U S A. June 7, 2005; 102 (23): 8233-8.          

Agrin regulates growth cone turning of Xenopus spinal motoneurons., Xu X, Fu AK, Ip FC, Wu CP, Duan S, Poo MM, Yuan XB, Ip NY., Development. October 1, 2005; 132 (19): 4309-16.

Anaesthetic sensitivity of fMLP-induced cell signalling in Xenopus oocytes., Wittmann S, Fröhlich D, Mietens A, Daniels S., Int Immunopharmacol. January 1, 2006; 6 (1): 61-70.

Hormonal regulation of the epithelial Na+ channel: from amphibians to mammals., Shane MA, Nofziger C, Blazer-Yost BL., Gen Comp Endocrinol. May 15, 2006; 147 (1): 85-92.

Deciphering the H-Ras pathway in Xenopus oocyte., Gaffré M, Dupré A, Valuckaite R, Suziedelis K, Jessus C, Haccard O., Oncogene. August 24, 2006; 25 (37): 5155-62.

Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development., Wu J, O'Donnell M, Gitler AD, Klein PS., Development. September 1, 2006; 133 (18): 3651-60.          

The endocrine-disrupting compound, nonylphenol, inhibits neurotrophin-dependent neurite outgrowth., Bevan CL, Porter DM, Schumann CR, Bryleva EY, Hendershot TJ, Liu H, Howard MJ, Henderson LP., Endocrinology. September 1, 2006; 147 (9): 4192-204.

Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides., Fujiwara Y, Kubo Y., J Physiol. October 1, 2006; 576 (Pt 1): 135-49.

Glial cell line-derived neurotrophic factor-mediated enteric neuronal survival involves glycogen synthase kinase-3beta phosphorylation and coupling with 14-3-3., Mwangi S, Anitha M, Fu H, Sitaraman SV, Srinivasan S., Neuroscience. November 17, 2006; 143 (1): 241-51.

Mutations in the inter-SH2 domain of the regulatory subunit of phosphoinositide 3-kinase: effects on catalytic subunit binding and holoenzyme function., Elis W, Lessmann E, Oelgeschlager M, Huber M., Biol Chem. December 1, 2006; 387 (12): 1567-73.

Regulation of human cone cyclic nucleotide-gated channels by endogenous phospholipids and exogenously applied phosphatidylinositol 3,4,5-trisphosphate., Bright SR, Rich ED, Varnum MD., Mol Pharmacol. January 1, 2007; 71 (1): 176-83.

PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation., Nie S, Chang C., Mech Dev. January 1, 2007; 124 (9-10): 657-67.                    

PP2A:B56epsilon is required for eye induction and eye field separation., Rorick AM, Mei W, Liette NL, Phiel C, El-Hodiri HM, Yang J., Dev Biol. February 15, 2007; 302 (2): 477-93.                  

Transgenic Xenopus with prx1 limb enhancer reveals crucial contribution of MEK/ERK and PI3K/AKT pathways in blastema formation during limb regeneration., Suzuki M, Satoh A, Ide H, Tamura K, Tamura K., Dev Biol. April 15, 2007; 304 (2): 675-86.              

Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4., Jeyaraj S, Boehmer C, Lang F, Palmada M., Biochem Biophys Res Commun. May 11, 2007; 356 (3): 629-35.

Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinases., Taruno A, Niisato N, Marunaka Y., Am J Physiol Renal Physiol. July 1, 2007; 293 (1): F128-38.

Ethanol increases the activity of rat excitatory amino acid transporter type 4 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase., Park HY, Kim JH, Zuo Z, Do SH., Alcohol Clin Exp Res. February 1, 2008; 32 (2): 348-54.

Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal., Yang PH, Cheung WK, Peng Y, He ML, Wu GQ, Xie D, Jiang BH, Huang QH, Chen Z, Lin MC, Kung HF., J Biol Chem. March 28, 2008; 283 (13): 8486-95.

Intracellular signal transduction by the extracellular calcium-sensing receptor of Xenopus melanotrope cells., van den Hurk MJ, Cruijsen PM, Schoeber JP, Scheenen WJ, Roubos EW, Jenks BG., Gen Comp Endocrinol. June 1, 2008; 157 (2): 156-64.

Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositides., Li G, Rajala A, Wiechmann AF, Anderson RE, Rajala RV., J Neurochem. December 1, 2008; 107 (5): 1382-97.

TGF-beta induces connexin43 gene expression in normal murine mammary gland epithelial cells via activation of p38 and PI3K/AKT signaling pathways., Tacheau C, Fontaine J, Loy J, Mauviel A, Verrecchia F., J Cell Physiol. December 1, 2008; 217 (3): 759-68.

Alphaxalone, a neurosteroid anaesthetic, increases the activity of the glutamate transporter type 3 expressed in Xenopus oocytes., Ryu J, Cheong IY, Do SH, Zuo Z., Eur J Pharmacol. January 5, 2009; 602 (1): 23-7.

Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors., Mo G, Bernier LP, Zhao Q, Chabot-Doré AJ, Ase AR, Logothetis D, Cao CQ, Séguéla P., Mol Pain. August 11, 2009; 5 47.            

Intein-mediated site-specific conjugation of Quantum Dots to proteins in vivo., Charalambous A, Andreou M, Skourides PA., J Nanobiotechnology. December 10, 2009; 7 9.        

E3 ligase Nedd4 promotes axon branching by downregulating PTEN., Drinjakovic J, Jung H, Campbell DS, Strochlic L, Dwivedy A, Holt CE., Neuron. February 11, 2010; 65 (3): 341-57.                  

Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo., Jean S, Mikryukov A, Tremblay MG, Baril J, Guillou F, Bellenfant S, Moss T., Dev Cell. September 14, 2010; 19 (3): 426-39.              

Corticosterone decreases the activity of rat glutamate transporter type 3 expressed in Xenopus oocytes., Kang M, Ryu J, Kim JH, Na H, Zuo Z, Do SH., Steroids. December 12, 2010; 75 (13-14): 1113-8.

Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation., Je HS, Ji Y, Wang Y, Yang F, Wu W, Lu B., Mol Brain. January 7, 2011; 4 1.        

The kinase SGK1 in the endoderm and mesoderm promotes ectodermal survival by down-regulating components of the death-inducing signaling complex., Endo T, Kusakabe M, Sunadome K, Yamamoto T, Nishida E., Sci Signal. January 18, 2011; 4 (156): ra2.

A new in vitro system for activating the cell cycle checkpoint., Wang J, Engle S, Zhang Y, Zhang Y., Cell Cycle. February 1, 2011; 10 (3): 500-6.

IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition., Walsh LA, Damjanovski S., Cell Commun Signal. May 2, 2011; 9 (1): 10.            

Hydrogen peroxide stimulates the epithelial sodium channel through a phosphatidylinositide 3-kinase-dependent pathway., Ma HP., J Biol Chem. September 16, 2011; 286 (37): 32444-53.

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