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FoxO genes are dispensable during gastrulation but required for late embryogenesis in Xenopus laevis. , Schuff M, Siegel D , Bardine N, Oswald F, Donow C, Knöchel W ., Dev Biol. January 15, 2010; 337 (2): 259-73.
Neural ectoderm-secreted FGF initiates the expression of Nkx2.5 in cardiac progenitors via a p38 MAPK/ CREB pathway. , Keren-Politansky A, Keren A, Bengal E ., Dev Biol. November 15, 2009; 335 (2): 374-84.
Early activation of FGF and nodal pathways mediates cardiac specification independently of Wnt/beta-catenin signaling. , Samuel LJ, Latinkić BV., PLoS One. October 28, 2009; 4 (10): e7650.
Retinoic acid regulates anterior- posterior patterning within the lateral plate mesoderm of Xenopus. , Deimling SJ, Drysdale TA ., Mech Dev. October 1, 2009; 126 (10): 913-23.
NFAT directly regulates Nkx2-5 transcription during cardiac cell differentiation. , Chen Y , Chen Y , Cao X ., Biol Cell. June 1, 2009; 101 (6): 335-49.
The role of the visceral mesoderm in the development of the gastrointestinal tract. , McLin VA , Henning SJ, Jamrich M ., Gastroenterology. June 1, 2009; 136 (7): 2074-91.
Mitochondria and calcium signaling in embryonic development. , Cao X , Chen Y ., Semin Cell Dev Biol. May 1, 2009; 20 (3): 337-45.
Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5. , Espinoza-Lewis RA, Yu L, He F, Liu H , Tang R, Shi J, Sun X, Martin JF, Wang D, Yang J , Chen Y ., Dev Biol. March 15, 2009; 327 (2): 376-85.
Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. , Li Y, Rankin SA , Rankin SA , Sinner D , Kenny AP , Krieg PA , Zorn AM ., Genes Dev. November 1, 2008; 22 (21): 3050-63.
Cardiac differentiation in Xenopus requires the cyclin-dependent kinase inhibitor, p27Xic1. , Movassagh M, Philpott A ., Cardiovasc Res. August 1, 2008; 79 (3): 436-47.
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. , Zhu W, Shiojima I, Ito Y , Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M , Komuro I., Nature. July 17, 2008; 454 (7202): 345-9.
XHAPLN3 plays a key role in cardiogenesis by maintaining the hyaluronan matrix around heart anlage. , Ito Y , Seno S, Nakamura H, Fukui A , Asashima M ., Dev Biol. July 1, 2008; 319 (1): 34-45.
A crucial role of a high mobility group protein HMGA2 in cardiogenesis. , Monzen K, Ito Y , Naito AT, Kasai H, Hiroi Y, Hayashi D, Shiojima I, Yamazaki T, Miyazono K, Asashima M , Nagai R, Komuro I., Nat Cell Biol. May 1, 2008; 10 (5): 567-74.
HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus. , Nagao K, Taniyama Y, Kietzmann T, Doi T, Komuro I, Morishita R., J Biol Chem. April 25, 2008; 283 (17): 11841-9.
The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm. , Spagnoli FM , Brivanlou AH ., Development. February 1, 2008; 135 (3): 451-61.
Lessons from the lily pad: Using Xenopus to understand heart disease. , Bartlett HL, Weeks DL ., Drug Discov Today Dis Models. January 1, 2008; 5 (3): 141-146.
Redundancy and evolution of GATA factor requirements in development of the myocardium. , Peterkin T, Gibson A, Patient R ., Dev Biol. November 15, 2007; 311 (2): 623-35.
The mitochondrial respiratory chain controls intracellular calcium signaling and NFAT activity essential for heart formation in Xenopus laevis. , Chen Y , Yuen WH, Fu J, Huang G, Melendez AJ, Ibrahim FB, Lu H, Cao X ., Mol Cell Biol. September 1, 2007; 27 (18): 6420-32.
Transient early embryonic expression of Nkx2-5 mutations linked to congenital heart defects in human causes heart defects in Xenopus laevis. , Bartlett HL, Sutherland L, Kolker SJ, Welp C, Tajchman U, Desmarais V, Weeks DL ., Dev Dyn. September 1, 2007; 236 (9): 2475-84.
Left-sided embryonic expression of the BCL-6 corepressor, BCOR, is required for vertebrate laterality determination. , Hilton EN , Manson FD, Urquhart JE, Johnston JJ , Slavotinek AM, Hedera P, Stattin EL, Nordgren A, Biesecker LG, Black GC ., Hum Mol Genet. July 15, 2007; 16 (14): 1773-82.
Xenopus as a model system for vertebrate heart development. , Warkman AS , Krieg PA ., Semin Cell Dev Biol. February 1, 2007; 18 (1): 46-53.
Myoskeletin, a factor related to Myocardin, is expressed in somites and required for hypaxial muscle formation in Xenopus. , Zhao H , Rebbert ML, Dawid IB ., Int J Dev Biol. January 1, 2007; 51 (4): 315-20.
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. , Wu SM , Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH., Cell. December 15, 2006; 127 (6): 1137-50.
Characterization of myeloid cells derived from the anterior ventral mesoderm in the Xenopus laevis embryo. , Tashiro S, Sedohara A, Asashima M , Izutsu Y , Maéno M., Dev Growth Differ. October 1, 2006; 48 (8): 499-512.
Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart. , Allen BG , Allen-Brady K, Weeks DL ., Mech Dev. October 1, 2006; 123 (10): 719-29.
Retinoic acid signaling is essential for formation of the heart tube in Xenopus. , Collop AH, Broomfield JA, Chandraratna RA, Yong Z, Deimling SJ, Kolker SJ, Weeks DL , Drysdale TA ., Dev Biol. March 1, 2006; 291 (1): 96-109.
A gynogenetic screen to isolate naturally occurring recessive mutations in Xenopus tropicalis. , Noramly S, Zimmerman L , Cox A, Aloise R, Fisher M , Grainger RM ., Mech Dev. March 1, 2005; 122 (3): 273-87.
Myocardin is sufficient and necessary for cardiac gene expression in Xenopus. , Small EM , Warkman AS , Wang DZ, Sutherland LB, Olson EN, Krieg PA ., Development. March 1, 2005; 132 (5): 987-97.
Wnt11 facilitates embryonic stem cell differentiation to Nkx2.5-positive cardiomyocytes. , Terami H, Hidaka K, Katsumata T, Iio A, Morisaki T., Biochem Biophys Res Commun. December 17, 2004; 325 (3): 968-75.
Spatial and temporal expression patterns of Xenopus Nkx-2.3 gene in skin epidermis during metamorphosis. , Ma CM., Gene Expr Patterns. November 1, 2004; 5 (1): 129-34.
Characterization of Xenopus Phox2a and Phox2b defines expression domains within the embryonic nervous system and early heart field. , Talikka M , Stefani G, Brivanlou AH , Zimmerman K., Gene Expr Patterns. September 1, 2004; 4 (5): 601-7.
Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis. , Ueyama T, Kasahara H, Ishiwata T, Nie Q, Izumo S., Mol Cell Biol. December 1, 2003; 23 (24): 9222-32.
NKX2.5 mutations in patients with congenital heart disease. , McElhinney DB, Geiger E, Blinder J, Benson DW, Goldmuntz E., J Am Coll Cardiol. November 5, 2003; 42 (9): 1650-5.
Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. , Stennard FA , Costa MW, Elliott DA, Rankin S , Rankin S , Haast SJ, Lai D, McDonald LP, Niederreither K, Dolle P, Bruneau BG, Zorn AM , Harvey RP ., Dev Biol. October 15, 2003; 262 (2): 206-24.
Amphibian in vitro heart induction: a simple and reliable model for the study of vertebrate cardiac development. , Ariizumi T, Kinoshita M, Yokota C, Takano K, Fukuda K, Moriyama N, Malacinski GM, Asashima M ., Int J Dev Biol. September 1, 2003; 47 (6): 405-10.
The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2). , Nagel S, Kaufmann M, Drexler HG, MacLeod RA., Cancer Res. September 1, 2003; 63 (17): 5329-34.
Transgenic analysis of the atrialnatriuretic factor ( ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF. , Small EM , Krieg PA ., Dev Biol. September 1, 2003; 261 (1): 116-31.
Endothelin-converting enzyme-1 ( ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5. , Funke-Kaiser H, Lemmer J, Langsdorff CV, Thomas A, Kovacevic SD, Strasdat M, Behrouzi T, Zollmann FS, Paul M, Orzechowski HD., FASEB J. August 1, 2003; 17 (11): 1487-9.
Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart. , Ueyama T, Kasahara H, Ishiwata T, Yamasaki N, Izumo S., J Biol Chem. August 1, 2003; 278 (31): 28750-7.
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. , Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D., Nature. July 24, 2003; 424 (6947): 443-7.
PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5. , Ganga M, Espinoza HM, Cox CJ, Morton L, Hjalt TA, Lee Y , Amendt BA., J Biol Chem. June 20, 2003; 278 (25): 22437-45.
Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome. , Elliott DA, Kirk EP, Yeoh T, Chandar S, McKenzie F, Taylor P, Grossfeld P, Fatkin D, Jones O, Hayes P, Feneley M, Harvey RP ., J Am Coll Cardiol. June 4, 2003; 41 (11): 2072-6.
Expression of Nkx2-5-GFP bacterial artificial chromosome transgenic mice closely resembles endogenous Nkx2-5 gene activity. , Chi X, Zhang SX, Yu W, DeMayo FJ, Rosenberg SM, Schwartz RJ., Genesis. April 1, 2003; 35 (4): 220-6.
Chamber-specific differentiation of Nkx2.5-positive cardiac precursor cells from murine embryonic stem cells. , Hidaka K, Lee JK , Lee JK , Kim HS , Ihm CH, Iio A, Ogawa M, Nishikawa S, Kodama I, Morisaki T., FASEB J. April 1, 2003; 17 (6): 740-2.
Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes. , Kasahara H, Ueyama T, Wakimoto H, Liu MK, Maguire CT, Converso KL, Kang PM, Manning WJ, Lawitts J, Paul DL, Berul CI, Izumo S., J Mol Cell Cardiol. March 1, 2003; 35 (3): 243-56.
Too much Csx/ Nkx2-5 is as bad as too little? , Akazawa H, Komuro I., J Mol Cell Cardiol. March 1, 2003; 35 (3): 227-9.
Two novel frameshift mutations in NKX2.5 result in novel features including visceral inversus and sinus venosus type ASD. , Watanabe Y, Benson DW, Yano S, Akagi T, Yoshino M, Murray JC., J Med Genet. November 1, 2002; 39 (11): 807-11.
The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene. , Thattaliyath BD, Firulli BA, Firulli AB., J Mol Cell Cardiol. October 1, 2002; 34 (10): 1335-44.
Cardiomyogenic differentiation in cardiac myxoma expressing lineage-specific transcription factors. , Kodama H, Hirotani T, Suzuki Y, Ogawa S, Yamazaki K., Am J Pathol. August 1, 2002; 161 (2): 381-9.
Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity. , Sepulveda JL, Vlahopoulos S, Iyer D, Belaguli N, Schwartz RJ., J Biol Chem. July 12, 2002; 277 (28): 25775-82.