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Summary Expression Phenotypes Gene Literature (230) GO Terms (108) Nucleotides (126) Proteins (56) Interactants (833) Wiki
XB-GENEPAGE-487965

Papers associated with nkx2-5



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Regulation of primitive hematopoiesis by class I histone deacetylases., Shah RR, Koniski A, Shinde M, Blythe SA, Fass DM, Haggarty SJ, Palis J, Klein PS., Dev Dyn. February 1, 2013; 242 (2): 108-21.   


Prolonged FGF signaling is necessary for lung and liver induction in Xenopus., Shifley ET, Kenny AP, Rankin SA, Rankin SA, Zorn AM., BMC Dev Biol. September 18, 2012; 12 27.   


Dissociation of cardiogenic and postnatal myocardial activities of GATA4., Gallagher JM, Komati H, Roy E, Nemer M, Latinkić BV., Mol Cell Biol. June 1, 2012; 32 (12): 2214-23.

SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton., Langdon Y, Tandon P, Paden E, Duddy J, Taylor JM, Conlon FL., Development. March 1, 2012; 139 (5): 948-57.   


Inhibition of heart formation by lithium is an indirect result of the disruption of tissue organization within the embryo., Martin LK, Bratoeva M, Mezentseva NV, Bernanke JM, Remond MC, Ramsdell AF, Eisenberg CA, Eisenberg LM., Dev Growth Differ. February 1, 2012; 54 (2): 153-66.   


Tbx5 overexpression favors a first heart field lineage in murine embryonic stem cells and in Xenopus laevis embryos., Herrmann F, Bundschu K, Kühl SJ, Kühl M., Dev Dyn. December 1, 2011; 240 (12): 2634-45.   

Canonical WNT signaling enhances stem cell expression in the developing heart without a corresponding inhibition of cardiogenic differentiation., Martin LK, Mezentseva NV, Bratoeva M, Ramsdell AF, Eisenberg CA, Eisenberg LM., Stem Cells Dev. November 1, 2011; 20 (11): 1973-83.

Cardiac neural crest is dispensable for outflow tract septation in Xenopus., Lee YH, Saint-Jeannet JP., Development. May 1, 2011; 138 (10): 2025-34.   


Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes., Pearl EJ, Jarikji Z, Horb ME., Dev Biol. March 1, 2011; 351 (1): 135-45.   


Early cardiac morphogenesis defects caused by loss of embryonic macrophage function in Xenopus., Smith SJ, Mohun TJ., Mech Dev. January 1, 2011; 128 (5-6): 303-15.   


Fgf is required to regulate anterior-posterior patterning in the Xenopus lateral plate mesoderm., Deimling SJ, Drysdale TA., Mech Dev. January 1, 2011; 128 (7-10): 327-41.   


Claudin5 genes encoding tight junction proteins are required for Xenopus heart formation., Yamagishi M, Ito Y, Ariizumi T, Komazaki S, Danno H, Michiue T, Asashima M., Dev Growth Differ. September 1, 2010; 52 (7): 665-75.   


Focal adhesion kinase is essential for cardiac looping and multichamber heart formation., Doherty JT, Conlon FL, Mack CP, Taylor JM., Genesis. August 1, 2010; 48 (8): 492-504.   


Examining the cardiac NK-2 genes in early heart development., Bartlett H, Veenstra GJ, Weeks DL., Pediatr Cardiol. April 1, 2010; 31 (3): 335-41.

FoxO genes are dispensable during gastrulation but required for late embryogenesis in Xenopus laevis., Schuff M, Siegel D, Bardine N, Oswald F, Donow C, Knöchel W., Dev Biol. January 15, 2010; 337 (2): 259-73.   


Characterization of molecular markers to assess cardiac cushions formation in Xenopus., Lee YH, Lee YH, Saint-Jeannet JP., Dev Dyn. December 1, 2009; 238 (12): 3257-65.   


Neural ectoderm-secreted FGF initiates the expression of Nkx2.5 in cardiac progenitors via a p38 MAPK/CREB pathway., Keren-Politansky A, Keren A, Bengal E., Dev Biol. November 15, 2009; 335 (2): 374-84.   


Early activation of FGF and nodal pathways mediates cardiac specification independently of Wnt/beta-catenin signaling., Samuel LJ, Latinkić BV., PLoS One. October 28, 2009; 4 (10): e7650.   


Comparative gene expression analysis and fate mapping studies suggest an early segregation of cardiogenic lineages in Xenopus laevis., Gessert S, Kühl M., Dev Biol. October 15, 2009; 334 (2): 395-408.   


Retinoic acid regulates anterior-posterior patterning within the lateral plate mesoderm of Xenopus., Deimling SJ, Drysdale TA., Mech Dev. October 1, 2009; 126 (10): 913-23.   


Coordinating the timing of cardiac precursor development during gastrulation: a new role for Notch signaling., Miazga CM, McLaughlin KA., Dev Biol. September 15, 2009; 333 (2): 285-96.   


NFAT directly regulates Nkx2-5 transcription during cardiac cell differentiation., Chen Y, Cao X., Biol Cell. June 1, 2009; 101 (6): 335-49.

In vitro organogenesis from undifferentiated cells in Xenopus., Asashima M, Ito Y, Chan T, Michiue T, Nakanishi M, Suzuki K, Hitachi K, Okabayashi K, Kondow A, Ariizumi T., Dev Dyn. June 1, 2009; 238 (6): 1309-20.   


The role of the visceral mesoderm in the development of the gastrointestinal tract., McLin VA, Henning SJ, Jamrich M., Gastroenterology. June 1, 2009; 136 (7): 2074-91.

Mitochondria and calcium signaling in embryonic development., Cao X, Chen Y., Semin Cell Dev Biol. May 1, 2009; 20 (3): 337-45.   


Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5., Espinoza-Lewis RA, Yu L, He F, Liu H, Tang R, Shi J, Sun X, Martin JF, Wang D, Yang J, Chen Y., Dev Biol. March 15, 2009; 327 (2): 376-85.   


Wnt6 signaling regulates heart muscle development during organogenesis., Lavery DL, Martin J, Turnbull YD, Hoppler S., Dev Biol. November 15, 2008; 323 (2): 177-88.   


Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling., Li Y, Rankin SA, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM., Genes Dev. November 1, 2008; 22 (21): 3050-63.   


DM-GRASP/ALCAM/CD166 is required for cardiac morphogenesis and maintenance of cardiac identity in first heart field derived cells., Gessert S, Maurus D, Brade T, Walther P, Pandur P, Kühl M., Dev Biol. September 1, 2008; 321 (1): 150-61.   


Fli1 acts at the top of the transcriptional network driving blood and endothelial development., Liu F, Walmsley M, Rodaway A, Patient R., Curr Biol. August 26, 2008; 18 (16): 1234-40.   


Cardiac differentiation in Xenopus requires the cyclin-dependent kinase inhibitor, p27Xic1., Movassagh M, Philpott A., Cardiovasc Res. August 1, 2008; 79 (3): 436-47.   


Xenopus zinc finger transcription factor IA1 (Insm1) expression marks anteroventral noradrenergic neuron progenitors in Xenopus embryos., Parlier D, Ariza A, Christulia F, Genco F, Vanhomwegen J, Kricha S, Souopgui J, Bellefroid EJ., Dev Dyn. August 1, 2008; 237 (8): 2147-57.   


GATA4 and GATA5 are essential for heart and liver development in Xenopus embryos., Haworth KE, Kotecha S, Mohun TJ, Latinkic BV., BMC Dev Biol. July 28, 2008; 8 74.   


IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis., Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I., Nature. July 17, 2008; 454 (7202): 345-9.   


XHAPLN3 plays a key role in cardiogenesis by maintaining the hyaluronan matrix around heart anlage., Ito Y, Seno S, Nakamura H, Fukui A, Asashima M., Dev Biol. July 1, 2008; 319 (1): 34-45.   


A crucial role of a high mobility group protein HMGA2 in cardiogenesis., Monzen K, Ito Y, Naito AT, Kasai H, Hiroi Y, Hayashi D, Shiojima I, Yamazaki T, Miyazono K, Asashima M, Nagai R, Komuro I., Nat Cell Biol. May 1, 2008; 10 (5): 567-74.   


HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus., Nagao K, Taniyama Y, Kietzmann T, Doi T, Komuro I, Morishita R., J Biol Chem. April 25, 2008; 283 (17): 11841-9.   


Vertebrate CASTOR is required for differentiation of cardiac precursor cells at the ventral midline., Christine KS, Conlon FL., Dev Cell. April 1, 2008; 14 (4): 616-23.   


The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm., Spagnoli FM, Brivanlou AH., Development. February 1, 2008; 135 (3): 451-61.   


Lessons from the lily pad: Using Xenopus to understand heart disease., Bartlett HL, Weeks DL., Drug Discov Today Dis Models. January 1, 2008; 5 (3): 141-146.

Redundancy and evolution of GATA factor requirements in development of the myocardium., Peterkin T, Gibson A, Patient R., Dev Biol. November 15, 2007; 311 (2): 623-35.   


The amphibian second heart field: Xenopus islet-1 is required for cardiovascular development., Brade T, Gessert S, Kühl M, Pandur P., Dev Biol. November 15, 2007; 311 (2): 297-310.   


SHP-2 is required for the maintenance of cardiac progenitors., Langdon YG, Goetz SC, Berg AE, Swanik JT, Conlon FL., Development. November 1, 2007; 134 (22): 4119-30.   


The mitochondrial respiratory chain controls intracellular calcium signaling and NFAT activity essential for heart formation in Xenopus laevis., Chen Y, Yuen WH, Fu J, Huang G, Melendez AJ, Ibrahim FB, Lu H, Cao X., Mol Cell Biol. September 1, 2007; 27 (18): 6420-32.

Transient early embryonic expression of Nkx2-5 mutations linked to congenital heart defects in human causes heart defects in Xenopus laevis., Bartlett HL, Sutherland L, Kolker SJ, Welp C, Tajchman U, Desmarais V, Weeks DL., Dev Dyn. September 1, 2007; 236 (9): 2475-84.   


The secreted serine protease xHtrA1 stimulates long-range FGF signaling in the early Xenopus embryo., Hou S, Maccarana M, Min TH, Strate I, Pera EM., Dev Cell. August 1, 2007; 13 (2): 226-41.   


Left-sided embryonic expression of the BCL-6 corepressor, BCOR, is required for vertebrate laterality determination., Hilton EN, Manson FD, Urquhart JE, Johnston JJ, Slavotinek AM, Hedera P, Stattin EL, Nordgren A, Biesecker LG, Black GC., Hum Mol Genet. July 15, 2007; 16 (14): 1773-82.   


Xenopus as a model system for vertebrate heart development., Warkman AS, Krieg PA., Semin Cell Dev Biol. February 1, 2007; 18 (1): 46-53.   


Myoskeletin, a factor related to Myocardin, is expressed in somites and required for hypaxial muscle formation in Xenopus., Zhao H, Rebbert ML, Dawid IB., Int J Dev Biol. January 1, 2007; 51 (4): 315-20.   


Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart., Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH., Cell. December 15, 2006; 127 (6): 1137-50.

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