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Summary Expression Phenotypes Gene Literature (65) GO Terms (0) Nucleotides (310) Proteins (47) Interactants (332) Wiki
XB-GENEPAGE-947152

Papers associated with mad2l1



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Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily., Graff JM, Bansal A, Melton DA., Cell. May 17, 1996; 85 (4): 479-87.

Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores., Chen RH, Waters JC, Salmon ED, Murray AW., Science. October 11, 1996; 274 (5285): 242-6.

A transcriptional partner for MAD proteins in TGF-beta signalling., Chen X, Rubock MJ, Whitman M., Nature. October 24, 1996; 383 (6602): 691-6.

Cell cycle checkpoints: arresting progress in mitosis., Gorbsky GJ., Bioessays. March 1, 1997; 19 (3): 193-7.

Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation., O'Neill TJ, Zhu Y, Gustafson TA., J Biol Chem. April 11, 1997; 272 (15): 10035-40.

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity., Li Y, Gorbea C, Mahaffey D, Rechsteiner M, Benezra R., Proc Natl Acad Sci U S A. November 11, 1997; 94 (23): 12431-6.

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation., Fang G, Yu H, Kirschner MW., Genes Dev. June 15, 1998; 12 (12): 1871-83.

Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts., Lorca T, Castro A, Martinez AM, Vigneron S, Morin N, Sigrist S, Lehner C, Dorée M, Labbé JC., EMBO J. July 1, 1998; 17 (13): 3565-75.                  

Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores., Chen RH, Shevchenko A, Mann M, Murray AW., J Cell Biol. October 19, 1998; 143 (2): 283-95.                    

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5., Kapoor TM, Mayer TU, Coughlin ML, Mitchison TJ., J Cell Biol. September 4, 2000; 150 (5): 975-88.                    

CENP-E as an essential component of the mitotic checkpoint in vitro., Abrieu A, Kahana JA, Wood KW, Cleveland DW., Cell. September 15, 2000; 102 (6): 817-26.

The APC is dispensable for first meiotic anaphase in Xenopus oocytes., Peter M, Castro A, Lorca T, Le Peuch C, Magnaghi-Jaulin L, Dorée M, Labbé JC., Nat Cell Biol. January 1, 2001; 3 (1): 83-7.

Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity., Sharp-Baker H, Chen RH., J Cell Biol. June 11, 2001; 153 (6): 1239-50.                  

Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint., Garcia MA, Vardy L, Koonrugsa N, Toda T., EMBO J. July 2, 2001; 20 (13): 3389-401.

Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint., Abrieu A, Magnaghi-Jaulin L, Kahana JA, Peter M, Castro A, Vigneron S, Lorca T, Cleveland DW, Labbé JC., Cell. July 13, 2001; 106 (1): 83-93.

MAD2B is an inhibitor of the anaphase-promoting complex., Chen J, Fang G., Genes Dev. July 15, 2001; 15 (14): 1765-70.

Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1., Pfleger CM, Salic A, Lee E, Lee E, Kirschner MW., Genes Dev. July 15, 2001; 15 (14): 1759-64.

Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1., Tang Z, Bharadwaj R, Li B, Yu H., Dev Cell. August 1, 2001; 1 (2): 227-37.

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint., Sironi L, Melixetian M, Faretta M, Prosperini E, Helin K, Musacchio A., EMBO J. November 15, 2001; 20 (22): 6371-82.

Checkpoint signals in grasshopper meiosis are sensitive to microtubule attachment, but tension is still essential., Nicklas RB, Waters JC, Salmon ED, Ward SC., J Cell Sci. December 1, 2001; 114 (Pt 23): 4173-83.

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins., Reimann JD, Gardner BE, Margottin-Goguet F, Jackson PK., Genes Dev. December 15, 2001; 15 (24): 3278-85.

The awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling., Millband DN, Campbell L, Hardwick KG., Trends Cell Biol. May 1, 2002; 12 (5): 205-9.

Spindle checkpoint requires Mad1-bound and Mad1-free Mad2., Chung E, Chen RH., Mol Biol Cell. May 1, 2002; 13 (5): 1501-11.

BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1., Chen RH., J Cell Biol. August 5, 2002; 158 (3): 487-96.              

The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity., McCleland ML, Gardner RD, Kallio MJ, Daum JR, Gorbsky GJ, Burke DJ, Stukenberg PT., Genes Dev. January 1, 2003; 17 (1): 101-14.

Analysis of Bub3 spindle checkpoint function in Xenopus egg extracts., Campbell L, Hardwick KG., J Cell Sci. February 15, 2003; 116 (Pt 4): 617-28.              

The Ran GTPase regulates kinetochore function., Arnaoutov A, Dasso M., Dev Cell. July 1, 2003; 5 (1): 99-111.

Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint., Chung E, Chen RH., Nat Cell Biol. August 1, 2003; 5 (8): 748-53.

The spindle checkpoint requires cyclin-dependent kinase activity., D'Angiolella V, Mari C, Nocera D, Rametti L, Grieco D., Genes Dev. October 15, 2003; 17 (20): 2520-5.

Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest., Tunquist BJ, Eyers PA, Chen LG, Lewellyn AL, Maller JL., J Cell Biol. December 22, 2003; 163 (6): 1231-42.            

Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression., Johnson VL, Scott MI, Holt SV, Hussein D, Taylor SS., J Cell Sci. March 15, 2004; 117 (Pt 8): 1577-89.

Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint., Xia G, Luo X, Habu T, Rizo J, Matsumoto T, Yu H., EMBO J. August 4, 2004; 23 (15): 3133-43.

The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes., Tsurumi C, Hoffmann S, Geley S, Graeser R, Polanski Z., J Cell Biol. December 20, 2004; 167 (6): 1037-50.                

Purification and assay of Mad2: a two-state inhibitor of anaphase-promoting complex/cyclosome., Luo X, Yu H., Methods Enzymol. January 1, 2005; 398 246-55.

Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts., Gadea BB, Ruderman JV., Mol Biol Cell. March 1, 2005; 16 (3): 1305-18.

ZW10 links mitotic checkpoint signaling to the structural kinetochore., Kops GJ, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR, Tagaya M, Cleveland DW., J Cell Biol. April 11, 2005; 169 (1): 49-60.              

Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores., Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ., Curr Biol. June 21, 2005; 15 (12): 1078-89.

Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores., Wong OK, Fang G., J Cell Biol. August 29, 2005; 170 (5): 709-19.            

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling., Mao Y, Desai A, Cleveland DW., J Cell Biol. September 12, 2005; 170 (6): 873-80.          

The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly., Orjalo AV, Arnaoutov A, Shen Z, Boyarchuk Y, Zeitlin SG, Fontoura B, Briggs S, Dasso M, Forbes DJ., Mol Biol Cell. September 1, 2006; 17 (9): 3806-18.

Mps1 phosphorylation by MAP kinase is required for kinetochore localization of spindle-checkpoint proteins., Zhao Y, Chen RH., Curr Biol. September 5, 2006; 16 (17): 1764-9.

Loading of the 3F3/2 antigen onto kinetochores is dependent on the ordered assembly of the spindle checkpoint proteins., Wong OK, Fang G., Mol Biol Cell. October 1, 2006; 17 (10): 4390-9.

Non-catalytic function for ATR in the checkpoint response., McSherry TD, Kitazono AA, Javaheri A, Kron SJ, Mueller PR., Cell Cycle. August 15, 2007; 6 (16): 2019-30.

BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment., Zhang J, Ahmad S, Mao Y., J Cell Biol. August 27, 2007; 178 (5): 773-84.              

Cdk1 phosphorylation of BubR1 controls spindle checkpoint arrest and Plk1-mediated formation of the 3F3/2 epitope., Wong OK, Fang G., J Cell Biol. November 19, 2007; 179 (4): 611-7.        

Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly., Emanuele MJ, Lan W, Jwa M, Miller SA, Chan CS, Stukenberg PT., J Cell Biol. April 21, 2008; 181 (2): 241-54.                

Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins., Tonge D, Chan K, Zhu N, Panjwani A, Arno M, Lynham S, Ward M, Snape A, Pizzey J., J Cell Sci. August 1, 2008; 121 (Pt 15): 2565-77.                        

Protein metamorphosis: the two-state behavior of Mad2., Luo X, Yu H., Structure. November 12, 2008; 16 (11): 1616-25.

BubR1 is an effector of multiple mitotic kinases that specifies kinetochore: microtubule attachments and checkpoint., Huang H, Yen TJ., Cell Cycle. April 15, 2009; 8 (8): 1164-7.

Oncogenic Adenomatous polyposis coli mutants impair the mitotic checkpoint through direct interaction with Mad2., Zhang J, Neisa R, Mao Y., Mol Biol Cell. May 1, 2009; 20 (9): 2381-8.

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