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Summary Expression Phenotypes Gene Literature (177) GO Terms (0) Nucleotides (44) Proteins (32) Interactants (264) Wiki
XB-GENEPAGE-985558

Papers associated with kcnh1



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Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels., Chen J, Seebohm G, Sanguinetti MC., Proc Natl Acad Sci U S A. September 17, 2002; 99 (19): 12461-6.

Cloning and functional characterization of the smooth muscle ether-a-go-go-related gene K+ channel. Potential role of a conserved amino acid substitution in the S4 region., Shoeb F, Malykhina AP, Akbarali HI., J Biol Chem. January 24, 2003; 278 (4): 2503-14.

C-terminal domains implicated in the functional surface expression of potassium channels., Jenke M, Sánchez A, Monje F, Stühmer W, Weseloh RM, Pardo LA., EMBO J. February 3, 2003; 22 (3): 395-403.

Structural basis of two-stage voltage-dependent activation in K+ channels., Silverman WR, Roux B, Papazian DM., Proc Natl Acad Sci U S A. March 4, 2003; 100 (5): 2935-40.

Molecular characterization, functional expression, and developmental profile of an ether à-go-go K+ channel in the tobacco hornworm Manduca sexta., Keyser MR, Anson BD, Titus SA, Ganetzky B, Witten JL., J Neurobiol. April 1, 2003; 55 (1): 73-85.

Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain., Sănchez-Chapula JA, Ferrer T, Navarro-Polanco RA, Sanguinetti MC., Mol Pharmacol. May 1, 2003; 63 (5): 1051-8.

BeKm-1 is a HERG-specific toxin that shares the structure with ChTx but the mechanism of action with ErgTx1., Zhang M, Korolkova YV, Liu J, Jiang M, Grishin EV, Tseng GN., Biophys J. May 1, 2003; 84 (5): 3022-36.

Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes., Liu J, Zhang M, Jiang M, Tseng GN., J Gen Physiol. June 1, 2003; 121 (6): 599-614.                                  

Gating currents associated with intramembrane charge displacement in HERG potassium channels., Piper DR, Varghese A, Sanguinetti MC, Tristani-Firouzi M., Proc Natl Acad Sci U S A. September 2, 2003; 100 (18): 10534-9.

Distribution and functional properties of human KCNH8 (Elk1) potassium channels., Zou A, Lin Z, Humble M, Creech CD, Wagoner PK, Krafte D, Jegla TJ, Wickenden AD., Am J Physiol Cell Physiol. December 1, 2003; 285 (6): C1356-66.

Modification of Kv2.1 K+ currents by the silent Kv10 subunits., Vega-Saenz de Miera EC., Brain Res Mol Brain Res. April 7, 2004; 123 (1-2): 91-103.

Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels., Dong DL, Li Z, Wang HZ, Du ZM, Song WH, Yang BF., Basic Clin Pharmacol Toxicol. May 1, 2004; 94 (5): 209-12.

Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents., Gessner G, Zacharias M, Bechstedt S, Schönherr R, Heinemann SH., Mol Pharmacol. May 1, 2004; 65 (5): 1120-9.

Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin., Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker EK, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2004; 369 (5): 462-72.

Comparison of kinetic properties of quinidine and dofetilide block of HERG channels., Tsujimae K, Suzuki S, Yamada M, Kurachi Y., Eur J Pharmacol. June 16, 2004; 493 (1-3): 29-40.

Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel., Subbiah RN, Clarke CE, Smith DJ, Zhao J, Campbell TJ, Vandenberg JI., J Physiol. July 15, 2004; 558 (Pt 2): 417-31.

Binding site in eag voltage sensor accommodates a variety of ions and is accessible in closed channel., Silverman WR, Bannister JP, Papazian DM., Biophys J. November 1, 2004; 87 (5): 3110-21.

Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels., Craven KB, Zagotta WN., J Gen Physiol. December 1, 2004; 124 (6): 663-77.                      

Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine., Sánchez-Chapula JA, Navarro-Polanco RA, Sanguinetti MC., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 484-91.

Gating charges in the activation and inactivation processes of the HERG channel., Zhang M, Liu J, Tseng GN., J Gen Physiol. December 1, 2004; 124 (6): 703-18.                    

Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors., Thomas D, Wu K, Wimmer AB, Zitron E, Hammerling BC, Kathöfer S, Lueck S, Bloehs R, Kreye VA, Kiehn J, Katus HA, Schoels W, Karle CA., J Mol Med (Berl). December 1, 2004; 82 (12): 826-37.

A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go-related gene (HERG) channels., Lin C, Cvetanovic I, Ke X, Ranade V, Somberg J., Am J Ther. January 1, 2005; 12 (4): 328-36.

Effect of beta-adrenoceptor blockers on human ether-a-go-go-related gene (HERG) potassium channels., Dupuis DS, Klaerke DA, Olesen SP., Basic Clin Pharmacol Toxicol. February 1, 2005; 96 (2): 123-30.

Inhibition of human ether-a-go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine., Choi SY, Koh YS, Jo SH., J Pharmacol Exp Ther. May 1, 2005; 313 (2): 888-95.

Modulating effect of ginseng saponins on heterologously expressed HERG currents in Xenopus oocytes., Kim CS, Son SJ, Kim HS, Kim YD, Lee KS, Jeon BH, Kim KJ, Park JK, Park JB., Acta Pharmacol Sin. May 1, 2005; 26 (5): 551-8.

Camguk/CASK enhances Ether-á-go-go potassium current by a phosphorylation-dependent mechanism., Marble DD, Hegle AP, Snyder ED, Dimitratos S, Bryant PJ, Wilson GF., J Neurosci. May 18, 2005; 25 (20): 4898-907.

Glycosylation of Eag1 (Kv10.1) potassium channels: intracellular trafficking and functional consequences., Napp J, Monje F, Stühmer W, Pardo LA., J Biol Chem. August 19, 2005; 280 (33): 29506-12.

Inhibitory effect of rhynchophylline on human ether-a-go-go related gene channel., Gui L, Li ZW, Du R, Yuan GH, Li W, Ren FX, Li J, Yang JG., Sheng Li Xue Bao. October 25, 2005; 57 (5): 648-52.

Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K+ channel voltage sensor., Bannister JP, Chanda B, Bezanilla F, Papazian DM., Proc Natl Acad Sci U S A. December 20, 2005; 102 (51): 18718-23.

The effects of sevoflurane and propofol on QT interval and heterologously expressed human ether-a-go-go related gene currents in Xenopus oocytes., Yamada M, Hatakeyama N, Malykhina AP, Yamazaki M, Momose Y, Akbarali HI., Anesth Analg. January 1, 2006; 102 (1): 98-103.

Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)., Hansen RS, Diness TG, Christ T, Demnitz J, Ravens U, Olesen SP, Grunnet M., Mol Pharmacol. January 1, 2006; 69 (1): 266-77.

Mechanism of action of a novel human ether-a-go-go-related gene channel activator., Casis O, Olesen SP, Sanguinetti MC., Mol Pharmacol. February 1, 2006; 69 (2): 658-65.

Chemical modification of the human ether-a-go-go-related gene (HERG) K+ current by the amino-group reagent trinitrobenzene sulfonic acid., Jo SH, Choi SY, Yun JH, Koh YS, Ho WK, Lee CO, Lee CO., Arch Pharm Res. April 1, 2006; 29 (4): 310-7.

The D3-dopaminergic agonist 7-hydroxy-dipropylaminotetralin (7-OH-DPAT) increases cardiac action potential duration and blocks human ether-a-go-go-related gene K+ channel., Torres-Jácome J, Tejeda-Chávez HR, Rodríguez-Menchaca AA, Sánchez-Chapula JA, Navarro-Polanco RA., J Cardiovasc Pharmacol. May 1, 2006; 47 (5): 656-62.

Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels., Clarke CE, Hill AP, Zhao J, Kondo M, Subbiah RN, Campbell TJ, Vandenberg JI., J Physiol. June 1, 2006; 573 (Pt 2): 291-304.

Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine., Lee SY, Kim YJ, Kim KT, Choe H, Jo SH., Br J Pharmacol. June 1, 2006; 148 (4): 499-509.

Differences between ion binding to eag and HERG voltage sensors contribute to differential regulation of activation and deactivation gating., Lin MC, Papazian DM., Channels (Austin). January 1, 2007; 1 (6): 429-37.

Structural requirements of human ether-a-go-go-related gene channels for block by bupivacaine., Siebrands CC, Friederich P., Anesthesiology. March 1, 2007; 106 (3): 523-31.

Maprotiline block of the human ether-a-go-go-related gene (HERG) K+ channel., Jo SH, Hong HK, Jung SJ, Chong SH, Yun JH, Koh YS, Choe H., Arch Pharm Res. April 1, 2007; 30 (4): 453-60.

Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization., Schwoerer AP, Blütner C, Brandt S, Binder S, Siebrands CC, Ehmke H, Friederich P., Anesthesiology. May 1, 2007; 106 (5): 967-76.

Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator., Perry M, Sachse FB, Sanguinetti MC., Proc Natl Acad Sci U S A. August 21, 2007; 104 (34): 13827-32.

A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator., Perry M, Sanguinetti MC., Mol Pharmacol. April 1, 2008; 73 (4): 1044-51.

Structural basis for ether-a-go-go-related gene K+ channel subtype-dependent activation by niflumic acid., Fernandez D, Sargent J, Sachse FB, Sanguinetti MC., Mol Pharmacol. April 1, 2008; 73 (4): 1159-67.

A tyrosine substitution in the cavity wall of a k channel induces an inverted inactivation., Klement G, Nilsson J, Arhem P, Elinder F., Biophys J. April 15, 2008; 94 (8): 3014-22.

Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)., Xu X, Recanatini M, Roberti M, Tseng GN., Mol Pharmacol. June 1, 2008; 73 (6): 1709-21.

[The persistent expression of HERG channel in Xenopus oocyte and alteration of current]., Wang XP, Li L, Zou AR, Tu DN, Liao YH., Zhongguo Ying Yong Sheng Li Xue Za Zhi. August 1, 2008; 24 (3): 329-33.

Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin., Tu DN, Zou AR, Liao YH, Du YM, Wang XP, Li L., Sheng Li Xue Bao. August 25, 2008; 60 (4): 525-34.

Block of HERG k channel by classic histamine h(1) receptor antagonist chlorpheniramine., Hong HK, Jo SH., Korean J Physiol Pharmacol. June 1, 2009; 13 (3): 215-20.

Divalent cations slow activation of EAG family K+ channels through direct binding to S4., Zhang X, Bursulaya B, Lee CC, Lee CC, Chen B, Pivaroff K, Jegla T., Biophys J. July 8, 2009; 97 (1): 110-20.

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels., Gustina AS, Trudeau MC., Proc Natl Acad Sci U S A. August 4, 2009; 106 (31): 13082-7.          

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