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Summary Expression Phenotypes Gene Literature (163) GO Terms (3) Nucleotides (613) Proteins (60) Interactants (996) Wiki
XB-GENEPAGE-966993

Papers associated with gmnn



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Geminin, an inhibitor of DNA replication, is degraded during mitosis., McGarry TJ, Kirschner MW., Cell. June 12, 1998; 93 (6): 1043-53.

Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation., Kroll KL, Salic AN, Evans LM, Kirschner MW., Development. August 1, 1998; 125 (16): 3247-58.                

Regulation of dorsal gene expression in Xenopus by the ventralizing homeodomain gene Vox., Melby AE, Clements WK, Kimelman D., Dev Biol. July 15, 1999; 211 (2): 293-305.            

Cell cycle-regulated proteolysis of mitotic target proteins., Bastians H, Topper LM, Gorbsky GL, Ruderman JV., Mol Biol Cell. November 1, 1999; 10 (11): 3927-41.

Xbra3 induces mesoderm and neural tissue in Xenopus laevis., Strong CF, Barnett MW, Hartman D, Jones EA, Stott D., Dev Biol. June 15, 2000; 222 (2): 405-19.                  

Imaging patterns of calcium transients during neural induction in Xenopus laevis embryos., Leclerc C, Webb SE, Daguzan C, Moreau M, Miller AL., J Cell Sci. October 1, 2000; 113 Pt 19 3519-29.                  

Cell cycle. License withheld--geminin blocks DNA replication., Lygerou Z, Nurse P., Science. December 22, 2000; 290 (5500): 2271-3.

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1., Wohlschlegel JA, Dwyer BT, Dhar SK, Cvetic C, Walter JC, Dutta A., Science. December 22, 2000; 290 (5500): 2309-12.

Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins., Gillespie PJ, Li A, Blow JJ., BMC Biochem. January 1, 2001; 2 15.                

Geminin bans replication licence., Madine M, Laskey R., Nat Cell Biol. February 1, 2001; 3 (2): E49-50.

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin., Tada S, Li A, Maiorano D, Méchali M, Blow JJ., Nat Cell Biol. February 1, 2001; 3 (2): 107-13.

foxD5a, a Xenopus winged helix gene, maintains an immature neural ectoderm via transcriptional repression that is dependent on the C-terminal domain., Sullivan SA, Akers L, Moody SA., Dev Biol. April 15, 2001; 232 (2): 439-57.            

Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem., Béguin P, Nagashima K, Gonoi T, Shibasaki T, Takahashi K, Kashima Y, Ozaki N, Geering K, Iwanaga T, Seino S., Nature. June 7, 2001; 411 (6838): 701-6.

Triggering ubiquitination of a CDK inhibitor at origins of DNA replication., Furstenthal L, Swanson C, Kaiser BK, Eldridge AG, Jackson PK., Nat Cell Biol. August 1, 2001; 3 (8): 715-22.

Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle., Okuno Y, McNairn AJ, den Elzen N, Pines J, Gilbert DM., EMBO J. August 1, 2001; 20 (15): 4263-77.

Microarray-based analysis of early development in Xenopus laevis., Altmann CR, Bell E, Sczyrba A, Pun J, Bekiranov S, Gaasterland T, Brivanlou AH., Dev Biol. August 1, 2001; 236 (1): 64-75.            

The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis., Quinn LM, Herr A, McGarry TJ, Richardson H., Genes Dev. October 15, 2001; 15 (20): 2741-54.    

Neural induction takes a transcriptional twist., Bainter JJ, Boos A, Kroll KL., Dev Dyn. November 1, 2001; 222 (3): 315-27.  

The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase., Nishitani H, Taraviras S, Lygerou Z, Nishimoto T., J Biol Chem. November 30, 2001; 276 (48): 44905-11.

Mammalian nuclei become licensed for DNA replication during late telophase., Dimitrova DS, Prokhorova TA, Blow JJ, Todorov IT, Gilbert DM., J Cell Sci. January 1, 2002; 115 (Pt 1): 51-9.

Cell cycle-dependent regulation of the association between origin recognition proteins and somatic cell chromatin., Sun WH, Coleman TR, DePamphilis ML., EMBO J. March 15, 2002; 21 (6): 1437-46.

Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import., Hodgson B, Li A, Tada S, Blow JJ., Curr Biol. April 16, 2002; 12 (8): 678-83.

Control of DNA replication licensing in a cell cycle., Nishitani H, Lygerou Z., Genes Cells. June 1, 2002; 7 (6): 523-34.        

Expression of geminin as a marker of cell proliferation in normal tissues and malignancies., Wohlschlegel JA, Kutok JL, Weng AP, Dutta A., Am J Pathol. July 1, 2002; 161 (1): 267-73.

Molecular cloning and characterization of dullard: a novel gene required for neural development., Satow R, Chan TC, Asashima M., Biochem Biophys Res Commun. July 5, 2002; 295 (1): 85-91.                  

Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract., Kobayashi T, Tada S, Tsuyama T, Murofushi H, Seki M, Enomoto T., J Cell Sci. August 1, 2002; 115 (Pt 15): 3159-69.

DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts., Stokes MP, Van Hatten R, Lindsay HD, Michael WM., J Cell Biol. September 2, 2002; 158 (5): 863-72.        

Crystallization and preliminary X-ray crystallographic analysis of human Geminin coiled-coil domain., Thépaut M, Hoh F, Dumas C, Calas B, Strub MP, Padilla A., Biochim Biophys Acta. September 23, 2002; 1599 (1-2): 149-51.

Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus., McGarry TJ., Mol Biol Cell. October 1, 2002; 13 (10): 3662-71.            

The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication., Van Hatten RA, Tutter AV, Holway AH, Khederian AM, Walter JC, Michael WM., J Cell Biol. November 25, 2002; 159 (4): 541-7.          

A role of topoisomerase II in linking DNA replication to chromosome condensation., Cuvier O, Hirano T., J Cell Biol. March 3, 2003; 160 (5): 645-55.              

Spatial distribution and specification of mammalian replication origins during G1 phase., Li F, Chen J, Solessio E, Gilbert DM., J Cell Biol. April 28, 2003; 161 (2): 257-66.            

Direct interaction of geminin and Six3 in eye development., Del Bene F, Tessmar-Raible K, Wittbrodt J., Nature. February 19, 2004; 427 (6976): 745-9.

Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination., Li A, Blow JJ., Nat Cell Biol. March 1, 2004; 6 (3): 260-7.

Negative regulation of geminin by CDK-dependent ubiquitination controls replication licensing., Li A, Blow JJ., Cell Cycle. April 1, 2004; 3 (4): 443-5.

Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis., Maiorano D, Rul W, Méchali M., Exp Cell Res. April 15, 2004; 295 (1): 138-49.

The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation., Oehlmann M, Score AJ, Blow JJ., J Cell Biol. April 26, 2004; 165 (2): 181-90.                  

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases., Li W, Kim SM, Lee J, Lee J, Dunphy WG., J Cell Biol. June 21, 2004; 165 (6): 801-12.                

A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication., Jares P, Luciani MG, Blow JJ., BMC Mol Biol. June 28, 2004; 5 5.          

A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition., Saxena S, Yuan P, Dhar SK, Senga T, Takeda D, Robinson H, Kornbluth S, Swaminathan K, Dutta A., Mol Cell. July 23, 2004; 15 (2): 245-58.

Geminin: a major DNA replication safeguard in higher eukaryotes., Melixetian M, Helin K., Cell Cycle. August 1, 2004; 3 (8): 1002-4.

Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis., Ballabeni A, Melixetian M, Zamponi R, Masiero L, Marinoni F, Helin K., EMBO J. August 4, 2004; 23 (15): 3122-32.

Structural basis for inhibition of the replication licensing factor Cdt1 by geminin., Lee C, Lee C, Hong B, Choi JM, Kim Y, Watanabe S, Ishimi Y, Enomoto T, Tada S, Kim Y, Cho Y., Nature. August 19, 2004; 430 (7002): 913-7.

Scc2 couples replication licensing to sister chromatid cohesion in Xenopus egg extracts., Gillespie PJ, Hirano T., Curr Biol. September 7, 2004; 14 (17): 1598-603.

Regulation of early events in chromosome replication., Diffley JF., Curr Biol. September 21, 2004; 14 (18): R778-86.

Geminin has dimerization, Cdt1-binding, and destruction domains that are required for biological activity., Benjamin JM, Torke SJ, Demeler B, McGarry TJ., J Biol Chem. October 29, 2004; 279 (44): 45957-68.

DNA replication licensing in somatic and germ cells., Eward KL, Obermann EC, Shreeram S, Loddo M, Fanshawe T, Williams C, Jung HI, Prevost AT, Blow JJ, Stoeber K, Williams GH., J Cell Sci. November 15, 2004; 117 (Pt 24): 5875-86.

Systematic screening for genes specifically expressed in the anterior neuroectoderm during early Xenopus development., Takahashi N, Tochimoto N, Ohmori SY, Mamada H, Itoh M, Inamori M, Shinga J, Osada S, Taira M., Int J Dev Biol. January 1, 2005; 49 (8): 939-51.                                    

Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs., Yoshida K, Takisawa H, Kubota Y., Genes Cells. January 1, 2005; 10 (1): 63-73.

Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts., Arias EE, Walter JC., Genes Dev. January 1, 2005; 19 (1): 114-26.

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