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Mapping the agonist binding site of the GABAA receptor: evidence for a beta-strand. , Boileau AJ, Evers AR, Davis AF, Czajkowski C., J Neurosci. June 15, 1999; 19 (12): 4847-54.
The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor. , Bamber BA, Beg AA, Twyman RE, Jorgensen EM., J Neurosci. July 1, 1999; 19 (13): 5348-59.
EDPC: a novel high affinity ligand for the benzodiazepine site on rat GABA(A) receptors. , Thomet U, Furtmüller R, Sieghart W, Le Hyaric-Almeida M, Rousseau JF, Dodd RH, Venault P, Chapouthier G, Sigel E., Neurosci Lett. July 9, 1999; 269 (2): 63-6.
Subunit-selective modulation of GABAA receptors by the non-steroidal anti-inflammatory agent, mefenamic acid. , Halliwell RF, Thomas P, Patten D, James CH, Martinez-Torres A, Miledi R , Smart TG., Eur J Neurosci. August 1, 1999; 11 (8): 2897-905.
Bicuculline block of small-conductance calcium-activated potassium channels. , Khawaled R, Bruening-Wright A, Adelman JP, Maylie J., Pflugers Arch. August 1, 1999; 438 (3): 314-21.
Permeability and single channel conductance of human homomeric rho1 GABAC receptors. , Wotring VE, Chang Y, Weiss DS., J Physiol. December 1, 1999; 521 Pt 2 327-36.
Response kinetics and pharmacological properties of heteromeric receptors formed by coassembly of GABA rho- and gamma 2-subunits. , Qian H, Ripps H., Proc Biol Sci. December 7, 1999; 266 (1436): 2419-25.
Modulation by extracellular pH of GABAA receptors expressed in Xenopus oocytes injected with rat brain mRNA. , Robello M, Balduzzi R, Cupello A., Int J Neurosci. January 1, 2000; 103 (1-4): 41-51.
The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. , Krasowski MD, Harrison NL., Br J Pharmacol. February 1, 2000; 129 (4): 731-43.
Subunit-dependent inhibition of human neuronal nicotinic acetylcholine receptors and other ligand-gated ion channels by dissociative anesthetics ketamine and dizocilpine. , Yamakura T, Chavez-Noriega LE, Harris RA., Anesthesiology. April 1, 2000; 92 (4): 1144-53.
Intravenous anesthetics differentially modulate ligand-gated ion channels. , Flood P, Krasowski MD., Anesthesiology. May 1, 2000; 92 (5): 1418-25.
Evidence for coassembly of mutant GABAC rho1 with GABAA gamma2S, glycine alpha1 and glycine alpha2 receptor subunits in vitro. , Pan ZH, Zhang D, Zhang X, Lipton SA., Eur J Neurosci. September 1, 2000; 12 (9): 3137-45.
Effects of thiopental and its optical isomers on nicotinic acetylcholine receptors. , Downie DL, Franks NP, Lieb WR., Anesthesiology. September 1, 2000; 93 (3): 774-83.
Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol. , Yamakura T, Harris RA., Anesthesiology. October 1, 2000; 93 (4): 1095-101.
Use of bicuculline, a GABA antagonist, as a template for the development of a new class of ligands showing positive allosteric modulation of the GABA(A) receptor. , Razet R, Thomet U, Furtmüller R, Jursky F, Sigel E, Sieghart W, Dodd RH., Bioorg Med Chem Lett. November 20, 2000; 10 (22): 2579-83.
Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms. , Walters RJ, Hadley SH, Morris KD, Amin J., Nat Neurosci. December 1, 2000; 3 (12): 1274-81.
Anion permeation in Ca(2+)-activated Cl(-) channels. , Qu Z, Hartzell HC., J Gen Physiol. December 1, 2000; 116 (6): 825-44.
Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment. , Horenstein J, Wagner DA, Czajkowski C, Akabas MH., Nat Neurosci. May 1, 2001; 4 (5): 477-85.
Anesthetic properties of 4-iodopropofol: implications for mechanisms of anesthesia. , Lingamaneni R, Krasowski MD, Jenkins A, Truong T, Giunta AL, Blackbeer J, MacIver MB, Harrison NL, Hemmings HC., Anesthesiology. June 1, 2001; 94 (6): 1050-7.
Allosteric modulation in spontaneously active mutant gamma-aminobutyric acidA receptors. , Findlay GS, Ueno S , Harrison NL, Harris RA., Neurosci Lett. June 1, 2001; 305 (1): 77-80.
Magnesium potentiation of the function of native and recombinant GABA(A) receptors. , Möykkynen T, Uusi-Oukari M, Heikkilä J, Lovinger DM, Lüddens H, Korpi ER., Neuroreport. July 20, 2001; 12 (10): 2175-9.
Modulation of recombinant GABA receptor/channel subunits by domain-specific antibodies in Xenopus oocytes. , Ekema GM, Zheng W, Wang L, Lu L., J Membr Biol. October 1, 2001; 183 (3): 205-13.
Affinity labeling of cysteine-mutants evidences contact residues in modeled receptor binding sites. , Perret P, Laube B, Schemm R, Betz H, Goeldner M, Foucaud B., J Recept Signal Transduct Res. January 1, 2002; 22 (1-4): 345-56.
Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement. , Greenfield LJ, Zaman SH, Sutherland ML, Lummis SC, Niemeyer MI, Barnard EA, Macdonald RL., Neuropharmacology. March 1, 2002; 42 (4): 502-21.
Droperidol inhibits GABA(A) and neuronal nicotinic receptor activation. , Flood P, Coates KM., Anesthesiology. April 1, 2002; 96 (4): 987-93.
Two different mechanisms of disinhibition produced by GABAA receptor mutations linked to epilepsy in humans. , Bianchi MT, Song L, Zhang H , Macdonald RL., J Neurosci. July 1, 2002; 22 (13): 5321-7.
Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. , Bowser DN, Wagner DA, Czajkowski C, Cromer BA, Parker MW, Wallace RH, Harkin LA, Mulley JC, Marini C, Berkovic SF, Williams DA, Jones MV, Petrou S., Proc Natl Acad Sci U S A. November 12, 2002; 99 (23): 15170-5.
Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement. , Baumann SW, Baur R, Sigel E., J Biol Chem. November 29, 2002; 277 (48): 46020-5.
Nonhalogenated alkanes cyclopropane and butane affect neurotransmitter-gated ion channel and G-protein-coupled receptors: differential actions on GABAA and glycine receptors. , Hara K, Eger EI, Laster MJ, Harris RA., Anesthesiology. December 1, 2002; 97 (6): 1512-20.
Neuronal representation of odourants in the olfactory bulb of Xenopus laevis tadpoles. , Czesnik D, Rössler W, Kirchner F, Gennerich A, Schild D., Eur J Neurosci. January 1, 2003; 17 (1): 113-8.
Characterization of wild-type (R100R) and mutated (Q100Q) GABAA alpha 6 subunit in Sardinian alcohol non-preferring rats (sNP). , Sanna A, Congeddu E, Porcella A, Saba L, Pistis M, Peis M, Marchese G, Ruiu S, Lobina C, Grayson DR, Gessa GL, Pani L., Brain Res. March 28, 2003; 967 (1-2): 98-105.
The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating. , Newell JG, Czajkowski C., J Biol Chem. April 11, 2003; 278 (15): 13166-72.
Effects of gamma2S subunit incorporation on GABAA receptor macroscopic kinetics. , Boileau AJ, Li T , Benkwitz C, Czajkowski C, Pearce RA., Neuropharmacology. June 1, 2003; 44 (8): 1003-12.
The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia. , Belelli D, Muntoni AL, Merrywest SD, Gentet LJ, Casula A, Callachan H, Madau P, Gemmell DK, Hamilton NM, Lambert JJ, Sillar KT , Peters JA., Neuropharmacology. July 1, 2003; 45 (1): 57-71.
Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current. , Eisenman LN, He Y, Fields C, Zorumski CF, Mennerick S., J Physiol. August 1, 2003; 550 (Pt 3): 679-91.
Inhibition of alpha-subunit glycine receptors by quinoxalines. , Meier J, Schmieden V., Neuroreport. August 6, 2003; 14 (11): 1507-10.
Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug. , Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER., Mol Pharmacol. September 1, 2003; 64 (3): 753-63.
On high- and low-affinity agonist sites in GABAA receptors. , Baur R, Sigel E., J Neurochem. October 1, 2003; 87 (2): 325-32.
A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation. , Chang CS , Olcese R, Olsen RW., J Biol Chem. October 31, 2003; 278 (44): 42821-8.
Activity of chlormethiazole at human recombinant GABA(A) and NMDA receptors. , Usala M, Thompson SA, Whiting PJ, Wafford KA., Br J Pharmacol. November 1, 2003; 140 (6): 1045-50.
Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA(A) receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster. , Priestley CM, Williamson EM, Wafford KA, Sattelle DB., Br J Pharmacol. December 1, 2003; 140 (8): 1363-72.
GABAA receptor modulation by the novel intravenous general anaesthetic E-6375. , Pau D, Belelli D, Callachan H, Peden DR, Dunlop JI, Peters JA, Guitart X, Gutierrez B, Lambert JJ., Neuropharmacology. December 1, 2003; 45 (8): 1029-40.
Defining the propofol binding site location on the GABAA receptor. , Bali M, Akabas MH., Mol Pharmacol. January 1, 2004; 65 (1): 68-76.
On the benzodiazepine binding pocket in GABAA receptors. , Berezhnoy D, Nyfeler Y, Gonthier A, Schwob H, Goeldner M, Sigel E., J Biol Chem. January 30, 2004; 279 (5): 3160-8.
Pharmacological properties of alpha 9 alpha 10 nicotinic acetylcholine receptors revealed by heterologous expression of subunit chimeras. , Baker ER, Zwart R, Sher E, Millar NS., Mol Pharmacol. February 1, 2004; 65 (2): 453-60.
Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. , Hall BJ, Chebib M, Hanrahan JR, Johnston GA ., Eur J Pharmacol. April 26, 2004; 491 (1): 1-8.
Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors. , Thompson SA, Wheat L, Brown NA, Wingrove PB, Pillai GV, Whiting PJ, Adkins C, Woodward CH, Smith AJ, Simpson PB, Collins I, Wafford KA., Br J Pharmacol. May 1, 2004; 142 (1): 97-106.
The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors. , Weir CJ, Ling AT, Belelli D, Wildsmith JA, Peters JA, Lambert JJ., Br J Anaesth. May 1, 2004; 92 (5): 704-11.
A TM2 residue in the beta1 subunit determines spontaneous opening of homomeric and heteromeric gamma-aminobutyric acid-gated ion channels. , Miko A, Werby E, Sun H, Healey J, Zhang L., J Biol Chem. May 28, 2004; 279 (22): 22833-40.
Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. , Huang SH, Duke RK, Chebib M, Sasaki K, Wada K, Johnston GA ., Eur J Pharmacol. June 28, 2004; 494 (2-3): 131-8.