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Summary Expression Phenotypes Gene Literature (78) GO Terms (14) Nucleotides (227) Proteins (56) Interactants (303) Wiki
XB-GENEPAGE-999034

Papers associated with furin



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Prohormone processing in Xenopus oocytes: characterization of cleavage signals and cleavage enzymes., Korner J, Chun J, O'Bryan L, Axel R., Proc Natl Acad Sci U S A. December 15, 1991; 88 (24): 11393-7.

Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases., Van de Ven WJ, Roebroek AJ, Van Duijnhoven HL., Crit Rev Oncog. January 1, 1993; 4 (2): 115-36.

Cloning and characterization of R-PTP-kappa, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region., Jiang YP, Wang H, D'Eustachio P, Musacchio JM, Schlessinger J, Sap J., Mol Cell Biol. May 1, 1993; 13 (5): 2942-51.

Processing of pro-islet amyloid polypeptide (proIAPP) by the prohormone convertase PC2., Badman MK, Shennan KI, Jermany JL, Docherty K, Clark A., FEBS Lett. January 15, 1996; 378 (3): 227-31.

Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues., Okada A, Saez S, Misumi Y, Basset P., Gene. February 7, 1997; 185 (2): 187-93.

A novel matrix metalloproteinase gene (XMMP) encoding vitronectin-like motifs is transiently expressed in Xenopus laevis early embryo development., Yang M, Murray MT, Kurkinen M., J Biol Chem. May 23, 1997; 272 (21): 13527-33.          

cDNA cloning and sequence analysis of the Xenopus laevis egg envelope glycoprotein gp43., Yang JC, Hedrick JL., Dev Growth Differ. August 1, 1997; 39 (4): 457-67.        

BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development., Cui Y, Jean F, Thomas G, Christian JL., EMBO J. August 17, 1998; 17 (16): 4735-43.

Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin., Roebroek AJ, Umans L, Pauli IG, Robertson EJ, van Leuven F, Van de Ven WJ, Constam DB., Development. December 1, 1998; 125 (24): 4863-76.

Molecular basis for oviductin-mediated processing from gp43 to gp41, the predominant glycoproteins of Xenopus egg envelopes., Kubo H, Matsushita M, Kotani M, Kawasaki H, Saido TC, Kawashima S, Katagiri C, Suzuki A., Dev Genet. January 1, 1999; 25 (2): 123-9.      

Isolation and characterisation of a cDNA encoding a zona pellucida protein (ZPB) from the marsupial Trichosurus vulpecula (brushtail possum)., Haines BP, Rathjen PD, Hope RM, Whyatt LM, Holland MK, Breed WG., Mol Reprod Dev. February 1, 1999; 52 (2): 174-82.

Xenopus laevis sperm receptor gp69/64 glycoprotein is a homolog of the mammalian sperm receptor ZP2., Tian J, Gong H, Lennarz WJ., Proc Natl Acad Sci U S A. February 2, 1999; 96 (3): 829-34.        

Comparison of ZP3 protein sequences among vertebrate species: to obtain a consensus sequence for immunocontraception., Zhu X, Naz RK., Front Biosci. March 1, 1999; 4 D212-5.

Egg envelope glycoprotein gp37 as a Xenopus homolog of mammalian ZP1, based on cDNA cloning., Kubo H, Kawano T, Tsubuki S, Kotani M, Kawasaki H, Kawashima S., Dev Growth Differ. August 1, 2000; 42 (4): 419-27.        

A hatching enzyme substrate in the Xenopus laevis egg envelope is a high molecular weight ZPA homolog., Lindsay LL, Wallace MA, Hedrick JL., Dev Growth Differ. June 1, 2001; 43 (3): 305-13.            

Primary structure and developmental expression of Dp ZP2, a vitelline envelope glycoprotein homolog of mouse ZP2, in Discoglossus pictus, one of the oldest living Anuran species., Vaccaro MC, Santo MG, Caputo M, Just M, Tian JD, Gong H, Lennarz WJ, Campanella C., Mol Reprod Dev. June 1, 2001; 59 (2): 133-43.

The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor., Cui Y, Hackenmiller R, Berg L, Jean F, Nakayama T, Thomas G, Christian JL., Genes Dev. November 1, 2001; 15 (21): 2797-802.

Matrix metalloproteinase-21, the human orthologue for XMMP, is expressed during fetal development and in cancer., Ahokas K, Lohi J, Lohi H, Elomaa O, Karjalainen-Lindsberg ML, Kere J, Saarialho-Kere U., Gene. November 13, 2002; 301 (1-2): 31-41.

The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein., Marchenko GN, Marchenko ND, Strongin AY., Biochem J. June 1, 2003; 372 (Pt 2): 503-15.

Epithelial sodium channels are activated by furin-dependent proteolysis., Hughey RP, Bruns JB, Kinlough CL, Harkleroad KL, Tong Q, Carattino MD, Johnson JP, Stockand JD, Kleyman TR., J Biol Chem. April 30, 2004; 279 (18): 18111-4.

Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells., Singh J, Itahana Y, Knight-Krajewski S, Kanagawa M, Campbell KP, Bissell MJ, Muschler J., Cancer Res. September 1, 2004; 64 (17): 6152-9.

Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4., Degnin C, Jean F, Thomas G, Christian JL., Mol Biol Cell. November 1, 2004; 15 (11): 5012-20.

Distinct pools of epithelial sodium channels are expressed at the plasma membrane., Hughey RP, Bruns JB, Kinlough CL, Kleyman TR., J Biol Chem. November 19, 2004; 279 (47): 48491-4.

XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins in Xenopus development., Birsoy B, Berg L, Williams PH, Smith JC, Wylie CC, Christian JL, Heasman J., Development. February 1, 2005; 132 (3): 591-602.                      

Proprotein convertase genes in Xenopus development., Nelsen S, Berg L, Wong C, Christian JL., Dev Dyn. July 1, 2005; 233 (3): 1038-44.    

Emilin1 links TGF-beta maturation to blood pressure homeostasis., Zacchigna L, Vecchione C, Notte A, Cordenonsi M, Dupont S, Maretto S, Cifelli G, Ferrari A, Maffei A, Fabbro C, Braghetta P, Marino G, Selvetella G, Aretini A, Colonnese C, Bettarini U, Russo G, Soligo S, Adorno M, Bonaldo P, Volpin D, Piccolo S, Lembo G, Bressan GM., Cell. March 10, 2006; 124 (5): 929-42.    

Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition., Sheng S, Carattino MD, Bruns JB, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. June 1, 2006; 290 (6): F1488-96.

The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit., Carattino MD, Sheng S, Bruns JB, Pilewski JM, Hughey RP, Kleyman TR., J Biol Chem. July 7, 2006; 281 (27): 18901-7.

CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces., Thomas JT, Prakash D, Weih K, Moos M., J Biol Chem. September 8, 2006; 281 (36): 26725-33.              

Subtilisin-like proprotein convertase activity is necessary for left-right axis determination in Xenopus neurula embryos., Toyoizumi R, Takeuchi S, Mogi K., Dev Genes Evol. October 1, 2006; 216 (10): 607-22.

Regulation of bone morphogenetic protein-4 activity by sequence elements within the prodomain., Sopory S, Nelsen SM, Degnin C, Wong C, Christian JL., J Biol Chem. November 10, 2006; 281 (45): 34021-31.

Xenopus fibrillin regulates directed convergence and extension., Skoglund P, Keller R., Dev Biol. January 15, 2007; 301 (2): 404-16.              

Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit., Bruns JB, Carattino MD, Sheng S, Maarouf AB, Weisz OA, Pilewski JM, Hughey RP, Kleyman TR., J Biol Chem. March 2, 2007; 282 (9): 6153-60.

Glycoproteins of the vitelline envelope of Amphibian oocyte: biological and molecular characterization of ZPC component (gp41) in Bufo arenarum., Barisone GA, Krapf D, Correa-Fiz F, Arranz SE, Cabada MO., Mol Reprod Dev. May 1, 2007; 74 (5): 629-40.

Vg1 has specific processing requirements that restrict its action to body axis patterning centers., Thomas JT, Moos M., Dev Biol. October 1, 2007; 310 (1): 129-39.          

Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development., Andersson O, Bertolino P, Ibáñez CF., Dev Biol. November 15, 2007; 311 (2): 500-11.

Defining an inhibitory domain in the alpha-subunit of the epithelial sodium channel., Carattino MD, Passero CJ, Steren CA, Maarouf AB, Pilewski JM, Myerburg MM, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. January 1, 2008; 294 (1): F47-52.

Identification of a novel pool of extracellular pro-myostatin in skeletal muscle., Anderson SB, Goldberg AL, Whitman M., J Biol Chem. March 14, 2008; 283 (11): 7027-35.

Preferential assembly of epithelial sodium channel (ENaC) subunits in Xenopus oocytes: role of furin-mediated endogenous proteolysis., Harris M, Garcia-Caballero A, Stutts MJ, Firsov D, Rossier BC., J Biol Chem. March 21, 2008; 283 (12): 7455-63.

Small molecule activator of the human epithelial sodium channel., Lu M, Echeverri F, Kalabat D, Laita B, Dahan DS, Smith RD, Xu H, Staszewski L, Yamamoto J, Ling J, Hwang N, Kimmich R, Li P, Patron E, Keung W, Patron A, Moyer BD., J Biol Chem. May 2, 2008; 283 (18): 11981-94.

Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins., Tonge D, Chan K, Zhu N, Panjwani A, Arno M, Lynham S, Ward M, Snape A, Pizzey J., J Cell Sci. August 1, 2008; 121 (Pt 15): 2565-77.                        

Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation., Carattino MD, Hughey RP, Kleyman TR., J Biol Chem. September 12, 2008; 283 (37): 25290-25295.

Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels., Diakov A, Bera K, Mokrushina M, Krueger B, Korbmacher C., J Physiol. October 1, 2008; 586 (19): 4587-608.

Single-channel analysis of functional epithelial sodium channel (ENaC) stability at the apical membrane of A6 distal kidney cells., Yu L, Helms MN, Yue Q, Eaton DC., Am J Physiol Renal Physiol. November 1, 2008; 295 (5): F1519-27.

Plasmin activates epithelial Na+ channels by cleaving the gamma subunit., Passero CJ, Mueller GM, Rondon-Berrios H, Tofovic SP, Hughey RP, Kleyman TR., J Biol Chem. December 26, 2008; 283 (52): 36586-91.

Genome-wide identification of Xenopus matrix metalloproteinases: conservation and unique duplications in amphibians., Fu L, Das B, Mathew S, Shi YB., BMC Genomics. February 17, 2009; 10 81.                  

Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences., Kudo H, Liu J, Jansen EJ, Ozawa A, Panula P, Martens GJ, Lindberg I., Endocrinology. March 1, 2009; 150 (3): 1393-9.

Site-specific cleavage of BMP4 by furin, PC6, and PC7., Nelsen SM, Christian JL., J Biol Chem. October 2, 2009; 284 (40): 27157-66.

Alternative mechanism of activation of the epithelial na+ channel by cleavage., Hu JC, Bengrine A, Lis A, Awayda MS., J Biol Chem. December 25, 2009; 284 (52): 36334-36345.

The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo., Ho DM, Yeo CY, Whitman M., Mech Dev. January 1, 2010; 127 (9-12): 485-95.                  

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