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R-Spondin 2 governs Xenopus left- right body axis formation by establishing an FGF signaling gradient. , Lee H , Lee H , Camuto CM, Niehrs C ., Nat Commun. February 2, 2024; 15 (1): 1003.
SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans. , DeGroot MS, Williams B, Chang TY, Maas Gamboa ML, Larus IM, Hong G, Fromme JC, Liu J ., PLoS Biol. August 1, 2023; 21 (8): e3002272.
Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd. , Lee H , Lee H , Sun R, Niehrs C ., J Biol Chem. February 1, 2022; 298 (2): 101586.
Activation by cleavage of the epithelial Na+ channel α and γ subunits independently coevolved with the vertebrate terrestrial migration. , Wang XP , Balchak DM, Gentilcore C, Clark NL, Kashlan OB., Elife. January 5, 2022; 11
Regulation of epithelial sodium channel activity by SARS-CoV-1 and SARS-CoV-2 proteins. , Grant SN, Lester HA., Biophys J. July 20, 2021; 120 (14): 2805-2813.
A novel class III endogenous retrovirus with a class I envelope gene in African frogs with an intact genome and developmentally regulated transcripts in Xenopus tropicalis. , Yedavalli VRK, Patil A, Parrish J, Kozak CA., Retrovirology. July 14, 2021; 18 (1): 20.
Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification. , Reis AH, Sokol SY ., Sci Rep. June 28, 2021; 11 (1): 13433.
Pinhead antagonizes Admp to promote notochord formation. , Itoh K, Ossipova O, Sokol SY ., iScience. June 25, 2021; 24 (6): 102520.
R-spondins are BMP receptor antagonists in Xenopus early embryonic development. , Lee H , Lee H , Seidl C, Sun R, Glinka A , Niehrs C ., Nat Commun. November 4, 2020; 11 (1): 5570.
Plasmin improves blood- gas barrier function in oedematous lungs by cleaving epithelial sodium channels. , Zhao R, Ali G, Nie HG, Chang Y, Bhattarai D, Su X, Zhao X, Matthay MA, Ji HL., Br J Pharmacol. July 1, 2020; 177 (13): 3091-3106.
The N terminus of α-ENaC mediates ENaC cleavage and activation by furin. , Kota P, Gentzsch M, Dang YL, Boucher RC, Stutts MJ., J Gen Physiol. August 6, 2018; 150 (8): 1179-1187.
Incorporation of the δ-subunit into the epithelial sodium channel (ENaC) generates protease-resistant ENaCs in Xenopus laevis. , Wichmann L, Vowinkel KS, Perniss A, Manzini I , Althaus M ., J Biol Chem. May 4, 2018; 293 (18): 6647-6658.
The NOTCH signaling pathway in normal and malignant blood cell production. , Suresh S, Irvine AE., J Cell Commun Signal. March 1, 2015; 9 (1): 5-13.
Determination of Alkali-Sensing Parts of the Insulin Receptor-Related Receptor Using the Bioinformatic Approach. , Deyev IE, Popova NV, Petrenko AG., Acta Naturae. January 1, 2015; 7 (2): 80-6.
Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second protease. , Carattino MD, Mueller GM, Palmer LG, Frindt G, Rued AC, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. November 1, 2014; 307 (9): F1080-7.
The R-spondin/ Lgr5/ Rnf43 module: regulator of Wnt signal strength. , de Lau W, Peng WC, Gros P, Clevers H., Genes Dev. February 15, 2014; 28 (4): 305-16.
Crystal structures of Lgr4 and its complex with R-spondin1. , Xu K, Xu Y , Xu Y , Rajashankar KR, Robev D, Nikolov DB., Structure. September 3, 2013; 21 (9): 1683-9.
Characterization of the molecular structure, expression and bioactivity of the TNFSF13B ( BAFF) gene of the South African clawed frog, Xenopus laevis. , Yang L, Zhou L, Zong X, Cao X , Ji X, Gu W, Zhang S., Int Immunopharmacol. March 1, 2013; 15 (3): 478-87.
Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel. , Haerteis S, Krappitz M, Diakov A, Krappitz A, Rauh R, Korbmacher C., J Gen Physiol. October 1, 2012; 140 (4): 375-89.
Tissue kallikrein activation of the epithelial Na channel. , Patel AB, Chao J, Palmer LG., Am J Physiol Renal Physiol. August 15, 2012; 303 (4): F540-50.
Energetic and structural basis for activation of the epithelial sodium channel by matriptase. , Kota P, García-Caballero A, Dang H, Gentzsch M, Stutts MJ, Dokholyan NV., Biochemistry. April 24, 2012; 51 (16): 3460-9.
TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site. , Passero CJ, Mueller GM, Myerburg MM, Carattino MD, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. January 1, 2012; 302 (1): F1-8.
A homolog of Subtilisin-like Proprotein Convertase 7 is essential to anterior neural development in Xenopus. , Senturker S, Thomas JT, Mateshaytis J, Moos M ., PLoS One. January 1, 2012; 7 (6): e39380.
LGR4 and LGR5 are R-spondin receptors mediating Wnt/ β-catenin and Wnt/PCP signalling. , Glinka A , Dolde C, Kirsch N, Huang YL, Kazanskaya O, Ingelfinger D, Boutros M , Cruciat CM, Niehrs C ., EMBO Rep. September 30, 2011; 12 (10): 1055-61.
Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel. , Passero CJ, Carattino MD, Kashlan OB, Myerburg MM, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. October 1, 2010; 299 (4): F854-61.
E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. , Yang T, Mendoza-Londono R, Lu H, Tao J, Li K, Keller B, Jiang MM, Shah R, Chen Y , Bertin TK, Engin F, Dabovic B, Rifkin DB, Hicks J, Jamrich M , Beaudet AL, Lee B., J Clin Invest. July 1, 2010; 120 (7): 2474-85.
Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines. , Song W, Wei S , Zhou Y, Lazrak A, Liu G , Londino JD, Squadrito GL, Matalon S., J Biol Chem. March 26, 2010; 285 (13): 9716-9728.
The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo. , Ho DM, Yeo CY, Whitman M ., Mech Dev. January 1, 2010; 127 (9-12): 485-95.
Alternative mechanism of activation of the epithelial na+ channel by cleavage. , Hu JC, Bengrine A, Lis A, Awayda MS., J Biol Chem. December 25, 2009; 284 (52): 36334-36345.
Site-specific cleavage of BMP4 by furin, PC6, and PC7. , Nelsen SM, Christian JL ., J Biol Chem. October 2, 2009; 284 (40): 27157-66.
Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences. , Kudo H, Liu J , Jansen EJ, Ozawa A, Panula P, Martens GJ, Lindberg I., Endocrinology. March 1, 2009; 150 (3): 1393-9.
Genome-wide identification of Xenopus matrix metalloproteinases: conservation and unique duplications in amphibians. , Fu L, Das B, Mathew S, Shi YB ., BMC Genomics. February 17, 2009; 10 81.
Plasmin activates epithelial Na+ channels by cleaving the gamma subunit. , Passero CJ, Mueller GM, Rondon-Berrios H, Tofovic SP, Hughey RP, Kleyman TR., J Biol Chem. December 26, 2008; 283 (52): 36586-91.
Single-channel analysis of functional epithelial sodium channel (ENaC) stability at the apical membrane of A6 distal kidney cells. , Yu L, Helms MN, Yue Q, Eaton DC., Am J Physiol Renal Physiol. November 1, 2008; 295 (5): F1519-27.
Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels. , Diakov A, Bera K, Mokrushina M, Krueger B, Korbmacher C., J Physiol. October 1, 2008; 586 (19): 4587-608.
Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation. , Carattino MD, Hughey RP, Kleyman TR., J Biol Chem. September 12, 2008; 283 (37): 25290-25295.
Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins. , Tonge D , Chan K, Zhu N, Panjwani A, Arno M, Lynham S, Ward M, Snape A, Pizzey J ., J Cell Sci. August 1, 2008; 121 (Pt 15): 2565-77.
Small molecule activator of the human epithelial sodium channel. , Lu M, Echeverri F, Kalabat D, Laita B, Dahan DS, Smith RD , Xu H, Staszewski L, Yamamoto J, Ling J, Hwang N, Kimmich R, Li P, Patron E, Keung W, Patron A, Moyer BD., J Biol Chem. May 2, 2008; 283 (18): 11981-94.
Preferential assembly of epithelial sodium channel (ENaC) subunits in Xenopus oocytes: role of furin-mediated endogenous proteolysis. , Harris M, Garcia-Caballero A, Stutts MJ, Firsov D, Rossier BC., J Biol Chem. March 21, 2008; 283 (12): 7455-63.
Identification of a novel pool of extracellular pro- myostatin in skeletal muscle. , Anderson SB, Goldberg AL, Whitman M ., J Biol Chem. March 14, 2008; 283 (11): 7027-35.
Defining an inhibitory domain in the alpha-subunit of the epithelial sodium channel. , Carattino MD, Passero CJ, Steren CA, Maarouf AB, Pilewski JM, Myerburg MM, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. January 1, 2008; 294 (1): F47-52.
Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. , Andersson O, Bertolino P, Ibáñez CF., Dev Biol. November 15, 2007; 311 (2): 500-11.
Vg1 has specific processing requirements that restrict its action to body axis patterning centers. , Thomas JT, Moos M ., Dev Biol. October 1, 2007; 310 (1): 129-39.
Glycoproteins of the vitelline envelope of Amphibian oocyte: biological and molecular characterization of ZPC component ( gp41) in Bufo arenarum. , Barisone GA, Krapf D, Correa-Fiz F, Arranz SE, Cabada MO., Mol Reprod Dev. May 1, 2007; 74 (5): 629-40.
Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit. , Bruns JB, Carattino MD, Sheng S, Maarouf AB, Weisz OA, Pilewski JM, Hughey RP, Kleyman TR., J Biol Chem. March 2, 2007; 282 (9): 6153-60.
Xenopus fibrillin regulates directed convergence and extension. , Skoglund P , Keller R ., Dev Biol. January 15, 2007; 301 (2): 404-16.
Regulation of bone morphogenetic protein-4 activity by sequence elements within the prodomain. , Sopory S, Nelsen SM, Degnin C, Wong C, Christian JL ., J Biol Chem. November 10, 2006; 281 (45): 34021-31.
Subtilisin-like proprotein convertase activity is necessary for left- right axis determination in Xenopus neurula embryos. , Toyoizumi R, Takeuchi S, Mogi K., Dev Genes Evol. October 1, 2006; 216 (10): 607-22.
CDMP1/ GDF5 has specific processing requirements that restrict its action to joint surfaces. , Thomas JT, Prakash D, Weih K, Moos M ., J Biol Chem. September 8, 2006; 281 (36): 26725-33.
The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit. , Carattino MD, Sheng S, Bruns JB, Pilewski JM, Hughey RP, Kleyman TR., J Biol Chem. July 7, 2006; 281 (27): 18901-7.