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Summary Expression Phenotypes Gene Literature (156) GO Terms (9) Nucleotides (134) Proteins (60) Interactants (536) Wiki
XB-GENEPAGE-491845

Papers associated with chek1



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Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response., Lee J, Gold DA, Shevchenko A, Shevchenko A, Dunphy WG., Mol Biol Cell. November 1, 2005; 16 (11): 5269-82.

Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP., Kim SM, Kumagai A, Lee J, Lee J, Dunphy WG., J Biol Chem. November 18, 2005; 280 (46): 38355-64.

Changes in regulatory phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during normal cell cycle progression and checkpoint arrests., Stanford JS, Ruderman JV., Mol Biol Cell. December 1, 2005; 16 (12): 5749-60.

Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint., Petersen P, Chou DM, You Z, Hunter T, Walter JC, Walter G., Mol Cell Biol. March 1, 2006; 26 (5): 1997-2011.

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures., Yoo HY, Jeong SY, Dunphy WG., Genes Dev. April 1, 2006; 20 (7): 772-83.

Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus., Lupardus PJ, Cimprich KA., Mol Biol Cell. April 1, 2006; 17 (4): 1559-69.

Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling., Yan S, Lindsay HD, Michael WM., J Cell Biol. April 24, 2006; 173 (2): 181-6.          

Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling., Bomgarden RD, Lupardus PJ, Soni DV, Yee MC, Ford JM, Cimprich KA., EMBO J. June 7, 2006; 25 (11): 2605-14.

The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1., Hashimoto Y, Tsujimura T, Sugino A, Takisawa H., Genes Cells. September 1, 2006; 11 (9): 993-1007.

Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells., Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, Bachs O, Agell N., Cancer Res. September 1, 2006; 66 (17): 8672-9.

Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function., Chini CC, Chen J., J Biol Chem. November 3, 2006; 281 (44): 33276-82.

Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision., Davidson IF, Li A, Blow JJ., Mol Cell. November 3, 2006; 24 (3): 433-43.              

Claspin: timing the cell cycle arrest when the genome is damaged., Freire R, van Vugt MA, Mamely I, Medema RH., Cell Cycle. December 1, 2006; 5 (24): 2831-4.

Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK)., Uckun FM, Dibirdik I, Qazi S, Vassilev A, Ma H, Mao C, Benyumov A, Emami KH., Bioorg Med Chem. January 15, 2007; 15 (2): 800-14.

Geminin prevents rereplication during xenopus development., Kerns SL, Torke SJ, Benjamin JM, McGarry TJ., J Biol Chem. February 23, 2007; 282 (8): 5514-21.

Linking PCNA-dependent replication and ATR by human Claspin., Brondello JM, Ducommun B, Fernandez A, Lamb NJ., Biochem Biophys Res Commun. March 23, 2007; 354 (4): 1028-33.

The structural determinants of checkpoint activation., MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA., Genes Dev. April 15, 2007; 21 (8): 898-903.

Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM., Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., J Biol Chem. June 15, 2007; 282 (24): 17501-6.

Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts., Errico A, Costanzo V, Hunt T., Proc Natl Acad Sci U S A. September 18, 2007; 104 (38): 14929-34.

Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos., Peng A, Lewellyn AL, Maller JL., Mol Cell Biol. October 1, 2007; 27 (19): 6852-62.

Maternal cyclin B levels "Chk" the onset of DNA replication checkpoint control in Drosophila., Yellajoshyula D, Patterson ES, Kroll KL., Bioessays. October 1, 2007; 29 (10): 949-52.

Wee1 kinase alters cyclin E/Cdk2 and promotes apoptosis during the early embryonic development of Xenopus laevis., Wroble BN, Finkielstein CV, Sible JC., BMC Dev Biol. October 25, 2007; 7 119.          

Plx1 is required for chromosomal DNA replication under stressful conditions., Trenz K, Errico A, Costanzo V., EMBO J. March 19, 2008; 27 (6): 876-85.              

Chk1 is activated at the midblastula transition in Xenopus laevis embryos independently of DNA content and the cyclin E/Cdk2 developmental timer., Adjerid N, Wroble BN, Sible JC., Cell Cycle. April 15, 2008; 7 (8): 1112-6.

Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress., Davuluri G, Gong W, Yusuff S, Lorent K, Muthumani M, Dolan AC, Pack M., PLoS Genet. October 1, 2008; 4 (10): e1000240.              

The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control., Tsuji T, Lau E, Chiang GG, Jiang W., Mol Cell. December 26, 2008; 32 (6): 862-9.

TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks., Yan S, Michael WM., J Cell Biol. March 23, 2009; 184 (6): 793-804.            

The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest., Isoda M, Kanemori Y, Nakajo N, Uchida S, Yamashita K, Ueno H, Sagata N., Mol Biol Cell. April 1, 2009; 20 (8): 2186-95.              

A quantitative model of the effect of unreplicated DNA on cell cycle progression in frog egg extracts., Zwolak J, Adjerid N, Bagci EZ, Tyson JJ, Sible JC., J Theor Biol. September 7, 2009; 260 (1): 110-20.

Checkpoint signaling from a single DNA interstrand crosslink., Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J., Mol Cell. September 11, 2009; 35 (5): 704-15.

Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase., Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A., J Biol Chem. November 27, 2009; 284 (48): 33107-14.

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis., Taylor EM, Cecillon SM, Bonis A, Chapman JR, Povirk LF, Lindsay HD., Nucleic Acids Res. January 1, 2010; 38 (2): 441-54.        

Origin-dependent initiation of DNA replication within telomeric sequences., Kurth I, Gautier J., Nucleic Acids Res. January 1, 2010; 38 (2): 467-76.          

CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells., Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M., J Cell Sci. January 15, 2010; 123 (Pt 2): 225-35.

Treslin collaborates with TopBP1 in triggering the initiation of DNA replication., Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Cell. February 5, 2010; 140 (3): 349-59.                        

Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks., Lee J, Lee J, Dunphy WG., Mol Biol Cell. March 15, 2010; 21 (6): 926-35.            

Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM., Wawrousek KE, Fortini BK, Polaczek P, Chen L, Liu Q, Dunphy WG, Campbell JL., Cell Cycle. March 15, 2010; 9 (6): 1156-66.

Continued primer synthesis at stalled replication forks contributes to checkpoint activation., Van C, Yan S, Michael WM, Waga S, Cimprich KA., J Cell Biol. April 19, 2010; 189 (2): 233-46.              

Drf1-dependent kinase interacts with Claspin through a conserved protein motif., Gold DA, Dunphy WG., J Biol Chem. April 23, 2010; 285 (17): 12638-46.

Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex., Kundu LR, Kumata Y, Kakusho N, Watanabe S, Furukohri A, Waga S, Seki M, Masai H, Enomoto T, Tada S., Nucleic Acids Res. September 1, 2010; 38 (16): 5409-18.              

Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation., Lee SY, Lau AT, Jeong CH, Shim JH, Kim HG, Kim J, Bode AM, Dong Z., J Biol Chem. September 17, 2010; 285 (38): 29525-34.                  

A new in vitro system for activating the cell cycle checkpoint., Wang J, Engle S, Zhang Y, Zhang Y., Cell Cycle. February 1, 2011; 10 (3): 500-6.

Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts., Le Breton C, Hennion M, Arimondo PB, Hyrien O., PLoS One. April 15, 2011; 6 (4): e18554.          

Phosphorylation of Claspin is triggered by the nucleocytoplasmic ratio at the Xenopus laevis midblastula transition., Gotoh T, Kishimoto T, Sible JC., Dev Biol. May 15, 2011; 353 (2): 302-8.          

Essential roles of Xenopus TRF2 in telomere end protection and replication., Muraki K, Nabetani A, Nishiyama A, Ishikawa F., Genes Cells. June 1, 2011; 16 (6): 728-39.

Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair., Peterson SE, Li Y, Chait BT, Gottesman ME, Baer R, Gautier J., J Cell Biol. September 5, 2011; 194 (5): 705-20.              

RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks., Hashimoto Y, Puddu F, Costanzo V., Nat Struct Mol Biol. December 4, 2011; 19 (1): 17-24.          

Geminin is required for zygotic gene expression at the Xenopus mid-blastula transition., Kerns SL, Schultz KM, Barry KA, Thorne TM, McGarry TJ., PLoS One. January 1, 2012; 7 (5): e38009.                        

The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A., Moghe S, Jiang F, Miura Y, Cerny RL, Tsai MY, Furukawa M., Biol Open. February 15, 2012; 1 (2): 82-91.                

Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts., Kumar S, Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Cell Cycle. March 15, 2012; 11 (6): 1183-94.

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