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Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus. , Lupardus PJ, Cimprich KA., Mol Biol Cell. April 1, 2006; 17 (4): 1559-69.
Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. , Petersen P, Chou DM, You Z, Hunter T, Walter JC , Walter G., Mol Cell Biol. March 1, 2006; 26 (5): 1997-2011.
Changes in regulatory phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during normal cell cycle progression and checkpoint arrests. , Stanford JS, Ruderman JV ., Mol Biol Cell. December 1, 2005; 16 (12): 5749-60.
Phosphorylation of Chk1 by ATM- and Rad3-related ( ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP. , Kim SM, Kumagai A , Lee J , Lee J , Dunphy WG ., J Biol Chem. November 18, 2005; 280 (46): 38355-64.
Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response. , Lee J , Gold DA, Shevchenko A, Shevchenko A, Dunphy WG ., Mol Biol Cell. November 1, 2005; 16 (11): 5269-82.
Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway. , Clarke CA, Bennett LN, Clarke PR., J Biol Chem. October 21, 2005; 280 (42): 35337-45.
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. , Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG , Rathmell JC, Kornbluth S ., Cell. October 7, 2005; 123 (1): 89-103.
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. , Clarke CA, Clarke PR., Biochem J. June 1, 2005; 388 (Pt 2): 705-12.
Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases. , Kanemori Y, Uto K, Sagata N ., Proc Natl Acad Sci U S A. May 3, 2005; 102 (18): 6279-84.
Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable. , de Vries HI, Uyetake L, Lemstra W, Brunsting JF, Su TT, Kampinga HH, Sibon OC., J Cell Sci. May 1, 2005; 118 (Pt 9): 1833-42.
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. , Byun TS, Pacek M, Yee MC, Walter JC , Cimprich KA., Genes Dev. May 1, 2005; 19 (9): 1040-52.
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus. , Luciani MG, Oehlmann M, Blow JJ ., J Cell Sci. December 1, 2004; 117 (Pt 25): 6019-30.
Claspin and the activated form of ATR- ATRIP collaborate in the activation of Chk1. , Kumagai A , Kim SM, Dunphy WG ., J Biol Chem. November 26, 2004; 279 (48): 49599-608.
Geminin has dimerization, Cdt1-binding, and destruction domains that are required for biological activity. , Benjamin JM, Torke SJ, Demeler B, McGarry TJ., J Biol Chem. October 29, 2004; 279 (44): 45957-68.
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism. , Uto K, Inoue D, Shimuta K, Nakajo N, Sagata N ., EMBO J. August 18, 2004; 23 (16): 3386-96.
The DNA damage checkpoint in embryonic cell cycles is dependent on the DNA-to-cytoplasmic ratio. , Conn CW, Lewellyn AL, Maller JL ., Dev Cell. August 1, 2004; 7 (2): 275-81.
ATR and ATM regulate the timing of DNA replication origin firing. , Shechter D , Costanzo V, Gautier J ., Nat Cell Biol. July 1, 2004; 6 (7): 648-55.
A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication. , Jares P, Luciani MG, Blow JJ ., BMC Mol Biol. June 28, 2004; 5 5.
Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases. , Li W , Kim SM, Lee J , Lee J , Dunphy WG ., J Cell Biol. June 21, 2004; 165 (6): 801-12.
Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. , Yoo HY, Kumagai A , Shevchenko A, Shevchenko A, Dunphy WG ., Cell. May 28, 2004; 117 (5): 575-88.
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. , Lin SY, Li K, Stewart GS, Elledge SJ., Proc Natl Acad Sci U S A. April 27, 2004; 101 (17): 6484-9.
The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. , Oehlmann M, Score AJ, Blow JJ ., J Cell Biol. April 26, 2004; 165 (2): 181-90.
Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation. , Katsuragi Y, Sagata N ., Mol Biol Cell. April 1, 2004; 15 (4): 1680-9.
Altered expression of Chk1 disrupts cell cycle remodeling at the midblastula transition in Xenopus laevis embryos. , Petrus MJ, Wilhelm DE, Murakami M, Kappas NC, Carter AD, Wroble BN , Sible JC ., Cell Cycle. February 1, 2004; 3 (2): 212-7.
Claspin, a regulator of Chk1 in DNA replication stress pathway. , Chini CC, Chen J ., DNA Repair (Amst). January 1, 2004; 3 (8-9): 1033-7.
Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation. , Jeong SY, Kumagai A , Lee J , Lee J , Dunphy WG ., J Biol Chem. November 21, 2003; 278 (47): 46782-8.
Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin. , Parrilla-Castellar ER, Karnitz LM., J Biol Chem. November 14, 2003; 278 (46): 45507-11.
DNA damage-induced replication arrest in Xenopus egg extracts. , Stokes MP, Michael WM., J Cell Biol. October 27, 2003; 163 (2): 245-55.
Regulation of Cdc2/ cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II. , Hutchins JR, Dikovskaya D, Clarke PR., Mol Biol Cell. October 1, 2003; 14 (10): 4003-14.
XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus. , Jones RE, Chapman JR, Puligilla C, Murray JM, Car AM, Ford CC , Lindsay HD ., Mol Biol Cell. September 1, 2003; 14 (9): 3898-910.
Human claspin is required for replication checkpoint control. , Chini CC, Chen J ., J Biol Chem. August 8, 2003; 278 (32): 30057-62.
Expression of cell-cycle regulators during Xenopus oogenesis. , Furuno N , Kawasaki A, Sagata N ., Gene Expr Patterns. May 1, 2003; 3 (2): 165-8.
Loss of XChk1 function triggers apoptosis after the midblastula transition in Xenopus laevis embryos. , Carter AD, Sible JC , Sible JC ., Mech Dev. March 1, 2003; 120 (3): 315-23.
Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. , Lee J , Lee J , Kumagai A , Dunphy WG ., Mol Cell. February 1, 2003; 11 (2): 329-40.
Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1. , Kumagai A , Dunphy WG ., Nat Cell Biol. February 1, 2003; 5 (2): 161-5.
Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest. , Capasso H, Palermo C, Wan S, Rao H, John UP, O'Connell MJ, Walworth NC., J Cell Sci. December 1, 2002; 115 (Pt 23): 4555-64.
Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus. , McGarry TJ., Mol Biol Cell. October 1, 2002; 13 (10): 3662-71.
A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. , Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA., Genes Dev. September 15, 2002; 16 (18): 2327-32.
DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. , Stokes MP, Van Hatten R, Lindsay HD , Michael WM., J Cell Biol. September 2, 2002; 158 (5): 863-72.
The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint. , You Z, Kong L, Newport J., J Biol Chem. July 26, 2002; 277 (30): 27088-93.
Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition. , Shimuta K, Nakajo N, Uto K, Hayano Y, Okazaki K, Sagata N ., EMBO J. July 15, 2002; 21 (14): 3694-703.
Signalling pathways in oocyte meiotic maturation. , Schmitt A, Nebreda AR., J Cell Sci. June 15, 2002; 115 (Pt 12): 2457-9.
The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. , Kang D, Chen J , Wong J, Fang G., J Cell Biol. January 21, 2002; 156 (2): 249-59.
Inactivation of the checkpoint kinase Cds1 is dependent on cyclin B- Cdc2 kinase activation at the meiotic G(2)/M-phase transition in Xenopus oocytes. , Gotoh T, Ohsumi K, Matsui T, Takisawa H, Kishimoto T., J Cell Sci. September 1, 2001; 114 (Pt 18): 3397-406.
Positive regulation of Wee1 by Chk1 and 14-3-3 proteins. , Lee J , Kumagai A , Dunphy WG ., Mol Biol Cell. March 1, 2001; 12 (3): 551-63.
Cytoplasmic occurrence of the Chk1/ Cdc25 pathway and regulation of Chk1 in Xenopus oocytes. , Oe T, Nakajo N, Katsuragi Y, Okazaki K, Sagata N ., Dev Biol. January 1, 2001; 229 (1): 250-61.
Activation of Xenopus Chk1 by mutagenesis of threonine-377. , Wang SX, Dunphy WG ., FEBS Lett. December 29, 2000; 487 (2): 277-81.
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. , Hekmat-Nejad M, You Z, Yee MC, Newport JW, Cimprich KA., Curr Biol. December 1, 2000; 10 (24): 1565-73.
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. , Guo Z, Kumagai A , Wang SX, Dunphy WG ., Genes Dev. November 1, 2000; 14 (21): 2745-56.
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. , Kumagai A , Dunphy WG ., Mol Cell. October 1, 2000; 6 (4): 839-49.