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Summary Expression Phenotypes Gene Literature (162) GO Terms (13) Nucleotides (102) Proteins (50) Interactants (457) Wiki
XB-GENEPAGE-1012721

Papers associated with atr



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Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation., Gambus A, Blow JJ., Cell Cycle. April 15, 2013; 12 (8): 1225-32.                


A role for the MRN complex in ATR activation via TOPBP1 recruitment., Duursma AM, Driscoll R, Elias JE, Cimprich KA., Mol Cell. April 11, 2013; 50 (1): 116-22.


Activation of DSB processing requires phosphorylation of CtIP by ATR., Peterson SE, Li Y, Wu-Baer F, Chait BT, Baer R, Yan H, Gottesman ME, Gautier J., Mol Cell. February 21, 2013; 49 (4): 657-67.


WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling., Yan S, Willis J., Biochem Biophys Res Commun. February 15, 2013; 431 (3): 466-71.


SUMO2/3 modification of cyclin E contributes to the control of replication origin firing., Bonne-Andrea C, Kahli M, Mechali F, Lemaitre JM, Bossis G, Coux O., Nat Commun. January 1, 2013; 4 1850.        


Study of the DNA damage checkpoint using Xenopus egg extracts., Willis J, DeStephanis D, Patel Y, Gowda V, Yan S., J Vis Exp. November 5, 2012; (69): e4449.


Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks., Lee EM, Trinh TT, Shim HJ, Park SY, Nguyen TT, Kim MJ, Song YH., DNA Repair (Amst). September 1, 2012; 11 (9): 741-52.


Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase., Sareen A, Chaudhury I, Adams N, Sobeck A., Nucleic Acids Res. September 1, 2012; 40 (17): 8425-39.          


The conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1., Liu S, Song N, Zou L., Cell Cycle. July 15, 2012; 11 (14): 2711-6.


Removal of shelterin reveals the telomere end-protection problem., Sfeir A, de Lange T., Science. May 4, 2012; 336 (6081): 593-7.


Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts., Recolin B, Van der Laan S, Maiorano D., Nucleic Acids Res. April 1, 2012; 40 (8): 3431-42.        


Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts., Kumar S, Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Cell Cycle. March 15, 2012; 11 (6): 1183-94.


Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair., Peterson SE, Li Y, Chait BT, Gottesman ME, Baer R, Gautier J., J Cell Biol. September 5, 2011; 194 (5): 705-20.              


Essential roles of Xenopus TRF2 in telomere end protection and replication., Muraki K, Nabetani A, Nishiyama A, Ishikawa F., Genes Cells. June 1, 2011; 16 (6): 728-39.


Phosphorylation of Claspin is triggered by the nucleocytoplasmic ratio at the Xenopus laevis midblastula transition., Gotoh T, Kishimoto T, Sible JC., Dev Biol. May 15, 2011; 353 (2): 302-8.          


Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts., Le Breton C, Hennion M, Arimondo PB, Hyrien O., PLoS One. April 15, 2011; 6 (4): e18554.          


A new in vitro system for activating the cell cycle checkpoint., Wang J, Engle S, Zhang Y, Zhang Y., Cell Cycle. February 1, 2011; 10 (3): 500-6.


CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts., Ramírez-Lugo JS, Yoo HY, Yoon SJ, Dunphy WG., Cell Cycle. February 1, 2011; 10 (3): 469-80.


A novel role for greatwall kinase in recovery from DNA damage., Peng A, Yamamoto TM, Goldberg ML, Maller JL., Cell Cycle. November 1, 2010; 9 (21): 4364-9.


Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex., Kundu LR, Kumata Y, Kakusho N, Watanabe S, Furukohri A, Waga S, Seki M, Masai H, Enomoto T, Tada S., Nucleic Acids Res. September 1, 2010; 38 (16): 5409-18.              


Continued primer synthesis at stalled replication forks contributes to checkpoint activation., Van C, Yan S, Michael WM, Waga S, Cimprich KA., J Cell Biol. April 19, 2010; 189 (2): 233-46.              


Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks., Lee J, Lee J, Dunphy WG., Mol Biol Cell. March 15, 2010; 21 (6): 926-35.            


Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis)., Hayes TB, Khoury V, Narayan A, Nazir M, Park A, Brown T, Adame L, Chan E, Buchholz D, Stueve T, Gallipeau S., Proc Natl Acad Sci U S A. March 9, 2010; 107 (10): 4612-7.            


Treslin collaborates with TopBP1 in triggering the initiation of DNA replication., Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Cell. February 5, 2010; 140 (3): 349-59.                        


CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells., Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M., J Cell Sci. January 15, 2010; 123 (Pt 2): 225-35.


Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase., Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A., J Biol Chem. November 27, 2009; 284 (48): 33107-14.


The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways., Sobeck A, Stone S, Landais I, de Graaf B, Hoatlin ME., J Biol Chem. September 18, 2009; 284 (38): 25560-8.


Checkpoint signaling from a single DNA interstrand crosslink., Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J., Mol Cell. September 11, 2009; 35 (5): 704-15.


Molecular interactions between magainin 2 and model membranes in situ., Nguyen KT, Le Clair SV, Ye S, Chen Z., J Phys Chem B. September 10, 2009; 113 (36): 12358-63.


Studying the DNA damage response using in vitro model systems., Garner E, Costanzo V., DNA Repair (Amst). September 2, 2009; 8 (9): 1025-37.


Responding to chromosomal breakage during M-phase: insights from a cell-free system., Smith E, Costanzo V., Cell Div. July 14, 2009; 4 15.  


An ATM and ATR dependent pathway targeting centrosome dependent spindle assembly., Brown N, Costanzo V., Cell Cycle. July 1, 2009; 8 (13): 1997-2001.


The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM., Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Mol Biol Cell. May 1, 2009; 20 (9): 2351-60.


TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks., Yan S, Michael WM., J Cell Biol. March 23, 2009; 184 (6): 793-804.            


An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63., Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, Vindigni A, Costanzo V., Nat Cell Biol. March 1, 2009; 11 (3): 278-85.


The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control., Tsuji T, Lau E, Chiang GG, Jiang W., Mol Cell. December 26, 2008; 32 (6): 862-9.


Fanconi anemia proteins stabilize replication forks., Wang LC, Stone S, Hoatlin ME, Gautier J., DNA Repair (Amst). December 1, 2008; 7 (12): 1973-81.


DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts., Labit H, Perewoska I, Germe T, Hyrien O, Marheineke K., Nucleic Acids Res. October 1, 2008; 36 (17): 5623-34.              


PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage., Göhler T, Munoz IM, Rouse J, Blow JJ., DNA Repair (Amst). May 3, 2008; 7 (5): 775-87.


Plx1 is required for chromosomal DNA replication under stressful conditions., Trenz K, Errico A, Costanzo V., EMBO J. March 19, 2008; 27 (6): 876-85.              


Telomere capping and cellular checkpoints: clues from fruit flies., Ciapponi L, Cenci G., Cytogenet Genome Res. January 1, 2008; 122 (3-4): 365-73.


Probing ATR activation with model DNA templates., Cimprich KA., Cell Cycle. October 1, 2007; 6 (19): 2348-54.


The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR., Lee J, Lee J, Kumagai A, Dunphy WG., J Biol Chem. September 21, 2007; 282 (38): 28036-44.


Non-catalytic function for ATR in the checkpoint response., McSherry TD, Kitazono AA, Javaheri A, Kron SJ, Mueller PR., Cell Cycle. August 15, 2007; 6 (16): 2019-30.


Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM., Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., J Biol Chem. June 15, 2007; 282 (24): 17501-6.


DNA structure-induced recruitment and activation of the Fanconi anemia pathway protein FANCD2., Sobeck A, Stone S, Hoatlin ME., Mol Cell Biol. June 1, 2007; 27 (12): 4283-92.


The structural determinants of checkpoint activation., MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA., Genes Dev. April 15, 2007; 21 (8): 898-903.


Linking PCNA-dependent replication and ATR by human Claspin., Brondello JM, Ducommun B, Fernandez A, Lamb NJ., Biochem Biophys Res Commun. March 23, 2007; 354 (4): 1028-33.


Analyzing the ATR-mediated checkpoint using Xenopus egg extracts., Lupardus PJ, Van C, Cimprich KA., Methods. February 1, 2007; 41 (2): 222-31.


Claspin: timing the cell cycle arrest when the genome is damaged., Freire R, van Vugt MA, Mamely I, Medema RH., Cell Cycle. December 1, 2006; 5 (24): 2831-4.

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