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Summary Expression Phenotypes Gene Literature (162) GO Terms (13) Nucleotides (102) Proteins (50) Interactants (457) Wiki
XB-GENEPAGE-1012721

Papers associated with atr



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Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function., Chini CC, Chen J., J Biol Chem. November 3, 2006; 281 (44): 33276-82.

Retinoic acid signalling is required for specification of pronephric cell fate., Cartry J, Nichane M, Ribes V, Colas A, Riou JF, Pieler T, Dollé P, Bellefroid EJ, Umbhauer M., Dev Biol. November 1, 2006; 299 (1): 35-51.                  

Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities., Chang DJ, Lupardus PJ, Cimprich KA., J Biol Chem. October 27, 2006; 281 (43): 32081-8.

The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1., Hashimoto Y, Tsujimura T, Sugino A, Takisawa H., Genes Cells. September 1, 2006; 11 (9): 993-1007.

Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells., Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, Bachs O, Agell N., Cancer Res. September 1, 2006; 66 (17): 8672-9.

Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling., Bomgarden RD, Lupardus PJ, Soni DV, Yee MC, Ford JM, Cimprich KA., EMBO J. June 7, 2006; 25 (11): 2605-14.

Xenopus CDC7/DRF1 complex is required for the initiation of DNA replication., Silva T, Bradley RH, Gao Y, Coue M., J Biol Chem. April 28, 2006; 281 (17): 11569-76.

Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling., Yan S, Lindsay HD, Michael WM., J Cell Biol. April 24, 2006; 173 (2): 181-6.          

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks., Trenz K, Smith E, Smith S, Costanzo V., EMBO J. April 19, 2006; 25 (8): 1764-74.

Retinoids restore normal cyclic nucleotide sensitivity of mutant ion channels associated with cone dystrophy., Tetreault ML, Horrigan DM, Kim JA, Zimmerman AL., Mol Vis. April 10, 2006; 12 1699-705.

Pesticide mixtures, endocrine disruption, and amphibian declines: are we underestimating the impact?, Hayes TB, Case P, Chui S, Chung D, Haeffele C, Haston K, Lee M, Mai VP, Marjuoa Y, Parker J, Tsui M., Environ Health Perspect. April 1, 2006; 114 Suppl 1 (Suppl 1): 40-50.                        

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures., Yoo HY, Jeong SY, Dunphy WG., Genes Dev. April 1, 2006; 20 (7): 772-83.

Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus., Lupardus PJ, Cimprich KA., Mol Biol Cell. April 1, 2006; 17 (4): 1559-69.

TopBP1 activates the ATR-ATRIP complex., Kumagai A, Lee J, Lee J, Yoo HY, Dunphy WG., Cell. March 10, 2006; 124 (5): 943-55.

TOPping up ATR activity., Bartek J, Mailand N., Cell. March 10, 2006; 124 (5): 888-90.

Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint., Petersen P, Chou DM, You Z, Hunter T, Walter JC, Walter G., Mol Cell Biol. March 1, 2006; 26 (5): 1997-2011.

Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks., Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, Hoatlin ME., Mol Cell Biol. January 1, 2006; 26 (2): 425-37.

Coordination of DNA synthesis and replicative unwinding by the S-phase checkpoint pathways., Nedelcheva-Veleva MN, Krastev DB, Stoynov SS., Nucleic Acids Res. January 1, 2006; 34 (15): 4138-46.        

Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP., Kim SM, Kumagai A, Lee J, Lee J, Dunphy WG., J Biol Chem. November 18, 2005; 280 (46): 38355-64.

Defining the retinoid binding site in the rod cyclic nucleotide-gated channel., Horrigan DM, Tetreault ML, Tsomaia N, Vasileiou C, Borhan B, Mierke DF, Crouch RK, Zimmerman AL., J Gen Physiol. November 1, 2005; 126 (5): 453-60.          

Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response., Lee J, Gold DA, Shevchenko A, Shevchenko A, Dunphy WG., Mol Biol Cell. November 1, 2005; 16 (11): 5269-82.

Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway., Clarke CA, Bennett LN, Clarke PR., J Biol Chem. October 21, 2005; 280 (42): 35337-45.

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system., Clarke CA, Clarke PR., Biochem J. June 1, 2005; 388 (Pt 2): 705-12.

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint., Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA., Genes Dev. May 1, 2005; 19 (9): 1040-52.

Dorsoventral patterning of the Xenopus eye: a collaboration of Retinoid, Hedgehog and FGF receptor signaling., Lupo G, Liu Y, Qiu R, Chandraratna RA, Barsacchi G, He RQ, Harris WA., Development. April 1, 2005; 132 (7): 1737-48.                    

ATM and ATR check in on origins: a dynamic model for origin selection and activation., Shechter D, Gautier J., Cell Cycle. February 1, 2005; 4 (2): 235-8.

Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses., Yoo HY, Shevchenko A, Shevchenko A, Dunphy WG., J Biol Chem. December 17, 2004; 279 (51): 53353-64.

Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus., Luciani MG, Oehlmann M, Blow JJ., J Cell Sci. December 1, 2004; 117 (Pt 25): 6019-30.

Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1., Kumagai A, Kim SM, Dunphy WG., J Biol Chem. November 26, 2004; 279 (48): 49599-608.

Xenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends., McSherry TD, Mueller PR., Mol Cell Biol. November 1, 2004; 24 (22): 9968-85.

Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures., Sar F, Lindsey-Boltz LA, Subramanian D, Croteau DL, Hutsell SQ, Griffith JD, Sancar A., J Biol Chem. September 17, 2004; 279 (38): 39289-95.

Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint., Marheineke K, Hyrien O., J Biol Chem. July 2, 2004; 279 (27): 28071-81.

ATR and ATM regulate the timing of DNA replication origin firing., Shechter D, Costanzo V, Gautier J., Nat Cell Biol. July 1, 2004; 6 (7): 648-55.

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases., Li W, Kim SM, Lee J, Lee J, Dunphy WG., J Cell Biol. June 21, 2004; 165 (6): 801-12.                

Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase., Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Cell. May 28, 2004; 117 (5): 575-88.

Mre11 assembles linear DNA fragments into DNA damage signaling complexes., Costanzo V, Paull T, Gottesman M, Gautier J., PLoS Biol. May 1, 2004; 2 (5): E110.          

All-trans-retinal is a closed-state inhibitor of rod cyclic nucleotide-gated ion channels., McCabe SL, Pelosi DM, Tetreault M, Miri A, Nguitragool W, Kovithvathanaphong P, Mahajan R, Zimmerman AL., J Gen Physiol. May 1, 2004; 123 (5): 521-31.                

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation., Lin SY, Li K, Stewart GS, Elledge SJ., Proc Natl Acad Sci U S A. April 27, 2004; 101 (17): 6484-9.

Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation., Katsuragi Y, Sagata N., Mol Biol Cell. April 1, 2004; 15 (4): 1680-9.

Xenopus cell-free extracts to study the DNA damage response., Costanzo V, Robertson K, Gautier J., Methods Mol Biol. January 1, 2004; 280 213-27.

Regulation of DNA replication by ATR: signaling in response to DNA intermediates., Shechter D, Costanzo V, Gautier J., DNA Repair (Amst). January 1, 2004; 3 (8-9): 901-8.

Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation., Jeong SY, Kumagai A, Lee J, Lee J, Dunphy WG., J Biol Chem. November 21, 2003; 278 (47): 46782-8.

Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin., Parrilla-Castellar ER, Karnitz LM., J Biol Chem. November 14, 2003; 278 (46): 45507-11.

ATM/ATR-independent inhibition of cyclin B accumulation in response to hydroxyurea in nontransformed cell lines is altered in tumour cell lines., Florensa R, Bachs O, Agell N., Oncogene. November 13, 2003; 22 (51): 8283-92.

Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest., Yanow SK, Gold DA, Yoo HY, Dunphy WG., J Biol Chem. October 17, 2003; 278 (42): 41083-92.

The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon., Post SM, Tomkinson AE, Lee EY., Nucleic Acids Res. October 1, 2003; 31 (19): 5568-75.

XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus., Jones RE, Chapman JR, Puligilla C, Murray JM, Car AM, Ford CC, Lindsay HD., Mol Biol Cell. September 1, 2003; 14 (9): 3898-910.

Human claspin is required for replication checkpoint control., Chini CC, Chen J., J Biol Chem. August 8, 2003; 278 (32): 30057-62.

Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17., Lee J, Lee J, Kumagai A, Dunphy WG., Mol Cell. February 1, 2003; 11 (2): 329-40.

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1., Kumagai A, Dunphy WG., Nat Cell Biol. February 1, 2003; 5 (2): 161-5.

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