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Summary Expression Phenotypes Gene Literature (162) GO Terms (13) Nucleotides (102) Proteins (50) Interactants (457) Wiki
XB-GENEPAGE-1012721

Papers associated with atr



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Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals., Das P, Inoue H, Baker JC, Beppu H, Kawabata M, Harland RM, Miyazono K, Padgett RW., Genes Cells. February 1, 1999; 4 (2): 123-34.  

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts., Guo Z, Kumagai A, Wang SX, Dunphy WG., Genes Dev. November 1, 2000; 14 (21): 2745-56.

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint., Hekmat-Nejad M, You Z, Yee MC, Newport JW, Cimprich KA., Curr Biol. December 1, 2000; 10 (24): 1565-73.

Increased XRALDH2 activity has a posteriorizing effect on the central nervous system of Xenopus embryos., Chen Y, Pollet N, Niehrs C, Pieler T., Mech Dev. March 1, 2001; 101 (1-2): 91-103.        

Aphidicolin triggers a block to replication origin firing in Xenopus egg extracts., Marheineke K, Hyrien O., J Biol Chem. May 18, 2001; 276 (20): 17092-100.

Conjugation of a magainin analogue with lipophilic acids controls hydrophobicity, solution assembly, and cell selectivity., Avrahami D, Shai Y., Biochemistry. February 19, 2002; 41 (7): 2254-63.

The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint., You Z, Kong L, Newport J., J Biol Chem. July 26, 2002; 277 (30): 27088-93.

A requirement for replication in activation of the ATR-dependent DNA damage checkpoint., Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA., Genes Dev. September 15, 2002; 16 (18): 2327-32.

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling., Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO., J Biol Chem. September 20, 2002; 277 (38): 34727-35.                

Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest., Capasso H, Palermo C, Wan S, Rao H, John UP, O'Connell MJ, Walworth NC., J Cell Sci. December 1, 2002; 115 (Pt 23): 4555-64.

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366., Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR., Biochem J. December 1, 2002; 368 (Pt 2): 507-16.

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication., Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J., Mol Cell. January 1, 2003; 11 (1): 203-13.

Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17., Lee J, Lee J, Kumagai A, Dunphy WG., Mol Cell. February 1, 2003; 11 (2): 329-40.

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1., Kumagai A, Dunphy WG., Nat Cell Biol. February 1, 2003; 5 (2): 161-5.

Human claspin is required for replication checkpoint control., Chini CC, Chen J., J Biol Chem. August 8, 2003; 278 (32): 30057-62.

XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus., Jones RE, Chapman JR, Puligilla C, Murray JM, Car AM, Ford CC, Lindsay HD., Mol Biol Cell. September 1, 2003; 14 (9): 3898-910.

The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon., Post SM, Tomkinson AE, Lee EY., Nucleic Acids Res. October 1, 2003; 31 (19): 5568-75.

Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest., Yanow SK, Gold DA, Yoo HY, Dunphy WG., J Biol Chem. October 17, 2003; 278 (42): 41083-92.

ATM/ATR-independent inhibition of cyclin B accumulation in response to hydroxyurea in nontransformed cell lines is altered in tumour cell lines., Florensa R, Bachs O, Agell N., Oncogene. November 13, 2003; 22 (51): 8283-92.

Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin., Parrilla-Castellar ER, Karnitz LM., J Biol Chem. November 14, 2003; 278 (46): 45507-11.

Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation., Jeong SY, Kumagai A, Lee J, Lee J, Dunphy WG., J Biol Chem. November 21, 2003; 278 (47): 46782-8.

Xenopus cell-free extracts to study the DNA damage response., Costanzo V, Robertson K, Gautier J., Methods Mol Biol. January 1, 2004; 280 213-27.

Regulation of DNA replication by ATR: signaling in response to DNA intermediates., Shechter D, Costanzo V, Gautier J., DNA Repair (Amst). January 1, 2004; 3 (8-9): 901-8.

Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation., Katsuragi Y, Sagata N., Mol Biol Cell. April 1, 2004; 15 (4): 1680-9.

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation., Lin SY, Li K, Stewart GS, Elledge SJ., Proc Natl Acad Sci U S A. April 27, 2004; 101 (17): 6484-9.

Mre11 assembles linear DNA fragments into DNA damage signaling complexes., Costanzo V, Paull T, Gottesman M, Gautier J., PLoS Biol. May 1, 2004; 2 (5): E110.          

All-trans-retinal is a closed-state inhibitor of rod cyclic nucleotide-gated ion channels., McCabe SL, Pelosi DM, Tetreault M, Miri A, Nguitragool W, Kovithvathanaphong P, Mahajan R, Zimmerman AL., J Gen Physiol. May 1, 2004; 123 (5): 521-31.                

Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase., Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Cell. May 28, 2004; 117 (5): 575-88.

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases., Li W, Kim SM, Lee J, Lee J, Dunphy WG., J Cell Biol. June 21, 2004; 165 (6): 801-12.                

ATR and ATM regulate the timing of DNA replication origin firing., Shechter D, Costanzo V, Gautier J., Nat Cell Biol. July 1, 2004; 6 (7): 648-55.

Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint., Marheineke K, Hyrien O., J Biol Chem. July 2, 2004; 279 (27): 28071-81.

Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures., Sar F, Lindsey-Boltz LA, Subramanian D, Croteau DL, Hutsell SQ, Griffith JD, Sancar A., J Biol Chem. September 17, 2004; 279 (38): 39289-95.

Xenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends., McSherry TD, Mueller PR., Mol Cell Biol. November 1, 2004; 24 (22): 9968-85.

Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1., Kumagai A, Kim SM, Dunphy WG., J Biol Chem. November 26, 2004; 279 (48): 49599-608.

Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus., Luciani MG, Oehlmann M, Blow JJ., J Cell Sci. December 1, 2004; 117 (Pt 25): 6019-30.

Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses., Yoo HY, Shevchenko A, Shevchenko A, Dunphy WG., J Biol Chem. December 17, 2004; 279 (51): 53353-64.

ATM and ATR check in on origins: a dynamic model for origin selection and activation., Shechter D, Gautier J., Cell Cycle. February 1, 2005; 4 (2): 235-8.

Dorsoventral patterning of the Xenopus eye: a collaboration of Retinoid, Hedgehog and FGF receptor signaling., Lupo G, Liu Y, Qiu R, Chandraratna RA, Barsacchi G, He RQ, Harris WA., Development. April 1, 2005; 132 (7): 1737-48.                    

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint., Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA., Genes Dev. May 1, 2005; 19 (9): 1040-52.

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system., Clarke CA, Clarke PR., Biochem J. June 1, 2005; 388 (Pt 2): 705-12.

Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway., Clarke CA, Bennett LN, Clarke PR., J Biol Chem. October 21, 2005; 280 (42): 35337-45.

Defining the retinoid binding site in the rod cyclic nucleotide-gated channel., Horrigan DM, Tetreault ML, Tsomaia N, Vasileiou C, Borhan B, Mierke DF, Crouch RK, Zimmerman AL., J Gen Physiol. November 1, 2005; 126 (5): 453-60.          

Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response., Lee J, Gold DA, Shevchenko A, Shevchenko A, Dunphy WG., Mol Biol Cell. November 1, 2005; 16 (11): 5269-82.

Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP., Kim SM, Kumagai A, Lee J, Lee J, Dunphy WG., J Biol Chem. November 18, 2005; 280 (46): 38355-64.

Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks., Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, Hoatlin ME., Mol Cell Biol. January 1, 2006; 26 (2): 425-37.

Coordination of DNA synthesis and replicative unwinding by the S-phase checkpoint pathways., Nedelcheva-Veleva MN, Krastev DB, Stoynov SS., Nucleic Acids Res. January 1, 2006; 34 (15): 4138-46.        

Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint., Petersen P, Chou DM, You Z, Hunter T, Walter JC, Walter G., Mol Cell Biol. March 1, 2006; 26 (5): 1997-2011.

TopBP1 activates the ATR-ATRIP complex., Kumagai A, Lee J, Lee J, Yoo HY, Dunphy WG., Cell. March 10, 2006; 124 (5): 943-55.

TOPping up ATR activity., Bartek J, Mailand N., Cell. March 10, 2006; 124 (5): 888-90.

Pesticide mixtures, endocrine disruption, and amphibian declines: are we underestimating the impact?, Hayes TB, Case P, Chui S, Chung D, Haeffele C, Haston K, Lee M, Mai VP, Marjuoa Y, Parker J, Tsui M., Environ Health Perspect. April 1, 2006; 114 Suppl 1 (Suppl 1): 40-50.                        

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