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Drosophila dSmad2 and Atr-I transmit activin/ TGFbeta signals. , Das P, Inoue H, Baker JC , Beppu H, Kawabata M, Harland RM , Miyazono K, Padgett RW., Genes Cells. February 1, 1999; 4 (2): 123-34.
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. , Guo Z, Kumagai A , Wang SX, Dunphy WG ., Genes Dev. November 1, 2000; 14 (21): 2745-56.
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. , Hekmat-Nejad M, You Z, Yee MC, Newport JW, Cimprich KA., Curr Biol. December 1, 2000; 10 (24): 1565-73.
Aphidicolin triggers a block to replication origin firing in Xenopus egg extracts. , Marheineke K , Hyrien O ., J Biol Chem. May 18, 2001; 276 (20): 17092-100.
The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint. , You Z, Kong L, Newport J., J Biol Chem. July 26, 2002; 277 (30): 27088-93.
A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. , Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA., Genes Dev. September 15, 2002; 16 (18): 2327-32.
Ionizing radiation induces ataxia telangiectasia mutated kinase ( ATM)-mediated phosphorylation of LKB1/ STK11 at Thr-366. , Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR., Biochem J. December 1, 2002; 368 (Pt 2): 507-16.
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. , Costanzo V, Shechter D , Lupardus PJ, Cimprich KA, Gottesman M, Gautier J ., Mol Cell. January 1, 2003; 11 (1): 203-13.
Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. , Lee J , Lee J , Kumagai A , Dunphy WG ., Mol Cell. February 1, 2003; 11 (2): 329-40.
ATM/ ATR-independent inhibition of cyclin B accumulation in response to hydroxyurea in nontransformed cell lines is altered in tumour cell lines. , Florensa R, Bachs O, Agell N., Oncogene. November 13, 2003; 22 (51): 8283-92.
Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin. , Parrilla-Castellar ER, Karnitz LM., J Biol Chem. November 14, 2003; 278 (46): 45507-11.
Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation. , Jeong SY, Kumagai A , Lee J , Lee J , Dunphy WG ., J Biol Chem. November 21, 2003; 278 (47): 46782-8.
Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation. , Katsuragi Y, Sagata N ., Mol Biol Cell. April 1, 2004; 15 (4): 1680-9.
ATR and ATM regulate the timing of DNA replication origin firing. , Shechter D , Costanzo V, Gautier J ., Nat Cell Biol. July 1, 2004; 6 (7): 648-55.
Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint. , Marheineke K , Hyrien O ., J Biol Chem. July 2, 2004; 279 (27): 28071-81.
Xenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends. , McSherry TD, Mueller PR ., Mol Cell Biol. November 1, 2004; 24 (22): 9968-85.
Claspin and the activated form of ATR- ATRIP collaborate in the activation of Chk1. , Kumagai A , Kim SM, Dunphy WG ., J Biol Chem. November 26, 2004; 279 (48): 49599-608.
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus. , Luciani MG, Oehlmann M, Blow JJ ., J Cell Sci. December 1, 2004; 117 (Pt 25): 6019-30.
Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. , Yoo HY, Shevchenko A, Shevchenko A, Dunphy WG ., J Biol Chem. December 17, 2004; 279 (51): 53353-64.
ATM and ATR check in on origins: a dynamic model for origin selection and activation. , Shechter D , Gautier J ., Cell Cycle. February 1, 2005; 4 (2): 235-8.
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. , Byun TS, Pacek M, Yee MC, Walter JC , Cimprich KA., Genes Dev. May 1, 2005; 19 (9): 1040-52.
Phosphorylation of Chk1 by ATM- and Rad3-related ( ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP. , Kim SM, Kumagai A , Lee J , Lee J , Dunphy WG ., J Biol Chem. November 18, 2005; 280 (46): 38355-64.
Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. , Petersen P, Chou DM, You Z, Hunter T, Walter JC , Walter G., Mol Cell Biol. March 1, 2006; 26 (5): 1997-2011.
TopBP1 activates the ATR- ATRIP complex. , Kumagai A , Lee J , Lee J , Yoo HY, Dunphy WG ., Cell. March 10, 2006; 124 (5): 943-55.
TOPping up ATR activity. , Bartek J, Mailand N., Cell. March 10, 2006; 124 (5): 888-90.
Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus. , Lupardus PJ, Cimprich KA., Mol Biol Cell. April 1, 2006; 17 (4): 1559-69.
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. , Trenz K, Smith E, Smith S, Costanzo V., EMBO J. April 19, 2006; 25 (8): 1764-74.
Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling. , Yan S , Lindsay HD , Michael WM., J Cell Biol. April 24, 2006; 173 (2): 181-6.
Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling. , Bomgarden RD, Lupardus PJ, Soni DV, Yee MC, Ford JM, Cimprich KA., EMBO J. June 7, 2006; 25 (11): 2605-14.
The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1. , Hashimoto Y, Tsujimura T, Sugino A, Takisawa H., Genes Cells. September 1, 2006; 11 (9): 993-1007.
Chk1- and claspin-dependent but ATR/ ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells. , Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, Bachs O, Agell N., Cancer Res. September 1, 2006; 66 (17): 8672-9.
Analyzing the ATR-mediated checkpoint using Xenopus egg extracts. , Lupardus PJ, Van C, Cimprich KA., Methods. February 1, 2007; 41 (2): 222-31.
Linking PCNA-dependent replication and ATR by human Claspin. , Brondello JM, Ducommun B, Fernandez A, Lamb NJ., Biochem Biophys Res Commun. March 23, 2007; 354 (4): 1028-33.
Ataxia-telangiectasia mutated ( ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. , Yoo HY, Kumagai A , Shevchenko A, Shevchenko A, Dunphy WG ., J Biol Chem. June 15, 2007; 282 (24): 17501-6.
Non-catalytic function for ATR in the checkpoint response. , McSherry TD, Kitazono AA, Javaheri A, Kron SJ, Mueller PR ., Cell Cycle. August 15, 2007; 6 (16): 2019-30.
The Rad9- Hus1- Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. , Lee J , Lee J , Kumagai A , Dunphy WG ., J Biol Chem. September 21, 2007; 282 (38): 28036-44.
Probing ATR activation with model DNA templates. , Cimprich KA., Cell Cycle. October 1, 2007; 6 (19): 2348-54.
DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts. , Labit H, Perewoska I, Germe T, Hyrien O , Marheineke K ., Nucleic Acids Res. October 1, 2008; 36 (17): 5623-34.
An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. , Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, Vindigni A, Costanzo V., Nat Cell Biol. March 1, 2009; 11 (3): 278-85.
An ATM and ATR dependent pathway targeting centrosome dependent spindle assembly. , Brown N, Costanzo V., Cell Cycle. July 1, 2009; 8 (13): 1997-2001.
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ ATM pathways. , Sobeck A, Stone S, Landais I, de Graaf B, Hoatlin ME ., J Biol Chem. September 18, 2009; 284 (38): 25560-8.
Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase. , Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A., J Biol Chem. November 27, 2009; 284 (48): 33107-14.
CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. , Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M., J Cell Sci. January 15, 2010; 123 (Pt 2): 225-35.
Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex. , Kundu LR, Kumata Y, Kakusho N, Watanabe S, Furukohri A, Waga S, Seki M, Masai H, Enomoto T, Tada S., Nucleic Acids Res. September 1, 2010; 38 (16): 5409-18.