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Xenopus as a model system for studying pigmentation and pigmentary disorders. , El Mir J, Nasrallah A, Thézé N , Cario M, Fayyad-Kazan H, Thiébaud P , Rezvani HR., Pigment Cell Melanoma Res. June 7, 2024;
RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis. , Wong S, Tan YX, Loh AYT, Tan KY, Lee H , Aziz Z, Nelson SF, Özkan E, Kayserili H, Escande-Beillard N, Reversade B ., EMBO Mol Med. May 8, 2023; 15 (5): e17078.
A convergent molecular network underlying autism and congenital heart disease. , Rosenthal SB, Willsey HR , Xu Y , Xu Y , Mei Y, Dea J, Wang S, Curtis C, Sempou E, Khokha MK , Chi NC, Willsey AJ, Fisch KM, Ideker T., Cell Syst. November 17, 2021; 12 (11): 1094-1107.e6.
Sprouty2 regulates positioning of retinal progenitors through suppressing the Ras/Raf/MAPK pathway. , Sun J, Yoon J, Lee M, Hwang YS, Daar IO ., Sci Rep. August 13, 2020; 10 (1): 13752.
A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF- ERK Pathway. , Popov IK, Hiatt SM, Whalen S, Keren B, Ruivenkamp C, van Haeringen A, Chen MJ, Cooper GM, Korf BR, Chang C ., Front Physiol. January 1, 2019; 10 388.
Expression variation and covariation impair analog and enable binary signaling control. , Kovary KM, Taylor B, Zhao ML, Teruel MN., Mol Syst Biol. May 14, 2018; 14 (5): e7997.
Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells. , Zhang Z , Lei A, Xu L, Chen L, Chen Y , Chen Y , Zhang X, Gao Y, Yang X, Zhang M, Cao Y , Cao Y ., J Biol Chem. August 4, 2017; 292 (31): 12842-12859.
Reversible optogenetic control of kinase activity during differentiation and embryonic development. , Krishnamurthy VV, Khamo JS, Mei W, Turgeon AJ, Ashraf HM, Mondal P, Patel DB, Risner N, Cho EE, Yang J , Zhang K., Development. November 1, 2016; 143 (21): 4085-4094.
B-Raf and C-Raf are required for melanocyte stem cell self-maintenance. , Valluet A, Druillennec S, Barbotin C, Dorard C, Monsoro-Burq AH , Larcher M, Pouponnot C, Baccarini M, Larue L, Eychène A., Cell Rep. October 25, 2012; 2 (4): 774-80.
Activation of extracellular signal-regulated kinases during dehydration in the African clawed frog, Xenopus laevis. , Malik AI, Storey KB ., J Exp Biol. August 1, 2009; 212 (Pt 16): 2595-603.
CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation. , Ritt DA, Zhou M, Conrads TP, Veenstra TD, Copeland TD, Morrison DK., Curr Biol. January 23, 2007; 17 (2): 179-84.
B-Raf and C-Raf are required for Ras-stimulated p42 MAP kinase activation in Xenopus egg extracts. , Yue J, Xiong W, Ferrell JE ., Oncogene. June 1, 2006; 25 (23): 3307-15.
Oncogenic Met receptor induces cell-cycle progression in Xenopus oocytes independent of direct Grb2 and Shc binding or Mos synthesis, but requires phosphatidylinositol 3-kinase and Raf signaling. , Mood K, Saucier C, Ishimura A, Bong YS, Lee HS , Park M, Daar IO ., J Cell Physiol. April 1, 2006; 207 (1): 271-85.
Functional interactions of Raf and MEK with Jun-N-terminal kinase ( JNK) result in a positive feedback loop on the oncogenic Ras signaling pathway. , Adler V, Qu Y, Smith SJ , Izotova L, Pestka S, Kung HF, Lin M, Friedman FK, Chie L, Chung D, Boutjdir M, Pincus MR., Biochemistry. August 16, 2005; 44 (32): 10784-95.
Differential roles of p39Mos-Xp42Mpk1 cascade proteins on Raf1 phosphorylation and spindle morphogenesis in Xenopus oocytes. , Bodart JF, Baert FY, Sellier C, Duesbery NS , Flament S, Vilain JP., Dev Biol. July 15, 2005; 283 (2): 373-83.
Regulation of Raf-1 by direct feedback phosphorylation. , Dougherty MK, Müller J, Ritt DA, Zhou M, Zhou XZ , Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK., Mol Cell. January 21, 2005; 17 (2): 215-24.
Cation diffusion facilitator proteins modulate Raf-1 activity. , Jirakulaporn T, Muslin AJ., J Biol Chem. June 25, 2004; 279 (26): 27807-15.
Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition. , Tran NH, Frost JA., J Biol Chem. March 28, 2003; 278 (13): 11221-6.
Role of 14-3-3 proteins in early Xenopus development. , Wu C , Muslin AJ., Mech Dev. November 1, 2002; 119 (1): 45-54.
SNT1/ FRS2 mediates germinal vesicle breakdown induced by an activated FGF receptor1 in Xenopus oocytes. , Mood K, Friesel R, Daar IO ., J Biol Chem. September 6, 2002; 277 (36): 33196-204.
Signalling pathways in oocyte meiotic maturation. , Schmitt A, Nebreda AR., J Cell Sci. June 15, 2002; 115 (Pt 12): 2457-9.
Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR). , Zhou M, Horita DA, Waugh DS, Byrd RA, Morrison DK., J Mol Biol. January 18, 2002; 315 (3): 435-46.
Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation. , MacNicol MC, Muslin AJ, MacNicol AM ., J Biol Chem. February 11, 2000; 275 (6): 3803-9.
In vitro binding of free cdc2 and raf kinase to membrane vesicles: a possible new regulatory mechanism for cdc2 kinase activation in Xenopus oocyte. , De Smedt V, Crozet N, Jessus C ., Microsc Res Tech. April 1, 1999; 45 (1): 13-30.
Inhibition of small G proteins by clostridium sordellii lethal toxin activates cdc2 and MAP kinase in Xenopus oocytes. , Rime H, Talbi N, Popoff MR, Suziedelis K, Jessus C , Ozon R., Dev Biol. December 15, 1998; 204 (2): 592-602.
Raf-1 kinase, a potential regulator of intracellular pH in Xenopus oocytes. , Kang MG, Kulisz A, Wasserman WJ ., Biol Cell. October 1, 1998; 90 (6-7): 477-85.
Inactivation of protein kinase A is not required for c- mos translation during meiotic maturation of Xenopus oocytes. , Faure S , Morin N , Dorée M., Oncogene. September 10, 1998; 17 (10): 1215-21.
Identification of residues in the cysteine-rich domain of Raf-1 that control Ras binding and Raf-1 activity. , Winkler DG, Cutler RE, Drugan JK, Campbell S, Morrison DK, Cooper JA., J Biol Chem. August 21, 1998; 273 (34): 21578-84.
Autoregulation of the Raf-1 serine/threonine kinase. , Cutler RE, Stephens RM, Saracino MR, Morrison DK., Proc Natl Acad Sci U S A. August 4, 1998; 95 (16): 9214-9.
14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. , Petosa C, Masters SC, Bankston LA, Pohl J, Wang B, Fu H, Liddington RC., J Biol Chem. June 26, 1998; 273 (26): 16305-10.
The immunophilin FKBP65 forms an association with the serine/threonine kinase c-Raf-1. , Coss MC, Stephens RM, Morrison DK, Winterstein D, Smith LM, Simek SL., Cell Growth Differ. January 1, 1998; 9 (1): 41-8.
Characterization of the intracellular signalling pathways that underlie growth-factor-stimulated glucose transport in Xenopus oocytes: evidence for ras- and rho-dependent pathways of phosphatidylinositol 3-kinase activation. , Thomson FJ, Jess TJ, Moyes C, Plevin R, Gould GW., Biochem J. August 1, 1997; 325 ( Pt 3) 637-43.
Mammalian Raf-1 is activated by mutations that restore Raf signaling in Drosophila. , Cutler RE, Morrison DK., EMBO J. April 15, 1997; 16 (8): 1953-60.
Cyclic AMP inhibitors inhibits PDGF-stimulated mitogen-activated protein kinase activity in rat aortic smooth muscle cells via inactivation of c-Raf-1 kinase and induction of MAP kinase phosphatase-1. , Plevin R, Malarkey K, Aidulis D, McLees A, Gould GW., Cell Signal. January 1, 1997; 9 (3-4): 323-8.
The dominant negative effects of H-Ras harboring a Gly to Ala mutation at position 60. , Sung YJ, Hwang MC, Hwang YW., J Biol Chem. November 29, 1996; 271 (48): 30537-43.
Inhibition of Raf/ MAPK signaling in Xenopus oocyte extracts by Raf-1-specific peptides. , Radziwill G, Steinhusen U, Aitken A, Moelling K., Biochem Biophys Res Commun. October 3, 1996; 227 (1): 20-6.
Involvement of Ras/Raf/ AP-1 in BMP-4 signaling during Xenopus embryonic development. , Xu RH, Dong Z, Maeno M, Kim J , Suzuki A , Ueno N , Sredni D, Colburn NH, Kung HF., Proc Natl Acad Sci U S A. January 23, 1996; 93 (2): 834-8.
Mechanisms regulating Raf-1 activity in signal transduction pathways. , Morrison DK., Mol Reprod Dev. December 1, 1995; 42 (4): 507-14.
Regulation of Raf-1-dependent signaling during early Xenopus development. , MacNicol AM , Muslin AJ, Howard EL, Kikuchi A, MacNicol MC, Williams LT., Mol Cell Biol. December 1, 1995; 15 (12): 6686-93.
Mesoderm induction in Xenopus caused by activation of MAP kinase. , Umbhauer M , Marshall CJ, Mason CS, Old RW , Smith JC ., Nature. July 6, 1995; 376 (6535): 58-62.
14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner. , Michaud NR, Fabian JR, Mathes KD, Morrison DK., Mol Cell Biol. June 1, 1995; 15 (6): 3390-7.
Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. , Galaktionov K, Jessus C , Beach D., Genes Dev. May 1, 1995; 9 (9): 1046-58.
Two distinct Raf domains mediate interaction with Ras. , Brtva TR, Drugan JK, Ghosh S, Terrell RS, Campbell-Burk S, Bell RM, Der CJ., J Biol Chem. April 28, 1995; 270 (17): 9809-12.
MAP kinase-dependent pathways in cell cycle control. , Pelech SL, Charest DL., Prog Cell Cycle Res. January 1, 1995; 1 33-52.
Raf-1 N-terminal sequences necessary for Ras-Raf interaction and signal transduction. , Pumiglia K, Chow YH, Fabian J, Morrison D, Decker S, Jove R., Mol Cell Biol. January 1, 1995; 15 (1): 398-406.
Activation of Raf-1 by 14-3-3 proteins. , Fantl WJ, Muslin AJ, Kikuchi A, Martin JA, MacNicol AM , Gross RW, Williams LT., Nature. October 13, 1994; 371 (6498): 612-4.
Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP. , Scheffler JE, Waugh DS, Bekesi E, Kiefer SE, LoSardo JE, Neri A, Prinzo KM, Tsao KL, Wegrzynski B, Emerson SD., J Biol Chem. September 2, 1994; 269 (35): 22340-6.
Characterization of recombinant Xenopus MAP kinase kinases mutated at potential phosphorylation sites. , Gotoh Y, Matsuda S, Takenaka K, Hattori S, Iwamatsu A, Ishikawa M, Kosako H, Nishida E ., Oncogene. July 1, 1994; 9 (7): 1891-8.
A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function. , Fabian JR, Vojtek AB, Cooper JA, Morrison DK., Proc Natl Acad Sci U S A. June 21, 1994; 91 (13): 5982-6.
R-ras interacts with rasGAP, neurofibromin and c-raf but does not regulate cell growth or differentiation. , Rey I, Taylor-Harris P, van Erp H, Hall A., Oncogene. March 1, 1994; 9 (3): 685-92.