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Male-transmitted transgenerational effects of the herbicide linuron on DNA methylation profiles in Xenopus tropicalis brain and testis. , Roza M, Eriksson ANM, Svanholm S, Berg C, Karlsson O., Sci Total Environ. May 1, 2024; 923 170949.
Resection of DNA double-strand breaks activates Mre11- Rad50- Nbs1- and Rad9- Hus1- Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts. , Tatsukawa K, Sakamoto R, Kawasoe Y, Kubota Y, Tsurimoto T, Takahashi TS, Ohashi E., Nucleic Acids Res. April 12, 2024; 52 (6): 3146-3163.
Profiling ubiquitin signalling with UBIMAX reveals DNA damage- and SCFβ-Trcp1-dependent ubiquitylation of the actin-organizing protein Dbn1. , Colding-Christensen CS, Kakulidis ES, Arroyo-Gomez J, Hendriks IA, Arkinson C, Fábián Z, Gambus A, Mailand N, Duxin JP , Nielsen ML., Nat Commun. December 14, 2023; 14 (1): 8293.
POLθ prevents MRE11- NBS1- CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps. , Mann A, Ramirez-Otero MA, De Antoni A, Hanthi YW, Sannino V, Baldi G, Falbo L, Schrempf A, Bernardo S, Loizou J, Costanzo V., Mol Cell. November 17, 2022; 82 (22): 4218-4231.e8.
MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks. , Montales K, Ruis K, Lindsay H , Michael WM., PLoS One. August 2, 2022; 17 (8): e0271905.
Mre11 exonuclease activity promotes irreversible mitotic progression under replication stress. , Hashimoto Y, Tanaka H., Life Sci Alliance. March 15, 2022; 5 (6):
Structure-function analysis of TOPBP1's role in ATR signaling using the DSB-mediated ATR activation in Xenopus egg extracts (DMAX) system. , Montales K, Kim A, Ruis K, Michael WM., Sci Rep. January 11, 2021; 11 (1): 467.
Conservation and divergence of protein pathways in the vertebrate heart. , Federspiel JD, Tandon P , Wilczewski CM, Wasson L, Herring LE, Venkatesh SS, Cristea IM, Conlon FL ., PLoS Biol. September 6, 2019; 17 (9): e3000437.
RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR. , Lyu K, Kumagai A , Dunphy WG ., Cell Cycle. April 1, 2019; 18 (8): 898-913.
Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. , Schrank BR, Aparicio T , Li Y, Chang W, Chait BT, Gundersen GG, Gottesman ME, Gautier J ., Nature. July 1, 2018; 559 (7712): 61-66.
Dna2 initiates resection at clean DNA double-strand breaks. , Paudyal SC, Li S, Yan H, Hunter T, You Z., Nucleic Acids Res. November 16, 2017; 45 (20): 11766-11781.
Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection. , Zadorozhny K, Sannino V, Beláň O, Mlčoušková J, Špírek M, Costanzo V, Krejčí L., Cell Rep. October 10, 2017; 21 (2): 333-340.
Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments. , Kolinjivadi AM, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, Técher H, Baldi G, Shen R, Ciccia A, Pellegrini L, Krejci L, Costanzo V., Mol Cell. September 7, 2017; 67 (5): 867-881.e7.
Cip29 is phosphorylated following activation of the DNA damage response in Xenopus egg extracts. , Holden J, Taylor EM, Lindsay HD ., PLoS One. July 10, 2017; 12 (7): e0181131.
Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response. , Li Z, Li J, Kong Y, Yan S , Ahmad N, Liu X., Cancer Res. June 15, 2017; 77 (12): 3169-3180.
Mdc1 modulates the interaction between TopBP1 and the MRN complex during DNA damage checkpoint responses. , Choi SH, Yoo HY., Biochem Biophys Res Commun. October 7, 2016; 479 (1): 5-11.
Xenopus Mcm10 is a CDK-substrate required for replication fork stability. , Chadha GS, Gambus A, Gillespie PJ, Blow JJ ., Cell Cycle. August 17, 2016; 15 (16): 2183-2195.
The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair. , Liao S, Tammaro M, Yan H., Nucleic Acids Res. July 8, 2016; 44 (12): 5689-701.
MCM8-9 complex promotes resection of double-strand break ends by MRE11- RAD50- NBS1 complex. , Lee KY, Im JS, Shibata E, Park J , Handa N, Kowalczykowski SC, Dutta A ., Nat Commun. July 28, 2015; 6 7744.
Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining. , Soni A, Siemann M, Grabos M, Murmann T, Pantelias GE, Iliakis G., Nucleic Acids Res. June 1, 2014; 42 (10): 6380-92.
Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. , Chen C , Zhang L, Huang NJ, Huang B, Kornbluth S ., Proc Natl Acad Sci U S A. December 17, 2013; 110 (51): 20605-10.
The Mre11- Rad50- Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. , Lee J , Dunphy WG ., Mol Biol Cell. May 1, 2013; 24 (9): 1343-53.
A role for the MRN complex in ATR activation via TOPBP1 recruitment. , Duursma AM, Driscoll R, Elias JE, Cimprich KA., Mol Cell. April 11, 2013; 50 (1): 116-22.
The MRN- CtIP pathway is required for metaphase chromosome alignment. , Rozier L, Guo Y, Peterson S, Sato M, Baer R, Gautier J , Mao Y., Mol Cell. March 28, 2013; 49 (6): 1097-107.
Analysis of MRE11's function in the 5'-->3' processing of DNA double-strand breaks. , Liao S, Guay C, Toczylowski T, Yan H., Nucleic Acids Res. May 1, 2012; 40 (10): 4496-506.
Time-dependent predominance of nonhomologous DNA end-joining pathways during embryonic development in mice. , Chiruvella KK, Sebastian R, Sharma S, Karande AA, Choudhary B, Raghavan SC., J Mol Biol. March 30, 2012; 417 (3): 197-211.
Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts. , Kumar S , Yoo HY, Kumagai A , Shevchenko A, Shevchenko A, Dunphy WG ., Cell Cycle. March 15, 2012; 11 (6): 1183-94.
RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks. , Hashimoto Y, Puddu F, Costanzo V., Nat Struct Mol Biol. December 4, 2011; 19 (1): 17-24.
Brca2, Rad51 and Mre11: performing balancing acts on replication forks. , Costanzo V., DNA Repair (Amst). October 10, 2011; 10 (10): 1060-5.
Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair. , Peterson SE, Li Y, Chait BT, Gottesman ME, Baer R, Gautier J ., J Cell Biol. September 5, 2011; 194 (5): 705-20.
CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts. , Ramírez-Lugo JS, Yoo HY, Yoon SJ , Dunphy WG ., Cell Cycle. February 1, 2011; 10 (3): 469-80.
Replication protein A promotes 5'-->3' end processing during homology-dependent DNA double-strand break repair. , Yan H, Toczylowski T, McCane J, Chen C , Liao S., J Cell Biol. January 24, 2011; 192 (2): 251-61.
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. , Hashimoto Y, Ray Chaudhuri A, Lopes M, Costanzo V., Nat Struct Mol Biol. November 1, 2010; 17 (11): 1305-11.
Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/ Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM. , Wawrousek KE, Fortini BK, Polaczek P, Chen L, Liu Q, Dunphy WG , Campbell JL ., Cell Cycle. March 15, 2010; 9 (6): 1156-66.
The Mre11/ Rad50/ Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis. , Taylor EM, Cecillon SM, Bonis A, Chapman JR, Povirk LF, Lindsay HD ., Nucleic Acids Res. January 1, 2010; 38 (2): 441-54.
CtIP links DNA double-strand break sensing to resection. , You Z, Shi LZ, Zhu Q, Wu P, Zhang YW , Basilio A, Tonnu N, Verma IM, Berns MW, Hunter T., Mol Cell. December 25, 2009; 36 (6): 954-69.
PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. , Di Virgilio M, Ying CY, Gautier J ., DNA Repair (Amst). November 2, 2009; 8 (11): 1311-20.
The Mre11- Rad50- Nbs1 complex mediates activation of TopBP1 by ATM. , Yoo HY, Kumagai A , Shevchenko A, Shevchenko A, Dunphy WG ., Mol Biol Cell. May 1, 2009; 20 (9): 2351-60.
Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends. , Liao S, Toczylowski T, Yan H., Nucleic Acids Res. November 1, 2008; 36 (19): 6091-100.
Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites. , Xu C, Wu L, Cui G, Botuyan MV, Chen J , Mer G., J Mol Biol. August 29, 2008; 381 (2): 361-72.
Ku80 removal from DNA through double strand break-induced ubiquitylation. , Postow L, Ghenoiu C, Woo EM, Krutchinsky AN, Chait BT, Funabiki H ., J Cell Biol. August 11, 2008; 182 (3): 467-79.
Mre11- Rad50- Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. , Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V., EMBO J. July 23, 2008; 27 (14): 1953-62.
A forward chemical genetic screen reveals an inhibitor of the Mre11- Rad50- Nbs1 complex. , Dupré A , Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH , Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, Gautier J ., Nat Chem Biol. February 1, 2008; 4 (2): 119-25.
Telomere capping and cellular checkpoints: clues from fruit flies. , Ciapponi L, Cenci G., Cytogenet Genome Res. January 1, 2008; 122 (3-4): 365-73.
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/ Rad50 complexes. , Bhaskara V, Dupré A , Lengsfeld B, Hopkins BB, Chan A, Lee JH , Zhang X, Gautier J , Zakian V, Paull TT., Mol Cell. March 9, 2007; 25 (5): 647-61.
Two-step activation of ATM by DNA and the Mre11- Rad50- Nbs1 complex. , Dupré A , Boyer-Chatenet L, Gautier J ., Nat Struct Mol Biol. May 1, 2006; 13 (5): 451-7.
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. , Trenz K, Smith E, Smith S, Costanzo V., EMBO J. April 19, 2006; 25 (8): 1764-74.
Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. , Di Virgilio M, Gautier J ., J Cell Biol. December 5, 2005; 171 (5): 765-71.
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. , You Z, Chahwan C, Bailis J, Hunter T, Russell P., Mol Cell Biol. July 1, 2005; 25 (13): 5363-79.
Mre11 assembles linear DNA fragments into DNA damage signaling complexes. , Costanzo V, Paull T, Gottesman M, Gautier J ., PLoS Biol. May 1, 2004; 2 (5): E110.