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Branched microtubule nucleation and dynein transport organize RanGTP asters in Xenopus laevis egg extract. , Scrofani J, Ruhnow F, Chew WX, Normanno D, Nedelec F, Surrey T, Vernos I ., Mol Biol Cell. January 1, 2024; 35 (1): ar12.
Aurora A phosphorylates Ndel1 to reduce the levels of Mad1 and NuMA at spindle poles. , Janczyk PŁ, Żyłkiewicz E, De Hoyos H, West T, Matson DR, Choi WC, Young HMR, Derewenda ZS, Stukenberg PT ., Mol Biol Cell. January 1, 2023; 34 (1): br1.
Organelle size scaling over embryonic development. , Wesley CC, Mishra S, Levy DL ., Wiley Interdiscip Rev Dev Biol. September 1, 2020; 9 (5): e376.
RanGTP induces an effector gradient of XCTK2 and importin α/β for spindle microtubule cross-linking. , Ems-McClung SC, Emch M, Zhang S, Mahnoor S, Weaver LN, Walczak CE., J Cell Biol. February 3, 2020; 219 (2):
Induction of a Spindle-Assembly-Competent M Phase in Xenopus Egg Extracts. , Bisht JS, Tomschik M , Gatlin JC ., Curr Biol. April 22, 2019; 29 (8): 1273-1285.e5.
Regulation of mitotic spindle assembly factor NuMA by Importin-β. , Chang CC , Huang TL, Shimamoto Y, Tsai SY, Hsia KC., J Cell Biol. November 6, 2017; 216 (11): 3453-3462.
The Ran-GTP gradient spatially regulates XCTK2 in the spindle. , Weaver LN, Ems-McClung SC, Chen SH, Yang G, Shaw SL, Walczak CE., Curr Biol. June 1, 2015; 25 (11): 1509-14.
Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration. , Bernis C, Swift-Taylor B, Nord M, Carmona S, Chook YM, Forbes DJ., Mol Biol Cell. April 1, 2014; 25 (7): 992-1009.
FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis. , Petridou NI, Skourides PA ., Nat Commun. January 1, 2014; 5 5240.
Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol. , Mitchison TJ , Nguyen P, Coughlin M, Groen AC., Mol Biol Cell. May 1, 2013; 24 (10): 1559-73.
Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein ( LGN) during asymmetric cell divisions. , Culurgioni S, Alfieri A, Pendolino V, Laddomada F, Mapelli M., Proc Natl Acad Sci U S A. December 27, 2011; 108 (52): 20998-1003.
Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts. , Halpin D, Kalab P, Wang J , Weis K, Heald R ., PLoS Biol. December 1, 2011; 9 (12): e1001225.
Microtubule assembly in meiotic extract requires glycogen. , Groen AC, Coughlin M, Mitchison TJ ., Mol Biol Cell. September 1, 2011; 22 (17): 3139-51.
A computational model predicts Xenopus meiotic spindle organization. , Loughlin R, Heald R , Nédélec F., J Cell Biol. December 27, 2010; 191 (7): 1239-49.
Directly probing the mechanical properties of the spindle and its matrix. , Gatlin JC , Matov A, Danuser G, Mitchison TJ , Salmon ED., J Cell Biol. February 22, 2010; 188 (4): 481-9.
Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity. , Zhang X, Ems-McClung SC, Walczak CE., Mol Biol Cell. July 1, 2008; 19 (7): 2752-65.
Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle. , Brown KS, Blower MD , Maresca TJ , Grammer TC , Harland RM , Heald R ., J Cell Biol. March 12, 2007; 176 (6): 765-70.
A role for NuSAP in linking microtubules to mitotic chromosomes. , Ribbeck K, Raemaekers T, Carmeliet G, Mattaj IW ., Curr Biol. February 6, 2007; 17 (3): 230-6.
The BRCA1/ BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. , Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC , Livingston DM ., Cell. November 3, 2006; 127 (3): 539-52.
Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. , Chang P, Coughlin M, Mitchison TJ ., Nat Cell Biol. November 1, 2005; 7 (11): 1133-9.
XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly. , Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ , Ohi R., Curr Biol. October 26, 2004; 14 (20): 1801-11.
Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles. , Gaetz J, Kapoor TM., J Cell Biol. August 16, 2004; 166 (4): 465-71.
Two protein 4.1 domains essential for mitotic spindle and aster microtubule dynamics and organization in vitro. , Krauss SW, Lee G, Chasis JA, Mohandas N, Heald R ., J Biol Chem. June 25, 2004; 279 (26): 27591-8.
Cyclin B degradation leads to NuMA release from dynein/dynactin and from spindle poles. , Gehmlich K, Haren L, Merdes A., EMBO Rep. January 1, 2004; 5 (1): 97-103.
XMAP215, XKCM1, NuMA, and cytoplasmic dynein are required for the assembly and organization of the transient microtubule array during the maturation of Xenopus oocytes. , Becker BE, Romney SJ, Gard DL ., Dev Biol. September 15, 2003; 261 (2): 488-505.
Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle. , Stenoien DL, Sen S, Mancini MA, Brinkley BR., Cell Motil Cytoskeleton. June 1, 2003; 55 (2): 134-46.
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. , Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J , Prigent C , Zheng Y., Nat Cell Biol. March 1, 2003; 5 (3): 242-8.
hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division. , Garrett S, Auer K, Compton DA, Kapoor TM., Curr Biol. December 10, 2002; 12 (23): 2055-9.
Two distinct domains of protein 4.1 critical for assembly of functional nuclei in vitro. , Krauss SW, Heald R , Lee G, Nunomura W, Gimm JA, Mohandas N, Chasis JA., J Biol Chem. November 15, 2002; 277 (46): 44339-46.
Assembly of centrosomal proteins and microtubule organization depends on PCM-1. , Dammermann A, Merdes A., J Cell Biol. October 28, 2002; 159 (2): 255-66.
Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. , Haren L, Merdes A., J Cell Sci. May 1, 2002; 115 (Pt 9): 1815-24.
[Clinical significance of fluoroscopic patterns specific for the mitotic spindle in patients with rheumatic diseases]. , Grypiotis P, Ruffatti A, Tonello M, Winzler C, Radu C, Zampieri S, Favaro M, Calligaro A, Todesco S., Reumatismo. January 1, 2002; 54 (3): 232-7.
A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization. , Du Q, Stukenberg PT , Macara IG., Nat Cell Biol. December 1, 2001; 3 (12): 1069-75.
Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. , Wiese C, Wilde A, Moore MS , Adam SA, Merdes A, Zheng Y., Science. January 26, 2001; 291 (5504): 653-6.
Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. , Nachury MV, Maresca TJ , Salmon WC, Waterman-Storer CM, Heald R , Weis K., Cell. January 12, 2001; 104 (1): 95-106.
Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. , Kapoor TM, Mayer TU , Coughlin ML, Mitchison TJ ., J Cell Biol. September 4, 2000; 150 (5): 975-88.
TPX2, A novel xenopus MAP involved in spindle pole organization. , Wittmann T, Wilm M, Karsenti E , Vernos I ., J Cell Biol. June 26, 2000; 149 (7): 1405-18.
NuMA: a nuclear protein involved in mitotic centrosome function. , Zeng C., Microsc Res Tech. June 1, 2000; 49 (5): 467-77.
A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)- D2/Eg7 for chromosome condensation in mitotic extract. , Steen RL, Cubizolles F, Le Guellec K, Collas P., J Cell Biol. May 1, 2000; 149 (3): 531-6.
The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle. , Mountain V, Simerly C, Howard L, Ando A, Schatten G, Compton DA., J Cell Biol. October 18, 1999; 147 (2): 351-66.
Beyond nuclear transport. Ran-GTP as a determinant of spindle assembly. , Kahana JA, Cleveland DW., J Cell Biol. September 20, 1999; 146 (6): 1205-10.
Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts. , Zhang C, Hughes M, Clarke PR., J Cell Sci. July 1, 1999; 112 ( Pt 14) 2453-61.
NuMA is a component of an insoluble matrix at mitotic spindle poles. , Dionne MA, Howard L, Compton DA., Cell Motil Cytoskeleton. January 1, 1999; 42 (3): 189-203.
Expanding the role of HsEg5 within the mitotic and post-mitotic phases of the cell cycle. , Whitehead CM, Rattner JB., J Cell Sci. September 1, 1998; 111 ( Pt 17) 2551-61.
The role of NuMA in the interphase nucleus. , Merdes A, Cleveland DW., J Cell Sci. January 1, 1998; 111 ( Pt 1) 71-9.
Pulse treatment of interphasic HeLa cells with nanomolar doses of docetaxel affects centrosome organization and leads to catastrophic exit of mitosis. , Paoletti A, Giocanti N, Favaudon V, Bornens M., J Cell Sci. October 1, 1997; 110 ( Pt 19) 2403-15.
Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes. , Gaglio T, Dionne MA, Compton DA., J Cell Biol. September 8, 1997; 138 (5): 1055-66.
A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. , Merdes A, Ramyar K, Vechio JD, Cleveland DW., Cell. November 1, 1996; 87 (3): 447-58.
Opposing motor activities are required for the organization of the mammalian mitotic spindle pole. , Gaglio T, Saredi A, Bingham JB, Hasbani MJ, Gill SR, Schroer TA, Compton DA., J Cell Biol. October 1, 1996; 135 (2): 399-414.
Two major autoantigen-antibody systems of the mitotic spindle apparatus. , Andrade LE, Chan EK, Peebles CL, Tan EM., Arthritis Rheum. October 1, 1996; 39 (10): 1643-53.