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Summary Expression Phenotypes Gene Literature (161) GO Terms (14) Nucleotides (553) Proteins (65) Interactants (344) Wiki
XB-GENEPAGE-5810263

Papers associated with tpx2



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Microtubule assembly in meiotic extract requires glycogen., Groen AC, Coughlin M, Mitchison TJ., Mol Biol Cell. September 1, 2011; 22 (17): 3139-51.            

Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation., Joukov V, De Nicolo A, Rodriguez A, Walter JC, Livingston DM., Proc Natl Acad Sci U S A. December 7, 2010; 107 (49): 21022-7.      

Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma., Li B, Qi XQ, Chen X, Huang X, Liu GY, Chen HR, Huang CG, Luo C, Lu YC., Dev Biol. September 17, 2010; 1352 200-7.

Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis., Bompard G, Rabeharivelo G, Frank M, Cau J, Delsert C, Morin N., J Cell Biol. September 6, 2010; 190 (5): 807-22.                    

Novel binding of the mitotic regulator TPX2 (target protein for Xenopus kinesin-like protein 2) to importin-alpha., Giesecke A, Stewart M., J Biol Chem. June 4, 2010; 285 (23): 17628-35.            

ISWI is a RanGTP-dependent MAP required for chromosome segregation., Yokoyama H, Rybina S, Santarella-Mellwig R, Mattaj IW, Karsenti E., J Cell Biol. December 14, 2009; 187 (6): 813-29.                    

Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A., Eckerdt F, Pascreau G, Phistry M, Lewellyn AL, DePaoli-Roach AA, Maller JL., Cell Cycle. August 1, 2009; 8 (15): 2413-9.

Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B., Hans F, Skoufias DA, Dimitrov S, Margolis RL., Mol Biol Cell. August 1, 2009; 20 (15): 3491-502.

Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly., Groen AC, Maresca TJ, Gatlin JC, Salmon ED, Mitchison TJ., Mol Biol Cell. June 1, 2009; 20 (11): 2766-73.

Biochemical characterization of GSK1070916, a potent and selective inhibitor of Aurora B and Aurora C kinases with an extremely long residence time1., Anderson K, Lai Z, McDonald OB, Stuart JD, Nartey EN, Hardwicke MA, Newlander K, Dhanak D, Adams J, Patrick D, Copeland RA, Tummino PJ, Yang J., Biochem J. May 13, 2009; 420 (2): 259-65.

Requirement for Nudel and dynein for assembly of the lamin B spindle matrix., Ma L, Tsai MY, Wang S, Lu B, Chen R, Yates JR, Zhu X, Zheng Y., Nat Cell Biol. March 1, 2009; 11 (3): 247-56.            

Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes., Pascreau G, Eckerdt F, Lewellyn AL, Prigent C, Maller JL., J Biol Chem. February 27, 2009; 284 (9): 5497-505.            

Plant TPX2 and related proteins., Evrard JL, Pieuchot L, Vos JW, Vernos I, Schmit AC., Plant Signal Behav. January 1, 2009; 4 (1): 69-72.

Learning about cancer from frogs: analysis of mitotic spindles in Xenopus egg extracts., Cross MK, Powers MA., Dis Model Mech. January 1, 2009; 2 (11-12): 541-7.      

CaM kinase II initiates meiotic spindle depolymerization independently of APC/C activation., Reber S, Over S, Kronja I, Gruss OJ., J Cell Biol. December 15, 2008; 183 (6): 1007-17.            

Hepatoma up-regulated protein is required for chromatin-induced microtubule assembly independently of TPX2., Casanova CM, Rybina S, Yokoyama H, Karsenti E, Mattaj IW., Mol Biol Cell. November 1, 2008; 19 (11): 4900-8.

MAP20, a microtubule-associated protein in the secondary cell walls of hybrid aspen, is a target of the cellulose synthesis inhibitor 2,6-dichlorobenzonitrile., Rajangam AS, Kumar M, Aspeborg H, Guerriero G, Arvestad L, Pansri P, Brown CJ, Hober S, Blomqvist K, Divne C, Ezcurra I, Mellerowicz E, Sundberg B, Bulone V, Teeri TT., Plant Physiol. November 1, 2008; 148 (3): 1283-94.

TPX2 in malignantly transformed human bronchial epithelial cells by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide., Zhang L, Huang H, Deng L, Chu M, Xu L, Fu J, Zhu Y, Zhang X, Liu S, Zhou Z, Wang Y., Toxicology. October 30, 2008; 252 (1-3): 49-55.

Dissecting the role of Aurora A during spindle assembly., Sardon T, Peset I, Petrova B, Vernos I., EMBO J. October 8, 2008; 27 (19): 2567-79.

The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown., Vos JW, Pieuchot L, Evrard JL, Janski N, Bergdoll M, de Ronde D, Perez LH, Sardon T, Vernos I, Schmit AC., Plant Cell. October 1, 2008; 20 (10): 2783-97.

A survivin-ran complex regulates spindle formation in tumor cells., Xia F, Canovas PM, Guadagno TM, Altieri DC., Mol Cell Biol. September 1, 2008; 28 (17): 5299-311.

A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly., Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ., J Cell Sci. July 15, 2008; 121 (Pt 14): 2293-300.

Myosin-10 and actin filaments are essential for mitotic spindle function., Woolner S, O'Brien LL, Wiese C, Bement WM., J Cell Biol. July 14, 2008; 182 (1): 77-88.                

Spindle pole regulation by a discrete Eg5-interacting domain in TPX2., Eckerdt F, Eyers PA, Lewellyn AL, Prigent C, Maller JL., Curr Biol. April 8, 2008; 18 (7): 519-25.                        

Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate., Yokoyama H, Gruss OJ, Rybina S, Caudron M, Schelder M, Wilm M, Mattaj IW, Karsenti E., J Cell Biol. March 10, 2008; 180 (5): 867-75.          

Evolution of a domain conserved in microtubule-associated proteins of eukaryotes., Rajangam AS, Yang H, Teeri TT, Arvestad L., Adv Appl Bioinform Chem. January 1, 2008; 1 51-69.                  

Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen., Morgan-Lappe SE, Tucker LA, Huang X, Zhang Q, Sarthy AV, Zakula D, Vernetti L, Schurdak M, Wang J, Fesik SW., Cancer Res. May 1, 2007; 67 (9): 4390-8.

A role for NuSAP in linking microtubules to mitotic chromosomes., Ribbeck K, Raemaekers T, Carmeliet G, Mattaj IW., Curr Biol. February 6, 2007; 17 (3): 230-6.

The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly., Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM., Cell. November 3, 2006; 127 (3): 539-52.

TPX2 is required for postmitotic nuclear assembly in cell-free Xenopus laevis egg extracts., O'Brien LL, Wiese C., J Cell Biol. June 5, 2006; 173 (5): 685-94.            

HURP is part of a Ran-dependent complex involved in spindle formation., Koffa MD, Casanova CM, Santarella R, Köcher T, Wilm M, Mattaj IW., Curr Biol. April 18, 2006; 16 (8): 743-54.

Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly., Tsai MY, Zheng Y., Curr Biol. December 6, 2005; 15 (23): 2156-63.

Function and regulation of Maskin, a TACC family protein, in microtubule growth during mitosis., Peset I, Seiler J, Sardon T, Bejarano LA, Rybina S, Vernos I., J Cell Biol. September 26, 2005; 170 (7): 1057-66.              

TPX or not TPX?, Karsenti E., Mol Cell. August 19, 2005; 19 (4): 431-2.

An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles., Ozlü N, Srayko M, Kinoshita K, Habermann B, O'toole ET, Müller-Reichert T, Schmalz N, Desai A, Hyman AA., Dev Cell. August 1, 2005; 9 (2): 237-48.

The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2., Eyers PA, Churchill ME, Maller JL., Cell Cycle. June 1, 2005; 4 (6): 784-9.

Mechanism of Aurora B activation by INCENP and inhibition by hesperadin., Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A., Mol Cell. April 29, 2005; 18 (3): 379-91.

Bipolarization and poleward flux correlate during Xenopus extract spindle assembly., Mitchison TJ, Maddox P, Groen A, Cameron L, Perlman Z, Ohi R, Desai A, Salmon ED, Kapoor TM., Mol Biol Cell. December 1, 2004; 15 (12): 5603-15.

Characterization of the TPX2 domains involved in microtubule nucleation and spindle assembly in Xenopus egg extracts., Brunet S, Sardon T, Zimmerman T, Wittmann T, Pepperkok R, Karsenti E, Vernos I., Mol Biol Cell. December 1, 2004; 15 (12): 5318-28.

Protein kinase A, which regulates intracellular transport, forms complexes with molecular motors on organelles., Kashina AS, Semenova IV, Ivanov PA, Potekhina ES, Zaliapin I, Rodionov VI., Curr Biol. October 26, 2004; 14 (20): 1877-81.        

XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly., Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R., Curr Biol. October 26, 2004; 14 (20): 1801-11.            

Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein., Satinover DL, Leach CA, Stukenberg PT, Brautigan DL., Proc Natl Acad Sci U S A. June 8, 2004; 101 (23): 8625-30.

Aurora A, meiosis and mitosis., Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV., Biol Cell. April 1, 2004; 96 (3): 215-29.

Determinants for Aurora-A activation and Aurora-B discrimination by TPX2., Bayliss R, Sardon T, Ebert J, Lindner D, Vernos I, Conti E., Cell Cycle. April 1, 2004; 3 (4): 404-7.

Regulation of Xenopus Aurora A activation by TPX2., Eyers PA, Maller JL., J Biol Chem. March 5, 2004; 279 (10): 9008-15.

Regulation of Aurora-A kinase on the mitotic spindle., Kufer TA, Nigg EA, Silljé HH., Chromosoma. December 1, 2003; 112 (4): 159-63.

Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation., Trieselmann N, Armstrong S, Rauw J, Wilde A., J Cell Sci. December 1, 2003; 116 (Pt 23): 4791-8.

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle., Bayliss R, Sardon T, Vernos I, Conti E., Mol Cell. October 1, 2003; 12 (4): 851-62.

Aurora A on the mitotic spindle is activated by the way it holds its partner., Glover DM., Mol Cell. October 1, 2003; 12 (4): 797-9.  

The quest for the holy "G" of chromosomal passengers., Burke DJ, Stukenberg PT., Dev Cell. August 1, 2003; 5 (2): 187-8.

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