Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Phenotypes Gene Literature (177) GO Terms (0) Nucleotides (44) Proteins (32) Interactants (264) Wiki
XB-GENEPAGE-985558

Papers associated with kcnh1



???displayGene.coCitedPapers???

???pagination.result.count???

???pagination.result.page??? ???pagination.result.prev??? 1 2 3 4 ???pagination.result.next???

Sort Newest To Oldest Sort Oldest To Newest

referenced by:


PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance., Perry M, Sachse FB, Abbruzzese J, Sanguinetti MC., Proc Natl Acad Sci U S A. November 24, 2009; 106 (47): 20075-80.


Inhibition of the human ether-a-go-go-related gene (HERG) K+ channels by Lindera erythrocarpa., Hong HK, Yoon WJ, Kim YH, Yoo ES, Jo SH., J Korean Med Sci. December 1, 2009; 24 (6): 1089-98.            


Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652., Xing J, Ma J, Zhang P, Fan X., Eur J Pharmacol. March 25, 2010; 630 (1-3): 1-9.


Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine., Hong HK, Park MH, Lee BH, Jo SH., Biochem Biophys Res Commun. April 9, 2010; 394 (3): 536-41.


Transfer of ion binding site from ether-a-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening., Lin MC, Abramson J, Papazian DM., J Gen Physiol. May 1, 2010; 135 (5): 415-31.                    


Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening., Es-Salah-Lamoureux Z, Fougere R, Xiong PY, Robertson GA, Fedida D., PLoS One. May 3, 2010; 5 (5): e10876.                    


Current inhibition of human EAG1 potassium channels by the Ca2+ binding protein S100B., Sahoo N, Tröger J, Heinemann SH, Schönherr R., FEBS Lett. September 24, 2010; 584 (18): 3896-900.


Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channel., de la Peña P, Alonso-Ron C, Machín A, Fernández-Trillo J, Carretero L, Domínguez P, Barros F., J Biol Chem. May 27, 2011; 286 (21): 19065-75.


Differential effects of ginsenoside metabolites on HERG k channel currents., Choi SH, Shin TJ, Hwang SH, Lee BH, Kang J, Kim HJ, Oh JW, Bae CS, Lee SH, Nah SY., J Ginseng Res. June 1, 2011; 35 (2): 191-9.        


Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction., Choi SH, Shin TJ, Hwang SH, Lee BH, Kang J, Kim HJ, Jo SH, Choe H, Nah SY., Eur J Pharmacol. August 1, 2011; 663 (1-3): 59-67.


R1 in the Shaker S4 occupies the gating charge transfer center in the resting state., Lin MC, Hsieh JY, Mock AF, Papazian DM., J Gen Physiol. August 1, 2011; 138 (2): 155-63.                  


Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant., Es-Salah-Lamoureux Z, Xiong PY, Goodchild SJ, Ahern CA, Fedida D., Biophys J. August 3, 2011; 101 (3): 662-70.


Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration., Lee BH, Lee SH, Chu D, Hyun JW, Choe H, Choi BH, Jo SH., Acta Pharmacol Sin. September 1, 2011; 32 (9): 1128-37.                  


Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway., Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M., J Biol Chem. November 11, 2011; 286 (45): 39091-9.


RNA editing in eag potassium channels: Biophysical consequences of editing a conserved S6 residue., Ryan MY, Maloney R, Fineberg JD, Reenan RA, Horn R., Channels (Austin). January 1, 2012; 6 (6): .


Pharmacophore modeling for hERG channel facilitation., Yamakawa Y, Furutani K, Inanobe A, Ohno Y, Kurachi Y., Biochem Biophys Res Commun. February 3, 2012; 418 (1): 161-6.


Identification and functional characterization of the novel human ether-a-go-go-related gene (hERG) R744P mutant associated with hereditary long QT syndrome 2., Aidery P, Kisselbach J, Gaspar H, Baldea I, Schweizer PA, Becker R, Katus HA, Thomas D., Biochem Biophys Res Commun. February 24, 2012; 418 (4): 830-5.


Cysteines control the N- and C-linker-dependent gating of KCNH1 potassium channels., Sahoo N, Schönherr R, Hoshi T, Heinemann SH., Biochim Biophys Acta. May 1, 2012; 1818 (5): 1187-95.


Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis., Van Slyke AC, Cheng YM, Mafi P, Allard CR, Hull CM, Shi YP, Claydon TW., Am J Physiol Cell Physiol. June 15, 2012; 302 (12): C1797-806.


Acute alteration of cardiac ECG, action potential, I(Kr) and the human ether-a-go-go-related gene (hERG) K+ channel by PCB 126 and PCB 77., Park MH, Park WS, Jo SH., Toxicol Appl Pharmacol. July 1, 2012; 262 (1): 60-9.


Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule., Garg V, Sachse FB, Sanguinetti MC., J Gen Physiol. September 1, 2012; 140 (3): 307-24.                            


Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels., Tan PS, Perry MD, Ng CA, Vandenberg JI, Hill AP., J Gen Physiol. September 1, 2012; 140 (3): 293-306.                


Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels., Twiner MJ, Doucette GJ, Rasky A, Huang XP, Roth BL, Sanguinetti MC., Chem Res Toxicol. September 17, 2012; 25 (9): 1975-84.


Kcnh1 voltage-gated potassium channels are essential for early zebrafish development., Stengel R, Rivera-Milla E, Sahoo N, Ebert C, Bollig F, Heinemann SH, Schönherr R, Englert C., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.            


Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer in vivo., Lobikin M, Chernet B, Lobo D, Levin M., Phys Biol. December 1, 2012; 9 (6): 065002.


Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P, Kisselbach J, Schweizer PA, Becker R, Katus HA, Thomas D., Gene. December 10, 2012; 511 (1): 26-33.        


The eag domain regulates hERG channel inactivation gating via a direct interaction., Gustina AS, Trudeau MC., J Gen Physiol. February 1, 2013; 141 (2): 229-41.                  


Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration., Hong HK, Lee BH, Park MH, Lee SH, Chu D, Kim WJ, Choe H, Hee Choi B, Jo SH., Eur J Pharmacol. February 28, 2013; 702 (1-3): 165-73.


Flavonoid regulation of EAG1 channels., Carlson AE, Brelidze TI, Zagotta WN., J Gen Physiol. March 1, 2013; 141 (3): 347-58.                  


ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels., Garg V, Stary-Weinzinger A, Sanguinetti MC., Mol Pharmacol. April 1, 2013; 83 (4): 805-13.


Mapping of interactions between the N- and C-termini and the channel core in HERG K+ channels., de la Peña P, Machín A, Fernández-Trillo J, Domínguez P, Barros F., Biochem J. May 1, 2013; 451 (3): 463-74.


External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor., Kazmierczak M, Zhang X, Chen B, Mulkey DK, Shi Y, Wagner PG, Pivaroff-Ward K, Sassic JK, Bayliss DA, Jegla T., J Gen Physiol. June 1, 2013; 141 (6): 721-35.                        


The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibrium., Dou Y, Goodchild SJ, Velde RV, Wu Y, Fedida D., Am J Physiol Cell Physiol. August 15, 2013; 305 (4): C468-78.


Blockade of the human ether-a-go-go-related gene potassium channel by ketamine., Zhang P, Xing J, Luo A, Feng J, Liu Z, Gao C, Ma J., J Pharm Pharmacol. September 1, 2013; 65 (9): 1321-8.


Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel., Park MH, Lee SH, Chu DH, Won KH, Choi BH, Choe H, Jo SH., J Pharmacol Sci. September 20, 2013; 123 (1): 67-77.


AMP-activated protein kinase regulates hERG potassium channel., Almilaji A, Munoz C, Elvira B, Fajol A, Pakladok T, Honisch S, Shumilina E, Lang F, Föller M., Pflugers Arch. November 1, 2013; 465 (11): 1573-82.


Up-regulation of hERG K⁺ channels by B-RAF., Pakladok T, Hosseinzadeh Z, Almilaji A, Lebedeva A, Shumilina E, Alesutan I, Lang F., PLoS One. January 1, 2014; 9 (1): e87457.          


The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels., Lin TF, Jow GM, Fang HY, Fu SJ, Wu HH, Chiu MM, Jeng CJ., PLoS One. January 1, 2014; 9 (10): e110423.                  


Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate., Thouta S, Sokolov S, Abe Y, Clark SJ, Cheng YM, Claydon TW., Biophys J. March 4, 2014; 106 (5): 1057-69.


Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr., Martinson AS, van Rossum DB, Diatta FH, Layden MJ, Rhodes SA, Martindale MQ, Jegla T., Proc Natl Acad Sci U S A. April 15, 2014; 111 (15): 5712-7.


Natural products as potential human ether-a-go-go-related gene channel inhibitors - screening of plant-derived alkaloids., Schramm A, Saxena P, Chlebek J, Cahlíková L, Baburin I, Hering S, Hamburger M., Planta Med. June 1, 2014; 80 (8-9): 740-6.


Natural products as potential human ether-a-go-go-related gene channel inhibitors - outcomes from a screening of widely used herbal medicines and edible plants., Schramm A, Jähne EA, Baburin I, Hering S, Hamburger M., Planta Med. August 1, 2014; 80 (12): 1045-50.


The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains., Lin TF, Lin IW, Chen SC, Wu HH, Yang CS, Fang HY, Chiu MM, Jeng CJ., J Biol Chem. August 15, 2014; 289 (33): 22815-22834.


Facile functional analysis of insect odorant receptors expressed in the fruit fly: validation with receptors from taxonomically distant and closely related species., Ueira-Vieira C, Kimbrell DA, de Carvalho WJ, Leal WS., Cell Mol Life Sci. December 1, 2014; 71 (23): 4675-80.


Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy., Simons C, Rash LD, Crawford J, Ma L, Cristofori-Armstrong B, Miller D, Ru K, Baillie GJ, Alanay Y, Jacquinet A, Debray FG, Verloes A, Shen J, Yesil G, Guler S, Yuksel A, Cleary JG, Grimmond SM, McGaughran J, King GF, Gabbett MT, Taft RJ., Nat Genet. January 1, 2015; 47 (1): 73-7.      


Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243., Wu W, Gardner A, Sanguinetti MC., Mol Pharmacol. January 1, 2015; 87 (3): 401-9.


Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels., Cristofori-Armstrong B, Soh MS, Talwar S, Brown DL, Griffin JD, Dekan Z, Stow JL, King GF, Lynch JW, Rash LD., Sci Rep. January 12, 2015; 5 14763.                                


Ether-à-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor., Li X, Martinson AS, Layden MJ, Diatta FH, Sberna AP, Simmons DK, Martindale MQ, Jegla TJ., J Exp Biol. February 15, 2015; 218 (Pt 4): 526-36.


Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Liu QN, Trudeau MC., PLoS One. April 22, 2015; 10 (4): e0123951.                


Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome., Kortüm F, Caputo V, Bauer CK, Stella L, Ciolfi A, Alawi M, Bocchinfuso G, Flex E, Paolacci S, Dentici ML, Grammatico P, Korenke GC, Leuzzi V, Mowat D, Nair LD, Nguyen TT, Thierry P, White SM, Dallapiccola B, Pizzuti A, Campeau PM, Tartaglia M, Kutsche K., Nat Genet. June 1, 2015; 47 (6): 661-7.      

???pagination.result.page??? ???pagination.result.prev??? 1 2 3 4 ???pagination.result.next???