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Summary Expression Phenotypes Gene Literature (34) GO Terms (3) Nucleotides (77) Proteins (39) Interactants (67) Wiki
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Papers associated with trpv5



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Structural conservation of the genes encoding CaT1, CaT2, and related cation channels., Peng JB, Brown EM, Hediger MA., Genomics. August 1, 2001; 76 (1-3): 99-109.

A single amino acid mutation results in a rapid inactivation of epithelial calcium channels., Suzuki M, Ohki G, Ishibashi K, Imai M., Biochem Biophys Res Commun. February 22, 2002; 291 (2): 278-85.

Role of aspartate residues in Ca(2+) affinity and permeation of the distal ECaC1., Jean K, Bernatchez G, Klein H, Garneau L, Sauvé R, Parent L., Am J Physiol Cell Physiol. April 1, 2002; 282 (4): C665-72.

Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6., Hoenderop JG, Voets T, Hoefs S, Weidema F, Prenen J, Nilius B, Bindels RJ., EMBO J. February 17, 2003; 22 (4): 776-85.

Regulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3 expressed in Xenopus oocytes., Embark HM, Setiawan I, Poppendieck S, van de Graaf SF, Boehmer C, Palmada M, Wieder T, Gerstberger R, Cohen P, Yun CC, Bindels RJ, Lang F., Cell Physiol Biochem. January 1, 2004; 14 (4-6): 203-12.

Outer pore topology of the ECaC-TRPV5 channel by cysteine scan mutagenesis., Dodier Y, Banderali U, Klein H, Topalak O, Dafi O, Simoes M, Bernatchez G, Sauvé R, Parent L., J Biol Chem. February 20, 2004; 279 (8): 6853-62.

80K-H as a new Ca2+ sensor regulating the activity of the epithelial Ca2+ channel transient receptor potential cation channel V5 (TRPV5)., Gkika D, Mahieu F, Nilius B, Hoenderop JG, Bindels RJ., J Biol Chem. June 18, 2004; 279 (25): 26351-7.

Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin., Lambers TT, Weidema AF, Nilius B, Hoenderop JG, Bindels RJ., J Biol Chem. July 9, 2004; 279 (28): 28855-61.

2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3., Hu HZ, Gu Q, Wang C, Colton CK, Tang J, Kinoshita-Kawada M, Lee LY, Wood JD, Zhu MX., J Biol Chem. August 20, 2004; 279 (34): 35741-8.

Molecular determinants in TRPV5 channel assembly., Chang Q, Gyftogianni E, van de Graaf SF, Hoefs S, Weidema FA, Bindels RJ, Hoenderop JG., J Biol Chem. December 24, 2004; 279 (52): 54304-11.

Requirement of PDZ domains for the stimulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase SGK1., Palmada M, Poppendieck S, Embark HM, van de Graaf SF, Boehmer C, Bindels RJ, Lang F., Cell Physiol Biochem. January 1, 2005; 15 (1-4): 175-82.

Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity., van de Graaf SF, van der Kemp AW, van den Berg D, van Oorschot M, Hoenderop JG, Bindels RJ., J Am Soc Nephrol. January 1, 2006; 17 (1): 26-30.

Renal Ca2+ handling in sgk1 knockout mice., Sandulache D, Grahammer F, Artunc F, Henke G, Hussain A, Nasir O, Mack A, Friedrich B, Vallon V, Wulff P, Kuhl D, Palmada M, Lang F., Pflugers Arch. July 1, 2006; 452 (4): 444-52.

Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4., van de Graaf SF, Hoenderop JG, van der Kemp AW, Gisler SM, Bindels RJ., Pflugers Arch. July 1, 2006; 452 (4): 407-17.

WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4., Jiang Y, Ferguson WB, Peng JB., Am J Physiol Renal Physiol. February 1, 2007; 292 (2): F545-54.

A role of the transient receptor potential domain of vanilloid receptor I in channel gating., García-Sanz N, Valente P, Gomis A, Fernández-Carvajal A, Fernández-Ballester G, Viana F, Belmonte C, Ferrer-Montiel A., J Neurosci. October 24, 2007; 27 (43): 11641-50.

Topology of the selectivity filter of a TRPV channel: rapid accessibility of contiguous residues from the external medium., Dodier Y, Dionne F, Raybaud A, Sauvé R, Parent L., Am J Physiol Cell Physiol. December 1, 2007; 293 (6): C1962-70.

Regulation of the epithelial calcium channel TRPV6 by the serum and glucocorticoid-inducible kinase isoforms SGK1 and SGK3., Böhmer C, Palmada M, Kenngott C, Lindner R, Klaus F, Laufer J, Lang F., FEBS Lett. December 11, 2007; 581 (29): 5586-90.

Mechanism of urinary calcium regulation by urinary magnesium and pH., Bonny O, Rubin A, Huang CL, Frawley WH, Pak CY, Moe OW., J Am Soc Nephrol. August 1, 2008; 19 (8): 1530-7.

WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membrane., Jiang Y, Cong P, Williams SR, Zhang W, Na T, Ma HP, Peng JB., Biochem Biophys Res Commun. October 17, 2008; 375 (2): 225-9.

WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway., Zhang W, Na T, Peng JB., Am J Physiol Renal Physiol. November 1, 2008; 295 (5): F1472-84.

The A563T variation of the renal epithelial calcium channel TRPV5 among African Americans enhances calcium influx., Na T, Zhang W, Jiang Y, Liang Y, Ma HP, Warnock DG, Peng JB., Am J Physiol Renal Physiol. May 1, 2009; 296 (5): F1042-51.

Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2., Zhang W, Na T, Wu G, Jing H, Peng JB., J Biol Chem. November 19, 2010; 285 (47): 36586-96.

Concerted actions of NHERF2 and WNK4 in regulating TRPV5., Jing H, Na T, Zhang W, Wu G, Liu C, Peng JB., Biochem Biophys Res Commun. January 28, 2011; 404 (4): 979-84.

Evolution of vertebrate transient receptor potential vanilloid 3 channels: opposite temperature sensitivity between mammals and western clawed frogs., Saito S, Fukuta N, Shingai R, Tominaga M., PLoS Genet. April 1, 2011; 7 (4): e1002041.              

The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties., Kovalevskaya NV, Bokhovchuk FM, Vuister GW., J Struct Funct Genomics. June 1, 2012; 13 (2): 91-100.          

Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity., Kovacs G, Montalbetti N, Franz MC, Graeter S, Simonin A, Hediger MA., Cell Calcium. October 1, 2013; 54 (4): 276-86.

The Xenopus TRPV6 homolog encodes a Mg(2+) -permeant channel that is inhibited by interaction with TRPC1., Courjaret R, Hubrack S, Daalis A, Dib M, Machaca K., J Cell Physiol. December 1, 2013; 228 (12): 2386-98.

The L530R variation associated with recurrent kidney stones impairs the structure and function of TRPV5., Wang L, Holmes RP, Peng JB., Biochem Biophys Res Commun. October 21, 2017; 492 (3): 362-367.                

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM., Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY., Nat Struct Mol Biol. January 1, 2018; 25 (1): 53-60.

Calcium Signaling in Vertebrate Development and Its Role in Disease., Paudel S, Sindelar R, Saha M., Int J Mol Sci. October 30, 2018; 19 (11):     

Expression of trpv channels during Xenopus laevis embryogenesis., Dong C, Paudel S, Amoh NY, Saha MS., Gene Expr Patterns. December 1, 2018; 30 64-70.          

Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses., Morini M, Bergqvist CA, Asturiano JF, Larhammar D, Dufour S., Front Endocrinol (Lausanne). January 1, 2022; 13 1013868.                    

Probing Conformational Transition of TRPV5 Induced by Mechanical Force Using Coarse-Grained Molecular Dynamics., Gu Y, Li Y, Ma B, Ren K, Cao C, Gu N., J Chem Inf Model. November 13, 2023; 63 (21): 6768-6777.

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