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Summary Expression Phenotypes Gene Literature (181) GO Terms (6) Nucleotides (120) Proteins (54) Interactants (221) Wiki
XB-GENEPAGE-981216

Papers associated with nav1



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Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels., Zhang MM, McArthur JR, Azam L, Bulaj G, Olivera BM, French RJ, Yoshikami D., Channels (Austin). January 1, 2009; 3 (1): 32-8.


Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit., Webb J, Wu FF, Cannon SC., Pflugers Arch. April 1, 2009; 457 (6): 1253-63.


The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channel., Yang YC, Hsieh JY, Kuo CC., J Gen Physiol. August 1, 2009; 134 (2): 95-113.                      


Membrane trauma and Na+ leak from Nav1.6 channels., Wang JA, Lin W, Morris T, Banderali U, Juranka PF, Morris CE., Am J Physiol Cell Physiol. October 1, 2009; 297 (4): C823-34.


Electric currents in Xenopus tadpole tail regeneration., Reid B, Song B, Zhao M., Dev Biol. November 1, 2009; 335 (1): 198-207.                


Blocking effect of methylflavonolamine on human Na(V)1.5 channels expressed in Xenopus laevis oocytes and on sodium currents in rabbit ventricular myocytes., Fan XR, Ma JH, Zhang PH, Xing JL., Acta Pharmacol Sin. March 1, 2010; 31 (3): 297-306.                  


An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors., Stürzebecher AS, Hu J, Smith ES, Frahm S, Santos-Torres J, Kampfrath B, Auer S, Lewin GR, Ibañez-Tallon I., J Physiol. May 15, 2010; 588 (Pt 10): 1695-707.        


Optogenetic localization and genetic perturbation of saccade-generating neurons in zebrafish., Schoonheim PJ, Arrenberg AB, Del Bene F, Baier H., J Neurosci. May 19, 2010; 30 (20): 7111-20.


Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome., Gui J, Wang T, Jones RP, Trump D, Zimmer T, Lei M., PLoS One. June 7, 2010; 5 (6): e10985.              


Pharmacological modulation of brain Nav1.2 and cardiac Nav1.5 subtypes by the local anesthetic ropivacaine., Cheng HW, Yang HT, Zhou JJ, Ji YH, Zhu HY., Neurosci Bull. August 1, 2010; 26 (4): 289-96.


Induction of vertebrate regeneration by a transient sodium current., Tseng AS, Beane WS, Lemire JM, Masi A, Levin M., J Neurosci. September 29, 2010; 30 (39): 13192-200.                    


Molecular determination of selectivity of the site 3 modulator (BmK I) to sodium channels in the CNS: a clue to the importance of Nav1.6 in BmK I-induced neuronal hyperexcitability., He H, Liu Z, Dong B, Zhou J, Zhu H, Ji Y., Biochem J. October 15, 2010; 431 (2): 289-98.


Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics., Arcisio-Miranda M, Muroi Y, Chowdhury S, Chanda B., J Gen Physiol. November 1, 2010; 136 (5): 541-54.                


Phyla- and Subtype-Selectivity of CgNa, a Na Channel Toxin from the Venom of the Giant Caribbean Sea Anemone Condylactis Gigantea., Billen B, Debaveye S, Béress L, Garateix A, Tytgat J., Front Pharmacol. November 23, 2010; 1 133.        


Localization of receptor site on insect sodium channel for depressant β-toxin BmK IT2., He H, Liu Z, Dong B, Zhang J, Shu X, Zhou J, Ji Y., PLoS One. January 7, 2011; 6 (1): e14510.            


Independent and joint modulation of rat Nav1.6 voltage-gated sodium channels by coexpression with the auxiliary β1 and β2 subunits., Tan J, Soderlund DM., Biochem Biophys Res Commun. April 22, 2011; 407 (4): 788-92.


Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BKβ1 and BKβ4 in rodent astrocytes., Seidel KN, Derst C, Salzmann M, Höltje M, Priller J, Markgraf R, Heinemann SH, Heilmann H, Skatchkov SN, Eaton MJ, Veh RW, Prüss H., Glia. June 1, 2011; 59 (6): 893-902.


μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve., Wilson MJ, Yoshikami D, Azam L, Gajewiak J, Olivera BM, Bulaj G, Zhang MM., Proc Natl Acad Sci U S A. June 21, 2011; 108 (25): 10302-7.


Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors., Bosmans F, Puopolo M, Martin-Eauclaire MF, Bean BP, Swartz KJ., J Gen Physiol. July 1, 2011; 138 (1): 59-72.                  


Navβ subunits modulate the inhibition of Nav1.8 by the analgesic gating modifier μO-conotoxin MrVIB., Wilson MJ, Zhang MM, Azam L, Olivera BM, Bulaj G, Yoshikami D., J Pharmacol Exp Ther. August 1, 2011; 338 (2): 687-93.


Extracellular proton modulation of the cardiac voltage-gated sodium channel, Nav1.5., Jones DK, Peters CH, Tolhurst SA, Claydon TW, Ruben PC., Biophys J. November 2, 2011; 101 (9): 2147-56.


Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis., Pai VP, Aw S, Shomrat T, Lemire JM, Levin M., Development. January 1, 2012; 139 (2): 313-23.                


Estimating the voltage-dependent free energy change of ion channels using the median voltage for activation., Chowdhury S, Chanda B., J Gen Physiol. January 1, 2012; 139 (1): 3-17.            


A proton leak current through the cardiac sodium channel is linked to mixed arrhythmia and the dilated cardiomyopathy phenotype., Gosselin-Badaroudine P, Keller DI, Huang H, Pouliot V, Chatelier A, Osswald S, Brink M, Chahine M., PLoS One. January 1, 2012; 7 (5): e38331.          


JZTX-XIII, a Kv channel gating modifier toxin from Chinese tarantula Chilobrachys jingzhao., Yuan C, Liu Z, Hu W, Gao T, Liang S., Toxicon. February 1, 2012; 59 (2): 265-71.


Infrared light excites cells by changing their electrical capacitance., Shapiro MG, Homma K, Villarreal S, Richter CP, Bezanilla F., Nat Commun. March 13, 2012; 3 736.          


Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin., McCavera SJ, Soderlund DM., Neurotoxicology. June 1, 2012; 33 (3): 384-90.


Pharmacological kinetics of BmK AS, a sodium channel site 4-specific modulator on Nav1.3., Liu ZR, Tao J, Dong BQ, Ding G, Cheng ZJ, He HQ, Ji YH., Neurosci Bull. June 1, 2012; 28 (3): 209-21.


18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels., Du YM, Xia CK, Zhao N, Dong Q, Lei M, Xia JH., Acta Pharmacol Sin. June 1, 2012; 33 (6): 752-60.            


A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors., Favreau P, Benoit E, Hocking HG, Carlier L, D' hoedt D, Leipold E, Markgraf R, Schlumberger S, Córdova MA, Gaertner H, Paolini-Bertrand M, Hartley O, Tytgat J, Heinemann SH, Bertrand D, Boelens R, Stöcklin R, Molgó J., Br J Pharmacol. July 1, 2012; 166 (5): 1654-68.


Gating pore currents and the resting state of Nav1.4 voltage sensor domains., Gosselin-Badaroudine P, Delemotte L, Moreau A, Klein ML, Chahine M., Proc Natl Acad Sci U S A. November 20, 2012; 109 (47): 19250-5.


Intermediate state trapping of a voltage sensor., Lacroix JJ, Pless SA, Maragliano L, Campos FV, Galpin JD, Ahern CA, Roux B, Bezanilla F., J Gen Physiol. December 1, 2012; 140 (6): 635-52.                      


Multiple pore conformations driven by asynchronous movements of voltage sensors in a eukaryotic sodium channel., Goldschen-Ohm MP, Capes DL, Oelstrom KM, Chanda B., Nat Commun. January 1, 2013; 4 1350.                


Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency., Kuang Z, Zhang MM, Gupta K, Gajewiak J, Gulyas J, Balaram P, Rivier JE, Olivera BM, Yoshikami D, Bulaj G, Norton RS., ACS Chem Biol. January 1, 2013; 8 (6): 1344-51.


Molecular mechanism of voltage sensing in voltage-gated proton channels., Gonzalez C, Rebolledo S, Perez ME, Larsson HP., J Gen Physiol. March 1, 2013; 141 (3): 275-85.              


Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: a periodic paralysis mutation in Na(V)1.4 (L689I)., Silva JR, Goldstein SA., J Gen Physiol. March 1, 2013; 141 (3): 323-34.            


Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: wild-type skeletal muscle Na(V)1.4., Silva JR, Goldstein SA., J Gen Physiol. March 1, 2013; 141 (3): 309-21.                


Characterization of N-terminally mutated cardiac Na(+) channels associated with long QT syndrome 3 and Brugada syndrome., Gütter C, Benndorf K, Zimmer T., Front Physiol. June 26, 2013; 4 153.            


Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker μ-KIIIA and its selenopeptide analogues., Walewska A, Han TS, Zhang MM, Yoshikami D, Bulaj G, Rolka K., Eur J Med Chem. July 1, 2013; 65 144-50.


Extracellular protons inhibit charge immobilization in the cardiac voltage-gated sodium channel., Jones DK, Claydon TW, Ruben PC., Biophys J. July 2, 2013; 105 (1): 101-7.


Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels., Capes DL, Goldschen-Ohm MP, Arcisio-Miranda M, Bezanilla F, Chanda B., J Gen Physiol. August 1, 2013; 142 (2): 101-12.              


Tuning voltage-gated channel activity and cellular excitability with a sphingomyelinase., Combs DJ, Shin HG, Xu Y, Xu Y, Ramu Y, Lu Z., J Gen Physiol. October 1, 2013; 142 (4): 367-80.                    


A naturally occurring amino acid substitution in the voltage-dependent sodium channel selectivity filter affects channel gating., Wu M, Ye N, Sengupta B, Zakon HH., J Comp Physiol A Neuroethol Sens Neural Behav Physiol. October 1, 2013; 199 (10): 829-42.


Analysis of the interaction of tarantula toxin Jingzhaotoxin-III (β-TRTX-Cj1α) with the voltage sensor of Kv2.1 uncovers the molecular basis for cross-activities on Kv2.1 and Nav1.5 channels., Tao H, Chen JJ, Xiao YC, Wu YY, Su HB, Li D, Wang HY, Deng MC, Wang MC, Liu ZH, Liang SP., Biochemistry. October 22, 2013; 52 (42): 7439-48.


Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models., Yang S, Xiao Y, Kang D, Liu J, Li Y, Undheim EA, Klint JK, Rong M, Lai R, King GF., Proc Natl Acad Sci U S A. October 22, 2013; 110 (43): 17534-9.


Identification of Navβ1 residues involved in the modulation of the sodium channel Nav1.4., Islas AA, Sánchez-Solano A, Scior T, Millan-PerezPeña L, Salinas-Stefanon EM., PLoS One. December 9, 2013; 8 (12): e81995.          


Crystallographic insights into sodium-channel modulation by the β4 subunit., Gilchrist J, Das S, Van Petegem F, Bosmans F., Proc Natl Acad Sci U S A. December 17, 2013; 110 (51): E5016-24.


Functional expression of Rat Nav1.6 voltage-gated sodium channels in HEK293 cells: modulation by the auxiliary β1 subunit., He B, Soderlund DM., PLoS One. January 1, 2014; 9 (1): e85188.        


The endocannabinoid anandamide inhibits voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 in Xenopus oocytes., Okura D, Horishita T, Ueno S, Yanagihara N, Sudo Y, Uezono Y, Sata T., Anesth Analg. March 1, 2014; 118 (3): 554-62.


A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain., Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN., Curr Biol. March 3, 2014; 24 (5): 473-83.

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