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Summary Expression Phenotypes Gene Literature (88) GO Terms (6) Nucleotides (160) Proteins (68) Interactants (1023) Wiki
XB-GENEPAGE-488221

Papers associated with ptch1



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Accumulation of inactivation in a cloned transient K+ channel (AKv1.1a) of Aplysia., Furukawa Y., J Neurophysiol. September 1, 1995; 74 (3): 1248-57.

Biochemical evidence that patched is the Hedgehog receptor., Marigo V, Davey RA, Zuo Y, Cunningham JM, Tabin CJ., Nature. November 14, 1996; 384 (6605): 176-9.

Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development., Marigo V, Johnson RL, Vortkamp A, Tabin CJ., Dev Biol. November 25, 1996; 180 (1): 273-83.

Hedgehog and patched gene expression in adult ocular tissues., Takabatake T, Ogawa M, Takahashi TC, Mizuno M, Okamoto M, Takeshima K., FEBS Lett. June 30, 1997; 410 (2-3): 485-9.

Evidence for the involvement of the Gli gene family in embryonic mouse lung development., Grindley JC, Bellusci S, Perkins D, Hogan BL., Dev Biol. August 15, 1997; 188 (2): 337-48.

Non-selective cation conductance in a Xenopus renal epithelial line., Nakagawa N, Mori M, Tamaki N, Okada Y., Kobe J Med Sci. October 1, 1997; 43 (5): 179-89.

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours., Dahmane N, Lee J, Lee J, Robins P, Heller P, Ruiz i Altaba A., Nature. October 23, 1997; 389 (6653): 876-81.

GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization., Shin SH, Kogerman P, Lindström E, Toftgárd R, Biesecker LG., Proc Natl Acad Sci U S A. March 16, 1999; 96 (6): 2880-4.

naked cuticle encodes an inducible antagonist of Wnt signalling., Zeng W, Wharton KA, Mack JA, Wang K, Gadbaw M, Suyama K, Klein PS, Scott MP., Nature. February 17, 2000; 403 (6771): 789-95.

Smoothened activates Galphai-mediated signaling in frog melanophores., DeCamp DL, Thompson TM, de Sauvage FJ, Lerner MR., J Biol Chem. August 25, 2000; 275 (34): 26322-7.

Distinct expression of two types of Xenopus Patched genes during early embryogenesis and hindlimb development., Takabatake T, Takahashi TC, Takabatake Y, Yamada K, Ogawa M, Takeshima K., Mech Dev. November 1, 2000; 98 (1-2): 99-104.   


The sonic hedgehog-patched-gli pathway in human development and disease., Villavicencio EH, Walterhouse DO, Iannaccone PM., Am J Hum Genet. November 1, 2000; 67 (5): 1047-54.

Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus., Zhang J, Rosenthal A, de Sauvage FJ, Shivdasani RA., Dev Biol. January 1, 2001; 229 (1): 188-202.   


Molecular cloning and expression analysis of the Hedgehog receptors XPtc1 and XSmo in Xenopus laevis., Koebernick K, Hollemann T, Pieler T., Mech Dev. February 1, 2001; 100 (2): 303-8.   

Patched1 interacts with cyclin B1 to regulate cell cycle progression., Barnes EA, Kong M, Ollendorff V, Donoghue DJ., EMBO J. May 1, 2001; 20 (9): 2214-23.

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1., Lewis PM, Dunn MP, McMahon JA, Logan M, Martin JF, St-Jacques B, McMahon AP., Cell. June 1, 2001; 105 (5): 599-612.

Notochord patterning of the endoderm., Cleaver O, Krieg PA., Dev Biol. June 1, 2001; 234 (1): 1-12.   


Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node., Zhang XM, Ramalho-Santos M, McMahon AP., Cell. June 15, 2001; 105 (6): 781-92.

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node., Zhang XM, Ramalho-Santos M, McMahon AP., Cell. July 27, 2001; 106 (2): 781-92.

Axes establishment during eye morphogenesis in Xenopus by coordinate and antagonistic actions of BMP4, Shh, and RA., Sasagawa S, Takabatake T, Takabatake Y, Muramatsu T, Takeshima K., Genesis. June 1, 2002; 33 (2): 86-96.   


Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney., Yu J, Carroll TJ, McMahon AP., Development. November 1, 2002; 129 (22): 5301-12.

A novel function for Hedgehog signalling in retinal pigment epithelium differentiation., Perron M, Boy S, Amato MA, Viczian A, Koebernick K, Pieler T, Harris WA., Development. April 1, 2003; 130 (8): 1565-77.   


A restrictive role for Hedgehog signalling during otic specification in Xenopus., Koebernick K, Hollemann T, Pieler T., Dev Biol. August 15, 2003; 260 (2): 325-38.   


Two bestrophins cloned from Xenopus laevis oocytes express Ca(2+)-activated Cl(-) currents., Qu Z, Wei RW, Mann W, Hartzell HC., J Biol Chem. December 5, 2003; 278 (49): 49563-72.   


Noggin inhibits chondrogenic but not osteogenic differentiation in mesodermal stem cell line C1 and skeletal cells., Nifuji A, Kellermann O, Noda M., Endocrinology. July 1, 2004; 145 (7): 3434-42.

Olfactory and lens placode formation is controlled by the hedgehog-interacting protein (Xhip) in Xenopus., Cornesse Y, Pieler T, Hollemann T., Dev Biol. January 15, 2005; 277 (2): 296-315.   


Expression profile of Xenopus banded hedgehog, a homolog of mouse Indian hedgehog, is related to the late development of endochondral ossification in Xenopus laevis., Moriishi T, Shibata Y, Tsukazaki T, Yamaguchi A., Biochem Biophys Res Commun. March 25, 2005; 328 (4): 867-73.

Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase., Koide T, Hayata T, Cho KW., Development. June 1, 2006; 133 (12): 2395-405.   


Hedgehog signaling regulates the amount of hypaxial muscle development during Xenopus myogenesis., Martin BL, Peyrot SM, Harland RM., Dev Biol. April 15, 2007; 304 (2): 722-34.   


Custom-designed zinc finger nucleases: what is next?, Wu J, Kandavelou K, Chandrasegaran S., Cell Mol Life Sci. November 1, 2007; 64 (22): 2933-44.

Correlation between Shh expression and DNA methylation status of the limb-specific Shh enhancer region during limb regeneration in amphibians., Yakushiji N, Suzuki M, Satoh A, Sagai T, Shiroishi T, Kobayashi H, Sasaki H, Ide H, Tamura K, Tamura K., Dev Biol. December 1, 2007; 312 (1): 171-82.   

A dual requirement for Iroquois genes during Xenopus kidney development., Alarcón P, Rodríguez-Seguel E, Fernández-González A, Rubio R, Gómez-Skarmeta JL., Development. October 1, 2008; 135 (19): 3197-207.   


Down syndrome critical region protein 5 regulates membrane localization of Wnt receptors, Dishevelled stability and convergent extension in vertebrate embryos., Shao M, Liu ZZ, Wang CD, Wang CD, Wang CD, Li HY, Carron C, Zhang HW, Shi DL., Development. June 1, 2009; 136 (12): 2121-31.   


Mad is required for wingless signaling in wing development and segment patterning in Drosophila., Eivers E, Fuentealba LC, Sander V, Clemens JC, Hartnett L, De Robertis EM., PLoS One. August 6, 2009; 4 (8): e6543.   


Alpha(1)-antitrypsin inhibits epithelial Na+ transport in vitro and in vivo., Lazrak A, Nita I, Subramaniyam D, Wei S, Song W, Ji HL, Janciauskiene S, Matalon S., Am J Respir Cell Mol Biol. September 1, 2009; 41 (3): 261-70.

In vivo spike-timing-dependent plasticity in the optic tectum of Xenopus laevis., Richards BA, Aizenman CD, Akerman CJ., Front Synaptic Neurosci. June 10, 2010; 2 7.   


A mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds., Nakane Y, Ikegami K, Ono H, Yamamoto N, Yoshida S, Hirunagi K, Ebihara S, Kubo Y, Yoshimura T., Proc Natl Acad Sci U S A. August 24, 2010; 107 (34): 15264-8.

Xenopus sonic hedgehog guides retinal axons along the optic tract., Gordon L, Mansh M, Kinsman H, Morris AR., Dev Dyn. November 1, 2010; 239 (11): 2921-32.   


A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription., He Z, Cai J, Lim JW, Kroll K, Ma L., J Biol Chem. March 4, 2011; 286 (9): 7279-89.   

Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord., Belgacem YH, Borodinsky LN., Proc Natl Acad Sci U S A. March 15, 2011; 108 (11): 4482-7.   


A revised model of Xenopus dorsal midline development: differential and separable requirements for Notch and Shh signaling., Peyrot SM, Wallingford JB, Harland RM., Dev Biol. April 15, 2011; 352 (2): 254-66.   


MIM regulates vertebrate neural tube closure., Liu W, Komiya Y, Mezzacappa C, Khadka DK, Runnels L, Habas R., Development. May 1, 2011; 138 (10): 2035-47.   


Hedgehog signaling regulates size of the dorsal aortae and density of the plexus during avian vascular development., Moran CM, Salanga MC, Krieg PA., Dev Dyn. June 1, 2011; 240 (6): 1354-64.   


The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo., Min TH, Kriebel M, Hou S, Pera EM., Dev Biol. October 1, 2011; 358 (1): 262-76.   


Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung., Lazrak A, Jurkuvenaite A, Chen L, Keeling KM, Collawn JF, Bedwell DM, Matalon S., Am J Physiol Lung Cell Mol Physiol. October 1, 2011; 301 (4): L557-67.

Functional clustering drives encoding improvement in a developing brain network during awake visual learning., Podgorski K, Dunfield D, Haas K., PLoS Biol. January 1, 2012; 10 (1): e1001236.   


ZFP932 suppresses cellular Hedgehog response and Patched1 transcription., Huang GJ, He Z, Ma L., Vitam Horm. January 1, 2012; 88 309-32.

Thyroid hormone-induced sonic hedgehog signal up-regulates its own pathway in a paracrine manner in the Xenopus laevis intestine during metamorphosis., Hasebe T, Kajita M, Fu L, Shi YB, Ishizuya-Oka A., Dev Dyn. February 1, 2012; 241 (2): 403-14.   


Indian hedgehog signaling is required for proper formation, maintenance and migration of Xenopus neural crest., Agüero TH, Fernández JP, López GA, Tríbulo C, Aybar MJ., Dev Biol. April 15, 2012; 364 (2): 99-113.   


Antagonistic cross-regulation between Wnt and Hedgehog signalling pathways controls post-embryonic retinal proliferation., Borday C, Cabochette P, Parain K, Mazurier N, Janssens S, Tran HT, Sekkali B, Bronchain O, Vleminckx K, Vleminckx K, Locker M, Perron M., Development. October 1, 2012; 139 (19): 3499-509.   

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