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Summary Expression Phenotypes Gene Literature (190) GO Terms (26) Nucleotides (140) Proteins (57) Interactants (149) Wiki
XB-GENEPAGE-5921461

Papers associated with kcnq1



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PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels., Lopes CM, Rohács T, Czirják G, Balla T, Enyedi P, Logothetis DE., J Physiol. April 1, 2005; 564 (Pt 1): 117-29.

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine., Schenzer A, Friedrich T, Pusch M, Saftig P, Jentsch TJ, Grötzinger J, Schwake M., J Neurosci. May 18, 2005; 25 (20): 5051-60.

Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome., Thomas D, Wimmer AB, Karle CA, Licka M, Alter M, Khalil M, Ulmer HE, Kathöfer S, Kiehn J, Katus HA, Schoels W, Koenen M, Zehelein J., Cardiovasc Res. August 15, 2005; 67 (3): 487-97.

The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes., Jensen HS, Callø K, Jespersen T, Jensen BS, Olesen SP., Brain Res Mol Brain Res. September 13, 2005; 139 (1): 52-62.

Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome., Grunnet M, Behr ER, Calloe K, Hofman-Bang J, Till J, Christiansen M, McKenna WJ, Olesen SP, Schmitt N., Heart Rhythm. November 1, 2005; 2 (11): 1238-49.

De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero., Hong K, Piper DR, Diaz-Valdecantos A, Brugada J, Oliva A, Burashnikov E, Santos-de-Soto J, Grueso-Montero J, Diaz-Enfante E, Brugada P, Sachse F, Sanguinetti MC, Brugada R., Cardiovasc Res. December 1, 2005; 68 (3): 433-40.

Functional coassembly of KCNQ4 with KCNE-beta- subunits in Xenopus oocytes., Strutz-Seebohm N, Seebohm G, Fedorenko O, Baltaev R, Engel J, Knirsch M, Lang F., Cell Physiol Biochem. January 1, 2006; 18 (1-3): 57-66.

Interaction of KCNE subunits with the KCNQ1 K+ channel pore., Panaghie G, Tai KK, Abbott GW., J Physiol. February 1, 2006; 570 (Pt 3): 455-67.

Differential roles of S6 domain hinges in the gating of KCNQ potassium channels., Seebohm G, Strutz-Seebohm N, Ureche ON, Baltaev R, Lampert A, Kornichuk G, Kamiya K, Wuttke TV, Lerche H, Sanguinetti MC, Lang F., Biophys J. March 15, 2006; 90 (6): 2235-44.

The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?, Jespersen T, Grunnet M, Rasmussen HB, Jørgensen NB, Jensen HS, Angelo K, Olesen SP, Klaerke DA., Biochem Biophys Res Commun. March 24, 2006; 341 (4): 979-88.

Structural determinants of M-type KCNQ (Kv7) K+ channel assembly., Schwake M, Athanasiadu D, Beimgraben C, Blanz J, Beck C, Jentsch TJ, Saftig P, Friedrich T., J Neurosci. April 5, 2006; 26 (14): 3757-66.

KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin., Ghosh S, Nunziato DA, Pitt GS., Circ Res. April 28, 2006; 98 (8): 1048-54.

Sudden infant death syndrome and long QT syndrome: an epidemiological and genetic study., Wedekind H, Bajanowski T, Friederich P, Breithardt G, Wülfing T, Siebrands C, Engeland B, Mönnig G, Haverkamp W, Brinkmann B, Schulze-Bahr E., Int J Legal Med. May 1, 2006; 120 (3): 129-37.

Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels., Diness TG, Hansen RS, Olesen SP, Grunnet M., Biochem Biophys Res Commun. May 19, 2006; 343 (4): 1224-33.

Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel., Bett GC, Morales MJ, Beahm DL, Duffey ME, Rasmusson RL., J Physiol. November 1, 2006; 576 (Pt 3): 755-67.

Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome., Zehelein J, Kathoefer S, Khalil M, Alter M, Thomas D, Brockmeier K, Ulmer HE, Katus HA, Koenen M., J Biol Chem. November 17, 2006; 281 (46): 35397-403.

Secondary structure of a KCNE cytoplasmic domain., Rocheleau JM, Gage SD, Kobertz WR., J Gen Physiol. December 1, 2006; 128 (6): 721-9.          

KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I(Ks) current amplitude in the heart., Wu DM, Jiang M, Zhang M, Liu XS, Korolkova YV, Tseng GN., Heart Rhythm. December 1, 2006; 3 (12): 1469-80.

The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes., Panaghie G, Abbott GW., J Gen Physiol. February 1, 2007; 129 (2): 121-33.                      

Mechanistic basis for the pathogenesis of long QT syndrome associated with a common splicing mutation in KCNQ1 gene., Tsuji K, Akao M, Ishii TM, Ohno S, Makiyama T, Takenaka K, Doi T, Haruna Y, Yoshida H, Nakashima T, Kita T, Horie M., J Mol Cell Cardiol. March 1, 2007; 42 (3): 662-9.

Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels., Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, Baltaev R, Mack AF, Korniychuk G, Choudhury A, Marks D, Pagano RE, Attali B, Pfeufer A, Kass RS, Sanguinetti MC, Tavare JM, Lang F., Circ Res. March 16, 2007; 100 (5): 686-92.

Upregulation of KCNE1 induces QT interval prolongation in patients with chronic heart failure., Watanabe E, Yasui K, Kamiya K, Yamaguchi T, Sakuma I, Honjo H, Ozaki Y, Morimoto S, Hishida H, Kodama I., Circ J. April 1, 2007; 71 (4): 471-8.

Probing the interaction between KCNE2 and KCNQ1 in their transmembrane regions., Liu XS, Zhang M, Jiang M, Wu DM, Tseng GN., J Membr Biol. April 1, 2007; 216 (2-3): 117-27.

Inactivation as a new regulatory mechanism for neuronal Kv7 channels., Jensen HS, Grunnet M, Olesen SP., Biophys J. April 15, 2007; 92 (8): 2747-56.

Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter., Lerche C, Bruhova I, Lerche H, Steinmeyer K, Wei AD, Strutz-Seebohm N, Lang F, Busch AE, Zhorov BS, Seebohm G., Mol Pharmacol. June 1, 2007; 71 (6): 1503-11.

A derivatized scorpion toxin reveals the functional output of heteromeric KCNQ1-KCNE K+ channel complexes., Morin TJ, Kobertz WR., ACS Chem Biol. July 20, 2007; 2 (7): 469-73.

KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channel., Nakajo K, Kubo Y., J Gen Physiol. September 1, 2007; 130 (3): 269-81.            

Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus., Chen H, Goldstein SA., Biophys J. October 1, 2007; 93 (7): 2332-40.

Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome., Tian C, Vanoye CG, Kang C, Welch RC, Kim HJ, George AL, Sanders CR., Biochemistry. October 16, 2007; 46 (41): 11459-72.

The KCNE1 beta-subunit exerts a transient effect on the KCNQ1 K+ channel., Poulsen AN, Klaerke DA., Biochem Biophys Res Commun. November 9, 2007; 363 (1): 133-9.

KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval., Lundby A, Ravn LS, Svendsen JH, Olesen SP, Schmitt N., Heart Rhythm. December 1, 2007; 4 (12): 1532-41.

An inactivation gate in the selectivity filter of KCNQ1 potassium channels., Gibor G, Yakubovich D, Rosenhouse-Dantsker A, Peretz A, Schottelndreier H, Seebohm G, Dascal N, Logothetis DE, Paas Y, Attali B., Biophys J. December 15, 2007; 93 (12): 4159-72.

Cardiac sodium channel gene variants and sudden cardiac death in women., Albert CM, Nam EG, Rimm EB, Jin HW, Hajjar RJ, Hunter DJ, MacRae CA, Ellinor PT., Circulation. January 1, 2008; 117 (1): 16-23.

KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channels., Rocheleau JM, Kobertz WR., J Gen Physiol. January 1, 2008; 131 (1): 59-68.        

KCNQ1 and KCNE1 K+ channel components are involved in early left-right patterning in Xenopus laevis embryos., Morokuma J, Blackiston D, Levin M., Cell Physiol Biochem. January 1, 2008; 21 (5-6): 357-72.

Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexes., Morin TJ, Kobertz WR., Proc Natl Acad Sci U S A. February 5, 2008; 105 (5): 1478-82.

S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels., Haitin Y, Yisharel I, Malka E, Shamgar L, Schottelndreier H, Peretz A, Paas Y, Attali B., PLoS One. April 9, 2008; 3 (4): e1935.                  

KCNE1 constrains the voltage sensor of Kv7.1 K+ channels., Shamgar L, Haitin Y, Yisharel I, Malka E, Schottelndreier H, Peretz A, Paas Y, Attali B., PLoS One. April 9, 2008; 3 (4): e1943.                    

KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains., Xu X, Jiang M, Hsu KL, Zhang M, Tseng GN., J Gen Physiol. June 1, 2008; 131 (6): 589-603.                    

Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks., Nakajo K, Kubo Y., J Physiol. June 15, 2008; 586 (12): 2827-40.

Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents., Yeung S, Schwake M, Pucovský V, Greenwood Ia., Br J Pharmacol. September 1, 2008; 155 (1): 62-72.

Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels., Restier L, Cheng L, Sanguinetti MC., J Physiol. September 1, 2008; 586 (17): 4179-91.

Voltage-dependent C-type inactivation in a constitutively open K+ channel., Panaghie G, Purtell K, Tai KK, Abbott GW., Biophys J. September 15, 2008; 95 (6): 2759-78.

Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells., Morokuma J, Blackiston D, Adams DS, Seebohm G, Trimmer B, Levin M., Proc Natl Acad Sci U S A. October 28, 2008; 105 (43): 16608-13.                                  

Cardiac ion channel gene mutations in sudden infant death syndrome., Otagiri T, Kijima K, Osawa M, Ishii K, Makita N, Matoba R, Umetsu K, Hayasaka K., Pediatr Res. November 1, 2008; 64 (5): 482-7.

Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels., Seebohm G, Strutz-Seebohm N, Ureche ON, Henrion U, Baltaev R, Mack AF, Korniychuk G, Steinke K, Tapken D, Pfeufer A, Kääb S, Bucci C, Attali B, Merot J, Tavare JM, Hoppe UC, Sanguinetti MC, Lang F., Circ Res. December 5, 2008; 103 (12): 1451-7.

Discovery of a novel activator of KCNQ1-KCNE1 K channel complexes., Mruk K, Kobertz WR., PLoS One. January 1, 2009; 4 (1): e4236.          

Long QT syndrome-associated mutations in the voltage sensor of I(Ks) channels., Henrion U, Strutz-Seebohm N, Duszenko M, Lang F, Seebohm G., Cell Physiol Biochem. January 1, 2009; 24 (1-2): 11-6.

PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors., Matavel A, Lopes CM., J Mol Cell Cardiol. May 1, 2009; 46 (5): 704-12.

Cell volume and membrane stretch independently control K+ channel activity., Hammami S, Willumsen NJ, Olsen HL, Morera FJ, Latorre R, Klaerke DA., J Physiol. May 15, 2009; 587 (Pt 10): 2225-31.

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