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Summary Expression Phenotypes Gene Literature (146) GO Terms (7) Nucleotides (233) Proteins (55) Interactants (912) Wiki
XB-GENEPAGE-485690

Papers associated with smad4



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ZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation., Wang C, Liu Z, Zeng Y, Zhou L, Long Q, Hassan IU, Zhang Y, Qi X, Cai D, Mao B, Lu G, Sun J, Yao Y, Deng Y, Zhao Q, Feng B, Zhou Q, Chan WY, Zhao H., EMBO Rep. February 1, 2024; 25 (2): 646-671.                                          

Prdm15 acts upstream of Wnt4 signaling in anterior neural development of Xenopus laevis., Saumweber E, Mzoughi S, Khadra A, Werberger A, Schumann S, Guccione E, Schmeisser MJ, Kühl SJ., Front Cell Dev Biol. January 1, 2024; 12 1316048.                            

Head organizer: Cerberus and IGF cooperate in brain induction in Xenopus embryos., Azbazdar Y, Pera EM, De Robertis EM., Cells Dev. December 16, 2023; 203897.                  

Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR., Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan MJ, Zenisek D, Warmflash A, Owens NDL, Khokha MK., Nat Commun. November 5, 2022; 13 (1): 6681.                                            

HMCES modulates the transcriptional regulation of nodal/activin and BMP signaling in mESCs., Liang T, Bai J, Zhou W, Lin H, Ma S, Zhu X, Tao Q, Xi Q., Cell Rep. July 12, 2022; 40 (2): 111038.                              

Signaling Control of Mucociliary Epithelia: Stem Cells, Cell Fates, and the Plasticity of Cell Identity in Development and Disease., Walentek P., Cells Tissues Organs. January 1, 2022; 211 (6): 736-753.

Smad2 and Smad3 differentially modulate chordin transcription via direct binding on the distal elements in gastrula Xenopus embryos., Kumar V, Umair Z, Kumar S, Kumar S, Lee U, Kim J., Biochem Biophys Res Commun. June 25, 2021; 559 168-175.          

The Multifaceted Roles of USP15 in Signal Transduction., Das T, Song EJ, Kim EE., Int J Mol Sci. April 29, 2021; 22 (9):       

Segregation of brain and organizer precursors is differentially regulated by Nodal signaling at blastula stage., Castro Colabianchi AM, Tavella MB, Boyadjián López LE, Rubinstein M, Franchini LF, López SL., Biol Open. February 25, 2021; 10 (2):                 

Dusp1 modulates activin/smad2 mediated germ layer specification via FGF signal inhibition in Xenopus embryos., Umair Z, Kumar S, Rafiq K, Kumar V, Reman ZU, Lee SH, Kim S, Lee JY, Lee U, Kim J., Anim Cells Syst (Seoul). November 27, 2020; 24 (6): 359-370.            

Tbx2 mediates dorsal patterning and germ layer suppression through inhibition of BMP/GDF and Activin/Nodal signaling., Reich S, Kayastha P, Teegala S, Weinstein DC., BMC Mol Cell Biol. May 28, 2020; 21 (1): 39.              

Repression of Inappropriate Gene Expression in the Vertebrate Embryonic Ectoderm., Reich S, Weinstein DC., Genes (Basel). November 6, 2019; 10 (11):         

Transcriptome profiling reveals male- and female-specific gene expression pattern and novel gene candidates for the control of sex determination and gonad development in Xenopus laevis., Piprek RP, Damulewicz M, Tassan JP, Kloc M, Kubiak JZ., Dev Genes Evol. May 1, 2019; 229 (2-3): 53-72.        

Fam46a regulates BMP-dependent pre-placodal ectoderm differentiation in Xenopus., Watanabe T, Yamamoto T, Tsukano K, Hirano S, Horikawa A, Michiue T., Development. October 26, 2018; 145 (20):                                     

Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells., Zhang Z, Lei A, Xu L, Chen L, Chen Y, Chen Y, Zhang X, Gao Y, Yang X, Zhang M, Cao Y, Cao Y., J Biol Chem. August 4, 2017; 292 (31): 12842-12859.        

Eomesodermin-At Dawn of Cell Fate Decisions During Early Embryogenesis., Probst S, Arnold SJ., Curr Top Dev Biol. January 1, 2017; 122 93-115.

Aberrant regulation of Wnt signaling in hepatocellular carcinoma., Liu LJ, Xie SX, Chen YT, Xue JL, Zhang CJ, Zhu F., World J Gastroenterol. September 7, 2016; 22 (33): 7486-99.      

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy., Raymond A, Liu B, Liang H, Wei C, Guindani M, Lu Y, Liang S, St John LS, Molldrem J, Nagarajan L., Oncotarget. December 30, 2014; 5 (24): 12675-93.              

Sox5 Is a DNA-binding cofactor for BMP R-Smads that directs target specificity during patterning of the early ectoderm., Nordin K, LaBonne C., Dev Cell. November 10, 2014; 31 (3): 374-382.                              

The tumor suppressor Smad4/DPC4 is regulated by phosphorylations that integrate FGF, Wnt, and TGF-β signaling., Demagny H, Araki T, De Robertis EM., Cell Rep. October 23, 2014; 9 (2): 688-700.

Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos., Kirmizitas A, Gillis WQ, Zhu H, Thomsen GH., Dev Biol. August 15, 2014; 392 (2): 358-67.                                

Spalt-like 4 promotes posterior neural fates via repression of pou5f3 family members in Xenopus., Young JJ, Kjolby RA, Kong NR, Monica SD, Harland RM., Development. April 1, 2014; 141 (8): 1683-93.                                                                

A potential molecular pathogenesis of cardiac/laterality defects in Oculo-Facio-Cardio-Dental syndrome., Tanaka K, Kato A, Angelocci C, Watanabe M, Kato Y., Dev Biol. March 1, 2014; 387 (1): 28-36.        

Commitment to nutritional endoderm in Eleutherodactylus coqui involves altered nodal signaling and global transcriptional repression., Chatterjee S, Elinson RP., J Exp Zool B Mol Dev Evol. January 1, 2014; 322 (1): 27-44.

Brain-specific promoter/exon I.f of the cyp19a1 (aromatase) gene in Xenopus laevis., Nakagawa T, Iwabuchi J., J Steroid Biochem Mol Biol. November 1, 2012; 132 (3-5): 247-55.

Signaling crosstalk between TGFβ and Dishevelled/Par1b., Mamidi A, Inui M, Manfrin A, Soligo S, Enzo E, Aragona M, Cordenonsi M, Wessely O, Dupont S, Piccolo S., Cell Death Differ. October 1, 2012; 19 (10): 1689-97.                    

Self-regulation of the head-inducing properties of the Spemann organizer., Inui M, Montagner M, Ben-Zvi D, Martello G, Soligo S, Manfrin A, Aragona M, Enzo E, Zacchigna L, Zanconato F, Azzolin L, Dupont S, Cordenonsi M, Piccolo S., Proc Natl Acad Sci U S A. September 18, 2012; 109 (38): 15354-9.                            

Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4., Warmflash A, Zhang Q, Sorre B, Vonica A, Siggia ED, Brivanlou AH., Proc Natl Acad Sci U S A. July 10, 2012; 109 (28): E1947-56.          

Bmp indicator mice reveal dynamic regulation of transcriptional response., Javier AL, Doan LT, Luong M, Reyes de Mochel NS, Sun A, Monuki ES, Cho KW., PLoS One. January 1, 2012; 7 (9): e42566.                

USP15 is a deubiquitylating enzyme for receptor-activated SMADs., Inui M, Manfrin A, Mamidi A, Martello G, Morsut L, Soligo S, Enzo E, Moro S, Polo S, Dupont S, Cordenonsi M, Piccolo S., Nat Cell Biol. September 25, 2011; 13 (11): 1368-75.

HEB and E2A function as SMAD/FOXH1 cofactors., Yoon SJ, Wills AE, Chuong E, Gupta R, Baker JC., Genes Dev. August 1, 2011; 25 (15): 1654-61.            

Role of BMP, FGF, calcium signaling, and Zic proteins in vertebrate neuroectodermal differentiation., Aruga J, Mikoshiba K., Neurochem Res. July 1, 2011; 36 (7): 1286-92.      

SNW1 is a critical regulator of spatial BMP activity, neural plate border formation, and neural crest specification in vertebrate embryos., Wu MY, Ramel MC, Howell M, Hill CS., PLoS Biol. February 15, 2011; 9 (2): e1000593.                              

Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning., Kozmikova I, Smolikova J, Vlcek C, Kozmik Z., PLoS One. February 3, 2011; 6 (2): e14650.                  

ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression., Masserdotti G, Badaloni A, Green YS, Croci L, Barili V, Bergamini G, Vetter ML, Consalez GG., J Biol Chem. October 1, 2010; 285 (40): 30814-24.              

The BMP pathway acts to directly regulate Tbx20 in the developing heart., Mandel EM, Kaltenbrun E, Callis TE, Zeng XX, Marques SR, Yelon D, Wang DZ, Conlon FL., Development. June 1, 2010; 137 (11): 1919-29.                  

TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling., Watanabe Y, Itoh S, Goto T, Ohnishi E, Inamitsu M, Itoh F, Satoh K, Wiercinska E, Yang W, Shi L, Tanaka A, Nakano N, Mommaas AM, Shibuya H, Ten Dijke P, Kato M., Mol Cell. January 15, 2010; 37 (1): 123-34.                                      

Rab5-mediated endocytosis of activin is not required for gene activation or long-range signalling in Xenopus., Hagemann AI, Xu X, Nentwich O, Hyvonen M, Smith JC., Development. August 1, 2009; 136 (16): 2803-13.                

High-sensitivity real-time imaging of dual protein-protein interactions in living subjects using multicolor luciferases., Hida N, Awais M, Takeuchi M, Ueno N, Tashiro M, Takagi C, Singh T, Hayashi M, Ohmiya Y, Ozawa T., PLoS One. June 12, 2009; 4 (6): e5868.            

Modeling and analysis of MH1 domain of Smads and their interaction with promoter DNA sequence motif., Makkar P, Metpally RP, Sangadala S, Reddy BV., J Mol Graph Model. April 1, 2009; 27 (7): 803-12.

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination., Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S., Cell. January 9, 2009; 136 (1): 123-35.  

TGF-beta induces connexin43 gene expression in normal murine mammary gland epithelial cells via activation of p38 and PI3K/AKT signaling pathways., Tacheau C, Fontaine J, Loy J, Mauviel A, Verrecchia F., J Cell Physiol. December 1, 2008; 217 (3): 759-68.

Generation of mice with a conditional allele for Trim33., Kim J, Kaartinen V., Genesis. June 1, 2008; 46 (6): 329-33.

A crucial role of a high mobility group protein HMGA2 in cardiogenesis., Monzen K, Ito Y, Naito AT, Kasai H, Hiroi Y, Hayashi D, Shiojima I, Yamazaki T, Miyazono K, Asashima M, Nagai R, Komuro I., Nat Cell Biol. May 1, 2008; 10 (5): 567-74.                  

HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus., Nagao K, Taniyama Y, Kietzmann T, Doi T, Komuro I, Morishita R., J Biol Chem. April 25, 2008; 283 (17): 11841-9.                        

Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice., Pangas SA, Li X, Umans L, Zwijsen A, Huylebroeck D, Gutierrez C, Wang D, Martin JF, Jamin SP, Behringer RR, Robertson EJ, Matzuk MM., Mol Cell Biol. January 1, 2008; 28 (1): 248-57.

Dkk3 is required for TGF-beta signaling during Xenopus mesoderm induction., Pinho S, Niehrs C., Differentiation. December 1, 2007; 75 (10): 957-67.            

Nuclear accumulation of Smad complexes occurs only after the midblastula transition in Xenopus., Saka Y, Hagemann AI, Piepenburg O, Smith JC., Development. December 1, 2007; 134 (23): 4209-18.

Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain., Dai F, Chang C, Lin X, Dai P, Mei L, Feng XH., Mol Cell Biol. September 1, 2007; 27 (17): 6183-94.

Negative regulation of Activin/Nodal signaling by SRF during Xenopus gastrulation., Yun CH, Choi SC, Park E, Kim SJ, Chung AS, Lee HK, Lee HK, Lee HJ, Lee HJ, Han JK., Development. February 1, 2007; 134 (4): 769-77.              

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