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Summary Expression Phenotypes Gene Literature (45) GO Terms (7) Nucleotides (101) Proteins (54) Interactants (173) Wiki
XB-GENEPAGE-920732

Papers associated with insr



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Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells., Ebina Y, Edery M, Ellis L, Standring D, Beaudoin J, Roth RA, Rutter WJ., Proc Natl Acad Sci U S A. December 1, 1985; 82 (23): 8014-8.

Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase., Morgan DO, Ho L, Korn LJ, Roth RA., Proc Natl Acad Sci U S A. January 1, 1986; 83 (2): 328-32.

Mitogenic signalling and protein phosphorylation in Xenopus oocytes., Maller JL., J Cyclic Nucleotide Protein Phosphor Res. January 1, 1986; 11 (7): 543-55.

Increased phosphorylation of ribosomal protein S6 following microinjection of insulin receptor-kinase into Xenopus oocytes., Maller JL, Pike LJ, Freidenberg GR, Cordera R, Stith BJ, Olefsky JM, Krebs EG., Nature. April 3, 1986; 320 (6061): 459-61.

Ras p21 as a potential mediator of insulin action in Xenopus oocytes., Korn LJ, Siebel CW, McCormick F, Roth RA., Science. May 15, 1987; 236 (4803): 840-3.

Activation of glucose uptake by insulin and insulin-like growth factor I in Xenopus oocytes., Janicot M, Lane MD., Proc Natl Acad Sci U S A. April 1, 1989; 86 (8): 2642-6.

Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes., Tonks NK, Cicirelli MF, Diltz CD, Krebs EG, Fischer EH., Mol Cell Biol. February 1, 1990; 10 (2): 458-63.

Reconstitution of an insulin signaling pathway in Xenopus laevis oocytes: coexpression of a mammalian insulin receptor and three different mammalian hexose transporters., Vera JC, Rosen OM., Mol Cell Biol. February 1, 1990; 10 (2): 743-51.

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor., Chen WJ, Goldstein JL, Brown MS., J Biol Chem. February 25, 1990; 265 (6): 3116-23.

Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos., Scavo L, Shuldiner AR, Serrano J, Dashner R, Roth J, de Pablo F., Proc Natl Acad Sci U S A. July 15, 1991; 88 (14): 6214-8.

The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains., Myers MG, White MF., Diabetes. May 1, 1993; 42 (5): 643-50.

Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes., Chuang LM, Myers MG, Seidner GA, Birnbaum MJ, White MF, Kahn CR., Proc Natl Acad Sci U S A. June 1, 1993; 90 (11): 5172-5.

Dephosphorylation of tyrosine phosphorylated synthetic peptides by rat liver phosphotyrosine protein phosphatase isoenzymes., Stefani M, Caselli A, Bucciantini M, Pazzagli L, Dolfi F, Camici G, Manao G, Ramponi G., FEBS Lett. July 12, 1993; 326 (1-3): 131-4.

Phylogeny of the insulin-like growth factors (IGFs) and receptors: a molecular approach., LeRoith D, Kavsan VM, Koval AP, Roberts CT., Mol Reprod Dev. August 1, 1993; 35 (4): 332-6; discussion 337-8.

Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase., Chuang LM, Myers MG, Backer JM, Shoelson SE, White MF, Birnbaum MJ, Kahn CR., Mol Cell Biol. November 1, 1993; 13 (11): 6653-60.

Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes., Chuang LM, Hausdorff SF, Myers MG, White MF, Birnbaum MJ, Kahn CR., J Biol Chem. November 4, 1994; 269 (44): 27645-9.

Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation., Liu XJ, Sorisky A, Zhu L, Pawson T., Mol Cell Biol. July 1, 1995; 15 (7): 3563-70.

Characterization of an insulin from the three-toed amphiuma (Amphibia: Urodela) with an N-terminally extended A-chain and high receptor-binding affinity., Conlon JM, Cavanaugh ES, Mynarcik DC, Whittaker J., Biochem J. January 1, 1996; 313 ( Pt 1) 283-7.

A peroxovanadium compound induces Xenopus oocyte maturation: inhibition by a neutralizing anti-insulin receptor antibody., Cummings C, Zhu L, Sorisky A, Liu XJ., Dev Biol. May 1, 1996; 175 (2): 338-46.

Mutant of insulin receptor substrate-1 incapable of activating phosphatidylinositol 3-kinase did not mediate insulin-stimulated maturation of Xenopus laevis oocytes., Yamamoto-Honda R, Honda Z, Ueki K, Tobe K, Kaburagi Y, Takahashi Y, Tamemoto H, Suzuki T, Itoh K, Akanuma Y, Yazaki Y, Kadowaki T., J Biol Chem. November 8, 1996; 271 (45): 28677-81.

Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation., O'Neill TJ, Zhu Y, Gustafson TA., J Biol Chem. April 11, 1997; 272 (15): 10035-40.

Occludin dephosphorylation in early development of Xenopus laevis., Cordenonsi M, Mazzon E, De Rigo L, Baraldo S, Meggio F, Citi S., J Cell Sci. December 1, 1997; 110 ( Pt 24) 3131-9.                

A rho-associated protein kinase, ROKalpha, binds insulin receptor substrate-1 and modulates insulin signaling., Farah S, Agazie Y, Ohan N, Ngsee JK, Liu XJ., J Biol Chem. February 20, 1998; 273 (8): 4740-6.

A novel insulin receptor substrate protein, xIRS-u, potentiates insulin signaling: functional importance of its pleckstrin homology domain., Ohan N, Bayaa M, Kumar P, Zhu L, Liu XJ., Mol Endocrinol. August 1, 1998; 12 (8): 1086-98.

RHO-associated protein kinase alpha potentiates insulin-induced MAP kinase activation in Xenopus oocytes., Ohan N, Agazie Y, Cummings C, Booth R, Bayaa M, Liu XJ., J Cell Sci. July 1, 1999; 112 ( Pt 13) 2177-84.

Expression pattern of insulin receptor mRNA during Xenopus laevis embryogenesis., Groigno L, Richard-Parpaillon L, Boujard D., Mech Dev. August 1, 1999; 86 (1-2): 151-4.        

The in vitro synthesized and processed human insulin receptor precursor binds insulin., Tsuda S, Kaihara M, Zhou X, Britos D, Arakaki R., FEBS Lett. August 20, 1999; 457 (1): 13-7.

Tyrosine phosphorylation of the kappa -opioid receptor regulates agonist efficacy., Appleyard SM, McLaughlin JP, Chavkin C., J Biol Chem. December 8, 2000; 275 (49): 38281-5.

Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase., Holland W, Morrison T, Chang Y, Wiernsperger N, Stith BJ., Biochem Pharmacol. June 1, 2004; 67 (11): 2081-91.

Identification of two functional estrogen response elements complexed with AP-1-like sites in the human insulin receptor gene promoter., García-Arencibia M, Dávila N, Campión J, Carmen Carranza M, Calle C., J Steroid Biochem Mol Biol. February 1, 2005; 94 (1-3): 1-14.

Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo., Chiu SL, Chen CM, Cline HT., Neuron. June 12, 2008; 58 (5): 708-19.

A novel, rapid, inhibitory effect of insulin on alpha1beta2gamma2s gamma-aminobutyric acid type A receptors., Williams DB., Neurosci Lett. September 26, 2008; 443 (1): 27-31.

Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositides., Li G, Rajala A, Wiechmann AF, Anderson RE, Rajala RV., J Neurochem. December 1, 2008; 107 (5): 1382-97.

Insulin receptor-related receptor as an extracellular alkali sensor., Deyev IE, Sohet F, Vassilenko KP, Serova OV, Popova NV, Zozulya SA, Burova EB, Houillier P, Rzhevsky DI, Berchatova AA, Murashev AN, Chugunov AO, Efremov RG, Nikol'sky NN, Bertelli E, Eladari D, Petrenko AG., Cell Metab. June 8, 2011; 13 (6): 679-89.

Xenopus laevis insulin receptor substrate IRS-1 is important for eye development., Bugner V, Aurhammer T, Kühl M., Dev Dyn. July 1, 2011; 240 (7): 1705-15.            

Plasma membrane events associated with the meiotic divisions in the amphibian oocyte: insights into the evolution of insulin transduction systems and cell signaling., Morrill GA, Kostellow AB, Moore RD, Gupta RK., BMC Dev Biol. January 23, 2013; 13 3.              

Exploiting polypharmacology for drug target deconvolution., Gujral TS, Peshkin L, Kirschner MW., Proc Natl Acad Sci U S A. April 1, 2014; 111 (13): 5048-53.        

Venus kinase receptors control reproduction in the platyhelminth parasite Schistosoma mansoni., Vanderstraete M, Gouignard N, Cailliau K, Morel M, Hahnel S, Leutner S, Beckmann S, Grevelding CG, Dissous C., PLoS Pathog. May 29, 2014; 10 (5): e1004138.              

MHC class I limits hippocampal synapse density by inhibiting neuronal insulin receptor signaling., Dixon-Salazar TJ, Fourgeaud L, Tyler CM, Poole JR, Park JJ, Boulanger LM., J Neurosci. August 27, 2014; 34 (35): 11844-56.

Determination of Alkali-Sensing Parts of the Insulin Receptor-Related Receptor Using the Bioinformatic Approach., Deyev IE, Popova NV, Petrenko AG., Acta Naturae. January 1, 2015; 7 (2): 80-6.      

Metabolic and immune impairments induced by the endocrine disruptors benzo[a]pyrene and triclosan in Xenopus tropicalis., Regnault C, Willison J, Veyrenc S, Airieau A, Méresse P, Fortier M, Fournier M, Brousseau P, Raveton M, Reynaud S., Chemosphere. July 1, 2016; 155 519-527.

Genetic and Physiological Effects of Insulin on Human Urate Homeostasis., Mandal AK, Leask MP, Estiverne C, Choi HK, Merriman TR, Mount DB., Front Physiol. January 1, 2021; 12 713710.              

Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study., Musale V, Moffett RC, Conlon JM, Flatt PR, Abdel-Wahab YH., Peptides. February 1, 2021; 136 170472.

Adverse effects and potential mechanisms of fluxapyroxad in Xenopus laevis on carbohydrate and lipid metabolism., Zhao Y, Jiao F, Tang T, Wu S, Wang F, Zhao X., Environ Pollut. September 1, 2023; 332 121710.              

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