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Summary Expression Phenotypes Gene Literature (109) GO Terms (8) Nucleotides (96) Proteins (50) Interactants (371) Wiki
XB-GENEPAGE-1000155

Papers associated with gcg



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cDNA cloning of proglucagon from the stomach and pancreas of the dog., Irwin DM., DNA Seq. November 1, 2001; 12 (4): 253-60.

Expression of amylase and other pancreatic genes in Xenopus., Horb ME, Slack JM., Mech Dev. May 1, 2002; 113 (2): 153-7.      

Molecular cloning and expression study of Xenopus latent TGF-beta binding protein-1 (LTBP-1)., Quarto N., Gene. May 15, 2002; 290 (1-2): 53-61.          

Comparative peptidomics of the endocrine pancreas: islet hormones from the clawed frog Xenopus laevis and the red-bellied newt Cynops pyrrhogaster., Conlon JM, Kim JB, Johansson A, Kikuyama S., J Endocrinol. December 1, 2002; 175 (3): 769-77.

Experimental conversion of liver to pancreas., Horb ME, Shen CN, Tosh D, Slack JM., Curr Biol. January 21, 2003; 13 (2): 105-15.    

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes., Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, Howard N, Srinivasan S, Silva JM, Molnes J, Edghill EL, Frayling TM, Temple IK, Mackay D, Shield JP, Sumnik Z, van Rhijn A, Wales JK, Clark P, Gorman S, Aisenberg J, Ellard S, Njølstad PR, Ashcroft FM, Hattersley AT., N Engl J Med. April 29, 2004; 350 (18): 1838-49.

p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus., Ciesiolka M, Delvaeye M, Van Imschoot G, Verschuere V, McCrea P, van Roy F, Vleminckx K, Vleminckx K., J Cell Sci. August 15, 2004; 117 (Pt 18): 4325-39.                      

Evolution of new hormone function: loss and gain of a receptor., Irwin DM, Wong K., J Hered. January 1, 2005; 96 (3): 205-11.

NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor., Itkin-Ansari P, Marcora E, Geron I, Tyrberg B, Demeterco C, Hao E, Padilla C, Ratineau C, Leiter A, Lee JE, Lee JE, Levine F., Dev Dyn. July 1, 2005; 233 (3): 946-53.

Wnt5 signaling in vertebrate pancreas development., Kim HJ, Schleiffarth JR, Jessurun J, Sumanas S, Petryk A, Lin S, Ekker SC., BMC Biol. October 24, 2005; 3 23.                    

Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue., Afelik S, Chen Y, Pieler T., Genes Dev. June 1, 2006; 20 (11): 1441-6.                        

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations., Pearson ER, Flechtner I, Njølstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, Ellard S, Søvik O, Polak M, Hattersley AT, Neonatal Diabetes International Collaborative Group., N Engl J Med. August 3, 2006; 355 (5): 467-77.

Target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (t-SNAREs) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels., Wolf-Goldberg T, Michaelevski I, Sheu L, Gaisano HY, Chikvashvili D, Lotan I., Mol Pharmacol. September 1, 2006; 70 (3): 818-28.

Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas., Jarikji ZH, Vanamala S, Beck CW, Wright CV, Leach SD, Horb ME., Dev Biol. April 15, 2007; 304 (2): 786-99.                

Gene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9)., Venoux M, Delmouly K, Milhavet O, Vidal-Eychenié S, Giorgi D, Rouquier S., BMC Genomics. September 9, 2008; 9 406.                      

Cloning, tissue distribution, and functional characterization of chicken glucagon receptor., Wang J, Wang Y, Li X, Li J, Leung FC., Poult Sci. December 1, 2008; 87 (12): 2678-88.

Xenopus pancreas development., Pearl EJ, Bilogan CK, Mukhi S, Brown DD, Horb ME., Dev Dyn. June 1, 2009; 238 (6): 1271-86.          

The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds., Jarikji Z, Horb LD, Shariff F, Mandato CA, Cho KW, Horb ME., Development. June 1, 2009; 136 (11): 1791-800.                  

Xenopus insm1 is essential for gastrointestinal and pancreatic endocrine cell development., Horb LD, Jarkji ZH, Horb ME., Dev Dyn. October 1, 2009; 238 (10): 2505-10.                

Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes., Villasenor A, Wang ZV, Rivera LB, Ocal O, Asterholm IW, Scherer PE, Brekken RA, Cleaver O, Wilkie TM., Dis Model Mech. January 1, 2010; 3 (9-10): 567-80.

The serendipitous origin of chordate secretin peptide family members., Cardoso JC, Vieira FA, Gomes AS, Power DM., BMC Evol Biol. May 6, 2010; 10 135.            

BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA., Horb LD, Horb ME., Dev Biol. September 15, 2010; 345 (2): 156-69.                

Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes., Pearl EJ, Jarikji Z, Horb ME., Dev Biol. March 1, 2011; 351 (1): 135-45.                    

Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin., Tam JK, Lau KW, Lee LT, Chu JY, Ng KM, Fournier A, Vaudry H, Chow BK., PLoS One. April 1, 2011; 6 (4): e19384.            

Incretin hormones and the expanding families of glucagon-like sequences and their receptors., Irwin DM, Prentice KJ., Diabetes Obes Metab. October 1, 2011; 13 Suppl 1 69-81.

Evolutionary expression of glucose-dependent-insulinotropic polypeptide (GIP)., Musson MC, Jepeal LI, Finnerty JR, Wolfe MM., Regul Pept. November 10, 2011; 171 (1-3): 26-34.

Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells., Oropeza D, Horb M., Genesis. March 1, 2012; 50 (3): 271-85.                        

Xenopus staufen2 is required for anterior endodermal organ formation., Bilogan CK, Horb ME., Genesis. March 1, 2012; 50 (3): 251-9.                      

Homeoprotein hhex-induced conversion of intestinal to ventral pancreatic precursors results in the formation of giant pancreata in Xenopus embryos., Zhao H, Han D, Dawid IB, Pieler T, Chen Y, Chen Y., Proc Natl Acad Sci U S A. May 29, 2012; 109 (22): 8594-9.                              

Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transcript variants., Huang G, Li J, Fu H, Yan Z, Bu G, He X, Wang Y., Domest Anim Endocrinol. July 1, 2012; 43 (1): 1-15.

Discovery of a novel glucagon-like peptide (GCGL) and its receptor (GCGLR) in chickens: evidence for the existence of GCGL and GCGLR genes in nonmammalian vertebrates., Wang Y, Meng F, Zhong Y, Huang G, Li J., Endocrinology. November 1, 2012; 153 (11): 5247-60.

Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells., Ojo OO, Conlon JM, Flatt PR, Abdel-Wahab YH., Biochem Biophys Res Commun. February 1, 2013; 431 (1): 14-8.    

A novel glucagon-related peptide (GCRP) and its receptor GCRPR account for coevolution of their family members in vertebrates., Park CR, Moon MJ, Park S, Kim DK, Cho EB, Millar RP, Hwang JI, Seong JY., PLoS One. June 11, 2013; 8 (6): e65420.              

A Novel Long-Acting Glucagon-Like Peptide-1 Agonist with Improved Efficacy in Insulin Secretion and β-Cell Growth., Kim HY, Hwang JI, Moon MJ, Seong JY., Endocrinol Metab (Seoul). September 1, 2014; 29 (3): 320-7.        

Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice., Ojo OO, Srinivasan DK, Owolabi BO, Conlon JM, Flatt PR, Abdel-Wahab YH., Biochim Biophys Acta. January 1, 2015; 1850 (1): 80-7.

Distinct action of the α-glucosidase inhibitor miglitol on SGLT3, enteroendocrine cells, and GLP1 secretion., Lee EY, Kaneko S, Jutabha P, Zhang X, Seino S, Jomori T, Anzai N, Miki T., J Endocrinol. March 1, 2015; 224 (3): 205-14.            

Functional Pairing of Class B1 Ligand-GPCR in Cephalochordate Provides Evidence of the Origin of PTH and PACAP/Glucagon Receptor Family., On JS, Duan C, Chow BK, Lee LT., Mol Biol Evol. August 1, 2015; 32 (8): 2048-59.

Tumor protein Tctp regulates axon development in the embryonic visual system., Roque CG, Wong HH, Lin JQ, Holt CE., Development. April 1, 2016; 143 (7): 1134-48.                                  

Design, synthesis and biological evaluation of PEGylated Xenopus glucagon-like peptide-1 derivatives as long-acting hypoglycemic agents., Han J, Wang Y, Meng Q, Li G, Huang F, Wu S, Fei Y, Zhou F, Fu J., Eur J Med Chem. May 26, 2017; 132 81-89.

Xenopus GLP-1-inspired discovery of novel GLP-1 receptor agonists as long-acting hypoglycemic and insulinotropic agents with significant therapeutic potential., Han J, Chen X, Wang Y, Fei Y, Zhou F, Zhang Y, Liu L, Si P, Fu J., Biochem Pharmacol. October 15, 2017; 142 155-167.

Micellar Nanomedicine of Novel Fatty Acid Modified Xenopus Glucagon-like Peptide-1: Improved Physicochemical Characteristics and Therapeutic Utilities for Type 2 Diabetes., Han J, Fei Y, Zhou F, Chen X, Zheng W, Fu J., Mol Pharm. November 6, 2017; 14 (11): 3954-3967.

Synthesis and pharmaceutical characterization of site specific mycophenolic acid-modified Xenopus glucagon-like peptide-1 analogs., Han J, Fu J, Sun L, Han Y, Mao Q, Liao F, Zheng X, Zhu K., Medchemcomm. November 7, 2017; 9 (1): 67-80.

Xenopus-derived glucagon-like peptide-1 and polyethylene-glycosylated glucagon-like peptide-1 receptor agonists: long-acting hypoglycaemic and insulinotropic activities with potential therapeutic utilities., Han J, Fei Y, Zhou F, Chen X, Zhang Y, Liu L, Fu J., Br J Pharmacol. February 1, 2018; 175 (3): 544-557.

Preparation and Pharmaceutical Characterizations of Lipidated Dimeric Xenopus Glucagon-Like Peptide-1 Conjugates., Han J, Zhou F, Fei Y, Chen X, Fu J, Qian H., Bioconjug Chem. February 21, 2018; 29 (2): 390-402.

Retinoic acid-induced expression of Hnf1b and Fzd4 is required for pancreas development in Xenopus laevis., Gere-Becker MB, Pommerenke C, Lingner T, Pieler T., Development. June 8, 2018; 145 (12):                                   

Lithocholic Acid-Based Peptide Delivery System for an Enhanced Pharmacological and Pharmacokinetic Profile of Xenopus GLP-1 Analogs., Han J, Chen X, Zhao L, Fu J, Sun L, Zhang Y, Zhou F, Fei Y., Mol Pharm. July 2, 2018; 15 (7): 2840-2856.

Rational design of dimeric lipidated Xenopus glucagon-like peptide 1 analogues as long-acting antihyperglycaemic agents., Han J, Huang Y, Chen X, Zhou F, Fei Y, Fu J., Eur J Med Chem. September 5, 2018; 157 177-187.

Lipidation and conformational constraining for prolonging the effects of peptides: Xenopus glucagon-like peptide 1 analogues with potent and long-acting hypoglycemic activity., Han J, Huang Y, Chen X, Zhou F, Fei Y, Fu J., Eur J Pharm Sci. October 15, 2018; 123 111-123.

Xenopus slc7a5 is essential for notochord function and eye development., Katada T, Sakurai H., Mech Dev. February 1, 2019; 155 48-59.                

The chronic administration of two novel long-acting Xenopus glucagon-like peptide-1 analogs xGLP159 and xGLP296 potently improved systemic metabolism and glycemic control in rodent models., Han J, Meng T, Chen X, Han Y, Fu J, Zhou F, Fei Y, Li C., FASEB J. June 1, 2019; 33 (6): 7113-7125.

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