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Summary Expression Phenotypes Gene Literature (161) GO Terms (14) Nucleotides (553) Proteins (65) Interactants (344) Wiki
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Papers associated with tpx2



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The C-terminal domain of TPX2 is made of alpha-helical tandem repeats., Sanchez-Pulido L, Perez L, Kuhn S, Vernos I, Andrade-Navarro MA., BMC Struct Biol. October 26, 2016; 16 (1): 17.      

TPX2 promotes glioma cell proliferation and invasion via activation of the AKT signaling pathway., Gu JJ, Zhang JH, Chen HJ, Wang SS., Oncol Lett. December 1, 2016; 12 (6): 5015-5022.                

How TPX2 helps microtubules branch out., Alfaro-Aco R, Petry S., Cell Cycle. January 1, 2017; 0.

TPX2 expression is associated with poor survival in gastric cancer., Tomii C, Inokuchi M, Takagi Y, Ishikawa T, Otsuki S, Uetake H, Kojima K, Kawano T., World J Surg Oncol. January 9, 2017; 15 (1): 14.          

Structural analysis of the role of TPX2 in branching microtubule nucleation., Alfaro-Aco R, Thawani A, Petry S., J Cell Biol. April 3, 2017; 216 (4): 983-997.              

Effects of TPX2 gene on radiotherapy sensitization in breast cancer stem cells., Huang C, Han Z, Wu D., Oncol Lett. August 1, 2017; 14 (2): 1531-1535.        

Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell., Yang J, Gao F, Xu X, Wang Y, Zhu S., Clin Exp Pharmacol Physiol. October 1, 2017; 44 (10): 1060-1068.

Regulation of mitotic spindle assembly factor NuMA by Importin-β., Chang CC, Huang TL, Shimamoto Y, Tsai SY, Hsia KC., J Cell Biol. November 6, 2017; 216 (11): 3453-3462.          

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches., McIntyre PJ, Collins PM, Vrzal L, Birchall K, Arnold LH, Mpamhanga C, Coombs PJ, Burgess SG, Richards MW, Winter A, Veverka V, Delft FV, Merritt A, Bayliss R., ACS Chem Biol. November 17, 2017; 12 (11): 2906-2914.

TPX2 promotes cell proliferation and migration via PLK1 in OC., Ma S, Rong X, Gao F, Yang Y, Wei L., Cancer Biomark. January 1, 2018; 22 (3): 443-451.

MiR-29a-5p inhibits proliferation and invasion and induces apoptosis in endometrial carcinoma via targeting TPX2., Jiang T, Sui D, You D, Yao S, Zhang L, Wang Y, Zhao J, Zhang Y., Cell Cycle. January 1, 2018; 17 (10): 1268-1278.

Aurora A activation in mitosis promoted by BuGZ., Huang Y, Li T, Ems-McClung SC, Walczak CE, Prigent C, Zhu X, Zhang X, Zheng Y., J Cell Biol. January 2, 2018; 217 (1): 107-116.                

TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer., Yan L, Li Q, Yang J, Qiao B., J Cell Biochem. February 1, 2018; 119 (2): 1791-1803.

MicroRNA-1294 inhibits the proliferation and enhances the chemosensitivity of glioma to temozolomide via the direct targeting of TPX2., Chen H, Liu L, Li X, Shi Y, Liu N., Am J Cancer Res. February 1, 2018; 8 (2): 291-301.

Clinical value of Xenopus kinesin-like protein 2 as a prognostic marker in patients with digestive system cancers: a systematic review and meta-analysis., Wang G, Wang Q, Li Z, Liu C, He X., Onco Targets Ther. March 5, 2018; 11 1229-1243.            

Subcellular scaling: does size matter for cell division?, Heald R, Gibeaux R., Curr Opin Cell Biol. June 1, 2018; 52 88-95.

Spindle assembly in egg extracts of the Marsabit clawed frog, Xenopus borealis., Kitaoka M, Heald R, Gibeaux R., Cytoskeleton (Hoboken). June 1, 2018; 75 (6): 244-257.

Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules., Song JG, King MR, Zhang R, Kadzik RS, Thawani A, Petry S., J Cell Biol. July 2, 2018; 217 (7): 2417-2428.          

Overexpression of TPX2 is associated with progression and prognosis of prostate cancer., Zou J, Huang RY, Jiang FN, Chen DX, Wang C, Han ZD, Liang YX, Zhong WD., Oncol Lett. September 1, 2018; 16 (3): 2823-2832.            

Dissecting Protein Complexes in Branching Microtubule Nucleation Using Meiotic Xenopus Egg Extracts., Song JG, Petry S., Cold Spring Harb Protoc. September 4, 2018; 2018 (9):


TPX2 level correlates with cholangiocarcinoma cell proliferation, apoptosis, and EMT., Zou Z, Zheng B, Li J, Lv X, Zhang H, Yu F, Kong L, Li Y, Yu M, Fang L, Liang B., Biomed Pharmacother. November 1, 2018; 107 1286-1293.

Prognostic and clinical value of Targeting protein for Xenopus kinesin-like protein 2 in patients with gastrointestinal tract cancers: A meta-analysis., Liu W, Xu J, Zhang C., Medicine (Baltimore). November 1, 2018; 97 (46): e13303.          

Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer., Chen M, Zhang H, Zhang G, Zhong A, Ma Q, Kai J, Tong Y, Xie S, Wang Y, Zheng H, Guo L, Lu R., Biochem Biophys Res Commun. December 9, 2018; 507 (1-4): 74-82.          

Importin α Partitioning to the Plasma Membrane Regulates Intracellular Scaling., Brownlee C, Heald R., Cell. February 7, 2019; 176 (4): 805-815.e8.                  

Spatiotemporal organization of branched microtubule networks., Thawani A, Stone HA, Shaevitz JW, Petry S., Elife. May 8, 2019; 8                   

The clinical significance and prognostic value of Xenopus kinesin-like protein 2 expressions in human tumors: A systematic review and meta-analysis., Yang W, Wan H, Shan R, Wen W, Li J, Luo D, Wan RH., J Cell Physiol. September 1, 2019; 234 (9): 14991-14998.

Prognostic significance of TPX2 and NIBP in esophageal cancer., Sui C, Song Z, Yu H, Wang H., Oncol Lett. October 1, 2019; 18 (4): 4221-4229.      

Kif2a Scales Meiotic Spindle Size in Hymenochirus boettgeri., Miller KE, Session AM, Heald R., Curr Biol. November 4, 2019; 29 (21): 3720-3727.e5.                  

HnRNP-F promotes cell proliferation by regulating TPX2 in bladder cancer., Li F, Su M, Zhao H, Xie W, Cao S, Xu Y, Xu Y, Chen W, Wang L, Hou L, Tan W., Am J Transl Res. November 15, 2019; 11 (11): 7035-7048.

TPX2 as a Novel Prognostic Indicator and Promising Therapeutic Target in Triple-negative Breast Cancer., Jiang Y, Liu Y, Tan X, Yu S, Luo J., Clin Breast Cancer. December 1, 2019; 19 (6): 450-455.

TPX2 silencing exerts anti‑tumor effects on hepatocellular carcinoma by regulating the PI3K/AKT signaling pathway., Huang DH, Jian J, Li S, Zhang Y, Liu LZ., Int J Mol Med. December 1, 2019; 44 (6): 2113-2122.          

Integrated Bioinformatic Analysis Identifies Networks and Promising Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma., Ji Y, Yin Y, Zhang W., Int J Genomics. January 1, 2020; 2020 2061024.              

Structural bioinformatics predicts that the Retinitis Pigmentosa-28 protein of unknown function FAM161A is a homologue of the microtubule nucleation factor Tpx2., Levine TP., F1000Res. January 1, 2020; 9 1052.          

Biochemical reconstitution of branching microtubule nucleation., Alfaro-Aco R, Thawani A, Petry S., Elife. January 14, 2020; 9                                   

Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation., King MR, Petry S., Nat Commun. January 14, 2020; 11 (1): 270.                            

Therapeutic Rationale to Target Highly Expressed Aurora kinase A Conferring Poor Prognosis in Cholangiocarcinoma., Ding X, Huang T, Peng C, Ahn KS, Andersen JB, Lewinska M, Cao Y, Xu G, Chen G, Kong B, Friess H, Shen S, Roberts LR, Wang L, Zou X., J Cancer. February 3, 2020; 11 (8): 2241-2251.              

Long non-coding RNA LINC00337 induces autophagy and chemoresistance to cisplatin in esophageal squamous cell carcinoma cells via upregulation of TPX2 by recruiting E2F4., Yang C, Shen S, Zheng X, Ye K, Ge H, Sun Y, Lu Y., FASEB J. May 1, 2020; 34 (5): 6055-6069.

Cell division cycle proteinising prognostic biomarker of breast cancer., Cheng L, Huang YZ, Chen WX, Shi L, Li Z, Zhang X, Dai XY, Wei JF, Ding Q., Biosci Rep. May 29, 2020; 40 (5):


Tumor-Suppressive MicroRNA-216b Binds to TPX2, Activating the p53 Signaling in Human Cutaneous Squamous Cell Carcinoma., Feng C, Zhang HL, Zeng A, Bai M, Wang XJ., Mol Ther Nucleic Acids. June 5, 2020; 20 186-195.            

Cell Biology: Tubulin Contributes to Spindle Size Scaling., Levy DL., Curr Biol. June 8, 2020; 30 (11): R637-R639.  

Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin., Douglas P, Ye R, Radhamani S, Cobban A, Jenkins NP, Bartlett E, Roveredo J, Kettenbach AN, Lees-Miller SP., Mol Cell Biol. June 15, 2020; 40 (13):                   

The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy., Thawani A, Rale MJ, Coudray N, Bhabha G, Stone HA, Shaevitz JW, Petry S., Elife. June 15, 2020; 9                           

The critical role of dysregulated Hh-FOXM1-TPX2 signaling in human hepatocellular carcinoma cell proliferation., Wang Y, Wang H, Yan Z, Li G, Hu G, Zhang H, Huang D, Wang Y, Zhang X, Yan Y, Lu Q, Cheng M, Luo S., Cell Commun Signal. July 28, 2020; 18 (1): 116.              

CircPOSTN/miR-361-5p/TPX2 axis regulates cell growth, apoptosis and aerobic glycolysis in glioma cells., Long N, Chu L, Jia J, Peng S, Gao Y, Yang H, Yang Y, Zhao Y, Liu J., Cancer Cell Int. August 6, 2020; 20 374.                  

Overexpression of TPX2 predicts poor clinical outcome and is associated with immune infiltration in hepatic cell cancer., Zhu H, Liu J, Feng J, Zhang Q, Bian T, Li X, Sun H, Zhang J, Liu Y., Medicine (Baltimore). December 4, 2020; 99 (49): e23554.            

Identification of estrogen receptor target genes involved in gonadal feminization caused by estrogen in Xenopus laevis., Li Y, Li J, Shen Y, Xiong Y, Li X, Qin Z., Aquat Toxicol. January 21, 2021; 232 105760.      

High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability., Matson DR, Denu RA, Zasadil LM, Burkard ME, Weaver BA, Flynn C, Stukenberg PT., BMC Cancer. February 23, 2021; 21 (1): 186.

Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry., Tavernier N, Thomas Y, Vigneron S, Maisonneuve P, Orlicky S, Mader P, Regmi SG, Van Hove L, Levinson NM, Gasmi-Seabrook G, Joly N, Poteau M, Velez-Aguilera G, Gavet O, Castro A, Dasso M, Lorca T, Sicheri F, Pintard L., Nat Commun. March 26, 2021; 12 (1): 1899.                  

The Cytoskeleton and Its Roles in Self-Organization Phenomena: Insights from Xenopus Egg Extracts., Geisterfer ZM, Guilloux G, Gatlin JC, Gatlin JC, Gibeaux R., Cells. August 26, 2021; 10 (9):         

Comprehensive Analysis of the Oncogenic Role of Targeting Protein for Xklp2 (TPX2) in Human Malignancies., Shao T, Jiang X, Bao G, Li C, Guo C., Dis Markers. January 1, 2022; 2022 7571066.

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