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Summary Expression Phenotypes Gene Literature (161) GO Terms (14) Nucleotides (553) Proteins (65) Interactants (344) Wiki
XB-GENEPAGE-5810263

Papers associated with tpx2



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Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein., Wittmann T, Boleti H, Antony C, Karsenti E, Vernos I., J Cell Biol. November 2, 1998; 143 (3): 673-85.                

Regulation of melanosome movement in the cell cycle by reversible association with myosin V., Rogers SL, Karcher RL, Roland JT, Minin AA, Steffen W, Gelfand VI., J Cell Biol. September 20, 1999; 146 (6): 1265-76.              

TPX2, A novel xenopus MAP involved in spindle pole organization., Wittmann T, Wilm M, Karsenti E, Vernos I., J Cell Biol. June 26, 2000; 149 (7): 1405-18.                    

Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity., Gruss OJ, Carazo-Salas RE, Schatz CA, Guarguaglini G, Kast J, Wilm M, Le Bot N, Vernos I, Karsenti E, Mattaj IW., Cell. January 12, 2001; 104 (1): 83-93.

Human TPX2 is required for targeting Aurora-A kinase to the spindle., Kufer TA, Silljé HH, Körner R, Gruss OJ, Meraldi P, Nigg EA., J Cell Biol. August 19, 2002; 158 (4): 617-23.          

Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells., Gruss OJ, Wittmann M, Yokoyama H, Pepperkok R, Kufer T, Silljé H, Karsenti E, Mattaj IW, Vernos I., Nat Cell Biol. November 1, 2002; 4 (11): 871-9.

Activation of myosin V-based motility and F-actin-dependent network formation of endoplasmic reticulum during mitosis., Wollert T, Weiss DG, Gerdes HH, Kuznetsov SA., J Cell Biol. November 25, 2002; 159 (4): 571-7.          

hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division., Garrett S, Auer K, Compton DA, Kapoor TM., Curr Biol. December 10, 2002; 12 (23): 2055-9.

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly., Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J, Prigent C, Zheng Y., Nat Cell Biol. March 1, 2003; 5 (3): 242-8.

A novel mechanism for activation of the protein kinase Aurora A., Eyers PA, Erikson E, Chen LG, Maller JL., Curr Biol. April 15, 2003; 13 (8): 691-7.

Importin alpha-regulated nucleation of microtubules by TPX2., Schatz CA, Santarella R, Hoenger A, Karsenti E, Mattaj IW, Gruss OJ, Carazo-Salas RE., EMBO J. May 1, 2003; 22 (9): 2060-70.

The quest for the holy "G" of chromosomal passengers., Burke DJ, Stukenberg PT., Dev Cell. August 1, 2003; 5 (2): 187-8.

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle., Bayliss R, Sardon T, Vernos I, Conti E., Mol Cell. October 1, 2003; 12 (4): 851-62.

Aurora A on the mitotic spindle is activated by the way it holds its partner., Glover DM., Mol Cell. October 1, 2003; 12 (4): 797-9.  

Regulation of Aurora-A kinase on the mitotic spindle., Kufer TA, Nigg EA, Silljé HH., Chromosoma. December 1, 2003; 112 (4): 159-63.

Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation., Trieselmann N, Armstrong S, Rauw J, Wilde A., J Cell Sci. December 1, 2003; 116 (Pt 23): 4791-8.

Regulation of Xenopus Aurora A activation by TPX2., Eyers PA, Maller JL., J Biol Chem. March 5, 2004; 279 (10): 9008-15.

Aurora A, meiosis and mitosis., Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV., Biol Cell. April 1, 2004; 96 (3): 215-29.

Determinants for Aurora-A activation and Aurora-B discrimination by TPX2., Bayliss R, Sardon T, Ebert J, Lindner D, Vernos I, Conti E., Cell Cycle. April 1, 2004; 3 (4): 404-7.

Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein., Satinover DL, Leach CA, Stukenberg PT, Brautigan DL., Proc Natl Acad Sci U S A. June 8, 2004; 101 (23): 8625-30.

Protein kinase A, which regulates intracellular transport, forms complexes with molecular motors on organelles., Kashina AS, Semenova IV, Ivanov PA, Potekhina ES, Zaliapin I, Rodionov VI., Curr Biol. October 26, 2004; 14 (20): 1877-81.        

XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly., Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R., Curr Biol. October 26, 2004; 14 (20): 1801-11.            

Bipolarization and poleward flux correlate during Xenopus extract spindle assembly., Mitchison TJ, Maddox P, Groen A, Cameron L, Perlman Z, Ohi R, Desai A, Salmon ED, Kapoor TM., Mol Biol Cell. December 1, 2004; 15 (12): 5603-15.

Characterization of the TPX2 domains involved in microtubule nucleation and spindle assembly in Xenopus egg extracts., Brunet S, Sardon T, Zimmerman T, Wittmann T, Pepperkok R, Karsenti E, Vernos I., Mol Biol Cell. December 1, 2004; 15 (12): 5318-28.

Mechanism of Aurora B activation by INCENP and inhibition by hesperadin., Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A., Mol Cell. April 29, 2005; 18 (3): 379-91.

The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2., Eyers PA, Churchill ME, Maller JL., Cell Cycle. June 1, 2005; 4 (6): 784-9.

An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles., Ozlü N, Srayko M, Kinoshita K, Habermann B, O'toole ET, Müller-Reichert T, Schmalz N, Desai A, Hyman AA., Dev Cell. August 1, 2005; 9 (2): 237-48.

TPX or not TPX?, Karsenti E., Mol Cell. August 19, 2005; 19 (4): 431-2.

Function and regulation of Maskin, a TACC family protein, in microtubule growth during mitosis., Peset I, Seiler J, Sardon T, Bejarano LA, Rybina S, Vernos I., J Cell Biol. September 26, 2005; 170 (7): 1057-66.              

Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly., Tsai MY, Zheng Y., Curr Biol. December 6, 2005; 15 (23): 2156-63.

HURP is part of a Ran-dependent complex involved in spindle formation., Koffa MD, Casanova CM, Santarella R, Köcher T, Wilm M, Mattaj IW., Curr Biol. April 18, 2006; 16 (8): 743-54.

TPX2 is required for postmitotic nuclear assembly in cell-free Xenopus laevis egg extracts., O'Brien LL, Wiese C., J Cell Biol. June 5, 2006; 173 (5): 685-94.            

The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly., Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM., Cell. November 3, 2006; 127 (3): 539-52.

A role for NuSAP in linking microtubules to mitotic chromosomes., Ribbeck K, Raemaekers T, Carmeliet G, Mattaj IW., Curr Biol. February 6, 2007; 17 (3): 230-6.

Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen., Morgan-Lappe SE, Tucker LA, Huang X, Zhang Q, Sarthy AV, Zakula D, Vernetti L, Schurdak M, Wang J, Fesik SW., Cancer Res. May 1, 2007; 67 (9): 4390-8.

Evolution of a domain conserved in microtubule-associated proteins of eukaryotes., Rajangam AS, Yang H, Teeri TT, Arvestad L., Adv Appl Bioinform Chem. January 1, 2008; 1 51-69.                  

Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate., Yokoyama H, Gruss OJ, Rybina S, Caudron M, Schelder M, Wilm M, Mattaj IW, Karsenti E., J Cell Biol. March 10, 2008; 180 (5): 867-75.          

Spindle pole regulation by a discrete Eg5-interacting domain in TPX2., Eckerdt F, Eyers PA, Lewellyn AL, Prigent C, Maller JL., Curr Biol. April 8, 2008; 18 (7): 519-25.                        

Myosin-10 and actin filaments are essential for mitotic spindle function., Woolner S, O'Brien LL, Wiese C, Bement WM., J Cell Biol. July 14, 2008; 182 (1): 77-88.                

A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly., Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ., J Cell Sci. July 15, 2008; 121 (Pt 14): 2293-300.

A survivin-ran complex regulates spindle formation in tumor cells., Xia F, Canovas PM, Guadagno TM, Altieri DC., Mol Cell Biol. September 1, 2008; 28 (17): 5299-311.

The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown., Vos JW, Pieuchot L, Evrard JL, Janski N, Bergdoll M, de Ronde D, Perez LH, Sardon T, Vernos I, Schmit AC., Plant Cell. October 1, 2008; 20 (10): 2783-97.

Dissecting the role of Aurora A during spindle assembly., Sardon T, Peset I, Petrova B, Vernos I., EMBO J. October 8, 2008; 27 (19): 2567-79.

TPX2 in malignantly transformed human bronchial epithelial cells by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide., Zhang L, Huang H, Deng L, Chu M, Xu L, Fu J, Zhu Y, Zhang X, Liu S, Zhou Z, Wang Y., Toxicology. October 30, 2008; 252 (1-3): 49-55.

Hepatoma up-regulated protein is required for chromatin-induced microtubule assembly independently of TPX2., Casanova CM, Rybina S, Yokoyama H, Karsenti E, Mattaj IW., Mol Biol Cell. November 1, 2008; 19 (11): 4900-8.

MAP20, a microtubule-associated protein in the secondary cell walls of hybrid aspen, is a target of the cellulose synthesis inhibitor 2,6-dichlorobenzonitrile., Rajangam AS, Kumar M, Aspeborg H, Guerriero G, Arvestad L, Pansri P, Brown CJ, Hober S, Blomqvist K, Divne C, Ezcurra I, Mellerowicz E, Sundberg B, Bulone V, Teeri TT., Plant Physiol. November 1, 2008; 148 (3): 1283-94.

CaM kinase II initiates meiotic spindle depolymerization independently of APC/C activation., Reber S, Over S, Kronja I, Gruss OJ., J Cell Biol. December 15, 2008; 183 (6): 1007-17.            

Plant TPX2 and related proteins., Evrard JL, Pieuchot L, Vos JW, Vernos I, Schmit AC., Plant Signal Behav. January 1, 2009; 4 (1): 69-72.

Learning about cancer from frogs: analysis of mitotic spindles in Xenopus egg extracts., Cross MK, Powers MA., Dis Model Mech. January 1, 2009; 2 (11-12): 541-7.      

Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes., Pascreau G, Eckerdt F, Lewellyn AL, Prigent C, Maller JL., J Biol Chem. February 27, 2009; 284 (9): 5497-505.            

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