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Summary Expression Phenotypes Gene Literature (96) GO Terms (10) Nucleotides (187) Proteins (62) Interactants (295) Wiki
XB-GENEPAGE-976057

Papers associated with cdc45



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TopBP1 utilises a bipartite GINS binding mode to support genome replication., Day M, Tetik B, Parlak M, Almeida-Hernández Y, Räschle M, Kaschani F, Siegert H, Marko A, Sanchez-Garcia E, Kaiser M, Barker IA, Pearl LH, Oliver AW, Boos D., Nat Commun. February 27, 2024; 15 (1): 1797.              

BRCA1 and ELK-1 regulate neural progenitor cell fate in the optic tectum in response to visual experience in Xenopus laevis tadpoles., Huang LC, McKeown CR, He HY, Ta AC, Cline HT., Proc Natl Acad Sci U S A. January 16, 2024; 121 (3): e2316542121.                        

The structural mechanism of dimeric DONSON in replicative helicase activation., Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A., Mol Cell. November 16, 2023; 83 (22): 4017-4031.e9.                              

DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation., Kingsley G, Skagia A, Passaretti P, Fernandez-Cuesta C, Reynolds-Winczura A, Koscielniak K, Gambus A., Nucleic Acids Res. October 13, 2023; 51 (18): 9748-9763.                  

In silico protein interaction screening uncovers DONSON's role in replication initiation., Lim Y, Tamayo-Orrego L, Schmid E, Tarnauskaite Z, Kochenova OV, Gruar R, Muramatsu S, Lynch L, Schlie AV, Carroll PL, Chistol G, Reijns MAM, Kanemaki MT, Jackson AP, Walter JC., Science. September 22, 2023; 381 (6664): eadi3448.

Novel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation., Hashimoto Y, Sadano K, Miyata N, Ito H, Tanaka H., EMBO J. September 4, 2023; 42 (17): e114131.                          

Rif1 restrains the rate of replication origin firing in Xenopus laevis., Haccard O, Ciardo D, Narrissamprakash H, Bronchain O, Kumagai A, Dunphy WG, Goldar A, Marheineke K., Commun Biol. July 29, 2023; 6 (1): 788.                                

RTEL1 and MCM10 overcome topological stress during vertebrate replication termination., Campos LV, Van Ravenstein SX, Vontalge EJ, Greer BH, Heintzman DR, Kavlashvili T, McDonald WH, Rose KL, Eichman BF, Dewar JM., Cell Rep. February 28, 2023; 42 (2): 112109.                            

The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase., Tarcan Z, Poovathumkadavil D, Skagia A, Gambus A., J Biol Chem. August 1, 2022; 298 (8): 102234.                          

The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair., Semlow DR, MacKrell VA, Walter JC., Nat Struct Mol Biol. May 1, 2022; 29 (5): 451-462.

Polo-like kinase 1 (Plk1) regulates DNA replication origin firing and interacts with Rif1 in Xenopus., Ciardo D, Haccard O, Narassimprakash H, Cornu D, Guerrera IC, Goldar A, Marheineke K., Nucleic Acids Res. September 27, 2021; 49 (17): 9851-9869.                                        

Multistep mechanism of G-quadruplex resolution during DNA replication., Sato K, Martin-Pintado N, Post H, Altelaar M, Knipscheer P., Sci Adv. September 24, 2021; 7 (39): eabf8653.

The DNA replication fork suppresses CMG unloading from chromatin before termination., Low E, Chistol G, Zaher MS, Kochenova OV, Walter JC., Genes Dev. November 1, 2020; 34 (21-22): 1534-1545.

DNA methylation dynamics underlie metamorphic gene regulation programs in Xenopus tadpole brain., Kyono Y, Raj S, Sifuentes CJ, Buisine N, Sachs L, Denver RJ., Dev Biol. June 15, 2020; 462 (2): 180-196.                                                    

Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination., Heintzman DR, Campos LV, Byl JAW, Osheroff N, Dewar JM., Cell Rep. October 8, 2019; 29 (2): 422-436.e5.                

Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity., Priego Moreno S, Jones RM, Poovathumkadavil D, Scaramuzza S, Gambus A., Life Sci Alliance. April 12, 2019; 2 (2):                       

RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR., Lyu K, Kumagai A, Dunphy WG., Cell Cycle. April 1, 2019; 18 (8): 898-913.              

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements., Deng L, Wu RA, Sonneville R, Kochenova OV, Labib K, Pellman D, Walter JC., Mol Cell. March 7, 2019; 73 (5): 915-929.e6.                              

TRAIP is a master regulator of DNA interstrand crosslink repair., Wu RA, Semlow DR, Kamimae-Lanning AN, Kochenova OV, Chistol G, Hodskinson MR, Amunugama R, Sparks JL, Wang M, Deng L, Mimoso CA, Low E, Patel KJ, Walter JC., Nature. March 1, 2019; 567 (7747): 267-272.                          

Claspin - checkpoint adaptor and DNA replication factor., Smits VAJ, Cabrera E, Freire R, Gillespie DA., FEBS J. February 1, 2019; 286 (3): 441-455.

Mitotic entry drives replisome disassembly at stalled replication forks., Hashimoto Y, Tanaka H., Biochem Biophys Res Commun. November 17, 2018; 506 (1): 108-113.      

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading., Amunugama R, Willcox S, Wu RA, Abdullah UB, El-Sagheer AH, Brown T, McHugh PJ, Griffith JD, Walter JC., Cell Rep. June 19, 2018; 23 (12): 3419-3428.        

The Eukaryotic CMG Helicase at the Replication Fork: Emerging Architecture Reveals an Unexpected Mechanism., Li H, O'Donnell ME., Bioessays. March 1, 2018; 40 (3):


Suppression of targeting of Dbf4-dependent kinase to pre-replicative complex in G0 nuclei., Okada T, Okabe G, Tak YS, Mimura S, Takisawa H, Kubota Y., Genes Cells. February 1, 2018; 23 (2): 94-104.

MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication., Kumagai A, Dunphy WG., Mol Biol Cell. November 1, 2017; 28 (22): 2998-3012.              

An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7., Perez-Arnaiz P, Bruck I, Colbert MK, Kaplan DL., Nucleic Acids Res. July 7, 2017; 45 (12): 7261-7275.                

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1., Alver RC, Chadha GS, Gillespie PJ, Blow JJ., Cell Rep. March 7, 2017; 18 (10): 2508-2520.                

p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair., Fullbright G, Rycenga HB, Gruber JD, Long DT., Mol Cell Biol. November 14, 2016; 36 (23): 2983-2994.

Xenopus Mcm10 is a CDK-substrate required for replication fork stability., Chadha GS, Gambus A, Gillespie PJ, Blow JJ., Cell Cycle. August 17, 2016; 15 (16): 2183-2195.            

Structure of human Cdc45 and implications for CMG helicase function., Simon AC, Sannino V, Costanzo V, Pellegrini L., Nat Commun. May 18, 2016; 7 11638.                

Direct non transcriptional role of NF-Y in DNA replication., Benatti P, Belluti S, Miotto B, Neusiedler J, Dolfini D, Drac M, Basile V, Schwob E, Mantovani R, Blow JJ, Imbriano C., Biochim Biophys Acta. April 1, 2016; 1863 (4): 673-85.

Studying essential DNA metabolism proteins in Xenopus egg extract., Sannino V, Kolinjivadi AM, Baldi G, Costanzo V., Int J Dev Biol. January 1, 2016; 60 (7-8-9): 221-227.

The mechanism of DNA replication termination in vertebrates., Dewar JM, Budzowska M, Walter JC., Nature. September 17, 2015; 525 (7569): 345-50.                            

DNA interstrand cross-link repair requires replication-fork convergence., Zhang J, Dewar JM, Budzowska M, Motnenko A, Cohn MA, Walter JC., Nat Struct Mol Biol. March 1, 2015; 22 (3): 242-7.      

Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication., Guo C, Kumagai A, Schlacher K, Shevchenko A, Shevchenko A, Dunphy WG., Mol Cell. February 5, 2015; 57 (3): 492-505.

RecQ4 promotes the conversion of the pre-initiation complex at a site-specific origin for DNA unwinding in Xenopus egg extracts., Sanuki Y, Kubota Y, Kanemaki MT, Takahashi TS, Mimura S, Takisawa H., Cell Cycle. January 1, 2015; 14 (7): 1010-23.

Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiation., Gao Y, Yao J, Poudel S, Romer E, Abu-Niaaj L, Leffak M., J Biol Chem. December 26, 2014; 289 (52): 35987-6000.

NCOA4 transcriptional coactivator inhibits activation of DNA replication origins., Bellelli R, Castellone MD, Guida T, Limongello R, Dathan NA, Merolla F, Cirafici AM, Affuso A, Masai H, Costanzo V, Grieco D, Fusco A, Santoro M, Carlomagno F., Mol Cell. July 3, 2014; 55 (1): 123-37.

Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1., Poh WT, Chadha GS, Gillespie PJ, Kaldis P, Blow JJ., Open Biol. January 8, 2014; 4 (1): 130138.                

Mta2 promotes Tipin-dependent maintenance of replication fork integrity., Errico A, Aze A, Costanzo V., Cell Cycle. January 1, 2014; 13 (13): 2120-8.                

Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts., Taylor EM, Bonsu NM, Price RJ, Lindsay HD., Nucleic Acids Res. September 1, 2013; 41 (16): 7725-37.              

DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts., Gaggioli V, Le Viet B, Germe T, Hyrien O., Nucleic Acids Res. August 1, 2013; 41 (15): 7313-31.                

Cdc45 is a critical effector of myc-dependent DNA replication stress., Srinivasan SV, Dominguez-Sola D, Wang LC, Hyrien O, Gautier J., Cell Rep. May 30, 2013; 3 (5): 1629-39.

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks., Lee J, Dunphy WG., Mol Biol Cell. May 1, 2013; 24 (9): 1343-53.          

Evolutionary diversification of eukaryotic DNA replication machinery., Aves SJ, Liu Y, Richards TA., Subcell Biochem. January 1, 2012; 62 19-35.

RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks., Hashimoto Y, Puddu F, Costanzo V., Nat Struct Mol Biol. December 4, 2011; 19 (1): 17-24.          

Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication., Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., J Cell Biol. June 13, 2011; 193 (6): 995-1007.                

MCM2-7 form double hexamers at licensed origins in Xenopus egg extract., Gambus A, Khoudoli GA, Jones RC, Blow JJ., J Biol Chem. April 1, 2011; 286 (13): 11855-64.                

Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex., Kundu LR, Kumata Y, Kakusho N, Watanabe S, Furukohri A, Waga S, Seki M, Masai H, Enomoto T, Tada S., Nucleic Acids Res. September 1, 2010; 38 (16): 5409-18.              

GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication., Balestrini A, Cosentino C, Errico A, Garner E, Costanzo V., Nat Cell Biol. May 1, 2010; 12 (5): 484-91.        

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