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XB-GENEPAGE-950264
Papers associated with hcn1
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Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4., Abbott GW., Sci Rep. December 6, 2016; 6 38412.  |
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Gabapentin Modulates HCN4 Channel Voltage-Dependence., Tae HS, Smith KM, Phillips AM, Boyle KA, Li M, Forster IC, Hatch RJ, Richardson R, Hughes DI, Graham BA, Petrou S, Reid CA., Front Pharmacol. May 26, 2017; 8 554.  |
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Gain-of-function HCN2 variants in genetic epilepsy., Li M, Maljevic S, Phillips AM, Petrovski S, Hildebrand MS, Burgess R, Mount T, Zara F, Striano P, Schubert J, Thiele H, Nürnberg P, Wong M, Weisenberg JL, Thio LL, Lerche H, Scheffer IE, Berkovic SF, Petrou S, Reid CA., Hum Mutat. February 1, 2018; 39 (2): 202-209. |
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Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK., Schmidpeter PAM, Gao X, Uphadyay V, Rheinberger J, Nimigean CM., J Gen Physiol. June 4, 2018; 150 (6): 821-834.  |
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Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family., Alvarez-Baron CP, Klenchin VA, Chanda B., J Gen Physiol. August 6, 2018; 150 (8): 1203-1213.  |
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The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function., Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N., FASEB J. November 1, 2018; 32 (11): 6159-6173.  |
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Bipolar switching by HCN voltage sensor underlies hyperpolarization activation., Cowgill J, Klenchin VA, Alvarez-Baron C, Tewari D, Blair A, Chanda B., Proc Natl Acad Sci U S A. January 8, 2019; 116 (2): 670-678.  |
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Alkylphenol inverse agonists of HCN1 gating: H-bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency., Joyce RL, Beyer NP, Vasilopoulos G, Woll KA, Hall AC, Eckenhoff RG, Barman DN, Warren JD, Tibbs GR, Goldstein PA., Biochem Pharmacol. May 1, 2019; 163 493-508. |
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The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms., Wang ZJ, Blanco I, Hayoz S, Brelidze TI., J Biol Chem. June 12, 2020; 295 (24): 8164-8173. |
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External Cd2+ and protons activate the hyperpolarization-gated K+ channel KAT1 at the voltage sensor., Zhou Y, Assmann SM, Jegla T., J Gen Physiol. January 4, 2021; 153 (1):  |
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Cation leak underlies neuronal excitability in an HCN1 developmental and epileptic encephalopathy., Bleakley LE, McKenzie CE, Soh MS, Forster IC, Pinares-Garcia P, Sedo A, Kathirvel A, Churilov L, Jancovski N, Maljevic S, Berkovic SF, Scheffer IE, Petrou S, Santoro B, Reid CA., Brain. August 17, 2021; 144 (7): 2060-2073. |
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Biophysical analysis of an HCN1 epilepsy variant suggests a critical role for S5 helix Met-305 in voltage sensor to pore domain coupling., Hung A, Forster IC, Mckenzie CE, Berecki G, Petrou S, Kathirvel A, Soh MS, Reid CA., Prog Biophys Mol Biol. November 1, 2021; 166 156-172. |
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Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids., Mayar S, Memarpoor-Yazdi M, Makky A, Eslami Sarokhalil R, D'Avanzo N., Front Mol Neurosci. April 6, 2022; 15 848540.  |
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Cation leak: a common functional defect causing HCN1 developmental and epileptic encephalopathy., McKenzie CE, Forster IC, Soh MS, Phillips AM, Bleakley LE, Russ-Hall SJ, Myers KA, Scheffer IE, Reid CA., Brain Commun. January 1, 2023; 5 (3): fcad156. |
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Advancements in the use of xenopus oocytes for modelling neurological disease for novel drug discovery., O'Connor EC, Kambara K, Bertrand D., Expert Opin Drug Discov. February 1, 2024; 19 (2): 173-187.  |
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