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Summary Expression Phenotypes Gene Literature (105) GO Terms (5) Nucleotides (93) Proteins (35) Interactants (862) Wiki
XB-GENEPAGE-6258962

Papers associated with lefty



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The miR-430/427/302 family controls mesendodermal fate specification via species-specific target selection., Rosa A, Spagnoli FM, Brivanlou AH., Dev Cell. April 1, 2009; 16 (4): 517-27.    

Distinct Xenopus Nodal ligands sequentially induce mesendoderm and control gastrulation movements in parallel to the Wnt/PCP pathway., Luxardi G, Marchal L, Thomé V, Kodjabachian L., Development. February 1, 2010; 137 (3): 417-26.          

APOBEC2, a selective inhibitor of TGFβ signaling, regulates left-right axis specification during early embryogenesis., Vonica A, Rosa A, Arduini BL, Brivanlou AH., Dev Biol. February 1, 2011; 350 (1): 13-23.                

Rapid differential transport of Nodal and Lefty on sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus., Marjoram L, Wright C., Development. February 1, 2011; 138 (3): 475-85.            

Essential roles of fibronectin in the development of the left-right embryonic body plan., Pulina MV, Hou SY, Mittal A, Julich D, Whittaker CA, Holley SA, Hynes RO, Astrof S., Dev Biol. June 15, 2011; 354 (2): 208-20.

HEB and E2A function as SMAD/FOXH1 cofactors., Yoon SJ, Wills AE, Chuong E, Gupta R, Baker JC., Genes Dev. August 1, 2011; 25 (15): 1654-61.            

Laterality defects are influenced by timing of treatments and animal model., Vandenberg LN., Differentiation. January 1, 2012; 83 (1): 26-37.          

Neurally Derived Tissues in Xenopus laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry., Pai VP, Vandenberg LN, Blackiston D, Levin M., Stem Cells Int. January 1, 2012; 2012 353491.          

Linking early determinants and cilia-driven leftward flow in left-right axis specification of Xenopus laevis: a theoretical approach., Schweickert A, Walentek P, Thumberger T, Danilchik M., Differentiation. February 1, 2012; 83 (2): S67-77.      

RFX2 is broadly required for ciliogenesis during vertebrate development., Chung MI, Peyrot SM, LeBoeuf S, Park TJ, McGary KL, Marcotte EM, Wallingford JB., Dev Biol. March 1, 2012; 363 (1): 155-65.                                                          

BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo., Katsu K, Tokumori D, Tatsumi N, Suzuki A, Yokouchi Y., Dev Biol. March 1, 2012; 363 (1): 15-26.

Self-regulation of the head-inducing properties of the Spemann organizer., Inui M, Montagner M, Ben-Zvi D, Martello G, Soligo S, Manfrin A, Aragona M, Enzo E, Zacchigna L, Zanconato F, Azzolin L, Dupont S, Cordenonsi M, Piccolo S., Proc Natl Acad Sci U S A. September 18, 2012; 109 (38): 15354-9.                            

Serotonin has early, cilia-independent roles in Xenopus left-right patterning., Vandenberg LN, Lemire JM, Levin M., Dis Model Mech. January 1, 2013; 6 (1): 261-8.    

TBX3 Directs Cell-Fate Decision toward Mesendoderm., Weidgang CE, Russell R, Tata PR, Kühl SJ, Illing A, Müller M, Lin Q, Brunner C, Boeckers TM, Bauer K, Kartikasari AE, Guo Y, Radenz M, Bernemann C, Weiß M, Seufferlein T, Zenke M, Iacovino M, Kyba M, Schöler HR, Kühl M, Liebau S, Kleger A., Stem Cell Reports. August 29, 2013; 1 (3): 248-65.                

Dvr1 transfers left-right asymmetric signals from Kupffer's vesicle to lateral plate mesoderm in zebrafish., Peterson AG, Wang X, Yost HJ., Dev Biol. October 1, 2013; 382 (1): 198-208.    

Developmental mechanisms directing early anterior forebrain specification in vertebrates., Andoniadou CL, Martinez-Barbera JP., Cell Mol Life Sci. October 1, 2013; 70 (20): 3739-52.        

Left-right asymmetry: lessons from Cancún., Burdine RD, Caspary T., Development. November 1, 2013; 140 (22): 4465-70.    

It's never too early to get it Right: A conserved role for the cytoskeleton in left-right asymmetry., Vandenberg LN, Lemire JM, Levin M., Commun Integr Biol. November 1, 2013; 6 (6): e27155.          

Wave pinning and spatial patterning in a mathematical model of Antivin/Lefty-Nodal signalling., Middleton AM, King JR, Loose M., J Math Biol. December 1, 2013; 67 (6-7): 1393-424.

The Xenopus homologue of Down syndrome critical region protein 6 drives dorsoanterior gene expression and embryonic axis formation by antagonising polycomb group proteins., Li HY, Grifone R, Saquet A, Carron C, Shi DL., Development. December 1, 2013; 140 (24): 4903-13.                                

The evolution and conservation of left-right patterning mechanisms., Blum M, Feistel K, Thumberger T, Schweickert A., Development. April 1, 2014; 141 (8): 1603-13.              

The chicken left right organizer has nonmotile cilia which are lost in a stage-dependent manner in the talpid(3) ciliopathy., Stephen LA, Johnson EJ, Davis GM, McTeir L, Pinkham J, Jaberi N, Davey MG., Genesis. June 1, 2014; 52 (6): 600-13.            

Hierarchical molecular events driven by oocyte-specific factors lead to rapid and extensive reprogramming., Jullien J, Miyamoto K, Pasque V, Allen GE, Bradshaw CR, Garrett NJ, Halley-Stott RP, Kimura H, Ohsumi K, Gurdon JB., Mol Cell. August 21, 2014; 55 (4): 524-36.              

Developmental enhancers are marked independently of zygotic Nodal signals in Xenopus., Gupta R, Wills A, Ucar D, Baker J., Dev Biol. November 1, 2014; 395 (1): 38-49.            

Genome-wide view of TGFβ/Foxh1 regulation of the early mesendoderm program., Chiu WT, Charney Le R, Blitz IL, Fish MB, Li Y, Biesinger J, Xie X, Cho KW., Development. December 1, 2014; 141 (23): 4537-47.                                  

Initiation and maintenance of pluripotency gene expression in the absence of cohesin., Lavagnolli T, Gupta P, Hörmanseder E, Mira-Bontenbal H, Dharmalingam G, Carroll T, Gurdon JB, Fisher AG, Merkenschlager M., Genes Dev. January 1, 2015; 29 (1): 23-38.              

Insulin-like factor regulates neural induction through an IGF1 receptor-independent mechanism., Haramoto Y, Takahashi S, Oshima T, Onuma Y, Ito Y, Asashima M., Sci Rep. January 12, 2015; 5 11603.                                  

E2a is necessary for Smad2/3-dependent transcription and the direct repression of lefty during gastrulation., Wills AE, Baker JC., Dev Cell. February 9, 2015; 32 (3): 345-57.                  

Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes., Tuazon FB, Mullins MC., Semin Cell Dev Biol. June 1, 2015; 42 118-33.

The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry., Endicott SJ, Basu B, Khokha M, Brueckner M., Development. December 1, 2015; 142 (23): 4068-79.                                  

Conserved roles for cytoskeletal components in determining laterality., McDowell GS, Lemire JM, Paré JF, Cammarata G, Lowery LA, Levin M., Integr Biol (Camb). March 14, 2016; 8 (3): 267-86.

Nodal signalling in Xenopus: the role of Xnr5 in left/right asymmetry and heart development., Tadjuidje E, Kofron M, Mir A, Wylie C, Heasman J, Cha SW., Open Biol. August 1, 2016; 6 (8):             

Leftward Flow Determines Laterality in Conjoined Twins., Tisler M, Thumberger T, Schneider I, Schweickert A, Blum M., Curr Biol. February 20, 2017; 27 (4): 543-548.                

Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis., Pitcairn E, Harris H, Epiney J, Pai VP, Lemire JM, Ye B, Shi NQ, Levin M, McLaughlin KA., Commun Integr Biol. May 10, 2017; 10 (3): e1309488.                            

The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis., Gao Q, Zhang J, Wang X, Liu Y, He R, Liu X, Wang F, Feng J, Yang D, Wang Z, Meng A, Yan X., Nat Commun. June 7, 2017; 8 15279.              

XenMine: A genomic interaction tool for the Xenopus community., Reid CD, Karra K, Chang J, Piskol R, Li Q, Li JB, Cherry JM, Baker JC., Dev Biol. June 15, 2017; 426 (2): 155-164.          

Id genes are essential for early heart formation., Cunningham TJ, Yu MS, McKeithan WL, Spiering S, Carrette F, Huang CT, Bushway PJ, Tierney M, Albini S, Giacca M, Mano M, Puri PL, Sacco A, Ruiz-Lozano P, Riou JF, Umbhauer M, Duester G, Mercola M, Colas AR., Genes Dev. July 1, 2017; 31 (13): 1325-1338.                

Xenopus pitx3 target genes lhx1 and xnr5 are identified using a novel three-fluor flow cytometry-based analysis of promoter activation and repression., Hooker LN, Smoczer C, Abbott S, Fakhereddin M, Hudson JW, Crawford MJ., Dev Dyn. September 1, 2017; 246 (9): 657-669.                    

HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner., Pai VP, Willocq V, Pitcairn EJ, Lemire JM, Paré JF, Shi NQ, McLaughlin KA, Levin M., Biol Open. October 15, 2017; 6 (10): 1445-1457.                              

A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates., Plouhinec JL, Medina-Ruiz S, Borday C, Bernard E, Vert JP, Eisen MB, Harland RM, Monsoro-Burq AH., PLoS Biol. October 19, 2017; 15 (10): e2004045.                                              

Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish., Bisgrove BW, Su YC, Yost HJ., Elife. November 15, 2017; 6                 

A Conserved Role of the Unconventional Myosin 1d in Laterality Determination., Tingler M, Kurz S, Maerker M, Ott T, Fuhl F, Schweickert A, LeBlanc-Straceski JM, Noselli S, Blum M., Curr Biol. March 5, 2018; 28 (5): 810-816.e3.                

An Early Function of Polycystin-2 for Left-Right Organizer Induction in Xenopus., Vick P, Kreis J, Schneider I, Tingler M, Getwan M, Thumberger T, Beyer T, Schweickert A, Blum M., iScience. April 27, 2018; 2 76-85.                                        

Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis., Ding Y, Colozza G, Sosa EA, Moriyama Y, Rundle S, Salwinski L, De Robertis EM., Proc Natl Acad Sci U S A. September 25, 2018; 115 (39): E9135-E9144.                    

WDR5 regulates left-right patterning via chromatin-dependent and -independent functions., Kulkarni SS, Khokha MK., Development. November 28, 2018; 145 (23):                 

Mechanical strain, novel genes and evolutionary insights: news from the frog left-right organizer., Blum M, Ott T., Curr Opin Genet Dev. June 1, 2019; 56 8-14.      

Skeletal muscle differentiation drives a dramatic downregulation of RNA polymerase III activity and differential expression of Polr3g isoforms., McQueen C, Hughes GL, Pownall ME., Dev Biol. October 1, 2019; 454 (1): 74-84.                        

The Actin-Family Protein Arp4 Is a Novel Suppressor for the Formation and Functions of Nuclear F-Actin., Yamazaki S, Gerhold C, Yamamoto K, Ueno Y, Grosse R, Miyamoto K, Harata M., Cells. March 19, 2020; 9 (3):           

Chromatin accessibility and histone acetylation in the regulation of competence in early development., Esmaeili M, Blythe SA, Tobias JW, Zhang K, Yang J, Klein PS., Dev Biol. June 1, 2020; 462 (1): 20-35.                

RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis., Kim H, Lee YS, Kim SM, Jang S, Choi H, Lee JW, Kim TD, Kim VN., Dev Cell. April 19, 2021; 56 (8): 1118-1130.e6.                                  

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