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Summary Expression Phenotypes Gene Literature (147) GO Terms (7) Nucleotides (233) Proteins (55) Interactants (919) Wiki
XB-GENEPAGE-485690

Papers associated with smad4



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Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase., Zhang Y, Zhang Y, Chang C, Gehling DJ, Hemmati-Brivanlou A, Derynck R., Proc Natl Acad Sci U S A. January 30, 2001; 98 (3): 974-9.        

Identification of two regulatory elements within the high mobility group box transcription factor XTCF-4., Pukrop T, Gradl D, Henningfeld KA, Knochel W, Wedlich D, Kuhl M., J Biol Chem. March 23, 2001; 276 (12): 8968-78.

Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling., Shimizu K, Bourillot PY, Nielsen SJ, Zorn AM, Gurdon JB., Mol Cell Biol. June 1, 2001; 21 (12): 3901-12.

The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling., Attisano L, Silvestri C, Izzi L, Labbé E., Mol Cell Endocrinol. June 30, 2001; 180 (1-2): 3-11.

TGF-beta signalling pathways in early Xenopus development., Hill CS., Curr Opin Genet Dev. October 1, 2001; 11 (5): 533-40.    

Expression cloning of Xenopus Os4, an evolutionarily conserved gene, which induces mesoderm and dorsal axis., Zohn IE, Brivanlou AH., Dev Biol. November 1, 2001; 239 (1): 118-31.                    

Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability., Maurice D, Pierreux CE, Howell M, Wilentz RE, Owen MJ, Hill CS., J Biol Chem. November 16, 2001; 276 (46): 43175-81.

LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1., Smith DP, Rayter SI, Niederlander C, Spicer J, Jones CM, Ashworth A., Hum Mol Genet. December 1, 2001; 10 (25): 2869-77.

Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif., Randall RA, Germain S, Inman GJ, Bates PA, Hill CS., EMBO J. January 15, 2002; 21 (1-2): 145-56.

Autoregulation of Xvent-2B; direct interaction and functional cooperation of Xvent-2 and Smad1., Henningfeld KA, Friedle H, Rastegar S, Knöchel W., J Biol Chem. January 18, 2002; 277 (3): 2097-103.                

Smad10 is required for formation of the frog nervous system., LeSueur JA, Fortuno ES, McKay RM, Graff JM., Dev Cell. June 1, 2002; 2 (6): 771-83.            

A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements., Howell M, Inman GJ, Hill CS., Development. June 1, 2002; 129 (12): 2823-34.    

Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ)., Shim S, Bae N, Han JK., Nucleic Acids Res. July 15, 2002; 30 (14): 3107-17.    

A component of the ARC/Mediator complex required for TGF beta/Nodal signalling., Kato Y, Habas R, Katsuyama Y, Näär AM, He X., Nature. August 8, 2002; 418 (6898): 641-6.

Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron., Watanabe M, Rebbert ML, Andreazzoli M, Takahashi N, Toyama R, Zimmerman S, Whitman M, Dawid IB., Dev Dyn. December 1, 2002; 225 (4): 448-56.

Stoichiometry of active smad-transcription factor complexes on DNA., Inman GJ, Hill CS., J Biol Chem. December 27, 2002; 277 (52): 51008-16.

Negative regulation of BMP signaling by the ski oncoprotein., Luo K., J Bone Joint Surg Am. January 1, 2003; 85-A Suppl 3 39-43.

Regulation of the rat follicle-stimulating hormone beta-subunit promoter by activin., Suszko MI, Lo DJ, Suh H, Camper SA, Woodruff TK., Mol Endocrinol. March 1, 2003; 17 (3): 318-32.

Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein., Warming S, Liu P, Suzuki T, Akagi K, Lindtner S, Pavlakis GN, Jenkins NA, Copeland NG., Blood. March 1, 2003; 101 (5): 1934-40.

Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling., Lee PS, Chang C, Liu D, Derynck R., J Biol Chem. July 25, 2003; 278 (30): 27853-63.

[The role of Smads and related transcription factors in the signal transduction of bone morphogenetic protein inducing bone formation]., Xu XL, Dai KR, Tang TT., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. September 1, 2003; 17 (5): 359-62.

Evidence for antagonism of BMP-4 signals by MAP kinase during Xenopus axis determination and neural specification., Sater AK, El-Hodiri HM, Goswami M, Alexander TB, Al-Sheikh O, Etkin LD, Akif Uzman J., Differentiation. September 1, 2003; 71 (7): 434-44.                

Activin/Nodal signals mediate the ventral expression of myf-5 in Xenopus gastrula embryos., Chen Y, Lin GF, Hu R, Chen Y, Ding X., Biochem Biophys Res Commun. October 10, 2003; 310 (1): 121-7.

Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes., Ku MC, Stewart S, Hata A., Biochem Biophys Res Commun. November 21, 2003; 311 (3): 702-7.

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski., Takeda M, Mizuide M, Oka M, Watabe T, Inoue H, Suzuki H, Fujita T, Imamura T, Miyazono K, Miyazawa K., Mol Biol Cell. March 1, 2004; 15 (3): 963-72.                

Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells., De Bosscher K, Hill CS, Nicolás FJ., Biochem J. April 1, 2004; 379 (Pt 1): 209-16.

Smad2 and Smad3 coordinately regulate craniofacial and endodermal development., Liu Y, Festing M, Thompson JC, Hester M, Rankin S, Rankin S, El-Hodiri HM, Zorn AM, Weinstein M., Dev Biol. June 15, 2004; 270 (2): 411-26.  

Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling., Sekiya T, Oda T, Matsuura K, Akiyama T., Biochem Biophys Res Commun. July 30, 2004; 320 (3): 680-4.

The POU factor Oct-25 regulates the Xvent-2B gene and counteracts terminal differentiation in Xenopus embryos., Cao Y, Cao Y, Knöchel S, Donow C, Miethe J, Kaufmann E, Knöchel W., J Biol Chem. October 15, 2004; 279 (42): 43735-43.                  

MAB21L2, a vertebrate member of the Male-abnormal 21 family, modulates BMP signaling and interacts with SMAD1., Baldessari D, Badaloni A, Longhi R, Zappavigna V, Consalez GG., BMC Cell Biol. December 21, 2004; 5 (1): 48.              

Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1., Messenger NJ, Kabitschke C, Andrews R, Grimmer D, Núñez Miguel R, Blundell TL, Smith JC, Wardle FC., Dev Cell. April 1, 2005; 8 (4): 599-610.  

Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase., Dupont S, Zacchigna L, Cordenonsi M, Soligo S, Adorno M, Rugge M, Piccolo S., Cell. April 8, 2005; 121 (1): 87-99.                                  

Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling., Datto M, Wang XF., Cell. April 8, 2005; 121 (1): 2-4.

Notch signaling modulates the nuclear localization of carboxy-terminal-phosphorylated smad2 and controls the competence of ectodermal cells for activin A., Abe T, Furue M, Kondow A, Matsuzaki K, Asashima M., Mech Dev. May 1, 2005; 122 (5): 671-80.            

Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning., Plisov S, Tsang M, Shi G, Boyle S, Yoshino K, Dunwoodie SL, Dawid IB, Shioda T, Perantoni AO, de Caestecker MP., J Am Soc Nephrol. June 1, 2005; 16 (6): 1632-44.

The novel Smad-interacting protein Smicl regulates Chordin expression in the Xenopus embryo., Collart C, Verschueren K, Rana A, Smith JC, Huylebroeck D., Development. October 1, 2005; 132 (20): 4575-86.        

Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads., Schmierer B, Hill CS., Mol Cell Biol. November 1, 2005; 25 (22): 9845-58.

GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos., Levine AJ, Brivanlou AH., Development. January 1, 2006; 133 (2): 209-16.            

XBP1 forms a regulatory loop with BMP-4 and suppresses mesodermal and neural differentiation in Xenopus embryos., Cao Y, Cao Y, Knöchel S, Oswald F, Donow C, Zhao H, Knöchel W., Mech Dev. January 1, 2006; 123 (1): 84-96.      

Smads oppose Hox transcriptional activities., Li X, Nie S, Chang C, Qiu T, Cao X., Exp Cell Res. April 1, 2006; 312 (6): 854-64.

Genetic screens for mutations affecting development of Xenopus tropicalis., Goda T, Abu-Daya A, Carruthers S, Clark MD, Stemple DL, Zimmerman LB., PLoS Genet. June 1, 2006; 2 (6): e91.                        

Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanism., Yao LC, Blitz IL, Peiffer DA, Phin S, Wang Y, Ogata S, Cho KW, Arora K, Warrior R., Development. October 1, 2006; 133 (20): 4025-34.

Function of the two Xenopus smad4s in early frog development., Chang C, Brivanlou AH, Harland RM., J Biol Chem. October 13, 2006; 281 (41): 30794-803.                

Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides., Rana AA, Collart C, Gilchrist MJ, Smith JC., PLoS Genet. November 17, 2006; 2 (11): e193.                                    

The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter., Grocott T, Frost V, Maillard M, Johansen T, Wheeler GN, Dawes LJ, Wormstone IM, Chantry A., Nucleic Acids Res. January 1, 2007; 35 (3): 890-901.            

Negative regulation of Activin/Nodal signaling by SRF during Xenopus gastrulation., Yun CH, Choi SC, Park E, Kim SJ, Chung AS, Lee HK, Lee HK, Lee HJ, Lee HJ, Han JK., Development. February 1, 2007; 134 (4): 769-77.              

Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain., Dai F, Chang C, Lin X, Dai P, Mei L, Feng XH., Mol Cell Biol. September 1, 2007; 27 (17): 6183-94.

Dkk3 is required for TGF-beta signaling during Xenopus mesoderm induction., Pinho S, Niehrs C., Differentiation. December 1, 2007; 75 (10): 957-67.            

Nuclear accumulation of Smad complexes occurs only after the midblastula transition in Xenopus., Saka Y, Hagemann AI, Piepenburg O, Smith JC., Development. December 1, 2007; 134 (23): 4209-18.

Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice., Pangas SA, Li X, Umans L, Zwijsen A, Huylebroeck D, Gutierrez C, Wang D, Martin JF, Jamin SP, Behringer RR, Robertson EJ, Matzuk MM., Mol Cell Biol. January 1, 2008; 28 (1): 248-57.

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