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Summary Expression Phenotypes Gene Literature (177) GO Terms (0) Nucleotides (44) Proteins (32) Interactants (264) Wiki
XB-GENEPAGE-985558

Papers associated with kcnh1



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Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P, Kisselbach J, Schweizer PA, Becker R, Katus HA, Thomas D., Gene. December 10, 2012; 511 (1): 26-33.        

Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer in vivo., Lobikin M, Chernet B, Lobo D, Levin M., Phys Biol. December 1, 2012; 9 (6): 065002.

Kcnh1 voltage-gated potassium channels are essential for early zebrafish development., Stengel R, Rivera-Milla E, Sahoo N, Ebert C, Bollig F, Heinemann SH, Schönherr R, Englert C., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.            

Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels., Twiner MJ, Doucette GJ, Rasky A, Huang XP, Roth BL, Sanguinetti MC., Chem Res Toxicol. September 17, 2012; 25 (9): 1975-84.

Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule., Garg V, Sachse FB, Sanguinetti MC., J Gen Physiol. September 1, 2012; 140 (3): 307-24.                            

Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels., Tan PS, Perry MD, Ng CA, Vandenberg JI, Hill AP., J Gen Physiol. September 1, 2012; 140 (3): 293-306.                

Acute alteration of cardiac ECG, action potential, I(Kr) and the human ether-a-go-go-related gene (hERG) K+ channel by PCB 126 and PCB 77., Park MH, Park WS, Jo SH., Toxicol Appl Pharmacol. July 1, 2012; 262 (1): 60-9.

Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis., Van Slyke AC, Cheng YM, Mafi P, Allard CR, Hull CM, Shi YP, Claydon TW., Am J Physiol Cell Physiol. June 15, 2012; 302 (12): C1797-806.

Cysteines control the N- and C-linker-dependent gating of KCNH1 potassium channels., Sahoo N, Schönherr R, Hoshi T, Heinemann SH., Biochim Biophys Acta. May 1, 2012; 1818 (5): 1187-95.

Identification and functional characterization of the novel human ether-a-go-go-related gene (hERG) R744P mutant associated with hereditary long QT syndrome 2., Aidery P, Kisselbach J, Gaspar H, Baldea I, Schweizer PA, Becker R, Katus HA, Thomas D., Biochem Biophys Res Commun. February 24, 2012; 418 (4): 830-5.

Pharmacophore modeling for hERG channel facilitation., Yamakawa Y, Furutani K, Inanobe A, Ohno Y, Kurachi Y., Biochem Biophys Res Commun. February 3, 2012; 418 (1): 161-6.

RNA editing in eag potassium channels: Biophysical consequences of editing a conserved S6 residue., Ryan MY, Maloney R, Fineberg JD, Reenan RA, Horn R., Channels (Austin). January 1, 2012; 6 (6): .

Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway., Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M., J Biol Chem. November 11, 2011; 286 (45): 39091-9.

Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration., Lee BH, Lee SH, Chu D, Hyun JW, Choe H, Choi BH, Jo SH., Acta Pharmacol Sin. September 1, 2011; 32 (9): 1128-37.                  

Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant., Es-Salah-Lamoureux Z, Xiong PY, Goodchild SJ, Ahern CA, Fedida D., Biophys J. August 3, 2011; 101 (3): 662-70.

Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction., Choi SH, Shin TJ, Hwang SH, Lee BH, Kang J, Kim HJ, Jo SH, Choe H, Nah SY., Eur J Pharmacol. August 1, 2011; 663 (1-3): 59-67.

R1 in the Shaker S4 occupies the gating charge transfer center in the resting state., Lin MC, Hsieh JY, Mock AF, Papazian DM., J Gen Physiol. August 1, 2011; 138 (2): 155-63.                  

Differential effects of ginsenoside metabolites on HERG k channel currents., Choi SH, Shin TJ, Hwang SH, Lee BH, Kang J, Kim HJ, Oh JW, Bae CS, Lee SH, Nah SY., J Ginseng Res. June 1, 2011; 35 (2): 191-9.        

Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channel., de la Peña P, Alonso-Ron C, Machín A, Fernández-Trillo J, Carretero L, Domínguez P, Barros F., J Biol Chem. May 27, 2011; 286 (21): 19065-75.

Current inhibition of human EAG1 potassium channels by the Ca2+ binding protein S100B., Sahoo N, Tröger J, Heinemann SH, Schönherr R., FEBS Lett. September 24, 2010; 584 (18): 3896-900.

Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening., Es-Salah-Lamoureux Z, Fougere R, Xiong PY, Robertson GA, Fedida D., PLoS One. May 3, 2010; 5 (5): e10876.                    

Transfer of ion binding site from ether-a-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening., Lin MC, Abramson J, Papazian DM., J Gen Physiol. May 1, 2010; 135 (5): 415-31.                    

Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine., Hong HK, Park MH, Lee BH, Jo SH., Biochem Biophys Res Commun. April 9, 2010; 394 (3): 536-41.

Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652., Xing J, Ma J, Zhang P, Fan X., Eur J Pharmacol. March 25, 2010; 630 (1-3): 1-9.

Inhibition of the human ether-a-go-go-related gene (HERG) K+ channels by Lindera erythrocarpa., Hong HK, Yoon WJ, Kim YH, Yoo ES, Jo SH., J Korean Med Sci. December 1, 2009; 24 (6): 1089-98.            

PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance., Perry M, Sachse FB, Abbruzzese J, Sanguinetti MC., Proc Natl Acad Sci U S A. November 24, 2009; 106 (47): 20075-80.

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels., Gustina AS, Trudeau MC., Proc Natl Acad Sci U S A. August 4, 2009; 106 (31): 13082-7.          

Divalent cations slow activation of EAG family K+ channels through direct binding to S4., Zhang X, Bursulaya B, Lee CC, Lee CC, Chen B, Pivaroff K, Jegla T., Biophys J. July 8, 2009; 97 (1): 110-20.

Block of HERG k channel by classic histamine h(1) receptor antagonist chlorpheniramine., Hong HK, Jo SH., Korean J Physiol Pharmacol. June 1, 2009; 13 (3): 215-20.

Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin., Tu DN, Zou AR, Liao YH, Du YM, Wang XP, Li L., Sheng Li Xue Bao. August 25, 2008; 60 (4): 525-34.

[The persistent expression of HERG channel in Xenopus oocyte and alteration of current]., Wang XP, Li L, Zou AR, Tu DN, Liao YH., Zhongguo Ying Yong Sheng Li Xue Za Zhi. August 1, 2008; 24 (3): 329-33.

Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)., Xu X, Recanatini M, Roberti M, Tseng GN., Mol Pharmacol. June 1, 2008; 73 (6): 1709-21.

A tyrosine substitution in the cavity wall of a k channel induces an inverted inactivation., Klement G, Nilsson J, Arhem P, Elinder F., Biophys J. April 15, 2008; 94 (8): 3014-22.

A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator., Perry M, Sanguinetti MC., Mol Pharmacol. April 1, 2008; 73 (4): 1044-51.

Structural basis for ether-a-go-go-related gene K+ channel subtype-dependent activation by niflumic acid., Fernandez D, Sargent J, Sachse FB, Sanguinetti MC., Mol Pharmacol. April 1, 2008; 73 (4): 1159-67.

Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator., Perry M, Sachse FB, Sanguinetti MC., Proc Natl Acad Sci U S A. August 21, 2007; 104 (34): 13827-32.

Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization., Schwoerer AP, Blütner C, Brandt S, Binder S, Siebrands CC, Ehmke H, Friederich P., Anesthesiology. May 1, 2007; 106 (5): 967-76.

Maprotiline block of the human ether-a-go-go-related gene (HERG) K+ channel., Jo SH, Hong HK, Jung SJ, Chong SH, Yun JH, Koh YS, Choe H., Arch Pharm Res. April 1, 2007; 30 (4): 453-60.

Structural requirements of human ether-a-go-go-related gene channels for block by bupivacaine., Siebrands CC, Friederich P., Anesthesiology. March 1, 2007; 106 (3): 523-31.

Differences between ion binding to eag and HERG voltage sensors contribute to differential regulation of activation and deactivation gating., Lin MC, Papazian DM., Channels (Austin). January 1, 2007; 1 (6): 429-37.

Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels., Clarke CE, Hill AP, Zhao J, Kondo M, Subbiah RN, Campbell TJ, Vandenberg JI., J Physiol. June 1, 2006; 573 (Pt 2): 291-304.

Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine., Lee SY, Kim YJ, Kim KT, Choe H, Jo SH., Br J Pharmacol. June 1, 2006; 148 (4): 499-509.

The D3-dopaminergic agonist 7-hydroxy-dipropylaminotetralin (7-OH-DPAT) increases cardiac action potential duration and blocks human ether-a-go-go-related gene K+ channel., Torres-Jácome J, Tejeda-Chávez HR, Rodríguez-Menchaca AA, Sánchez-Chapula JA, Navarro-Polanco RA., J Cardiovasc Pharmacol. May 1, 2006; 47 (5): 656-62.

Chemical modification of the human ether-a-go-go-related gene (HERG) K+ current by the amino-group reagent trinitrobenzene sulfonic acid., Jo SH, Choi SY, Yun JH, Koh YS, Ho WK, Lee CO, Lee CO., Arch Pharm Res. April 1, 2006; 29 (4): 310-7.

Mechanism of action of a novel human ether-a-go-go-related gene channel activator., Casis O, Olesen SP, Sanguinetti MC., Mol Pharmacol. February 1, 2006; 69 (2): 658-65.

The effects of sevoflurane and propofol on QT interval and heterologously expressed human ether-a-go-go related gene currents in Xenopus oocytes., Yamada M, Hatakeyama N, Malykhina AP, Yamazaki M, Momose Y, Akbarali HI., Anesth Analg. January 1, 2006; 102 (1): 98-103.

Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)., Hansen RS, Diness TG, Christ T, Demnitz J, Ravens U, Olesen SP, Grunnet M., Mol Pharmacol. January 1, 2006; 69 (1): 266-77.

Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K+ channel voltage sensor., Bannister JP, Chanda B, Bezanilla F, Papazian DM., Proc Natl Acad Sci U S A. December 20, 2005; 102 (51): 18718-23.

Inhibitory effect of rhynchophylline on human ether-a-go-go related gene channel., Gui L, Li ZW, Du R, Yuan GH, Li W, Ren FX, Li J, Yang JG., Sheng Li Xue Bao. October 25, 2005; 57 (5): 648-52.

Glycosylation of Eag1 (Kv10.1) potassium channels: intracellular trafficking and functional consequences., Napp J, Monje F, Stühmer W, Pardo LA., J Biol Chem. August 19, 2005; 280 (33): 29506-12.

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