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Camguk/ CASK enhances Ether-á- go-go potassium current by a phosphorylation-dependent mechanism. , Marble DD, Hegle AP, Snyder ED, Dimitratos S, Bryant PJ, Wilson GF., J Neurosci. May 18, 2005; 25 (20): 4898-907.
Inhibition of human ether-a- go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine. , Choi SY, Koh YS, Jo SH., J Pharmacol Exp Ther. May 1, 2005; 313 (2): 888-95.
Modulating effect of ginseng saponins on heterologously expressed HERG currents in Xenopus oocytes. , Kim CS, Son SJ, Kim HS , Kim YD, Lee KS, Jeon BH, Kim KJ, Park JK , Park JB ., Acta Pharmacol Sin. May 1, 2005; 26 (5): 551-8.
Effect of beta-adrenoceptor blockers on human ether-a- go-go-related gene ( HERG) potassium channels. , Dupuis DS, Klaerke DA, Olesen SP., Basic Clin Pharmacol Toxicol. February 1, 2005; 96 (2): 123-30.
A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a- go-go-related gene ( HERG) channels. , Lin C, Cvetanovic I, Ke X, Ranade V, Somberg J., Am J Ther. January 1, 2005; 12 (4): 328-36.
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels. , Craven KB, Zagotta WN., J Gen Physiol. December 1, 2004; 124 (6): 663-77.
Block of wild-type and inactivation-deficient human ether-a- go-go-related gene K+ channels by halofantrine. , Sánchez-Chapula JA, Navarro-Polanco RA, Sanguinetti MC., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 484-91.
Gating charges in the activation and inactivation processes of the HERG channel. , Zhang M, Liu J , Tseng GN., J Gen Physiol. December 1, 2004; 124 (6): 703-18.
Activation of cardiac human ether-a- go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors. , Thomas D, Wu K, Wimmer AB, Zitron E, Hammerling BC, Kathöfer S, Lueck S, Bloehs R, Kreye VA, Kiehn J, Katus HA, Schoels W, Karle CA., J Mol Med (Berl). December 1, 2004; 82 (12): 826-37.
Binding site in eag voltage sensor accommodates a variety of ions and is accessible in closed channel. , Silverman WR, Bannister JP, Papazian DM., Biophys J. November 1, 2004; 87 (5): 3110-21.
Molecular basis of slow activation of the human ether-a- go-go related gene potassium channel. , Subbiah RN, Clarke CE, Smith DJ, Zhao J, Campbell TJ, Vandenberg JI., J Physiol. July 15, 2004; 558 (Pt 2): 417-31.
Comparison of kinetic properties of quinidine and dofetilide block of HERG channels. , Tsujimae K, Suzuki S, Yamada M, Kurachi Y., Eur J Pharmacol. June 16, 2004; 493 (1-3): 29-40.
Acidification alters antiarrhythmic drug blockade of the ether-a- go-go-related Gene ( HERG) Channels. , Dong DL, Li Z, Wang HZ, Du ZM, Song WH, Yang BF., Basic Clin Pharmacol Toxicol. May 1, 2004; 94 (5): 209-12.
Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents. , Gessner G, Zacharias M, Bechstedt S, Schönherr R, Heinemann SH., Mol Pharmacol. May 1, 2004; 65 (5): 1120-9.
Inhibition of human ether-a- go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. , Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker EK, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2004; 369 (5): 462-72.
Modification of Kv2.1 K+ currents by the silent Kv10 subunits. , Vega-Saenz de Miera EC., Brain Res Mol Brain Res. April 7, 2004; 123 (1-2): 91-103.
Distribution and functional properties of human KCNH8 ( Elk1) potassium channels. , Zou A, Lin Z, Humble M, Creech CD, Wagoner PK, Krafte D, Jegla TJ, Wickenden AD., Am J Physiol Cell Physiol. December 1, 2003; 285 (6): C1356-66.
Gating currents associated with intramembrane charge displacement in HERG potassium channels. , Piper DR, Varghese A, Sanguinetti MC, Tristani-Firouzi M., Proc Natl Acad Sci U S A. September 2, 2003; 100 (18): 10534-9.
Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes. , Liu J , Zhang M, Jiang M, Tseng GN., J Gen Physiol. June 1, 2003; 121 (6): 599-614.
Voltage-dependent profile of human ether-a- go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain. , Sănchez-Chapula JA, Ferrer T, Navarro-Polanco RA, Sanguinetti MC., Mol Pharmacol. May 1, 2003; 63 (5): 1051-8.
BeKm-1 is a HERG-specific toxin that shares the structure with ChTx but the mechanism of action with ErgTx1. , Zhang M, Korolkova YV, Liu J , Jiang M, Grishin EV, Tseng GN., Biophys J. May 1, 2003; 84 (5): 3022-36.
Molecular characterization, functional expression, and developmental profile of an ether à- go-go K+ channel in the tobacco hornworm Manduca sexta. , Keyser MR, Anson BD, Titus SA, Ganetzky B, Witten JL., J Neurobiol. April 1, 2003; 55 (1): 73-85.
Structural basis of two-stage voltage-dependent activation in K+ channels. , Silverman WR, Roux B, Papazian DM., Proc Natl Acad Sci U S A. March 4, 2003; 100 (5): 2935-40.
C-terminal domains implicated in the functional surface expression of potassium channels. , Jenke M, Sánchez A, Monje F, Stühmer W, Weseloh RM, Pardo LA., EMBO J. February 3, 2003; 22 (3): 395-403.
Cloning and functional characterization of the smooth muscle ether-a- go-go-related gene K+ channel. Potential role of a conserved amino acid substitution in the S4 region. , Shoeb F, Malykhina AP, Akbarali HI., J Biol Chem. January 24, 2003; 278 (4): 2503-14.
Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels. , Chen J , Seebohm G , Sanguinetti MC., Proc Natl Acad Sci U S A. September 17, 2002; 99 (19): 12461-6.
Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. , Schönherr R, Mannuzzu LM, Isacoff EY, Heinemann SH., Neuron. August 29, 2002; 35 (5): 935-49.
Calcium/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila eag potassium channel. , Wang Z, Wilson GF, Griffith LC., J Biol Chem. July 5, 2002; 277 (27): 24022-9.
Open channel block by KCB-328 [1-(2-amino-4-methanesulfonamidophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane hydrochloride] of the heterologously expressed human ether-a- go-go-related gene K+ channels. , Park JB , Choe H, Lee YK , Ha KC, Rhee KS, Ko JK, Joo CU, Chae SW, Kwak YG., J Pharmacol Exp Ther. July 1, 2002; 302 (1): 314-9.
Molecular determinants of voltage-dependent human ether-a- go-go related gene ( HERG) K+ channel block. , Sánchez-Chapula JA, Navarro-Polanco RA, Culberson C, Chen J , Sanguinetti MC., J Biol Chem. June 28, 2002; 277 (26): 23587-95.
Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels. , Tristani-Firouzi M, Chen J , Sanguinetti MC., J Biol Chem. May 24, 2002; 277 (21): 18994-9000.
Functional distinction of human EAG1 and EAG2 potassium channels. , Schönherr R, Gessner G, Löber K, Heinemann SH., FEBS Lett. March 13, 2002; 514 (2-3): 204-8.
The antidepressant drug fluoxetine is an inhibitor of human ether-a- go-go-related gene ( HERG) potassium channels. , Thomas D, Gut B, Wendt-Nordahl G, Kiehn J., J Pharmacol Exp Ther. February 1, 2002; 300 (2): 543-8.
Mapping the receptor site for ergtoxin, a specific blocker of ERG channels. , Pardo-López L, García-Valdés J, Gurrola GB, Robertson GA, Possani LD., FEBS Lett. January 2, 2002; 510 (1-2): 45-9.
Molecular determinants of inactivation and dofetilide block in ether a- go-go ( EAG) channels and EAG-related K(+) channels. , Ficker E, Jarolimek W, Brown AM., Mol Pharmacol. December 1, 2001; 60 (6): 1343-8.
The S4-S5 linker couples voltage sensing and activation of pacemaker channels. , Chen J , Mitcheson JS, Tristani-Firouzi M, Lin M, Sanguinetti MC., Proc Natl Acad Sci U S A. September 25, 2001; 98 (20): 11277-82.
High-affinity blockade of human ether-a- go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872. , Thomas D, Wendt-Nordahl G, Röckl K, Ficker E, Brown AM, Kiehn J., J Pharmacol Exp Ther. May 1, 2001; 297 (2): 753-61.
Inhibitory effects of berberine on IK1, IK, and HERG channels of cardiac myocytes. , Li BX, Yang BF, Zhou J, Xu CQ, Li YR., Acta Pharmacol Sin. February 1, 2001; 22 (2): 125-31.
Antiarrhythmic drug carvedilol inhibits HERG potassium channels. , Karle CA, Kreye VA, Thomas D, Röckl K, Kathöfer S, Zhang W, Kiehn J., Cardiovasc Res. February 1, 2001; 49 (2): 361-70.
Mg(2+) modulates voltage-dependent activation in ether-à- go-go potassium channels by binding between transmembrane segments S2 and S3. , Silverman WR, Tang CY , Mock AF, Huh KB, Papazian DM., J Gen Physiol. November 1, 2000; 116 (5): 663-78.
Sh and eag K(+) channel subunit interaction in frog oocytes depends on level and time of expression. , Chen ML, Hoshi T, Wu CF ., Biophys J. September 1, 2000; 79 (3): 1358-68.
Differential effects of amino-terminal distal and proximal domains in the regulation of human erg K(+) channel gating. , Viloria CG, Barros F, Giráldez T, Gómez-Varela D, de la Peña P., Biophys J. July 1, 2000; 79 (1): 231-46.
Altered gating of HERG potassium channels by cobalt and lanthanum. , Sanchez-Chapula JA, Sanguinetti MC., Pflugers Arch. June 1, 2000; 440 (2): 264-74.
Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 2nd communication: lack of central nervous system and cardiovascular effects. , Kreutner W, Hey JA, Chiu P, Barnett A., Arzneimittelforschung. May 1, 2000; 50 (5): 441-8.
Blockade of the HERG human cardiac K(+) channel by the antidepressant drug amitriptyline. , Jo SH, Youm JB, Lee CO , Lee CO , Earm YE, Ho WK., Br J Pharmacol. April 1, 2000; 129 (7): 1474-80.
Extracellular Mg(2+) modulates slow gating transitions and the opening of Drosophila ether-à- Go-Go potassium channels. , Tang CY , Bezanilla F, Papazian DM., J Gen Physiol. March 1, 2000; 115 (3): 319-38.
Cloning of components of a novel subthreshold-activating K(+) channel with a unique pattern of expression in the cerebral cortex. , Saganich MJ, Vega-Saenz de Miera E, Nadal MS, Baker H, Coetzee WA, Rudy B., J Neurosci. December 15, 1999; 19 (24): 10789-802.
Purification of an EH domain-binding protein from rat brain that modulates the gating of the rat ether-à- go-go channel. , Piros ET, Shen L, Huang XY ., J Biol Chem. November 19, 1999; 274 (47): 33677-83.
Voltage-shift of the current activation in HERG S4 mutation (R534C) in LQT2. , Nakajima T, Furukawa T, Hirano Y, Tanaka T, Sakurada H, Takahashi T, Nagai R, Itoh T, Katayama Y, Nakamura Y, Hiraoka M., Cardiovasc Res. November 1, 1999; 44 (2): 283-93.
Proton and zinc effects on HERG currents. , Anumonwo JM, Horta J, Delmar M, Taffet SM, Jalife J., Biophys J. July 1, 1999; 77 (1): 282-98.