Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation. , Calzaferri F, Narros-Fernández P, de Pascual R, de Diego AMG, Nicke A, Egea J, García AG, de Los Ríos C., J Med Chem. February 25, 2021; 64 (4): 2272-2290.
A Simplified Protocol to Incorporate the Fluorescent Unnatural Amino Acid ANAP into Xenopus laevis Oocyte-Expressed P2X7 Receptors. , Durner A, Nicke A., Methods Mol Biol. January 1, 2022; 2510 193-216.
Established Protocols for cRNA Expression and Voltage-Clamp Characterization of the P2X7 Receptor in Xenopus laevis Oocytes. , Schmalzing G, Markwardt F., Methods Mol Biol. January 1, 2022; 2510 157-192.
Derivation and Characterization of Murine and Amphibian Müller Glia Cell Lines. , Gallo RA, Qureshi F, Strong TA, Lang SH, Pino KA, Dvoriantchikova G, Pelaez D., Transl Vis Sci Technol. April 1, 2022; 11 (4): 4.
Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. , Whyte-Fagundes P, Taskina D, Safarian N, Zoidl C, Carlen PL, Donaldson LW, Zoidl GR., Commun Biol. May 18, 2022; 5 (1): 472.
Activation of endothelial NO synthase and P2X7 receptor modification mediates the cholinergic control of ATP-induced interleukin-1β release by mononuclear phagocytes. , Richter K , Asci N, Singh VK, Yakoob SH, Meixner M, Zakrzewicz A, Liese J, Hecker A, Wilker S, Stumpf S, Schlüter KD, Rohde M, Gödecke A, Padberg W, Manzini I , Schmalzing G, Grau V., Front Immunol. January 1, 2023; 14 1140592.
Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain. , Durner A, Durner E, Nicke A., Elife. January 4, 2023; 12
Two serial filters control P2X7 cation selectivity, Ser342 in the central pore and lateral acidic residues at the cytoplasmic interface. , Markwardt F, Schön EC, Raycheva M, Malisetty A, Hawro Yakoob S, Berthold M, Schmalzing G., PNAS Nexus. September 23, 2024; 3 (9): pgae349.
P2X7 receptors exhibit at least three modes of allosteric antagonism. , Oken AC, Ditter IA, Lisi NE, Krishnamurthy I, Godsey MH, Mansoor SE., Sci Adv. October 4, 2024; 10 (40): eado5084.