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Summary Expression Phenotypes Gene Literature (65) GO Terms (0) Nucleotides (60) Proteins (37) Interactants (75) Wiki
XB-GENEPAGE-950264

Papers associated with hcn1



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Functional heteromerization of HCN1 and HCN2 pacemaker channels., Ulens C, Tytgat J., J Biol Chem. March 2, 2001; 276 (9): 6069-72.

Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide., Chen S, Wang J, Siegelbaum SA., J Gen Physiol. May 1, 2001; 117 (5): 491-504.                  

Gi- and Gs-coupled receptors up-regulate the cAMP cascade to modulate HCN2, but not HCN1 pacemaker channels., Ulens C, Tytgat J., Pflugers Arch. September 1, 2001; 442 (6): 928-42.

Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions., Wang J, Chen S, Siegelbaum SA., J Gen Physiol. September 1, 2001; 118 (3): 237-50.              

Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: insights into structure-function relationships and multimerization., Xue T, Marbán E, Li RA., Circ Res. June 28, 2002; 90 (12): 1267-73.

Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels., Azene EM, Xue T, Li RA., J Physiol. March 1, 2003; 547 (Pt 2): 349-56.

Identification of a surface charged residue in the S3-S4 linker of the pacemaker (HCN) channel that influences activation gating., Henrikson CA, Xue T, Dong P, Sang D, Marban E, Li RA., J Biol Chem. April 18, 2003; 278 (16): 13647-54.

KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents., Decher N, Bundis F, Vajna R, Steinmeyer K., Pflugers Arch. September 1, 2003; 446 (6): 633-40.

Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels., Bell DC, Yao H, Saenger RC, Riley JH, Siegelbaum SA., J Gen Physiol. January 1, 2004; 123 (1): 5-19.            

S4 movement in a mammalian HCN channel., Vemana S, Pandey S, Larsson HP., J Gen Physiol. January 1, 2004; 123 (1): 21-32.                

Tyrosine kinase inhibition differentially regulates heterologously expressed HCN channels., Yu HG, Lu Z, Pan Z, Cohen IS., Pflugers Arch. January 1, 2004; 447 (4): 392-400.

Critical intra-linker interactions of HCN1-encoded pacemaker channels revealed by interchange of S3-S4 determinants., Tsang SY, Lesso H, Li RA., Biochem Biophys Res Commun. September 17, 2004; 322 (2): 652-8.

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction., Santoro B, Wainger BJ, Siegelbaum SA., J Neurosci. November 24, 2004; 24 (47): 10750-62.

Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels., Craven KB, Zagotta WN., J Gen Physiol. December 1, 2004; 124 (6): 663-77.                      

Pore-to-gate coupling of HCN channels revealed by a pore variant that contributes to gating but not permeation., Azene EM, Sang D, Tsang SY, Li RA., Biochem Biophys Res Commun. February 25, 2005; 327 (4): 1131-42.

Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties., Männikkö R, Pandey S, Larsson HP, Elinder F., J Gen Physiol. March 1, 2005; 125 (3): 305-26.                                          

Non-equilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers., Azene EM, Xue T, Marbán E, Tomaselli GF, Li RA., Cardiovasc Res. August 1, 2005; 67 (2): 263-73.

Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol., Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA., J Pharmacol Exp Ther. November 1, 2005; 315 (2): 517-25.

Suppression of ih contributes to propofol-induced inhibition of mouse cortical pyramidal neurons., Chen X, Shu S, Bayliss DA., J Neurophysiol. December 1, 2005; 94 (6): 3872-83.

Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels., Elinder F, Männikkö R, Pandey S, Larsson HP., J Physiol. September 1, 2006; 575 (Pt 2): 417-31.

Effects of perfluorooctane sulfonate on action potentials and currents in cultured rat cerebellar Purkinje cells., Harada KH, Ishii TM, Takatsuka K, Koizumi A, Ohmori H., Biochem Biophys Res Commun. December 8, 2006; 351 (1): 240-5.

Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels., Chen S, Wang J, Zhou L, George MS, Siegelbaum SA., J Gen Physiol. February 1, 2007; 129 (2): 175-88.                

Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation., Ishii TM, Nakashima N, Ohmori H., J Physiol. March 1, 2007; 579 (Pt 2): 291-301.

Panulirus interruptus Ih-channel gene PIIH: modification of channel properties by alternative splicing and role in rhythmic activity., Ouyang Q, Goeritz M, Harris-Warrick RM., J Neurophysiol. June 1, 2007; 97 (6): 3880-92.

Kinetic relationship between the voltage sensor and the activation gate in spHCN channels., Bruening-Wright A, Elinder F, Larsson HP., J Gen Physiol. July 1, 2007; 130 (1): 71-81.                

Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core., Lyashchenko AK, Redd KJ, Yang J, Tibbs GR., J Physiol. August 15, 2007; 583 (Pt 1): 37-56.

Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels., Cheng L, Kinard K, Rajamani R, Sanguinetti MC., J Pharmacol Exp Ther. September 1, 2007; 322 (3): 931-9.

Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C., Pian P, Bucchi A, Decostanzo A, Robinson RB, Siegelbaum SA., Pflugers Arch. October 1, 2007; 455 (1): 125-45.

Structural and functional determinants in the S5-P region of HCN-encoded pacemaker channels revealed by cysteine-scanning substitutions., Au KW, Siu CW, Lau CP, Tse HF, Li RA., Am J Physiol Cell Physiol. January 1, 2008; 294 (1): C136-44.

Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy., Tang B, Sander T, Craven KB, Hempelmann A, Escayg A., Neurobiol Dis. January 1, 2008; 29 (1): 59-70.

Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels., Vemana S, Pandey S, Larsson HP., Am J Physiol Cell Physiol. August 1, 2008; 295 (2): C557-65.

Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes., Zhang Q, Huang A, Lin YC, Yu HG., Biochim Biophys Acta. May 1, 2009; 1788 (5): 1138-47.

Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination., Bell DC, Turbendian HK, Valley MT, Zhou L, Riley JH, Siegelbaum SA, Tibbs GR., Pflugers Arch. June 1, 2009; 458 (2): 259-72.

Tanshinone IIA selectively enhances hyperpolarization-activated cyclic nucleotide-modulated (HCN) channel instantaneous current., Liang Q, Yang L, Wang Z, Huang S, Li S, Yang G., J Pharmacol Sci. July 1, 2009; 110 (3): 381-8.

State-dependent accessibility of the P-S6 linker of pacemaker (HCN) channels supports a dynamic pore-to-gate coupling model., Siu CW, Azene EM, Au KW, Lau CP, Tse HF, Li RA., J Membr Biol. July 1, 2009; 230 (1): 35-47.                    

Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring., Rozario AO, Turbendian HK, Fogle KJ, Olivier NB, Tibbs GR., Biochim Biophys Acta. September 1, 2009; 1788 (9): 1939-49.

Local anesthetic inhibits hyperpolarization-activated cationic currents., Meng QT, Xia ZY, Liu J, Bayliss DA, Chen X., Mol Pharmacol. May 1, 2011; 79 (5): 866-73.

A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties., Peigneur S, Billen B, Derua R, Waelkens E, Debaveye S, Béress L, Tytgat J., Biochem Pharmacol. July 1, 2011; 82 (1): 81-90.

Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels., Lolicato M, Nardini M, Gazzarrini S, Möller S, Bertinetti D, Herberg FW, Bolognesi M, Martin H, Fasolini M, Bertrand JA, Arrigoni C, Thiel G, Moroni A., J Biol Chem. December 30, 2011; 286 (52): 44811-20.

Asymmetric divergence in structure and function of HCN channel duplicates in Ciona intestinalis., Jackson HA, Hegle A, Nazzari H, Jegla T, Accili EA., PLoS One. January 1, 2012; 7 (11): e47590.                

Protein kinase C activation inhibits rat and human hyperpolarization activated cyclic nucleotide gated channel (HCN)1--mediated current in mammalian cells., Reetz O, Strauss U., Cell Physiol Biochem. January 1, 2013; 31 (4-5): 532-41.

HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain., Tibbs GR, Rowley TJ, Sanford RL, Herold KF, Proekt A, Hemmings HC, Andersen OS, Goldstein PA, Flood PD., J Pharmacol Exp Ther. June 1, 2013; 345 (3): 363-73.

Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP., Hu L, Santoro B, Saponaro A, Liu H, Moroni A, Siegelbaum S., J Gen Physiol. December 1, 2013; 142 (6): 599-612.                  

Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels., Wilkars W, Wollberg J, Mohr E, Han M, Chetkovich DM, Bähring R, Bender RA., FASEB J. May 1, 2014; 28 (5): 2177-90.

Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation., Mesirca P, Alig J, Torrente AG, Müller JC, Marger L, Rollin A, Marquilly C, Vincent A, Dubel S, Bidaud I, Fernandez A, Seniuk A, Engeland B, Singh J, Miquerol L, Ehmke H, Eschenhagen T, Nargeot J, Wickman K, Isbrandt D, Mangoni ME., Nat Commun. August 21, 2014; 5 4664.                

A di-arginine ER retention signal regulates trafficking of HCN1 channels from the early secretory pathway to the plasma membrane., Pan Y, Laird JG, Yamaguchi DM, Baker SA., Cell Mol Life Sci. February 1, 2015; 72 (4): 833-43.            

An N-Terminal ER Export Signal Facilitates the Plasma Membrane Targeting of HCN1 Channels in Photoreceptors., Pan Y, Laird JG, Yamaguchi DM, Baker SA., Invest Ophthalmol Vis Sci. June 1, 2015; 56 (6): 3514-21.

An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities., Wemhöner K, Kanyshkova T, Silbernagel N, Fernandez-Orth J, Bittner S, Kiper AK, Rinné S, Netter MF, Meuth SG, Budde T, Decher N., Front Mol Neurosci. November 3, 2015; 8 63.          

The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contain multiple S-palmitoylation sites., Itoh M, Ishihara K, Nakashima N, Takano M., J Physiol Sci. May 1, 2016; 66 (3): 241-8.

Patch-clamp fluorometry-based channel counting to determine HCN channel conductance., Liu C, Xie C, Grant K, Su Z, Gao W, Liu Q, Zhou L., J Gen Physiol. July 1, 2016; 148 (1): 65-76.          

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