Papers associated with cdkn1a

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	Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2., Havens CG, Walter JC., Mol Cell. July 10, 2009; 35 (1): 93-104.
	Normal levels of p27 are necessary for somite segmentation and determining pronephric organ size., Naylor RW, Collins RJ, Philpott A, Jones EA., Organogenesis. October 1, 2009; 5 (4): 201-10.
	TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling., Watanabe Y, Itoh S, Goto T, Ohnishi E, Inamitsu M, Itoh F, Satoh K, Wiercinska E, Yang W, Shi L, Tanaka A, Nakano N, Mommaas AM, Shibuya H, Ten Dijke P, Kato M., Mol Cell. January 15, 2010; 37 (1): 123-34.
	ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel., Barro-Soria R, Aldehni F, Almaça J, Witzgall R, Schreiber R, Kunzelmann K., Pflugers Arch. February 1, 2010; 459 (3): 485-97.
	Negative feedback regulation of Wnt4 signaling by EAF1 and EAF2/U19., Wan X, Ji W, Mei X, Zhou J, Liu JX, Fang C, Xiao W., PLoS One. February 9, 2010; 5 (2): e9118.
	Identification of a novel inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1)-mediated methylation of histone H3 Arg-17., Selvi BR, Batta K, Kishore AH, Mantelingu K, Varier RA, Balasubramanyam K, Pradhan SK, Dasgupta D, Sriram S, Agrawal S, Kundu TK., J Biol Chem. March 5, 2010; 285 (10): 7143-52.
	Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex., Kundu LR, Kumata Y, Kakusho N, Watanabe S, Furukohri A, Waga S, Seki M, Masai H, Enomoto T, Tada S., Nucleic Acids Res. September 1, 2010; 38 (16): 5409-18.
	The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA., Kim DH, Budhavarapu VN, Herrera CR, Nam HW, Kim YS, Yew PR., Mol Cell Biol. September 1, 2010; 30 (17): 4120-33.
	Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis., Bompard G, Rabeharivelo G, Frank M, Cau J, Delsert C, Morin N., J Cell Biol. September 6, 2010; 190 (5): 807-22.
	Phosphoinositides are essential coactivators for p21-activated kinase 1., Strochlic TI, Viaud J, Rennefahrt UE, Anastassiadis T, Peterson JR., Mol Cell. November 12, 2010; 40 (3): 493-500.
	Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4(Cdt2) -mediated proteolysis., Michishita M, Morimoto A, Ishii T, Komori H, Shiomi Y, Higuchi Y, Nishitani H., Genes Cells. January 1, 2011; 16 (1): 12-22.
	VentX trans-activates p53 and p16ink4a to regulate cellular senescence., Wu X, Gao H, Ke W, Hager M, Xiao S, Freeman MR, Zhu Z., J Biol Chem. April 8, 2011; 286 (14): 12693-701.
	Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase., Havens CG, Walter JC., Genes Dev. August 1, 2011; 25 (15): 1568-82.
	WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters., Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP., J Biol Chem. August 26, 2011; 286 (34): 30171-80.
	The development of the adult intestinal stem cells: Insights from studies on thyroid hormone-dependent amphibian metamorphosis., Shi YB, Hasebe T, Fu L, Fujimoto K, Ishizuya-Oka A., Cell Biosci. September 6, 2011; 1 (1): 30.
	Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants., Sapetto-Rebow B, McLoughlin SC, O'Shea LC, O'Leary O, Willer JR, Alvarez Y, Collery R, O'Sullivan J, Van Eeden F, Hensey C, Kennedy BN., BMC Dev Biol. November 23, 2011; 11 71.
	Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV., Shepelev MV, Korobko IV., Biochemistry (Mosc). January 1, 2012; 77 (1): 26-32.
	Inhibition of the prokaryotic pentameric ligand-gated ion channel ELIC by divalent cations., Zimmermann I, Marabelli A, Bertozzi C, Sivilotti LG, Dutzler R., PLoS Biol. January 1, 2012; 10 (11): e1001429.
	Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus., Park BY, Hong CS, Weaver JR, Rosocha EM, Saint-Jeannet JP., Dev Biol. February 1, 2012; 362 (1): 65-75.
	Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2., Havens CG, Shobnam N, Guarino E, Centore RC, Zou L, Kearsey SE, Walter JC., J Biol Chem. March 30, 2012; 287 (14): 11410-21.
	The p21-activated kinase Pak1 regulates induction and migration of the neural crest in Xenopus., Bisson N, Wedlich D, Moss T., Cell Cycle. April 1, 2012; 11 (7): 1316-24.
	The endocytic adapter E-Syt2 recruits the p21 GTPase activated kinase PAK1 to mediate actin dynamics and FGF signalling., Jean S, Tremblay MG, Herdman C, Guillou F, Moss T., Biol Open. August 15, 2012; 1 (8): 731-8.
	Spatial and temporal expressions of prune reveal a role in Müller gliogenesis during Xenopus retinal development., Bilitou A, De Marco N, Bello AM, Garzia L, Carotenuto P, Kim M, Campanella C, Ohnuma S, Zollo M., Gene. November 1, 2012; 509 (1): 93-103.
	PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowth., Santiago-Medina M, Gregus KA, Gomez TM., J Cell Sci. March 1, 2013; 126 (Pt 5): 1122-33.
	Proteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylation., Zhu XN, Kim DH, Lin HR, Budhavarapu VN, Rosenbaum HB, Mueller PR, Yew PR., Cell Div. April 22, 2013; 8 (1): 5.
	Myb promotes centriole amplification and later steps of the multiciliogenesis program., Tan FE, Vladar EK, Ma L, Fuentealba LC, Hoh R, Espinoza FH, Axelrod JD, Alvarez-Buylla A, Stearns T, Kintner C, Krasnow MA., Development. October 1, 2013; 140 (20): 4277-86.
	PCNA promotes processive DNA end resection by Exo1., Chen X, Paudyal SC, Chin RI, You Z., Nucleic Acids Res. November 1, 2013; 41 (20): 9325-38.
	FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors p21(Waf1) and p27(Kip1)., Dombrowski C, Helledie T, Ling L, Grünert M, Canning CA, Jones CM, Hui JH, Nurcombe V, van Wijnen AJ, Cool SM., Stem Cells. December 1, 2013; 31 (12): 2724-36.
	Thymine DNA glycosylase is a CRL4Cdt2 substrate., Slenn TJ, Morris B, Havens CG, Freeman RM, Takahashi TS, Walter JC., J Biol Chem. August 15, 2014; 289 (33): 23043-23055.
	EphA4-dependent Brachyury expression is required for dorsal mesoderm involution in the Xenopus gastrula., Evren S, Wen JW, Luu O, Damm EW, Nagel M, Winklbauer R., Development. October 1, 2014; 141 (19): 3649-61.
	Initiation and maintenance of pluripotency gene expression in the absence of cohesin., Lavagnolli T, Gupta P, Hörmanseder E, Mira-Bontenbal H, Dharmalingam G, Carroll T, Gurdon JB, Fisher AG, Merkenschlager M., Genes Dev. January 1, 2015; 29 (1): 23-38.
	Early development of the neural plate: new roles for apoptosis and for one of its main effectors caspase-3., Juraver-Geslin HA, Durand BC., Genesis. February 1, 2015; 53 (2): 203-24.
	Evolution of p53 transactivation specificity through the lens of a yeast-based functional assay., Lion M, Raimondi I, Donati S, Jousson O, Ciribilli Y, Inga A., PLoS One. February 10, 2015; 10 (2): e0116177.
	YAP controls retinal stem cell DNA replication timing and genomic stability., Cabochette P, Vega-Lopez G, Bitard J, Parain K, Chemouny R, Masson C, Borday C, Hedderich M, Henningfeld KA, Locker M, Bronchain O, Perron M., Elife. September 22, 2015; 4 e08488.
	Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination., He D, Marie C, Zhao C, Kim B, Wang J, Deng Y, Clavairoly A, Frah M, Wang H, He X, Hmidan H, Jones BV, Witte D, Zalc B, Zhou X, Choo DI, Martin DM, Parras C, Lu QR., Nat Neurosci. May 1, 2016; 19 (5): 678-89.
	MutSα maintains the mismatch repair capability by inhibiting PCNA unloading., Kawasoe Y, Tsurimoto T, Nakagawa T, Masukata H, Takahashi TS., Elife. July 12, 2016; 5
	CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart., Blech-Hermoni Y, Sullivan CB, Jenkins MW, Wessely O, Ladd AN., Dev Dyn. August 1, 2016; 245 (8): 854-73.
	Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors., Ying G, Gerstner CD, Frederick JM, Boye SL, Hauswirth WW, Baehr W., PLoS One. August 16, 2016; 11 (8): e0161236.
	TPX2 promotes glioma cell proliferation and invasion via activation of the AKT signaling pathway., Gu JJ, Zhang JH, Chen HJ, Wang SS., Oncol Lett. December 1, 2016; 12 (6): 5015-5022.
	Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish., Xiao C, Gao L, Hou Y, Xu C, Chang N, Wang F, Hu K, He A, Luo Y, Wang J, Peng J, Tang F, Zhu X, Xiong JW., Nat Commun. December 8, 2016; 7 13787.
	Translational profiling of retinal ganglion cell optic nerve regeneration in Xenopus laevis., Whitworth GB, Misaghi BC, Rosenthal DM, Mills EA, Heinen DJ, Watson AH, Ives CW, Ali SH, Bezold K, Marsh-Armstrong N, Watson FL., Dev Biol. June 15, 2017; 426 (2): 360-373.
	Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells., Zhang Z, Lei A, Xu L, Chen L, Chen Y, Chen Y, Zhang X, Gao Y, Yang X, Zhang M, Cao Y, Cao Y., J Biol Chem. August 4, 2017; 292 (31): 12842-12859.
	RNAs coordinate nuclear envelope assembly and DNA replication through ELYS recruitment to chromatin., Aze A, Fragkos M, Bocquet S, Cau J, Méchali M., Nat Commun. December 14, 2017; 8 (1): 2130.
	Regulation of c-MYC transcriptional activity by transforming growth factor-beta 1-stimulated clone 22., Zheng L, Suzuki H, Nakajo Y, Nakano A, Kato M., Cancer Sci. February 1, 2018; 109 (2): 395-402.
	PDGF-A suppresses contact inhibition during directional collective cell migration., Nagel M, Winklbauer R., Development. July 5, 2018; 145 (13):
	Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development., Konjikusic MJ, Yeetong P, Boswell CW, Lee C, Lee C, Roberson EC, Ittiwut R, Suphapeetiporn K, Ciruna B, Gurnett CA, Wallingford JB, Shotelersuk V, Gray RS., PLoS Genet. November 6, 2018; 14 (11): e1007817.
	Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer., Chen M, Zhang H, Zhang G, Zhong A, Ma Q, Kai J, Tong Y, Xie S, Wang Y, Zheng H, Guo L, Lu R., Biochem Biophys Res Commun. December 9, 2018; 507 (1-4): 74-82.
	Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance., Bustamante-Marin XM, Yin WN, Sears PR, Werner ME, Brotslaw EJ, Mitchell BJ, Jania CM, Zeman KL, Rogers TD, Herring LE, Refabért L, Thomas L, Amselem S, Escudier E, Legendre M, Grubb BR, Knowles MR, Zariwala MA, Ostrowski LE., Am J Hum Genet. February 7, 2019; 104 (2): 229-245.
	HnRNP-F promotes cell proliferation by regulating TPX2 in bladder cancer., Li F, Su M, Zhao H, Xie W, Cao S, Xu Y, Xu Y, Chen W, Wang L, Hou L, Tan W., Am J Transl Res. November 15, 2019; 11 (11): 7035-7048.
	TPX2 silencing exerts anti‑tumor effects on hepatocellular carcinoma by regulating the PI3K/AKT signaling pathway., Huang DH, Jian J, Li S, Zhang Y, Liu LZ., Int J Mol Med. December 1, 2019; 44 (6): 2113-2122.

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