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Summary Expression Phenotypes Gene Literature (190) GO Terms (26) Nucleotides (140) Proteins (57) Interactants (149) Wiki
XB-GENEPAGE-5921461

Papers associated with kcnq1



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Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks., Nakajo K, Kubo Y., J Physiol. June 15, 2008; 586 (12): 2827-40.

KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains., Xu X, Jiang M, Hsu KL, Zhang M, Tseng GN., J Gen Physiol. June 1, 2008; 131 (6): 589-603.                    

S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels., Haitin Y, Yisharel I, Malka E, Shamgar L, Schottelndreier H, Peretz A, Paas Y, Attali B., PLoS One. April 9, 2008; 3 (4): e1935.                  

KCNE1 constrains the voltage sensor of Kv7.1 K+ channels., Shamgar L, Haitin Y, Yisharel I, Malka E, Schottelndreier H, Peretz A, Paas Y, Attali B., PLoS One. April 9, 2008; 3 (4): e1943.                    

Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexes., Morin TJ, Kobertz WR., Proc Natl Acad Sci U S A. February 5, 2008; 105 (5): 1478-82.

Cardiac sodium channel gene variants and sudden cardiac death in women., Albert CM, Nam EG, Rimm EB, Jin HW, Hajjar RJ, Hunter DJ, MacRae CA, Ellinor PT., Circulation. January 1, 2008; 117 (1): 16-23.

KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channels., Rocheleau JM, Kobertz WR., J Gen Physiol. January 1, 2008; 131 (1): 59-68.        

KCNQ1 and KCNE1 K+ channel components are involved in early left-right patterning in Xenopus laevis embryos., Morokuma J, Blackiston D, Levin M., Cell Physiol Biochem. January 1, 2008; 21 (5-6): 357-72.

An inactivation gate in the selectivity filter of KCNQ1 potassium channels., Gibor G, Yakubovich D, Rosenhouse-Dantsker A, Peretz A, Schottelndreier H, Seebohm G, Dascal N, Logothetis DE, Paas Y, Attali B., Biophys J. December 15, 2007; 93 (12): 4159-72.

KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval., Lundby A, Ravn LS, Svendsen JH, Olesen SP, Schmitt N., Heart Rhythm. December 1, 2007; 4 (12): 1532-41.

The KCNE1 beta-subunit exerts a transient effect on the KCNQ1 K+ channel., Poulsen AN, Klaerke DA., Biochem Biophys Res Commun. November 9, 2007; 363 (1): 133-9.

Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome., Tian C, Vanoye CG, Kang C, Welch RC, Kim HJ, George AL, Sanders CR., Biochemistry. October 16, 2007; 46 (41): 11459-72.

Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus., Chen H, Goldstein SA., Biophys J. October 1, 2007; 93 (7): 2332-40.

KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channel., Nakajo K, Kubo Y., J Gen Physiol. September 1, 2007; 130 (3): 269-81.            

A derivatized scorpion toxin reveals the functional output of heteromeric KCNQ1-KCNE K+ channel complexes., Morin TJ, Kobertz WR., ACS Chem Biol. July 20, 2007; 2 (7): 469-73.

Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter., Lerche C, Bruhova I, Lerche H, Steinmeyer K, Wei AD, Strutz-Seebohm N, Lang F, Busch AE, Zhorov BS, Seebohm G., Mol Pharmacol. June 1, 2007; 71 (6): 1503-11.

Inactivation as a new regulatory mechanism for neuronal Kv7 channels., Jensen HS, Grunnet M, Olesen SP., Biophys J. April 15, 2007; 92 (8): 2747-56.

Upregulation of KCNE1 induces QT interval prolongation in patients with chronic heart failure., Watanabe E, Yasui K, Kamiya K, Yamaguchi T, Sakuma I, Honjo H, Ozaki Y, Morimoto S, Hishida H, Kodama I., Circ J. April 1, 2007; 71 (4): 471-8.

Probing the interaction between KCNE2 and KCNQ1 in their transmembrane regions., Liu XS, Zhang M, Jiang M, Wu DM, Tseng GN., J Membr Biol. April 1, 2007; 216 (2-3): 117-27.

Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels., Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, Baltaev R, Mack AF, Korniychuk G, Choudhury A, Marks D, Pagano RE, Attali B, Pfeufer A, Kass RS, Sanguinetti MC, Tavare JM, Lang F., Circ Res. March 16, 2007; 100 (5): 686-92.

Mechanistic basis for the pathogenesis of long QT syndrome associated with a common splicing mutation in KCNQ1 gene., Tsuji K, Akao M, Ishii TM, Ohno S, Makiyama T, Takenaka K, Doi T, Haruna Y, Yoshida H, Nakashima T, Kita T, Horie M., J Mol Cell Cardiol. March 1, 2007; 42 (3): 662-9.

The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes., Panaghie G, Abbott GW., J Gen Physiol. February 1, 2007; 129 (2): 121-33.                      

Secondary structure of a KCNE cytoplasmic domain., Rocheleau JM, Gage SD, Kobertz WR., J Gen Physiol. December 1, 2006; 128 (6): 721-9.          

KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I(Ks) current amplitude in the heart., Wu DM, Jiang M, Zhang M, Liu XS, Korolkova YV, Tseng GN., Heart Rhythm. December 1, 2006; 3 (12): 1469-80.

Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome., Zehelein J, Kathoefer S, Khalil M, Alter M, Thomas D, Brockmeier K, Ulmer HE, Katus HA, Koenen M., J Biol Chem. November 17, 2006; 281 (46): 35397-403.

Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel., Bett GC, Morales MJ, Beahm DL, Duffey ME, Rasmusson RL., J Physiol. November 1, 2006; 576 (Pt 3): 755-67.

Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels., Diness TG, Hansen RS, Olesen SP, Grunnet M., Biochem Biophys Res Commun. May 19, 2006; 343 (4): 1224-33.

Sudden infant death syndrome and long QT syndrome: an epidemiological and genetic study., Wedekind H, Bajanowski T, Friederich P, Breithardt G, Wülfing T, Siebrands C, Engeland B, Mönnig G, Haverkamp W, Brinkmann B, Schulze-Bahr E., Int J Legal Med. May 1, 2006; 120 (3): 129-37.

KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin., Ghosh S, Nunziato DA, Pitt GS., Circ Res. April 28, 2006; 98 (8): 1048-54.

Structural determinants of M-type KCNQ (Kv7) K+ channel assembly., Schwake M, Athanasiadu D, Beimgraben C, Blanz J, Beck C, Jentsch TJ, Saftig P, Friedrich T., J Neurosci. April 5, 2006; 26 (14): 3757-66.

The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?, Jespersen T, Grunnet M, Rasmussen HB, Jørgensen NB, Jensen HS, Angelo K, Olesen SP, Klaerke DA., Biochem Biophys Res Commun. March 24, 2006; 341 (4): 979-88.

Differential roles of S6 domain hinges in the gating of KCNQ potassium channels., Seebohm G, Strutz-Seebohm N, Ureche ON, Baltaev R, Lampert A, Kornichuk G, Kamiya K, Wuttke TV, Lerche H, Sanguinetti MC, Lang F., Biophys J. March 15, 2006; 90 (6): 2235-44.

Interaction of KCNE subunits with the KCNQ1 K+ channel pore., Panaghie G, Tai KK, Abbott GW., J Physiol. February 1, 2006; 570 (Pt 3): 455-67.

Functional coassembly of KCNQ4 with KCNE-beta- subunits in Xenopus oocytes., Strutz-Seebohm N, Seebohm G, Fedorenko O, Baltaev R, Engel J, Knirsch M, Lang F., Cell Physiol Biochem. January 1, 2006; 18 (1-3): 57-66.

De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero., Hong K, Piper DR, Diaz-Valdecantos A, Brugada J, Oliva A, Burashnikov E, Santos-de-Soto J, Grueso-Montero J, Diaz-Enfante E, Brugada P, Sachse F, Sanguinetti MC, Brugada R., Cardiovasc Res. December 1, 2005; 68 (3): 433-40.

Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome., Grunnet M, Behr ER, Calloe K, Hofman-Bang J, Till J, Christiansen M, McKenna WJ, Olesen SP, Schmitt N., Heart Rhythm. November 1, 2005; 2 (11): 1238-49.

The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes., Jensen HS, Callø K, Jespersen T, Jensen BS, Olesen SP., Brain Res Mol Brain Res. September 13, 2005; 139 (1): 52-62.

Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome., Thomas D, Wimmer AB, Karle CA, Licka M, Alter M, Khalil M, Ulmer HE, Kathöfer S, Kiehn J, Katus HA, Schoels W, Koenen M, Zehelein J., Cardiovasc Res. August 15, 2005; 67 (3): 487-97.

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine., Schenzer A, Friedrich T, Pusch M, Saftig P, Jentsch TJ, Grötzinger J, Schwake M., J Neurosci. May 18, 2005; 25 (20): 5051-60.

PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels., Lopes CM, Rohács T, Czirják G, Balla T, Enyedi P, Logothetis DE., J Physiol. April 1, 2005; 564 (Pt 1): 117-29.

hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics., Grunnet M, Olesen SP, Klaerke DA, Jespersen T., Biochem Biophys Res Commun. March 25, 2005; 328 (4): 1146-53.

Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels., Seebohm G, Westenskow P, Lang F, Sanguinetti MC., J Physiol. March 1, 2005; 563 (Pt 2): 359-68.

Analysis of QT Interval Prolongation With Heart Failure by Simulation of Repolarization Process., Yamaguchi T, Arafune T, Sakuma I, Watanabe E, Shibata N, Honjo H, Kodama I, Kamiya K., Conf Proc IEEE Eng Med Biol Soc. January 1, 2005; 2005 7309-12.

KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels., Gage SD, Kobertz WR., J Gen Physiol. December 1, 2004; 124 (6): 759-71.                  

Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome., Zehelein J, Thomas D, Khalil M, Wimmer AB, Koenen M, Licka M, Wu K, Kiehn J, Brockmeier K, Kreye VA, Karle CA, Katus HA, Ulmer HE, Schoels W., Biochim Biophys Acta. November 5, 2004; 1690 (3): 185-92.

Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif., Jespersen T, Rasmussen HB, Grunnet M, Jensen HS, Angelo K, Dupuis DS, Vogel LK, Jorgensen NK, Klaerke DA, Olesen SP., J Cell Sci. September 1, 2004; 117 (Pt 19): 4517-26.

External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites., Gibor G, Yakubovich D, Peretz A, Attali B., J Gen Physiol. July 1, 2004; 124 (1): 83-102.                                

Effective long-term control of cardiac events with beta-blockers in a family with a common LQT1 mutation., Wedekind H, Schwarz M, Hauenschild S, Djonlagic H, Haverkamp W, Breithardt G, Wülfing T, Pongs O, Isbrandt D, Schulze-Bahr E., Clin Genet. March 1, 2004; 65 (3): 233-41.

Association of the serum and glucocorticoid regulated kinase (sgk1) gene with QT interval., Busjahn A, Seebohm G, Maier G, Toliat MR, Nürnberg P, Aydin A, Luft FC, Lang F., Cell Physiol Biochem. January 1, 2004; 14 (3): 135-42.

The therapeutic potential of neuronal KCNQ channel modulators., Gribkoff VK., Expert Opin Ther Targets. December 1, 2003; 7 (6): 737-48.

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