Papers associated with kcnq2

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	Selective interaction of syntaxin 1A with KCNQ2: possible implications for specific modulation of presynaptic activity., Regev N, Degani-Katzav N, Korngreen A, Etzioni A, Siloni S, Alaimo A, Chikvashvili D, Villarroel A, Attali B, Lotan I., PLoS One. August 13, 2009; 4 (8): e6586.
	The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes., Blom SM, Schmitt N, Jensen HS., PLoS One. December 11, 2009; 4 (12): e8251.
	Pharmacological characterization of a novel positive modulator at alpha 4 beta 3 delta-containing extrasynaptic GABA(A) receptors., Hoestgaard-Jensen K, Dalby NO, Wolinsky TD, Murphey C, Jones KA, Rottländer M, Frederiksen K, Watson WP, Jensen K, Ebert B., Neuropharmacology. January 1, 2010; 58 (4-5): 702-11.
	The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus., Tzingounis AV, Heidenreich M, Kharkovets T, Spitzmaul G, Jensen HS, Nicoll RA, Jentsch TJ., Proc Natl Acad Sci U S A. June 1, 2010; 107 (22): 10232-7.
	A pore residue of the KCNQ3 potassium M-channel subunit controls surface expression., Gómez-Posada JC, Etxeberría A, Roura-Ferrer M, Areso P, Masin M, Murrell-Lagnado RD, Villarroel A., J Neurosci. July 7, 2010; 30 (27): 9316-23.
	Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state., Larsen AP, Steffensen AB, Grunnet M, Olesen SP., Biophys J. August 17, 2011; 101 (4): 818-27.
	Regulation of neuronal M-channel gating in an isoform-specific manner: functional interplay between calmodulin and syntaxin 1A., Etzioni A, Siloni S, Chikvashvilli D, Strulovich R, Sachyani D, Regev N, Greitzer-Antes D, Hirsch JA, Lotan I., J Neurosci. October 5, 2011; 31 (40): 14158-71.
	KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue., Nakajo K, Nishino A, Okamura Y, Kubo Y., J Gen Physiol. November 1, 2011; 138 (5): 521-35.
	Membrane depolarization increases membrane PtdIns(4,5)P2 levels through mechanisms involving PKC βII and PI4 kinase., Chen X, Zhang X, Jia C, Xu J, Gao H, Zhang G, Du X, Zhang H., J Biol Chem. November 18, 2011; 286 (46): 39760-7.
	Surface expression and subunit specific control of steady protein levels by the Kv7.2 helix A-B linker., Aivar P, Fernández-Orth J, Gomis-Perez C, Alberdi A, Alaimo A, Rodríguez MS, Giraldez T, Miranda P, Areso P, Villarroel A., PLoS One. January 1, 2012; 7 (10): e47263.
	Coupling of Ci-VSP modules requires a combination of structure and electrostatics within the linker., Hobiger K, Utesch T, Mroginski MA, Friedrich T., Biophys J. March 21, 2012; 102 (6): 1313-22.
	De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy., Barcia G, Fleming MR, Deligniere A, Gazula VR, Brown MR, Langouet M, Chen H, Kronengold J, Abhyankar A, Cilio R, Nitschke P, Kaminska A, Boddaert N, Casanova JL, Desguerre I, Munnich A, Dulac O, Kaczmarek LK, Colleaux L, Nabbout R., Nat Genet. November 1, 2012; 44 (11): 1255-9.
	Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P, Kisselbach J, Schweizer PA, Becker R, Katus HA, Thomas D., Gene. December 10, 2012; 511 (1): 26-33.
	The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential., Boehlen A, Schwake M, Dost R, Kunert A, Fidzinski P, Heinemann U, Gebhardt C., Br J Pharmacol. March 1, 2013; 168 (5): 1182-200.
	Dysfunction of the Heteromeric KV7.3/KV7.5 Potassium Channel is Associated with Autism Spectrum Disorders., Gilling M, Rasmussen HB, Calloe K, Sequeira AF, Baretto M, Oliveira G, Almeida J, Lauritsen MB, Ullmann R, Boonen SE, Brondum-Nielsen K, Kalscheuer VM, Tümer Z, Vicente AM, Schmitt N, Tommerup N., Front Genet. April 16, 2013; 4 54.
	The linker pivot in Ci-VSP: the key to unlock catalysis., Hobiger K, Utesch T, Mroginski MA, Seebohm G, Friedrich T., PLoS One. July 1, 2013; 8 (7): e70272.
	Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating., Zhang Q, Zhou P, Chen Z, Li M, Jiang H, Gao Z, Yang H., Proc Natl Acad Sci U S A. December 10, 2013; 110 (50): 20093-8.
	Dominant-negative effects of KCNQ2 mutations are associated with epileptic encephalopathy., Orhan G, Bock M, Schepers D, Ilina EI, Reichel SN, Löffler H, Jezutkovic N, Weckhuysen S, Mandelstam S, Suls A, Danker T, Guenther E, Scheffer IE, De Jonghe P, Lerche H, Maljevic S., Ann Neurol. March 1, 2014; 75 (3): 382-94.
	Capturing distinct KCNQ2 channel resting states by metal ion bridges in the voltage-sensor domain., Gourgy-Hacohen O, Kornilov P, Pittel I, Peretz A, Attali B, Paas Y., J Gen Physiol. December 1, 2014; 144 (6): 513-27.
	Atomic basis for therapeutic activation of neuronal potassium channels., Kim RY, Yau MC, Galpin JD, Seebohm G, Ahern CA, Pless SA, Kurata HT., Nat Commun. September 3, 2015; 6 8116.
	Regulation of the neuronal KCNQ2 channel by Src--a dual rearrangement of the cytosolic termini underlies bidirectional regulation of gating., Siloni S, Singer-Lahat D, Esa M, Tsemakhovich V, Chikvashvili D, Lotan I., J Cell Sci. September 15, 2015; 128 (18): 3489-501.
	Novel KCNQ3 Mutation in a Large Family with Benign Familial Neonatal Epilepsy: A Rare Cause of Neonatal Seizures., Maljevic S, Vejzovic S, Bernhard MK, Bertsche A, Weise S, Döcker M, Lerche H, Lemke JR, Merkenschlager A, Syrbe S., Mol Syndromol. September 1, 2016; 7 (4): 189-196.
	A novel muscarinic receptor-independent mechanism of KCNQ2/3 potassium channel blockade by Oxotremorine-M., Zwart R, Reed H, Clarke S, Sher E., Eur J Pharmacol. November 15, 2016; 791 221-228.
	KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk., Neverisky DL, Abbott GW., FASEB J. July 1, 2017; 31 (7): 2828-2838.
	PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels., Kim RY, Pless SA, Kurata HT., Proc Natl Acad Sci U S A. November 7, 2017; 114 (45): E9702-E9711.
	Direct neurotransmitter activation of voltage-gated potassium channels., Manville RW, Papanikolaou M, Abbott GW., Nat Commun. May 10, 2018; 9 (1): 1847.
	Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket., Manville RW, Abbott GW., Nat Commun. September 21, 2018; 9 (1): 3845.
	Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels., Manville RW, Abbott GW., Mol Pharmacol. October 1, 2018; 94 (4): 1155-1163.
	One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels., Yau MC, Kim RY, Wang CK, Li J, Ammar T, Yang RY, Pless SA, Kurata HT., J Gen Physiol. October 1, 2018; 150 (10): 1421-1431.
	Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation., De Silva AM, Manville RW, Abbott GW., Sci Adv. November 14, 2018; 4 (11): eaav0824.
	In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner., Manville RW, Abbott GW., Commun Biol. January 1, 2019; 2 401.
	Epilepsy-associated mutations in the voltage sensor of KCNQ3 affect voltage dependence of channel opening., Barro-Soria R., J Gen Physiol. February 4, 2019; 151 (2): 247-257.
	M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body β-Hydroxybutyrate., Manville RW, Papanikolaou M, Abbott GW., J Pharmacol Exp Ther. February 1, 2020; 372 (2): 148-156.
	Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine., Manville RW, Abbott GW., J Pharmacol Exp Ther. June 1, 2020; 373 (3): 391-401.
	Heteromeric Assembly of Truncated Neuronal Kv7 Channels: Implications for Neurologic Disease and Pharmacotherapy., Li J, Maghera J, Lamothe SM, Marco EJ, Kurata HT., Mol Pharmacol. September 1, 2020; 98 (3): 192-202.
	Familial neonatal seizures caused by the Kv7.3 selectivity filter mutation T313I., Maghera J, Li J, Lamothe SM, Braun M, Appendino JP, Au PYB, Kurata HT., Epilepsia Open. December 1, 2020; 5 (4): 562-573.
	The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels., Manville RW, Abbott GW., Cell Physiol Biochem. July 28, 2021; 55 (S3): 157-170.
	A convergent molecular network underlying autism and congenital heart disease., Rosenthal SB, Willsey HR, Xu Y, Xu Y, Mei Y, Dea J, Wang S, Curtis C, Sempou E, Khokha MK, Chi NC, Willsey AJ, Fisch KM, Ideker T., Cell Syst. November 17, 2021; 12 (11): 1094-1107.e6.
	Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels., Edmond MA, Hinojo-Perez A, Wu X, Perez Rodriguez ME, Barro-Soria R., Elife. June 1, 2022; 11

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