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Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. , Dupont S, Zacchigna L, Cordenonsi M, Soligo S, Adorno M, Rugge M, Piccolo S ., Cell. April 8, 2005; 121 (1): 87-99.
Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. , Datto M, Wang XF ., Cell. April 8, 2005; 121 (1): 2-4.
Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1. , Messenger NJ, Kabitschke C, Andrews R, Grimmer D, Núñez Miguel R, Blundell TL, Smith JC , Wardle FC., Dev Cell. April 1, 2005; 8 (4): 599-610.
MAB21L2, a vertebrate member of the Male-abnormal 21 family, modulates BMP signaling and interacts with SMAD1. , Baldessari D, Badaloni A, Longhi R, Zappavigna V, Consalez GG., BMC Cell Biol. December 21, 2004; 5 (1): 48.
The POU factor Oct-25 regulates the Xvent-2B gene and counteracts terminal differentiation in Xenopus embryos. , Cao Y , Cao Y , Knöchel S , Donow C, Miethe J, Kaufmann E, Knöchel W ., J Biol Chem. October 15, 2004; 279 (42): 43735-43.
Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. , Sekiya T, Oda T, Matsuura K, Akiyama T., Biochem Biophys Res Commun. July 30, 2004; 320 (3): 680-4.
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. , De Bosscher K, Hill CS , Nicolás FJ., Biochem J. April 1, 2004; 379 (Pt 1): 209-16.
Interaction with Smad4 is indispensable for suppression of BMP signaling by c- Ski. , Takeda M, Mizuide M, Oka M, Watabe T, Inoue H, Suzuki H, Fujita T, Imamura T, Miyazono K, Miyazawa K., Mol Biol Cell. March 1, 2004; 15 (3): 963-72.
Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes. , Ku MC, Stewart S, Hata A., Biochem Biophys Res Commun. November 21, 2003; 311 (3): 702-7.
Activin/ Nodal signals mediate the ventral expression of myf-5 in Xenopus gastrula embryos. , Chen Y , Lin GF , Hu R, Chen Y , Ding X., Biochem Biophys Res Commun. October 10, 2003; 310 (1): 121-7.
[The role of Smads and related transcription factors in the signal transduction of bone morphogenetic protein inducing bone formation]. , Xu XL, Dai KR, Tang TT., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. September 1, 2003; 17 (5): 359-62.
Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling. , Lee PS, Chang C , Liu D, Derynck R., J Biol Chem. July 25, 2003; 278 (30): 27853-63.
Regulation of the rat follicle-stimulating hormone beta-subunit promoter by activin. , Suszko MI, Lo DJ, Suh H, Camper SA, Woodruff TK., Mol Endocrinol. March 1, 2003; 17 (3): 318-32.
Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein. , Warming S, Liu P, Suzuki T, Akagi K, Lindtner S, Pavlakis GN, Jenkins NA, Copeland NG., Blood. March 1, 2003; 101 (5): 1934-40.
Negative regulation of BMP signaling by the ski oncoprotein. , Luo K., J Bone Joint Surg Am. January 1, 2003; 85-A Suppl 3 39-43.
Stoichiometry of active smad-transcription factor complexes on DNA. , Inman GJ, Hill CS ., J Biol Chem. December 27, 2002; 277 (52): 51008-16.
Regulation of the Lim-1 gene is mediated through conserved FAST-1/ FoxH1 sites in the first intron. , Watanabe M, Rebbert ML, Andreazzoli M , Takahashi N, Toyama R, Zimmerman S, Whitman M , Dawid IB ., Dev Dyn. December 1, 2002; 225 (4): 448-56.
A component of the ARC/Mediator complex required for TGF beta/ Nodal signalling. , Kato Y , Habas R , Katsuyama Y, Näär AM, He X ., Nature. August 8, 2002; 418 (6898): 641-6.
Smad10 is required for formation of the frog nervous system. , LeSueur JA, Fortuno ES, McKay RM, Graff JM ., Dev Cell. June 1, 2002; 2 (6): 771-83.
A novel Xenopus Smad-interacting forkhead transcription factor ( XFast-3) cooperates with XFast-1 in regulating gastrulation movements. , Howell M, Inman GJ, Hill CS ., Development. June 1, 2002; 129 (12): 2823-34.
Autoregulation of Xvent-2B; direct interaction and functional cooperation of Xvent-2 and Smad1. , Henningfeld KA , Friedle H, Rastegar S, Knöchel W ., J Biol Chem. January 18, 2002; 277 (3): 2097-103.
Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif. , Randall RA, Germain S, Inman GJ, Bates PA, Hill CS ., EMBO J. January 15, 2002; 21 (1-2): 145-56.
LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. , Smith DP, Rayter SI, Niederlander C, Spicer J, Jones CM , Ashworth A., Hum Mol Genet. December 1, 2001; 10 (25): 2869-77.
Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability. , Maurice D, Pierreux CE, Howell M, Wilentz RE, Owen MJ, Hill CS ., J Biol Chem. November 16, 2001; 276 (46): 43175-81.
Expression cloning of Xenopus Os4, an evolutionarily conserved gene, which induces mesoderm and dorsal axis. , Zohn IE, Brivanlou AH ., Dev Biol. November 1, 2001; 239 (1): 118-31.
The transcriptional role of Smads and FAST ( FoxH1) in TGFbeta and activin signalling. , Attisano L, Silvestri C, Izzi L, Labbé E., Mol Cell Endocrinol. June 30, 2001; 180 (1-2): 3-11.
Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling. , Shimizu K, Bourillot PY, Nielsen SJ, Zorn AM , Gurdon JB ., Mol Cell Biol. June 1, 2001; 21 (12): 3901-12.
Identification of two regulatory elements within the high mobility group box transcription factor XTCF-4. , Pukrop T, Gradl D , Henningfeld KA , Knochel W , Wedlich D , Kuhl M., J Biol Chem. March 23, 2001; 276 (12): 8968-78.
Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. , Wang W, Mariani FV , Harland RM , Luo K., Proc Natl Acad Sci U S A. December 19, 2000; 97 (26): 14394-9.
Recombinant expression and purification of smad proteins. , Funaba M, Mathews LS., Protein Expr Purif. December 1, 2000; 20 (3): 507-13.
Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus. , Pierreux CE, Nicolás FJ, Hill CS ., Mol Cell Biol. December 1, 2000; 20 (23): 9041-54.
Identification and characterization of constitutively active Smad2 mutants: evaluation of formation of Smad complex and subcellular distribution. , Funaba M, Mathews LS., Mol Endocrinol. October 1, 2000; 14 (10): 1583-91.
Expression regulation of hyaluronan synthase in corneal endothelial cells. , Usui T, Amano S, Oshika T, Suzuki K, Miyata K, Araie M, Heldin P, Yamashita H., Invest Ophthalmol Vis Sci. October 1, 2000; 41 (11): 3261-7.
Structural basis for the functional difference between Smad2 and Smad3 in FAST-2 (forkhead activin signal transducer-2)-mediated transcription. , Nagarajan RP, Chen Y ., Biochem J. August 15, 2000; 350 Pt 1 253-9.
Smad1 and Smad4 are components of the bone morphogenetic protein-4 ( BMP-4)-induced transcription complex of the Xvent-2B promoter. , Henningfeld KA , Rastegar S, Adler G, Knöchel W ., J Biol Chem. July 21, 2000; 275 (29): 21827-35.
A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction. , Kim RH, Wang D, Tsang M , Martin J, Huff C, de Caestecker MP, Parks WT, Meng X, Lechleider RJ, Wang T, Roberts AB ., Genes Dev. July 1, 2000; 14 (13): 1605-16.
Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB. , Nagarajan RP, Chen F, Li W , Vig E, Harrington MA, Nakshatri H, Chen Y ., Biochem J. June 15, 2000; 348 Pt 3 591-6.
Mouse smad8 phosphorylation downstream of BMP receptors ALK-2, ALK-3, and ALK-6 induces its association with Smad4 and transcriptional activity. , Kawai S, Faucheu C, Gallea S, Spinella-Jaegle S, Atfi A, Baron R, Roman SR., Biochem Biophys Res Commun. May 19, 2000; 271 (3): 682-7.
Heterogeneities in the biological and biochemical functions of Smad2 and Smad4 mutants naturally occurring in human lung cancers. , Yanagisawa K, Uchida K, Nagatake M, Masuda A, Sugiyama M, Saito T, Yamaki K, Takahashi T, Osada H., Oncogene. May 4, 2000; 19 (19): 2305-11.
Cloning and characterization of zebrafish smad2, smad3 and smad4. , Dick A, Mayr T, Bauer H, Meier A, Hammerschmidt M., Gene. April 4, 2000; 246 (1-2): 69-80.
Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. , Nishita M, Hashimoto MK, Ogata S, Laurent MN, Ueno N , Shibuya H , Cho KW ., Nature. February 17, 2000; 403 (6771): 781-5.
Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. , Germain S, Howell M, Esslemont GM, Hill CS ., Genes Dev. February 15, 2000; 14 (4): 435-51.
Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling. , Sirard C, Kim S, Mirtsos C, Tadich P, Hoodless PA, Itié A, Maxson R, Wrana JL, Mak TW., J Biol Chem. January 21, 2000; 275 (3): 2063-70.
Activation of Stat3 by cytokine receptor gp130 ventralizes Xenopus embryos independent of BMP-4. , Nishinakamura R, Matsumoto Y, Matsuda T, Ariizumi T, Heike T, Asashima M , Yokota T., Dev Biol. December 15, 1999; 216 (2): 481-90.
FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo. , Watanabe M, Whitman M ., Development. December 1, 1999; 126 (24): 5621-34.
Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding. , Nagarajan RP, Liu J , Chen Y ., J Biol Chem. October 29, 1999; 274 (44): 31229-35.
Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes. , Howell M, Itoh F, Pierreux CE, Valgeirsdottir S, Itoh S, ten Dijke P, Hill CS ., Dev Biol. October 15, 1999; 214 (2): 354-69.
The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis. , Yeo CY, Chen X, Whitman M ., J Biol Chem. September 10, 1999; 274 (37): 26584-90.
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. , Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH ., Nature. August 12, 1999; 400 (6745): 687-93.
Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals. , Christian JL , Nakayama T ., Bioessays. May 1, 1999; 21 (5): 382-90.