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Profile Publications (55)

Publications By Ethan Lee

Results 1 - 50 of 55 results

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Mosaicism-independent mechanisms contribute to Pcdh19-related epilepsy and repetitive behaviors in Xenopus., Park J, Lee E, Kim CH, Ohk J, Jung H., Proc Natl Acad Sci U S A. May 21, 2024; 121 (21): e2321388121.

The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling., Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E., Nat Commun. October 5, 2023; 14 (1): 6173.                                

USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling., Kassel S, Hanson AJ, Benchabane H, Saito-Diaz K, Cabel CR, Goldsmith L, Taha M, Kanuganti A, Ng VH, Xu G, Ye F, Picker J, Port F, Boutros M, Weiss VL, Robbins DJ, Thorne CA, Ahmed Y, Lee E., Sci Signal. February 7, 2023; 16 (771): eabn8372.

Tracking the movement of discrete gating charges in a voltage-gated potassium channel., Priest MF, Lee EE, Bezanilla F., Elife. November 15, 2021; 10                     

The acute effects of hydrocortisone on cardiac electrocardiography, action potentials, intracellular calcium, and contraction: The role of protein kinase C., Park MH, Park SI, Kim JH, Yu J, Lee EH, Seo SR, Jo SH., Mol Cell Endocrinol. August 20, 2019; 494 110488.

Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway., Neitzel LR, Spencer ZT, Nayak A, Cselenyi CS, Benchabane H, Youngblood CQ, Zouaoui A, Ng V, Stephens L, Hann T, Patton JG, Robbins D, Ahmed Y, Lee E., Mech Dev. April 1, 2019; 156 20-31.                              

Methodological improvements for fluorescence recordings in Xenopus laevis oocytes., Lee EEL, Bezanilla F., J Gen Physiol. February 4, 2019; 151 (2): 264-272.            

Chemical Screening Using Cell-Free Xenopus Egg Extract., Broadus MR, Lee E., Cold Spring Harb Protoc. August 1, 2018; 2018 (8):

Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling., Ng VH, Hang BI, Sawyer LM, Neitzel LR, Crispi EE, Rose KL, Popay TM, Zhong A, Lee LA, Tansey WP, Huppert S, Lee E., J Cell Sci. May 22, 2018; 131 (10):         

Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors., Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ., Sci Signal. June 27, 2017; 10 (485):

Development of light-driven gas-forming liposomes for efficient tumor treatment., Lee JM, Youn YS, Lee ES., Int J Pharm. June 15, 2017; 525 (1): 218-225.

The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development., Erdogan B, Cammarata GM, Lee EJ, Pratt BC, Francl AF, Rutherford EL, Lowery LA., Neural Dev. February 15, 2017; 12 (1): 3.        

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron., Broadus MR, Chen TW, Neitzel LR, Ng VH, Jodoin JN, Lee LA, Salic A, Robbins DJ, Capobianco AJ, Patton JG, Huppert SS, Lee E., Cell Rep. May 31, 2016; 15 (9): 1920-9.

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase., Wang Z, Tacchelly-Benites O, Yang E, Thorne CA, Nojima H, Lee E, Ahmed Y., Genetics. May 1, 2016; 203 (1): 269-81.

ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging., Lee E, Choi J, Jo Y, Kim JY, Jang YJ, Lee HM, Kim SY, Lee HJ, Cho K, Jung N, Hur EM, Jeong SJ, Moon C, Choe Y, Rhyu IJ, Kim H, Sun W., Sci Rep. January 11, 2016; 6 18631.                    

Reconstitution of the Cytoplasmic Regulation of the Wnt Signaling Pathway Using Xenopus Egg Extracts., Hyde AS, Hang BI, Lee E., Methods Mol Biol. January 1, 2016; 1481 101-9.

Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation., Meng L, Park JE, Kim TS, Lee EH, Park SY, Zhou M, Bang JK, Lee KS., Mol Cell Biol. August 1, 2015; 35 (15): 2626-40.

Peptoid-Substituted Hybrid Antimicrobial Peptide Derived from Papiliocin and Magainin 2 with Enhanced Bacterial Selectivity and Anti-inflammatory Activity., Shin A, Lee E, Jeon D, Park YG, Bang JK, Park YS, Shin SY, Kim Y., Biochemistry. June 30, 2015; 54 (25): 3921-31.

A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome., Lee EE, Ma J, Sacharidou A, Mi W, Salato VK, Nguyen N, Jiang Y, Pascual JM, North PE, Shaul PW, Mettlen M, Wang RC., Mol Cell. June 4, 2015; 58 (5): 845-53.

Distinct action of the α-glucosidase inhibitor miglitol on SGLT3, enteroendocrine cells, and GLP1 secretion., Lee EY, Kaneko S, Jutabha P, Zhang X, Seino S, Jomori T, Anzai N, Miki T., J Endocrinol. March 1, 2015; 224 (3): 205-14.            

Small-molecule high-throughput screening utilizing Xenopus egg extract., Broadus MR, Yew PR, Hann SR, Lee E., Methods Mol Biol. January 1, 2015; 1263 63-73.

The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex., Hainline SG, Rickmyre JL, Neitzel LR, Lee LA, Lee E., Biol Open. June 27, 2014; 3 (7): 669-76.          

Reconstitution Of β-catenin degradation in Xenopus egg extract., Chen TW, Broadus MR, Huppert SS, Lee E., J Vis Exp. June 17, 2014; (88):

Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks., Lee EM, Trinh TT, Shim HJ, Park SY, Nguyen TT, Kim MJ, Song YH., DNA Repair (Amst). September 1, 2012; 11 (9): 741-52.

Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs., Hang BI, Thorne CA, Robbins DJ, Huppert SS, Lee LA, Lee E., Bioorg Med Chem. March 15, 2012; 20 (6): 1869-77.

XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling., Hanson AJ, Wallace HA, Freeman TJ, Beauchamp RD, Lee LA, Lee E., Mol Cell. March 9, 2012; 45 (5): 619-28.  

A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts., Thorne CA, Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, Lee LA, Robbins DJ, Huppert SS, Lee E., J Biomol Screen. October 1, 2011; 16 (9): 995-1006.

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α., Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E., Nat Chem Biol. November 1, 2010; 6 (11): 829-36.

Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity., Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E., Sci Signal. May 11, 2010; 3 (121): ra37.

DeltaNp63 antagonizes p53 to regulate mesoderm induction in Xenopus laevis., Barton CE, Tahinci E, Barbieri CE, Johnson KN, Hanson AJ, Jernigan KK, Chen TW, Lee E, Pietenpol JA., Dev Biol. May 1, 2009; 329 (1): 130-9.            

Species-specific variation of RPA-interacting protein (RIP) splice isoforms., Kim K, Lee EJ, Lee SH, Seo T, Jang IS, Park J, Lee JH., BMB Rep. January 31, 2009; 42 (1): 22-7.

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin., Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E., Proc Natl Acad Sci U S A. June 10, 2008; 105 (23): 8032-7.        

Context-dependent activation or inhibition of Wnt-beta-catenin signaling by Kremen., Cselenyi CS, Lee E., Sci Signal. February 26, 2008; 1 (8): pe10.

Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription., Moore AC, Amann JM, Williams CS, Tahinci E, Farmer TE, Martinez JA, Yang G, Luce KS, Lee E, Hiebert SW., Mol Cell Biol. February 1, 2008; 28 (3): 977-87.

Lrp6 is required for convergent extension during Xenopus gastrulation., Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E., Development. November 1, 2007; 134 (22): 4095-106.

Lead discovery and optimization of T-type calcium channel blockers., Park JH, Choi JK, Lee E, Lee JK, Rhim H, Seo SH, Kim Y, Doddareddy MR, Pae AN, Kang J, Roh EJ., Bioorg Med Chem. February 1, 2007; 15 (3): 1409-19.

Optical frequency domain imaging with a rapidly swept laser in the 815-870 nm range., Lim H, de Boer JF, Park BH, Lee EC, Yelin R, Yun SH., Opt Express. June 26, 2006; 14 (13): 5937-44.

Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling., Morin RD, Chang E, Petrescu A, Liao N, Griffith M, Chow W, Kirkpatrick R, Butterfield YS, Young AC, Stott J, Barber S, Babakaiff R, Dickson MC, Matsuo C, Wong D, Yang GS, Smailus DE, Wetherby KD, Kwong PN, Grimwood J, Brinkley CP, Brown-John M, Reddix-Dugue ND, Mayo M, Schmutz J, Beland J, Park M, Gibson S, Olson T, Bouffard GG, Tsai M, Featherstone R, Chand S, Siddiqui AS, Jang W, Lee E, Klein SL, Blakesley RW, Zeeberg BR, Narasimhan S, Weinstein JN, Pennacchio CP, Myers RM, Green ED, Wagner L, Gerhard DS, Marra MA, Jones SJ, Holt RA., Genome Res. June 1, 2006; 16 (6): 796-803.

Characterization of peripherin/rds and rom-1 transport in rod photoreceptors of transgenic and knockout animals., Lee ES, Burnside B, Flannery JG., Invest Ophthalmol Vis Sci. May 1, 2006; 47 (5): 2150-60.

Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3)., Hu H, Endres CJ, Chang C, Umapathy NS, Lee EW, Fei YJ, Itagaki S, Swaan PW, Ganapathy V, Unadkat JD., Mol Pharmacol. May 1, 2006; 69 (5): 1542-53.

Zinc activates TREK-2 potassium channel activity., Kim JS, Park JY, Kang HW, Lee EJ, Bang H, Lee JH., J Pharmacol Exp Ther. August 1, 2005; 314 (2): 618-25.

Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator., Lee LA, Lee E, Anderson MA, Vardy L, Tahinci E, Ali SM, Kashevsky H, Benasutti M, Kirschner MW, Orr-Weaver TL., Dev Cell. March 1, 2005; 8 (3): 435-42.  

The Biomolecular Interaction Network Database and related tools 2005 update., Alfarano C, Andrade CE, Anthony K, Bahroos N, Bajec M, Bantoft K, Betel D, Bobechko B, Boutilier K, Burgess E, Buzadzija K, Cavero R, D'Abreo C, Donaldson I, Dorairajoo D, Dumontier MJ, Dumontier MR, Earles V, Farrall R, Feldman H, Garderman E, Gong Y, Gonzaga R, Grytsan V, Gryz E, Gu V, Haldorsen E, Halupa A, Haw R, Hrvojic A, Hurrell L, Isserlin R, Jack F, Juma F, Khan A, Kon T, Konopinsky S, Le V, Lee E, Ling S, Magidin M, Moniakis J, Montojo J, Moore S, Muskat B, Ng I, Paraiso JP, Parker B, Pintilie G, Pirone R, Salama JJ, Sgro S, Shan T, Shu Y, Siew J, Skinner D, Snyder K, Stasiuk R, Strumpf D, Tuekam B, Tao S, Wang Z, White M, Willis R, Wolting C, Wong S, Wrong A, Xin C, Yao R, Yates B, Zhang S, Zheng K, Pawson T, Ouellette BF, Hogue CW., Nucleic Acids Res. January 1, 2005; 33 (Database issue): D418-24.  

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team., Genome Res. October 1, 2004; 14 (10B): 2121-7.

The interface between cell and developmental biology., Tahinci E, Lee E., Curr Opin Genet Dev. August 1, 2004; 14 (4): 361-6.

Functional characterization of pendrin in a polarized cell system. Evidence for pendrin-mediated apical iodide efflux., Gillam MP, Sidhaye AR, Lee EJ, Rutishauser J, Stephan CW, Kopp P., J Biol Chem. March 26, 2004; 279 (13): 13004-10.

The Drosophila MOS ortholog is not essential for meiosis., Ivanovska I, Lee E, Kwan KM, Fenger DD, Orr-Weaver TL., Curr Biol. January 6, 2004; 14 (1): 75-80.  

The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway., Lee E, Salic A, Krüger R, Heinrich R, Kirschner MW., PLoS Biol. October 1, 2003; 1 (1): E10.                  

The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon., Post SM, Tomkinson AE, Lee EY., Nucleic Acids Res. October 1, 2003; 31 (19): 5568-75.

Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex., Pfleger CM, Lee E, Kirschner MW., Genes Dev. September 15, 2001; 15 (18): 2396-407.

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