Marc W. Kirschner - Publications

Publications (122)

XB-PERS-2118

Publications By Marc W. Kirschner

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Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands., Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW., Dev Biol. January 1, 2023; 493 67-79.
What makes the cell cycle tick? a celebration of the awesome power of biochemistry and the frog egg., Kirschner M., Mol Biol Cell. December 15, 2020; 31 (26): 2874-2878.
A cell type annotation Jamboree-Revival of а communal science forum., Peshkin L, Kirschner MW., Genesis. September 1, 2020; 58 (9): e23383.
The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution., Briggs JA, Weinreb C, Wagner DE, Megason S, Peshkin L, Kirschner MW, Klein AM., Science. June 1, 2018; 360 (6392):
Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg., Presler M, Van Itallie E, Klein AM, Kunz R, Coughlin ML, Peshkin L, Gygi SP, Wühr M, Kirschner MW., Proc Natl Acad Sci U S A. December 12, 2017; 114 (50): E10838-E10847.
On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development., Peshkin L, Wühr M, Pearl E, Haas W, Freeman RM, Gerhart JC, Klein AM, Horb M, Gygi SP, Kirschner MW., Dev Cell. November 9, 2015; 35 (3): 383-94.
The Nuclear Proteome of a Vertebrate., Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP., Curr Biol. October 19, 2015; 25 (20): 2663-71.
Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells., Klein AM, Mazutis L, Akartuna I, Tallapragada N, Veres A, Li V, Peshkin L, Weitz DA, Kirschner MW., Cell. May 21, 2015; 161 (5): 1187-201.
A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis., Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G., Cell. November 6, 2014; 159 (4): 844-56.
Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database., Wühr M, Freeman RM, Presler M, Horb ME, Peshkin L, Gygi S, Kirschner MW., Curr Biol. July 7, 2014; 24 (13): 1467-1475.
Exploiting polypharmacology for drug target deconvolution., Gujral TS, Peshkin L, Kirschner MW., Proc Natl Acad Sci U S A. April 1, 2014; 111 (13): 5048-53.
SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression., Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W., Cell Rep. August 29, 2013; 4 (4): 803-16.
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9., Gallop JL, Walrant A, Cantley LC, Kirschner MW., Proc Natl Acad Sci U S A. April 30, 2013; 110 (18): 7193-8.
Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster., Wühr M, Haas W, McAlister GC, Peshkin L, Rad R, Kirschner MW, Gygi SP., Anal Chem. November 6, 2012; 84 (21): 9214-21.
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner., Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, Mao X, Ma Q, Zamponi R, Bouwmeester T, Finan PM, Kirschner MW, Porter JA, Serluca FC, Cong F., Nature. April 29, 2012; 485 (7397): 195-200.
Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis., Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner M, Guillemot F, Philpott A., Development. October 1, 2011; 138 (19): 4267-77.
Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility., Yanai I, Peshkin L, Jorgensen P, Kirschner MW., Dev Cell. April 19, 2011; 20 (4): 483-96.
Remodeling of the metabolome during early frog development., Vastag L, Jorgensen P, Peshkin L, Wei R, Rabinowitz JD, Kirschner MW., PLoS One. February 4, 2011; 6 (2): e16881.
Self-assembly of filopodia-like structures on supported lipid bilayers., Lee K, Gallop JL, Rambani K, Kirschner MW., Science. September 10, 2010; 329 (5997): 1341-5.
Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling., Goentoro L, Kirschner MW., Mol Cell. December 11, 2009; 36 (5): 872-84.
The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus., Jorgensen P, Steen JA, Steen H, Kirschner MW., Development. May 1, 2009; 136 (9): 1539-48.
Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition., Wang R, He G, Nelman-Gonzalez M, Ashorn CL, Gallick GE, Stukenberg PT, Kirschner MW, Kuang J., Cell. March 23, 2007; 128 (6): 1119-32.
Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components., Peterson JR, Lebensohn AM, Pelish HE, Kirschner MW., Chem Biol. April 1, 2006; 13 (4): 443-52.
In vitro reconstitution of cdc42-mediated actin assembly using purified components., Ho HY, Rohatgi R, Lebensohn AM, Kirschner MW., Methods Enzymol. January 1, 2006; 406 174-90.
Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts., Lebensohn AM, Ma L, Ho HY, Kirschner MW., Methods Enzymol. January 1, 2006; 406 156-73.
A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis., Kwan KM, Kirschner MW., Development. October 1, 2005; 132 (20): 4599-610.
Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates., Rankin S, Ayad NG, Kirschner MW., Mol Cell. April 15, 2005; 18 (2): 185-200.
Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator., Lee LA, Lee E, Anderson MA, Vardy L, Tahinci E, Ali SM, Kashevsky H, Benasutti M, Kirschner MW, Orr-Weaver TL., Dev Cell. March 1, 2005; 8 (3): 435-42.
Identification of ubiquitin ligase substrates by in vitro expression cloning., Ayad NG, Rankin S, Ooi D, Rape M, Kirschner MW., Methods Enzymol. January 1, 2005; 399 404-14.
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation., Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK., Nat Struct Mol Biol. August 1, 2004; 11 (8): 747-55.
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex., Ho HY, Rohatgi R, Lebensohn AM, Le Ma, Li J, Gygi SP, Kirschner MW., Cell. July 23, 2004; 118 (2): 203-16.
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex., Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG., Nature. March 11, 2004; 428 (6979): 194-8.
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly., Campellone KG, Rankin S, Pawson T, Kirschner MW, Tipper DJ, Leong JM., J Cell Biol. February 2, 2004; 164 (3): 407-16.
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway., Lee E, Salic A, Krüger R, Heinrich R, Kirschner MW., PLoS Biol. October 1, 2003; 1 (1): E10.
Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula., Kwan KM, Kirschner MW., Development. May 1, 2003; 130 (9): 1961-72.
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC., Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, Kirschner MW., Cell. April 4, 2003; 113 (1): 101-13.
The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm., Collavin L, Kirschner MW., Development. February 1, 2003; 130 (4): 805-16.
Regulated proteolysis of Xom mediates dorsoventral pattern formation during early Xenopus development., Zhu Z, Kirschner M., Dev Cell. October 1, 2002; 3 (4): 557-68.
A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling., Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO., J Biol Chem. September 20, 2002; 277 (38): 34727-35.
Timing of events in mitosis., Georgi AB, Stukenberg PT, Kirschner MW., Curr Biol. January 22, 2002; 12 (2): 105-14.
Dual inhibition of sister chromatid separation at metaphase., Stemmann O, Zou H, Gerber SA, Gygi SP, Kirschner MW., Cell. December 14, 2001; 107 (6): 715-26.
The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction., Wan Y, Liu X, Kirschner MW., Mol Cell. November 1, 2001; 8 (5): 1027-39.
Molecular targets of vertebrate segmentation: two mechanisms control segmental expression of Xenopus hairy2 during somite formation., Davis RL, Turner DL, Evans LM, Kirschner MW., Dev Cell. October 1, 2001; 1 (4): 553-65.
CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family., Ho HY, Rohatgi R, Ma L, Kirschner MW., Proc Natl Acad Sci U S A. September 25, 2001; 98 (20): 11306-11.
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex., Pfleger CM, Lee E, Kirschner MW., Genes Dev. September 15, 2001; 15 (18): 2396-407.
A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions., Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW., Proc Natl Acad Sci U S A. September 11, 2001; 98 (19): 10624-9.
Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon., Lee E, Salic A, Kirschner MW., J Cell Biol. September 3, 2001; 154 (5): 983-93.
Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1., Pfleger CM, Salic A, Lee E, Kirschner MW., Genes Dev. July 15, 2001; 15 (14): 1759-64.
Pin1 acts catalytically to promote a conformational change in Cdc25., Stukenberg PT, Kirschner MW., Mol Cell. May 1, 2001; 7 (5): 1071-83.
LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome., Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA., Neuron. December 1, 2000; 28 (3): 665-79.

Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands., Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW., Dev Biol. January 1, 2023; 493 67-79.

What makes the cell cycle tick? a celebration of the awesome power of biochemistry and the frog egg., Kirschner M., Mol Biol Cell. December 15, 2020; 31 (26): 2874-2878.

A cell type annotation Jamboree-Revival of а communal science forum., Peshkin L, Kirschner MW., Genesis. September 1, 2020; 58 (9): e23383.

The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution., Briggs JA, Weinreb C, Wagner DE, Megason S, Peshkin L, Kirschner MW, Klein AM., Science. June 1, 2018; 360 (6392):

Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg., Presler M, Van Itallie E, Klein AM, Kunz R, Coughlin ML, Peshkin L, Gygi SP, Wühr M, Kirschner MW., Proc Natl Acad Sci U S A. December 12, 2017; 114 (50): E10838-E10847.

On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development., Peshkin L, Wühr M, Pearl E, Haas W, Freeman RM, Gerhart JC, Klein AM, Horb M, Gygi SP, Kirschner MW., Dev Cell. November 9, 2015; 35 (3): 383-94.

The Nuclear Proteome of a Vertebrate., Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP., Curr Biol. October 19, 2015; 25 (20): 2663-71.

Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells., Klein AM, Mazutis L, Akartuna I, Tallapragada N, Veres A, Li V, Peshkin L, Weitz DA, Kirschner MW., Cell. May 21, 2015; 161 (5): 1187-201.

A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis., Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G., Cell. November 6, 2014; 159 (4): 844-56.

Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database., Wühr M, Freeman RM, Presler M, Horb ME, Peshkin L, Gygi S, Kirschner MW., Curr Biol. July 7, 2014; 24 (13): 1467-1475.

Exploiting polypharmacology for drug target deconvolution., Gujral TS, Peshkin L, Kirschner MW., Proc Natl Acad Sci U S A. April 1, 2014; 111 (13): 5048-53.

SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression., Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W., Cell Rep. August 29, 2013; 4 (4): 803-16.

Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9., Gallop JL, Walrant A, Cantley LC, Kirschner MW., Proc Natl Acad Sci U S A. April 30, 2013; 110 (18): 7193-8.

Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster., Wühr M, Haas W, McAlister GC, Peshkin L, Rad R, Kirschner MW, Gygi SP., Anal Chem. November 6, 2012; 84 (21): 9214-21.

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner., Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, Mao X, Ma Q, Zamponi R, Bouwmeester T, Finan PM, Kirschner MW, Porter JA, Serluca FC, Cong F., Nature. April 29, 2012; 485 (7397): 195-200.

Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis., Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner M, Guillemot F, Philpott A., Development. October 1, 2011; 138 (19): 4267-77.

Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility., Yanai I, Peshkin L, Jorgensen P, Kirschner MW., Dev Cell. April 19, 2011; 20 (4): 483-96.

Remodeling of the metabolome during early frog development., Vastag L, Jorgensen P, Peshkin L, Wei R, Rabinowitz JD, Kirschner MW., PLoS One. February 4, 2011; 6 (2): e16881.

Self-assembly of filopodia-like structures on supported lipid bilayers., Lee K, Gallop JL, Rambani K, Kirschner MW., Science. September 10, 2010; 329 (5997): 1341-5.

Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling., Goentoro L, Kirschner MW., Mol Cell. December 11, 2009; 36 (5): 872-84.

The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus., Jorgensen P, Steen JA, Steen H, Kirschner MW., Development. May 1, 2009; 136 (9): 1539-48.

Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition., Wang R, He G, Nelman-Gonzalez M, Ashorn CL, Gallick GE, Stukenberg PT, Kirschner MW, Kuang J., Cell. March 23, 2007; 128 (6): 1119-32.

Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components., Peterson JR, Lebensohn AM, Pelish HE, Kirschner MW., Chem Biol. April 1, 2006; 13 (4): 443-52.

In vitro reconstitution of cdc42-mediated actin assembly using purified components., Ho HY, Rohatgi R, Lebensohn AM, Kirschner MW., Methods Enzymol. January 1, 2006; 406 174-90.

Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts., Lebensohn AM, Ma L, Ho HY, Kirschner MW., Methods Enzymol. January 1, 2006; 406 156-73.

A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis., Kwan KM, Kirschner MW., Development. October 1, 2005; 132 (20): 4599-610.

Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates., Rankin S, Ayad NG, Kirschner MW., Mol Cell. April 15, 2005; 18 (2): 185-200.

Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator., Lee LA, Lee E, Anderson MA, Vardy L, Tahinci E, Ali SM, Kashevsky H, Benasutti M, Kirschner MW, Orr-Weaver TL., Dev Cell. March 1, 2005; 8 (3): 435-42.

Identification of ubiquitin ligase substrates by in vitro expression cloning., Ayad NG, Rankin S, Ooi D, Rape M, Kirschner MW., Methods Enzymol. January 1, 2005; 399 404-14.

Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation., Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK., Nat Struct Mol Biol. August 1, 2004; 11 (8): 747-55.

Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex., Ho HY, Rohatgi R, Lebensohn AM, Le Ma, Li J, Gygi SP, Kirschner MW., Cell. July 23, 2004; 118 (2): 203-16.

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex., Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG., Nature. March 11, 2004; 428 (6979): 194-8.

Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly., Campellone KG, Rankin S, Pawson T, Kirschner MW, Tipper DJ, Leong JM., J Cell Biol. February 2, 2004; 164 (3): 407-16.

The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway., Lee E, Salic A, Krüger R, Heinrich R, Kirschner MW., PLoS Biol. October 1, 2003; 1 (1): E10.

Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula., Kwan KM, Kirschner MW., Development. May 1, 2003; 130 (9): 1961-72.

Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC., Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, Kirschner MW., Cell. April 4, 2003; 113 (1): 101-13.

The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm., Collavin L, Kirschner MW., Development. February 1, 2003; 130 (4): 805-16.

Regulated proteolysis of Xom mediates dorsoventral pattern formation during early Xenopus development., Zhu Z, Kirschner M., Dev Cell. October 1, 2002; 3 (4): 557-68.

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling., Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO., J Biol Chem. September 20, 2002; 277 (38): 34727-35.

Timing of events in mitosis., Georgi AB, Stukenberg PT, Kirschner MW., Curr Biol. January 22, 2002; 12 (2): 105-14.

Dual inhibition of sister chromatid separation at metaphase., Stemmann O, Zou H, Gerber SA, Gygi SP, Kirschner MW., Cell. December 14, 2001; 107 (6): 715-26.

The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction., Wan Y, Liu X, Kirschner MW., Mol Cell. November 1, 2001; 8 (5): 1027-39.

Molecular targets of vertebrate segmentation: two mechanisms control segmental expression of Xenopus hairy2 during somite formation., Davis RL, Turner DL, Evans LM, Kirschner MW., Dev Cell. October 1, 2001; 1 (4): 553-65.

CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family., Ho HY, Rohatgi R, Ma L, Kirschner MW., Proc Natl Acad Sci U S A. September 25, 2001; 98 (20): 11306-11.

Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex., Pfleger CM, Lee E, Kirschner MW., Genes Dev. September 15, 2001; 15 (18): 2396-407.

A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions., Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW., Proc Natl Acad Sci U S A. September 11, 2001; 98 (19): 10624-9.

Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon., Lee E, Salic A, Kirschner MW., J Cell Biol. September 3, 2001; 154 (5): 983-93.

Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1., Pfleger CM, Salic A, Lee E, Kirschner MW., Genes Dev. July 15, 2001; 15 (14): 1759-64.

Pin1 acts catalytically to promote a conformational change in Cdc25., Stukenberg PT, Kirschner MW., Mol Cell. May 1, 2001; 7 (5): 1071-83.

LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome., Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA., Neuron. December 1, 2000; 28 (3): 665-79.

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