Yoshiki Sasai - Publications

Publications (40)

XB-PERS-1733

Publications By Yoshiki Sasai

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Scaling of dorsal-ventral patterning by embryo size-dependent degradation of Spemann's organizer signals., Inomata H, Shibata T, Haraguchi T, Sasai Y., Cell. June 6, 2013; 153 (6): 1296-311.
pTransgenesis: a cross-species, modular transgenesis resource., Love NR, Thuret R, Chen Y, Ishibashi S, Sabherwal N, Paredes R, Alves-Silva J, Dorey K, Noble AM, Guille MJ, Sasai Y, Papalopulu N, Amaya E., Development. December 1, 2011; 138 (24): 5451-8.
Self-organizing optic-cup morphogenesis in three-dimensional culture., Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, Sekiguchi K, Adachi T, Sasai Y., Nature. April 7, 2011; 472 (7341): 51-6.
Intrinsic transition of embryonic stem-cell differentiation into neural progenitors., Kamiya D, Banno S, Sasai N, Ohgushi M, Inomata H, Watanabe K, Kawada M, Yakura R, Kiyonari H, Nakao K, Jakt LM, Nishikawa S, Sasai Y., Nature. February 24, 2011; 470 (7335): 503-9.
Jiraiya attenuates BMP signaling by interfering with type II BMP receptors in neuroectodermal patterning., Aramaki T, Sasai N, Yakura R, Sasai Y., Dev Cell. October 19, 2010; 19 (4): 547-61.
Anterior neural development requires Del1, a matrix-associated protein that attenuates canonical Wnt signaling via the Ror2 pathway., Takai A, Inomata H, Arakawa A, Yakura R, Matsuo-Takasaki M, Sasai Y., Development. October 1, 2010; 137 (19): 3293-302.
Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation., Inomata H, Haraguchi T, Sasai Y., Cell. September 5, 2008; 134 (5): 854-65.
Bridging the gap from frog research to human therapy: a tale of neural differentiation in Xenopus animal caps and human pluripotent cells., Sasai Y, Ogushi M, Nagase T, Ando S., Dev Growth Differ. June 1, 2008; 50 Suppl 1 S47-55.
Ectodermal factor restricts mesoderm differentiation by inhibiting p53., Sasai N, Yakura R, Kamiya D, Nakazawa Y, Sasai Y., Cell. May 30, 2008; 133 (5): 878-90.
The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo., Arakawa A, Matsuo-Takasaki M, Takai A, Inomata H, Matsumura M, Ikeya M, Takahashi K, Miyachi Y, Sasai N, Sasai Y., Dev Biol. June 1, 2007; 306 (1): 160-9.
XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination., Onai T, Matsuo-Takasaki M, Inomata H, Aramaki T, Matsumura M, Yakura R, Sasai N, Sasai Y., EMBO J. May 2, 2007; 26 (9): 2350-60.
Functional analysis of chick ONT1 reveals distinguishable activities among olfactomedin-related signaling factors., Sakuragi M, Sasai N, Ikeya M, Kawada M, Onai T, Katahira T, Nakamura H, Sasai Y., Mech Dev. February 1, 2006; 123 (2): 114-23.
An essential role of Xenopus Foxi1a for ventral specification of the cephalic ectoderm during gastrulation., Matsuo-Takasaki M, Matsumura M, Sasai Y., Development. September 1, 2005; 132 (17): 3885-94.
Developmental biology: a blank canvas no more., Sasai Y., Nature. May 26, 2005; 435 (7041): 433-4.
Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm., Sato T, Sasai N, Sasai Y., Development. May 1, 2005; 132 (10): 2355-63.
The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements., Sasai N, Nakazawa Y, Haraguchi T, Sasai Y., Nat Cell Biol. August 1, 2004; 6 (8): 741-8.
Xenopus XsalF: anterior neuroectodermal specification by attenuating cellular responsiveness to Wnt signaling., Onai T, Sasai N, Matsui M, Sasai Y., Dev Cell. July 1, 2004; 7 (1): 95-106.
[Regulatory mechanisms of early neural development: lessons from Xenopus, mouse and primate studies]., Sasai Y., Seikagaku. April 1, 2002; 74 (4): 297-303.
Dorsalization of the neural tube by Xenopus tiarin, a novel patterning factor secreted by the flanking nonneural head ectoderm., Tsuda H, Sasai N, Matsuo-Takasaki M, Sakuragi M, Murakami Y, Sasai Y., Neuron. February 14, 2002; 33 (4): 515-28.
Requirement of FoxD3-class signaling for neural crest determination in Xenopus., Sasai N, Mizuseki K, Sasai Y., Development. July 1, 2001; 128 (13): 2525-36.
Roles of Sox factors in neural determination: conserved signaling in evolution?, Sasai Y., Int J Dev Biol. January 1, 2001; 45 (1): 321-6.
Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity., Kawasaki H, Mizuseki K, Nishikawa S, Kaneko S, Kuwana Y, Nakanishi S, Nishikawa SI, Sasai Y., Neuron. October 1, 2000; 28 (1): 31-40.
Xenopus kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline., Matsui M, Mizuseki K, Nakatani J, Nakanishi S, Sasai Y., Proc Natl Acad Sci U S A. May 9, 2000; 97 (10): 5291-6.
Xenopus Xenf: an early endodermal nuclear factor that is regulated in a pathway distinct from Sox17 and Mix-related gene pathways., Nakatani J, Mizuseki K, Tsuda H, Nakanishi S, Sasai Y., Mech Dev. March 1, 2000; 91 (1-2): 81-9.
Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm., Kishi M, Mizuseki K, Sasai N, Yamazaki H, Shiota K, Nakanishi S, Sasai Y., Development. February 1, 2000; 127 (4): 791-800.
A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner., Yamanaka Y, Mizuno T, Sasai Y, Kishi M, Takeda H, Kim CH, Hibi M, Hirano T., Genes Dev. August 1, 1998; 12 (15): 2345-53.
SoxD: an essential mediator of induction of anterior neural tissues in Xenopus embryos., Mizuseki K, Kishi M, Shiota K, Nakanishi S, Sasai Y., Neuron. July 1, 1998; 21 (1): 77-85.
Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction., Mizuseki K, Kishi M, Matsui M, Nakanishi S, Sasai Y., Development. February 1, 1998; 125 (4): 579-87.
Ectodermal patterning in vertebrate embryos., Sasai Y, De Robertis EM., Dev Biol. February 1, 1997; 182 (1): 5-20.
Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps., Sasai Y, Lu B, Piccolo S, De Robertis EM., EMBO J. September 2, 1996; 15 (17): 4547-55.
The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor., Holley SA, Neul JL, Attisano L, Wrana JL, Sasai Y, O'Connor MB, De Robertis EM, Ferguson EL., Cell. August 23, 1996; 86 (4): 607-17.
Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4., Piccolo S, Sasai Y, Lu B, De Robertis EM., Cell. August 23, 1996; 86 (4): 589-98.
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer., Bouwmeester T, Kim S, Sasai Y, Lu B, De Robertis EM., Nature. August 15, 1996; 382 (6592): 595-601.
A common plan for dorsoventral patterning in Bilateria., De Robertis EM, Sasai Y., Nature. March 7, 1996; 380 (6569): 37-40.
The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA., Steinbeisser H, Fainsod A, Niehrs C, Sasai Y, De Robertis EM., EMBO J. November 1, 1995; 14 (21): 5230-43.
Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus., Sasai Y, Lu B, Steinbeisser H, De Robertis EM., Nature. October 26, 1995; 377 (6551): 757.
Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus., Sasai Y, Lu B, Steinbeisser H, De Robertis EM., Nature. July 27, 1995; 376 (6538): 333-6.
A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin., Holley SA, Jackson PD, Sasai Y, Lu B, De Robertis EM, Hoffmann FM, Ferguson EL., Nature. July 20, 1995; 376 (6537): 249-53.
Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes., Sasai Y, Lu B, Steinbeisser H, Geissert D, Gont LK, De Robertis EM., Cell. December 2, 1994; 79 (5): 779-90.
Molecular characterization of a functional cDNA for rat substance P receptor., Yokota Y, Sasai Y, Tanaka K, Fujiwara T, Tsuchida K, Shigemoto R, Kakizuka A, Ohkubo H, Nakanishi S., J Biol Chem. October 25, 1989; 264 (30): 17649-52.

Scaling of dorsal-ventral patterning by embryo size-dependent degradation of Spemann's organizer signals., Inomata H, Shibata T, Haraguchi T, Sasai Y., Cell. June 6, 2013; 153 (6): 1296-311.

pTransgenesis: a cross-species, modular transgenesis resource., Love NR, Thuret R, Chen Y, Ishibashi S, Sabherwal N, Paredes R, Alves-Silva J, Dorey K, Noble AM, Guille MJ, Sasai Y, Papalopulu N, Amaya E., Development. December 1, 2011; 138 (24): 5451-8.

Self-organizing optic-cup morphogenesis in three-dimensional culture., Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, Sekiguchi K, Adachi T, Sasai Y., Nature. April 7, 2011; 472 (7341): 51-6.

Intrinsic transition of embryonic stem-cell differentiation into neural progenitors., Kamiya D, Banno S, Sasai N, Ohgushi M, Inomata H, Watanabe K, Kawada M, Yakura R, Kiyonari H, Nakao K, Jakt LM, Nishikawa S, Sasai Y., Nature. February 24, 2011; 470 (7335): 503-9.

Jiraiya attenuates BMP signaling by interfering with type II BMP receptors in neuroectodermal patterning., Aramaki T, Sasai N, Yakura R, Sasai Y., Dev Cell. October 19, 2010; 19 (4): 547-61.

Anterior neural development requires Del1, a matrix-associated protein that attenuates canonical Wnt signaling via the Ror2 pathway., Takai A, Inomata H, Arakawa A, Yakura R, Matsuo-Takasaki M, Sasai Y., Development. October 1, 2010; 137 (19): 3293-302.

Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation., Inomata H, Haraguchi T, Sasai Y., Cell. September 5, 2008; 134 (5): 854-65.

Bridging the gap from frog research to human therapy: a tale of neural differentiation in Xenopus animal caps and human pluripotent cells., Sasai Y, Ogushi M, Nagase T, Ando S., Dev Growth Differ. June 1, 2008; 50 Suppl 1 S47-55.

Ectodermal factor restricts mesoderm differentiation by inhibiting p53., Sasai N, Yakura R, Kamiya D, Nakazawa Y, Sasai Y., Cell. May 30, 2008; 133 (5): 878-90.

The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo., Arakawa A, Matsuo-Takasaki M, Takai A, Inomata H, Matsumura M, Ikeya M, Takahashi K, Miyachi Y, Sasai N, Sasai Y., Dev Biol. June 1, 2007; 306 (1): 160-9.

XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination., Onai T, Matsuo-Takasaki M, Inomata H, Aramaki T, Matsumura M, Yakura R, Sasai N, Sasai Y., EMBO J. May 2, 2007; 26 (9): 2350-60.

Functional analysis of chick ONT1 reveals distinguishable activities among olfactomedin-related signaling factors., Sakuragi M, Sasai N, Ikeya M, Kawada M, Onai T, Katahira T, Nakamura H, Sasai Y., Mech Dev. February 1, 2006; 123 (2): 114-23.

An essential role of Xenopus Foxi1a for ventral specification of the cephalic ectoderm during gastrulation., Matsuo-Takasaki M, Matsumura M, Sasai Y., Development. September 1, 2005; 132 (17): 3885-94.

Developmental biology: a blank canvas no more., Sasai Y., Nature. May 26, 2005; 435 (7041): 433-4.

Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm., Sato T, Sasai N, Sasai Y., Development. May 1, 2005; 132 (10): 2355-63.

The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements., Sasai N, Nakazawa Y, Haraguchi T, Sasai Y., Nat Cell Biol. August 1, 2004; 6 (8): 741-8.

Xenopus XsalF: anterior neuroectodermal specification by attenuating cellular responsiveness to Wnt signaling., Onai T, Sasai N, Matsui M, Sasai Y., Dev Cell. July 1, 2004; 7 (1): 95-106.

[Regulatory mechanisms of early neural development: lessons from Xenopus, mouse and primate studies]., Sasai Y., Seikagaku. April 1, 2002; 74 (4): 297-303.

Dorsalization of the neural tube by Xenopus tiarin, a novel patterning factor secreted by the flanking nonneural head ectoderm., Tsuda H, Sasai N, Matsuo-Takasaki M, Sakuragi M, Murakami Y, Sasai Y., Neuron. February 14, 2002; 33 (4): 515-28.

Requirement of FoxD3-class signaling for neural crest determination in Xenopus., Sasai N, Mizuseki K, Sasai Y., Development. July 1, 2001; 128 (13): 2525-36.

Roles of Sox factors in neural determination: conserved signaling in evolution?, Sasai Y., Int J Dev Biol. January 1, 2001; 45 (1): 321-6.

Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity., Kawasaki H, Mizuseki K, Nishikawa S, Kaneko S, Kuwana Y, Nakanishi S, Nishikawa SI, Sasai Y., Neuron. October 1, 2000; 28 (1): 31-40.

Xenopus kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline., Matsui M, Mizuseki K, Nakatani J, Nakanishi S, Sasai Y., Proc Natl Acad Sci U S A. May 9, 2000; 97 (10): 5291-6.

Xenopus Xenf: an early endodermal nuclear factor that is regulated in a pathway distinct from Sox17 and Mix-related gene pathways., Nakatani J, Mizuseki K, Tsuda H, Nakanishi S, Sasai Y., Mech Dev. March 1, 2000; 91 (1-2): 81-9.

Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm., Kishi M, Mizuseki K, Sasai N, Yamazaki H, Shiota K, Nakanishi S, Sasai Y., Development. February 1, 2000; 127 (4): 791-800.

A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner., Yamanaka Y, Mizuno T, Sasai Y, Kishi M, Takeda H, Kim CH, Hibi M, Hirano T., Genes Dev. August 1, 1998; 12 (15): 2345-53.

SoxD: an essential mediator of induction of anterior neural tissues in Xenopus embryos., Mizuseki K, Kishi M, Shiota K, Nakanishi S, Sasai Y., Neuron. July 1, 1998; 21 (1): 77-85.

Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction., Mizuseki K, Kishi M, Matsui M, Nakanishi S, Sasai Y., Development. February 1, 1998; 125 (4): 579-87.

Ectodermal patterning in vertebrate embryos., Sasai Y, De Robertis EM., Dev Biol. February 1, 1997; 182 (1): 5-20.

Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps., Sasai Y, Lu B, Piccolo S, De Robertis EM., EMBO J. September 2, 1996; 15 (17): 4547-55.

The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor., Holley SA, Neul JL, Attisano L, Wrana JL, Sasai Y, O'Connor MB, De Robertis EM, Ferguson EL., Cell. August 23, 1996; 86 (4): 607-17.

Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4., Piccolo S, Sasai Y, Lu B, De Robertis EM., Cell. August 23, 1996; 86 (4): 589-98.

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer., Bouwmeester T, Kim S, Sasai Y, Lu B, De Robertis EM., Nature. August 15, 1996; 382 (6592): 595-601.

A common plan for dorsoventral patterning in Bilateria., De Robertis EM, Sasai Y., Nature. March 7, 1996; 380 (6569): 37-40.

The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA., Steinbeisser H, Fainsod A, Niehrs C, Sasai Y, De Robertis EM., EMBO J. November 1, 1995; 14 (21): 5230-43.

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus., Sasai Y, Lu B, Steinbeisser H, De Robertis EM., Nature. October 26, 1995; 377 (6551): 757.

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus., Sasai Y, Lu B, Steinbeisser H, De Robertis EM., Nature. July 27, 1995; 376 (6538): 333-6.

A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin., Holley SA, Jackson PD, Sasai Y, Lu B, De Robertis EM, Hoffmann FM, Ferguson EL., Nature. July 20, 1995; 376 (6537): 249-53.

Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes., Sasai Y, Lu B, Steinbeisser H, Geissert D, Gont LK, De Robertis EM., Cell. December 2, 1994; 79 (5): 779-90.

Molecular characterization of a functional cDNA for rat substance P receptor., Yokota Y, Sasai Y, Tanaka K, Fujiwara T, Tsuchida K, Shigemoto R, Kakizuka A, Ohkubo H, Nakanishi S., J Biol Chem. October 25, 1989; 264 (30): 17649-52.

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