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XB-PERS-1977
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Name: Dr. Jan-Michael M Peters
Position: Senior Scientist
Research Description:
My lab studies mitosis and chromosome biology, where we ask the questions: How is sister chromatid cohesion established and maintained? How does cohesin control chromatin structure and gene regulation? How is sister chromatid cohesion dissolved during mitosis? How does the APC/C initiate anaphase? Although mitosis has been studied for more than a century, our molecular understanding of this complex process is far from complete. From 2004 to 2009, the MitoCheck consortium, funded by the European Union, developed and applied genomic and proteomic approaches to study mitosis. The consortium used RNA interference screens to identify proteins required for mitosis in human cells, tagging of genes in bacterial artificial chromosomes (BACs) to enable intracellular localization and affinity purification of these proteins, and mass spectrometry to identify protein complexes and mitosis-specific phosphorylation sites on these. This work led to the identification of about 100 human protein complexes, many of which had been previously unknown or poorly characterized. Importantly, the approaches developed by MitoCheck will be generally applicable to high throughput analyses of other processes in mammalian cells. In a new project funded by the European Union, known as MitoSys (2010 to 2015), we are developing quantitative assays for mitosis.
Lab Memberships
Peters Lab
(Principal Investigator/Director)
Contact Information
Address:
IMP
Research Institute of Molecular Pathology
Vienna BioCenter
Vienna
Austria
Web Page: http://www.imp.ac.at/groups/jan-michael-peters